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Entry version 97 (08 May 2019)
Sequence version 1 (01 Feb 2005)
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Protein

Clathrin heavy chain linker domain-containing protein 1

Gene

Clhc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin heavy chain linker domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Clhc1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920574 Clhc1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003258721 – 596Clathrin heavy chain linker domain-containing protein 1Add BLAST596

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5M6W3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5M6W3

PRoteomics IDEntifications database

More...
PRIDEi
Q5M6W3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5M6W3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5M6W3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020461 Expressed in 62 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5M6W3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5M6W3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000020753

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5M6W3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili129 – 241Sequence analysisAdd BLAST113

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0985 Eukaryota
ENOG410XPH1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183166

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060111

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5M6W3

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERVGCNE

Database of Orthologous Groups

More...
OrthoDBi
665507at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5M6W3

TreeFam database of animal gene trees

More...
TreeFami
TF328858

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR012331 Clathrin_H-chain_linker
IPR017212 CLHC1
IPR032755 TSNAXIP1_N

The PANTHER Classification System

More...
PANTHERi
PTHR10292:SF11 PTHR10292:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15739 TSNAXIP1_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037469 Clathrin_H-chain-rel, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5M6W3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVQEVNTHA VLPPIVSRND KEFLESIQRY ITTETKRVGC KEEGPADEYY
60 70 80 90 100
TIYRNVFDKF SATDRKIIFQ VIDYVSAYKS ILTAIKKEYD AFIETIKKGR
110 120 130 140 150
RTAFYLHGKL KVLAKEPTAL VYHQRRAIQL EAKMRIIENN STAIQLQIDQ
160 170 180 190 200
MKQLRMEYDK KEVKLCAPSR QLWKPIPGMT LQDSVNLEAL NKHKQYLEDK
210 220 230 240 250
YIKLKQDMST MYVPAQKKAE LDEEMVVLLN RRDIAENLKK DRQFRHQRLQ
260 270 280 290 300
VISHTLTPWM KQNMRISFQD VMERIRKTKA IYGYDNIVDE IFEDDPNKKK
310 320 330 340 350
EAIVMLHYIE RFNDLISLGE YERAACFAAN SPKRILQNTS TMNKFKAIGK
360 370 380 390 400
IRGKPLPLLL FFEAIFNTSQ AFKRPINADL TMEGIKCGLS EERLDLVTHW
410 420 430 440 450
VTQEKLTFSE KAGDIIFAYG EQHTYHKPRC LALAQIIYNE CGLHRKALLC
460 470 480 490 500
LCKQGQIHEA MEHIQQSKDI NTDDLIQLIT ACPQIDLIRC LTQERNEKPP
510 520 530 540 550
FLSFGLAVLH MFSVDMKKVG MRLLQEVSKG EKDVIEHLVM SDLFCSLEKW
560 570 580 590
QEIANICLQN GFKILFNDIM SILRSQAGVS EISEDDTTNI MEHVFW
Length:596
Mass (Da):69,414
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFD336583827B224
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZMV8B7ZMV8_MOUSE
Clathrin heavy chain linker domain-...
Clhc1 1700034F02Rik
585Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118T → K in BAB24663 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK006591 mRNA Translation: BAB24663.1
BX284634 Genomic DNA No translation available.
BC137683 mRNA Translation: AAI37684.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48763.1

NCBI Reference Sequences

More...
RefSeqi
NP_001156993.1, NM_001163521.1
NP_082780.1, NM_028504.1
XP_006514881.1, XM_006514818.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000020753; ENSMUSP00000020753; ENSMUSG00000020461

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
73324

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:73324

UCSC genome browser

More...
UCSCi
uc007ihi.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006591 mRNA Translation: BAB24663.1
BX284634 Genomic DNA No translation available.
BC137683 mRNA Translation: AAI37684.1
CCDSiCCDS48763.1
RefSeqiNP_001156993.1, NM_001163521.1
NP_082780.1, NM_028504.1
XP_006514881.1, XM_006514818.1

3D structure databases

SMRiQ5M6W3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020753

PTM databases

iPTMnetiQ5M6W3
PhosphoSitePlusiQ5M6W3

Proteomic databases

MaxQBiQ5M6W3
PaxDbiQ5M6W3
PRIDEiQ5M6W3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020753; ENSMUSP00000020753; ENSMUSG00000020461
GeneIDi73324
KEGGimmu:73324
UCSCiuc007ihi.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
130162
MGIiMGI:1920574 Clhc1

Phylogenomic databases

eggNOGiKOG0985 Eukaryota
ENOG410XPH1 LUCA
GeneTreeiENSGT00950000183166
HOGENOMiHOG000060111
InParanoidiQ5M6W3
OMAiERVGCNE
OrthoDBi665507at2759
PhylomeDBiQ5M6W3
TreeFamiTF328858

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5M6W3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020461 Expressed in 62 organ(s), highest expression level in testis
ExpressionAtlasiQ5M6W3 baseline and differential
GenevisibleiQ5M6W3 MM

Family and domain databases

Gene3Di1.25.40.30, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR012331 Clathrin_H-chain_linker
IPR017212 CLHC1
IPR032755 TSNAXIP1_N
PANTHERiPTHR10292:SF11 PTHR10292:SF11, 1 hit
PfamiView protein in Pfam
PF15739 TSNAXIP1_N, 1 hit
PIRSFiPIRSF037469 Clathrin_H-chain-rel, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLHC1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5M6W3
Secondary accession number(s): B2RQ04, Q9D9Q4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 1, 2005
Last modified: May 8, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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