Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA polymerase III PolC-type

Gene

polC

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.UniRule annotationSAAS annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi346Magnesium 1; via tele nitrogenCombined sources1
Metal bindingi346Manganese; via tele nitrogenCombined sources1
Metal bindingi348Magnesium 1; via tele nitrogenCombined sources1
Metal bindingi348Manganese; via tele nitrogenCombined sources1
Metal bindingi355Zinc 1Combined sources1
Metal bindingi380Zinc 1; via tele nitrogenCombined sources1
Metal bindingi405Magnesium 1Combined sources1
Metal bindingi405Magnesium 2Combined sources1
Metal bindingi405ManganeseCombined sources1
Metal bindingi620Magnesium 2; via pros nitrogenCombined sources1
Metal bindingi670Magnesium 2Combined sources1
Metal bindingi743Magnesium 1Combined sources1
Metal bindingi745Zinc 1; via tele nitrogenCombined sources1
Metal bindingi919Zinc 2Combined sources1
Metal bindingi922Zinc 2Combined sources1
Metal bindingi944Zinc 2Combined sources1
Metal bindingi947Zinc 2Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymeraseUniRule annotationSAAS annotationImported, ExonucleaseUniRule annotationSAAS annotation, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotationSAAS annotation
LigandMagnesiumCombined sources, ManganeseCombined sources, Metal-bindingCombined sources, ZincCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase III PolC-typeUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
PolIIIUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polCUniRule annotationImported
Ordered Locus Names:GK1258Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGeobacillus kaustophilus (strain HTA426)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235909 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001172 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
235909.GK1258

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5L0J3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5L0J3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5L0J3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini343 – 410POLIIIAcInterPro annotationAdd BLAST68
Domaini428 – 594ExonucleaseInterPro annotationAdd BLAST167

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-C family. PolC subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DE5 Bacteria
COG2176 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000058064

KEGG Orthology (KO)

More...
KOi
K03763

Identification of Orthologs from Complete Genome Data

More...
OMAi
YYAAYFT

Database of Orthologous Groups

More...
OrthoDBi
POG091H01BK

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00356 DNApol_PolC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011708 DNA_pol3_alpha_NTPase_dom
IPR024754 DNA_polC-like_N_II
IPR028112 DNA_polC-type_N_I
IPR029460 DNAPol_HHH
IPR006054 DnaQ
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR012340 NA-bd_OB-fold
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR006308 PolC_gram_pos
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14480 DNA_pol3_a_NI, 1 hit
PF11490 DNA_pol3_a_NII, 1 hit
PF07733 DNA_pol3_alpha, 2 hits
PF14579 HHH_6, 1 hit
PF02811 PHP, 1 hit
PF00929 RNase_T, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00479 EXOIII, 1 hit
SM00481 POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249 SSF50249, 1 hit
SSF53098 SSF53098, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00573 dnaq, 1 hit
TIGR01405 polC_Gram_pos, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5L0J3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLRGEQTDV MVTKEQKERF LILLEQLKMT SDEWMPHFRE AAIRKVVIDK
60 70 80 90 100
EEKSWHFYFQ FDNVLPVHVY KTFADRLQTA FRHIAAVRHT MEVEAPRVTE
110 120 130 140 150
ADVQAYWPLC LAELQEGMSP LVDWLSRQTP ELKGNKLLVV ARHEAEALAI
160 170 180 190 200
KRRFAKKIAD VYASFGFPPL QLDVSVEPSK QEMEQFLAQK QQEDEERALA
210 220 230 240 250
VLTDLAREEE KAASAPPSGP LVIGYPIRDE EPVRRLETIV EEERRVVVQG
260 270 280 290 300
YVFDAEVSEL KSGRTLLTMK ITDYTNSILV KMFSRDKEDA ELMSGVKKGM
310 320 330 340 350
WVKVRGSVQN DTFVRDLVII ANDLNEIAAN ERQDTAPEGE KRVELHLHTP
360 370 380 390 400
MSQMDAVTSV TKLIEQAKKW GHPAIAVTDH AVVQSFPEAY SAAKKHGMKV
410 420 430 440 450
IYGLEANIVD DGVPIAYNET HRRLSEETYV VFDVETTGLS AVYNTIIELA
460 470 480 490 500
AVKVKDGEII DRFMSFANPG HPLSVTTMEL TGITDEMVKD APKPDEVLAR
510 520 530 540 550
FVDWAGDATL VAHNASFDIG FLNTGLARMG RGKIANPVID TLELARFLYP
560 570 580 590 600
DLKNHRLNTL CKKFDIELTQ HHRAIYDAEA TGHLLMRLLK EAEERGILFH
610 620 630 640 650
DELNSRTHSE ASYRLARPFH VTLLAQNETG LKNLFKLVSL SHIQYFHRVP
660 670 680 690 700
RIPRSVLVKH RDGLLVGSGC DKGELFDNLI QKAPEEVEDI ARFYDFLEVH
710 720 730 740 750
PPDVYKPLIE MDYVKDEEMI KNIIRSIVAL GEKLDIPVVA TGNVHYLNPE
760 770 780 790 800
DKIYRKILIH SQGGANPLNR HELPDVYFRT TNEMLDCFSF LGPEKAKEIV
810 820 830 840 850
VDNTQKIASL IGDVKPIKDE LYTPRIEGAD EEIREMSYRR AKEIYGDPLP
860 870 880 890 900
KLVEERLEKE LKSIIGHGFA VIYLISHKLV KKSLDDGYLV GSRGSVGSSF
910 920 930 940 950
VATMTEITEV NPLPPHYVCP NCKHSEFFND GSVGSGFDLP DKNCPRCGTK
960 970 980 990 1000
YKKDGHDIPF ETFLGFKGDK VPDIDLNFSG EYQPRAHNYT KVLFGEDNVY
1010 1020 1030 1040 1050
RAGTIGTVAD KTAYGFVKAY ASDHNLELRG AEIDRLAAGC TGVKRTTGQH
1060 1070 1080 1090 1100
PGGIIVVPDY MEIYDFTPIQ YPADDTSSEW RTTHFDFHSI HDNLLKLDIL
1110 1120 1130 1140 1150
GHDDPTVIRM LQDLSGIDPK TIPTDDPDVM GIFSSTEPLG VTPEQIMCNV
1160 1170 1180 1190 1200
GTIGIPEFGT RFVRQMLEET RPKTFSELVQ ISGLSHGTDV WLGNAQELIQ
1210 1220 1230 1240 1250
NGTCTLSEVI GCRDDIMVYL IYRGLEPSLA FKIMESVRKG KGLTPEFEAE
1260 1270 1280 1290 1300
MRKHDVPEWY IDSCKKIKYM FPKAHAAAYV LMAVRIAYFK VHHPLLYYAS
1310 1320 1330 1340 1350
YFTVRAEDFD LDAMIKGSAA IRKRIEEINA KGIQATAKEK SLLTVLEVAL
1360 1370 1380 1390 1400
EMCERGFSFK NIDLYRSQAT EFVIDGNSLI PPFNAIPGLG TNVAQAIVRA
1410 1420 1430 1440
REEGEFLSKE DLQQRGKLSK TLLEYLESRG CLDSLPDHNQ LSLF
Length:1,444
Mass (Da):163,115
Last modified:February 1, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28DD9C7824C5D03D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BA000043 Genomic DNA Translation: BAD75543.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAD75543; BAD75543; GK1258

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gka:GK1258

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA Translation: BAD75543.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F2BX-ray2.39A228-424[»]
A618-1444[»]
3F2CX-ray2.50A228-424[»]
A618-1444[»]
3F2DX-ray2.51A228-424[»]
A618-1444[»]
ProteinModelPortaliQ5L0J3
SMRiQ5L0J3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235909.GK1258

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD75543; BAD75543; GK1258
KEGGigka:GK1258

Phylogenomic databases

eggNOGiENOG4105DE5 Bacteria
COG2176 LUCA
HOGENOMiHOG000058064
KOiK03763
OMAiYYAAYFT
OrthoDBiPOG091H01BK

Miscellaneous databases

EvolutionaryTraceiQ5L0J3

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00356 DNApol_PolC, 1 hit
InterProiView protein in InterPro
IPR011708 DNA_pol3_alpha_NTPase_dom
IPR024754 DNA_polC-like_N_II
IPR028112 DNA_polC-type_N_I
IPR029460 DNAPol_HHH
IPR006054 DnaQ
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR012340 NA-bd_OB-fold
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR006308 PolC_gram_pos
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF14480 DNA_pol3_a_NI, 1 hit
PF11490 DNA_pol3_a_NII, 1 hit
PF07733 DNA_pol3_alpha, 2 hits
PF14579 HHH_6, 1 hit
PF02811 PHP, 1 hit
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SM00481 POLIIIAc, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00573 dnaq, 1 hit
TIGR01405 polC_Gram_pos, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5L0J3_GEOKA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5L0J3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: December 5, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again