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UniProtKB - Q5L478 (Q5L478_9HEPC)
Protein
Submitted name:
Nonstructural protein 5A
Gene
NS5A
Organism
Hepacivirus C
Status
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
- nucleoside-triphosphatase activity Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: InterPro
- serine-type endopeptidase activity Source: InterPro
- zinc ion binding Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Nonstructural protein 5AImported |
Gene namesi | Name:NS5AImported |
Organismi | Hepacivirus CImported |
Taxonomic identifieri | 11103 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Kitrinoviricota › Flasuviricetes › Amarillovirales › Flaviviridae › Hepacivirus |
Pathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL3307224 |
DrugBanki | DB09102, Daclatasvir DB11574, Elbasvir DB09027, Ledipasvir DB09296, Ombitasvir DB13878, Pibrentasvir DB11613, Velpatasvir |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 24 | HCV_NS5aInterPro annotationAdd BLAST | 23 | |
Domaini | 34 – 95 | HCV_NS5a_1aInterPro annotationAdd BLAST | 62 | |
Domaini | 96 – 196 | HCV_NS5a_1bInterPro annotationAdd BLAST | 101 | |
Domaini | 207 – 447 | HCV_NS5a_CInterPro annotationAdd BLAST | 241 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 216 – 247 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 379 – 447 | DisorderedSequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 223 – 245 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 379 – 393 | Polar residuesSequence analysisAdd BLAST | 15 |
Family and domain databases
Gene3Di | 2.20.25.210, 1 hit 2.20.25.220, 1 hit |
InterProi | View protein in InterPro IPR002868, HCV_NS5a IPR013193, HCV_NS5a_1B_dom IPR038568, HCV_NS5A_1B_sf IPR024350, HCV_NS5a_C IPR013192, NS5A_1a IPR038170, NS5A_1a_sf |
Pfami | View protein in Pfam PF01506, HCV_NS5a, 1 hit PF08300, HCV_NS5a_1a, 1 hit PF08301, HCV_NS5a_1b, 1 hit PF12941, HCV_NS5a_C, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q5L478-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SGSWLRDVWD WICTVLTDFK TWLQSKLLPR IPGVPFLSCQ RGYKGVWRGD
60 70 80 90 100
GIMHTTCPCG AQITGHVKNG SMRIVGPKTC SNTWHGTFPI NTYTTGPCTP
110 120 130 140 150
SPAPNYSRAL WRVAAEEYVE VTRVGDFHYV TGMTTDNVKC PCQVPAPEFF
160 170 180 190 200
TEVDGVRLHR YAPACKPLLR EEVTFMVGLN QYLVGSQLPC EPEPDVTVLT
210 220 230 240 250
SMLTDPSHIT AETAGRRLAR GSPPSLASSS ASQLSAPSLK ATCTTRHDSP
260 270 280 290 300
DADLIEANLL WRQEMGGNIT RVESENKVVI LDSFDPLQAE EDEREVSVPA
310 320 330 340 350
EILRKSRKFP RAMPIWARPD YNPPLLESWK DPDYVPPVVH GCPLPPAKAP
360 370 380 390 400
PIPPPRRKRT VVLTESTVSS ALAELATKTF GSSGSSAVDS GTATAPPDQL
410 420 430 440
PGDGDSGSDV ESYSSMPPLE GEPGDPDLSD GSWSTMSEEA SEDVVCC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 447 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY808015 Genomic RNA Translation: AAV83510.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY808015 Genomic RNA Translation: AAV83510.1 |
3D structure databases
SMRi | Q5L478 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q5L478 |
ChEMBLi | CHEMBL3307224 |
DrugBanki | DB09102, Daclatasvir DB11574, Elbasvir DB09027, Ledipasvir DB09296, Ombitasvir DB13878, Pibrentasvir DB11613, Velpatasvir |
Organism-specific databases
euHCVdbi | AY808015 |
Family and domain databases
Gene3Di | 2.20.25.210, 1 hit 2.20.25.220, 1 hit |
InterProi | View protein in InterPro IPR002868, HCV_NS5a IPR013193, HCV_NS5a_1B_dom IPR038568, HCV_NS5A_1B_sf IPR024350, HCV_NS5a_C IPR013192, NS5A_1a IPR038170, NS5A_1a_sf |
Pfami | View protein in Pfam PF01506, HCV_NS5a, 1 hit PF08300, HCV_NS5a_1a, 1 hit PF08301, HCV_NS5a_1b, 1 hit PF12941, HCV_NS5a_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5L478_9HEPC | |
Accessioni | Q5L478Primary (citable) accession number: Q5L478 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 1, 2005 |
Last sequence update: | February 1, 2005 | |
Last modified: | September 29, 2021 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |