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Entry version 120 (02 Jun 2021)
Sequence version 1 (01 Feb 2005)
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Protein

Ferrous iron transport protein B

Gene

feoB

Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transporter of a GTP-driven Fe2+ uptake system.

UniRule annotationARBA annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi126MagnesiumCombined sources1
Metal bindingi128MagnesiumCombined sources1
Metal bindingi211MagnesiumCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Iron transportUniRule annotation, Transport
LigandGTP-bindingUniRule annotationARBA annotation, Iron, MagnesiumCombined sources, Metal-bindingCombined sources, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ferrous iron transport protein BUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:feoBImported
Ordered Locus Names:stu0608Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri264199 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001170 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei281 – 299HelicalUniRule annotationAdd BLAST19
Transmembranei344 – 368HelicalUniRule annotationAdd BLAST25
Transmembranei453 – 473HelicalUniRule annotationAdd BLAST21
Transmembranei512 – 531HelicalUniRule annotationAdd BLAST20
Transmembranei609 – 631HelicalUniRule annotationAdd BLAST23
Transmembranei638 – 660HelicalUniRule annotationAdd BLAST23
Transmembranei672 – 691HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
264199.stu0608

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5M586

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5M586

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 162FeoB-type GInterPro annotationAdd BLAST162

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0370, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013350_2_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
MEMPDYE

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01879, FeoB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003373, Fe2_transport_prot-B
IPR011640, Fe2_transport_prot_B_C
IPR041069, FeoB_Cyto
IPR030389, G_FEOB_dom
IPR011642, Gate_dom
IPR006073, GTP-bd
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07664, FeoB_C, 1 hit
PF17910, FeoB_Cyto, 1 hit
PF02421, FeoB_N, 1 hit
PF07670, Gate, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00326, GTP1OBG

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00437, feoB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51711, G_FEOB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5M586-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEIALIGNP NSGKTSLFNL ITGHNQRVGN WPGVTVERKS GLVKKNKDLE
60 70 80 90 100
IQDLPGIYSM SPYSPEEKVA RDYLLSQRAD SILNVVDATN LERNLYLTTQ
110 120 130 140 150
LIETGIPVTI ALNMIDVLDG QGKKINVDKL SYHLGVPVVA TSALKQTGVD
160 170 180 190 200
QVVKKAAHTT TSTVGDLAFP IYDDRLEAAI SQILEVLGNS VPQRSARFYA
210 220 230 240 250
IKLFEQDSLV EAELDLSQFQ RKEIEDIIRI TEEIFTEDAE SIVINERYAF
260 270 280 290 300
IERVCQMAES HTEDFALTLS DKIDRIVTNR ILALPIFSVV MYLVYFLSIQ
310 320 330 340 350
TVGTMWTDWA NDVLFGKYVP DLVSSGLDYL QVQDWLKSLI VDGIVAGIGT
360 370 380 390 400
VLGFLPQIFV LFICLGVLED IGYMSRIAFV MDRIFRRFGL SGKSFIPMLI
410 420 430 440 450
STGCGVPAVM SSRTIENERD RRITIMTATF MPCSAKLEII ALIAGAFFPG
460 470 480 490 500
NSFVAPSTYF IGIATIILSG IALKKTSFLG GLTSPFIMEL PAYHWPKVLS
510 520 530 540 550
VLRYAFGKAM SFVKRAGTII FSLTVLIWFM SNYNFMLQNV DTEVSILATL
560 570 580 590 600
GKGLSWIFEP LGFGNWQATV AALAGLAAKE TVVATFGILY HNSSEAGLAT
610 620 630 640 650
ALQADYSALA AYSFLIFNLL CAPCFAAIGA IKREMANLRW TVGAIGFQTG
660 670 680 690 700
LAYCVSLILY QFGQVLLYGN PISLWTLVAV LFLVTMIYFV VRKPRQIKDK
710
IITLENLQEA NS
Length:712
Mass (Da):78,700
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD54840A567688ECF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000023 Genomic DNA Translation: AAV60314.1

NCBI Reference Sequences

More...
RefSeqi
WP_002946712.1, NC_006448.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAV60314; AAV60314; stu0608

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stl:stu0608

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|264199.4.peg.616

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000023 Genomic DNA Translation: AAV60314.1
RefSeqiWP_002946712.1, NC_006448.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B1VX-ray1.85A1-270[»]
3B1WX-ray2.50A/B/C/D1-270[»]
3B1XX-ray2.61A/B1-270[»]
3B1YX-ray2.50A1-270[»]
3B1ZX-ray2.65A1-270[»]
3LX5X-ray1.90A1-270[»]
3LX8X-ray2.90A1-270[»]
3SS8X-ray2.51A/B1-270[»]
3TAHX-ray1.85A/B1-270[»]
4NONX-ray2.50A/B1-260[»]
SMRiQ5M586
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi264199.stu0608

Genome annotation databases

EnsemblBacteriaiAAV60314; AAV60314; stu0608
KEGGistl:stu0608
PATRICifig|264199.4.peg.616

Phylogenomic databases

eggNOGiCOG0370, Bacteria
HOGENOMiCLU_013350_2_0_9
OMAiMEMPDYE

Miscellaneous databases

EvolutionaryTraceiQ5M586

Family and domain databases

CDDicd01879, FeoB, 1 hit
InterProiView protein in InterPro
IPR003373, Fe2_transport_prot-B
IPR011640, Fe2_transport_prot_B_C
IPR041069, FeoB_Cyto
IPR030389, G_FEOB_dom
IPR011642, Gate_dom
IPR006073, GTP-bd
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF07664, FeoB_C, 1 hit
PF17910, FeoB_Cyto, 1 hit
PF02421, FeoB_N, 1 hit
PF07670, Gate, 2 hits
PRINTSiPR00326, GTP1OBG
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00437, feoB, 1 hit
PROSITEiView protein in PROSITE
PS51711, G_FEOB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5M586_STRT2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5M586
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: June 2, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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