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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76SubstrateUniRule annotation1
Metal bindingi225ManganeseUniRule annotation1
Metal bindingi245Manganese; via tele nitrogenUniRule annotation1
Binding sitei267SubstrateUniRule annotation1
Active sitei269UniRule annotation1
Metal bindingi292ManganeseUniRule annotation1
Binding sitei383GTPUniRule annotation1
Binding sitei414GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi268 – 273GTPUniRule annotation6
Nucleotide bindingi508 – 511GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processGluconeogenesis
LigandGTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCABO218497:G1GI1-939-MONOMER
UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:CAB884
OrganismiChlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus)
Taxonomic identifieri218497 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000001012 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001035941 – 603Phosphoenolpyruvate carboxykinase [GTP]Add BLAST603

Proteomic databases

PRIDEiQ5L4X1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi218497.CAB884

Structurei

3D structure databases

ProteinModelPortaliQ5L4X1
SMRiQ5L4X1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni216 – 218Substrate bindingUniRule annotation3
Regioni381 – 383Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0M Bacteria
COG1274 LUCA
HOGENOMiHOG000191700
KOiK01596
OMAiCWLALTD
OrthoDBiPOG091H0B4F

Family and domain databases

CDDicd00819 PEPCK_GTP, 1 hit
Gene3Di3.40.449.10, 2 hits
3.90.228.20, 2 hits
HAMAPiMF_00452 PEPCK_GTP, 1 hit
InterProiView protein in InterPro
IPR018091 PEP_carboxykin_GTP_CS
IPR013035 PEP_carboxykinase_C
IPR008209 PEP_carboxykinase_GTP
IPR035077 PEP_carboxykinase_GTP_C
IPR035078 PEP_carboxykinase_GTP_N
IPR008210 PEP_carboxykinase_N
PANTHERiPTHR11561 PTHR11561, 1 hit
PfamiView protein in Pfam
PF00821 PEPCK_C, 1 hit
PF17297 PEPCK_N, 1 hit
PIRSFiPIRSF001348 PEP_carboxykinase_GTP, 1 hit
SUPFAMiSSF68923 SSF68923, 1 hit
PROSITEiView protein in PROSITE
PS00505 PEPCK_GTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q5L4X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVWSEAIQ HKDLKQWIQE VAELVTPKDI RICNGSDSEY VEIYGLMQQS
60 70 80 90 100
GVAIPLNRDV HPNCFLVRSS PEDVARVEQF TFICTKEQKD AGPTNNWRDP
110 120 130 140 150
EEMRQELHGL FRGCMRGRTL YVVPFCMGPL NSPFSLIGVE ITDSPYVVCS
160 170 180 190 200
MKIMTRMGEE VLKALGTSGS FHKCLHSVGV PLAPGEKDLA WPCNPQHMRI
210 220 230 240 250
VHFQDDSSVM SFGSGYGGNA LLGKKCVALR LASYIARSQG WLAEHMLIIG
260 270 280 290 300
VTNPEGQKKY FAASFPSACG KTNLAMLKPK IPGWKVECVG DDIAWIRPGP
310 320 330 340 350
DGRLYAVNPE FGFFGVAPGT SATTNPNALA TCTSNSIFTN VALTPDGDVW
360 370 380 390 400
WEGLTSQPPE GLIDWQGKPW KPGGAPAAHP NSRFTTPVQQ CPVLDPQWNS
410 420 430 440 450
PEGVPIEAMI FGGRRSETIP LVYEALSWQH GVTIGASMSS ATTAASVGEQ
460 470 480 490 500
GKLRHDPFAM LPFCGYNMAH YFDHWLSFAS NTSLKLPKIY GVNWFRKDKN
510 520 530 540 550
GNFIWPGFSD NLRVLEWIFR RTNGEESIAK KTPIGYLPEE SALNLEGLNL
560 570 580 590 600
STQALQDLLS VDVPGWLKEV ANVREYCKIF GSDLPQAITD ELFRIENELK

IIK
Length:603
Mass (Da):66,780
Last modified:June 21, 2005 - v1
Checksum:iBF614C7F35CDC83F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848038 Genomic DNA Translation: CAH64324.1
RefSeqiWP_011097399.1, NC_004552.2

Genome annotation databases

EnsemblBacteriaiCAH64324; CAH64324; CAB884
KEGGicab:CAB884

Similar proteinsi

Entry informationi

Entry nameiPCKG_CHLAB
AccessioniPrimary (citable) accession number: Q5L4X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 21, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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