UniProtKB - Q5KU39 (VPS41_MOUSE)
Vacuolar protein sorting-associated protein 41 homolog
Vps41
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 790 – 838 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 49 |
GO - Molecular functioni
- identical protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- microtubule binding Source: MGI
- protein self-association Source: MGI
- Rab GTPase binding Source: GO_Central
GO - Biological processi
- cellular response to starvation Source: GO_Central
- endosomal vesicle fusion Source: MGI
- endosome to lysosome transport Source: MGI
- Golgi vesicle transport Source: MGI
- late endosome to lysosome transport Source: MGI
- macroautophagy Source: GO_Central
- protein targeting to vacuole Source: GO_Central
- regulated exocytosis Source: MGI
Keywordsi
Biological process | Autophagy, Protein transport, Transport |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 41 homologAlternative name(s): VAM2 homolog Short name: mVAM2 |
Gene namesi | Name:Vps41 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929215, Vps41 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network By similarity
Lysosome
- Lysosome By similarity
Endosome
- Endosome membrane By similarity
- Late endosome By similarity
- Early endosome By similarity
Other locations
- clathrin-coated vesicle By similarity
Cytoskeleton
- microtubule cytoskeleton Source: MGI
Cytosol
- cytosol Source: MGI
Endosome
- early endosome Source: MGI
- endosome membrane Source: MGI
- late endosome Source: MGI
- late endosome membrane Source: MGI
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: MGI
Other locations
- AP-3 adaptor complex Source: Ensembl
- clathrin complex Source: Ensembl
- clathrin-coated vesicle Source: MGI
- Golgi-associated vesicle Source: MGI
- HOPS complex Source: MGI
- membrane Source: MGI
Keywords - Cellular componenti
Cytoplasmic vesicle, Endosome, Golgi apparatus, Lysosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253020 | 1 – 853 | Vacuolar protein sorting-associated protein 41 homologAdd BLAST | 853 |
Proteomic databases
EPDi | Q5KU39 |
MaxQBi | Q5KU39 |
PaxDbi | Q5KU39 |
PeptideAtlasi | Q5KU39 |
PRIDEi | Q5KU39 |
PTM databases
iPTMneti | Q5KU39 |
PhosphoSitePlusi | Q5KU39 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000041236, Expressed in rostral migratory stream and 306 other tissues |
Genevisiblei | Q5KU39, MM |
Interactioni
Subunit structurei
Component of the putative homotypic fusion and vacuole protein sorting (HOPS) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS39 and VPS41.
Interacts with RILP, MON1B.
Interacts with ARL8B (GTP-bound form); involved in recruitment to lysosomes and probably hierarchial assembly of the HOPS complex at lysosomal membranes. In vitro can self-assemble into a lattice. Associates with adaptor protein complex 3 (AP-3) and clathrin:AP-3 complexes (By similarity).
Interacts with STX17; this interaction is increased in the absence of TMEM39A (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
- microtubule binding Source: MGI
- protein self-association Source: MGI
- Rab GTPase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 229988, 11 interactors |
IntActi | Q5KU39, 11 interactors |
MINTi | Q5KU39 |
STRINGi | 10090.ENSMUSP00000072729 |
Miscellaneous databases
RNActi | Q5KU39, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 567 – 711 | CHCRAdd BLAST | 145 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 539 | Interaction with ARL8BBy similarityAdd BLAST | 539 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 790 – 838 | RING-type; atypicalPROSITE-ProRule annotationAdd BLAST | 49 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2066, Eukaryota |
GeneTreei | ENSGT00390000000481 |
HOGENOMi | CLU_001285_2_2_1 |
InParanoidi | Q5KU39 |
OMAi | RCSLGLI |
OrthoDBi | 722805at2759 |
PhylomeDBi | Q5KU39 |
TreeFami | TF300451 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000547, Clathrin_H-chain/VPS_repeat IPR011990, TPR-like_helical_dom_sf IPR016902, VPS41 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR036322, WD40_repeat_dom_sf IPR001841, Znf_RING |
Pfami | View protein in Pfam PF00637, Clathrin, 1 hit |
PIRSFi | PIRSF028921, VPS41, 1 hit |
SMARTi | View protein in SMART SM00299, CLH, 1 hit |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50236, CHCR, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAEAEEQETE SLEESTDESE EESEEEPKLK YERLSNGVTE ILQKDAASCM
60 70 80 90 100
TVHDKFLALG THYGKVYLLD VQGNITQKFD VSPVKINQIS LDDSGEHMGV
110 120 130 140 150
CSEDGKLQVF GLYSGEEFHE TFDCPIKIIA VHPQFVRSSC KQFVTGGKKL
160 170 180 190 200
LLFERTWMNR WKSSVLHEGE GNIRSVKWRG HLIAWANNMG VKVFDITSKQ
210 220 230 240 250
RISNVPRDDI SLRPDMYPCS LCWKDNVTLI IGWGTSIKIC SVKERHASEM
260 270 280 290 300
RDLPSRYVEI VSQFETEFYI SGLAPLCDQL VVLSYVKEVS EKTEREYCAR
310 320 330 340 350
PRLDIIQPLP ETCEEISSDA LTVRGFQENE CRDYHLEYSE GESLFYVVSP
360 370 380 390 400
RDVVVAKERD QDDHIDWLLE KKKYEEALMA AEISQRNIKR HKILDIGLAY
410 420 430 440 450
VNHLVERGEY DMAARKCQKI LGKNASLWEY EVYKFKEIGQ LKAISPYLPR
460 470 480 490 500
GDPVLKPLIY EMILHEFLES DYEGFATLIR EWPGDLYNNS VIVQAVRDHL
510 520 530 540 550
KKDSQNKTLL KTLAELYTYD KNYGNALEIY LTLRHKDVFQ LIHKHNLFSS
560 570 580 590 600
IKDKIVLLMD FDSEKAVDML LDNEDKISIK KVVEELEDRP ELQHVYLHKL
610 620 630 640 650
FKRDHHKGQR YHEKQISLYA EYDRPNLLPF LRDSTHCPLE KALEICQQRN
660 670 680 690 700
FVEETVYLLS RMGNSRSALK MIMEELHDVD KAIEFAKEQD DGELWEDLIL
710 720 730 740 750
YSIDKPPFIT GLLNNIGTHV DPILLIHRIK EGMEIPNLRD SLVKILQDYN
760 770 780 790 800
LQILLREGCK KILVADSLSL LKKMHRTQMK GVLVDEENIC ESCLSPILPT
810 820 830 840 850
DAAKPFSVVV FHCRHMFHKE CLPMPSMNAP AQYCNICSAK NRGPGSAILE
MKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | T → K in BAE37664 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 190 | G → C in BAC34707 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 401 | V → L in AAN73032 (Ref. 2) Curated | 1 | |
Sequence conflicti | 427 – 428 | LW → HR in AAN73032 (Ref. 2) Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028843 mRNA Translation: BAD88410.1 AF327407 mRNA Translation: AAN73032.1 AK051658 mRNA Translation: BAC34707.1 AK164177 mRNA Translation: BAE37664.1 BC023243 mRNA Translation: AAH23243.1 BC049916 mRNA Translation: AAH49916.1 BC119362 mRNA Translation: AAI19363.1 BC125299 mRNA Translation: AAI25300.1 |
CCDSi | CCDS26257.1 |
RefSeqi | NP_742118.3, NM_172120.4 |
Genome annotation databases
Ensembli | ENSMUST00000072961; ENSMUSP00000072729; ENSMUSG00000041236 |
GeneIDi | 218035 |
KEGGi | mmu:218035 |
UCSCi | uc007pok.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028843 mRNA Translation: BAD88410.1 AF327407 mRNA Translation: AAN73032.1 AK051658 mRNA Translation: BAC34707.1 AK164177 mRNA Translation: BAE37664.1 BC023243 mRNA Translation: AAH23243.1 BC049916 mRNA Translation: AAH49916.1 BC119362 mRNA Translation: AAI19363.1 BC125299 mRNA Translation: AAI25300.1 |
CCDSi | CCDS26257.1 |
RefSeqi | NP_742118.3, NM_172120.4 |
3D structure databases
SMRi | Q5KU39 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229988, 11 interactors |
IntActi | Q5KU39, 11 interactors |
MINTi | Q5KU39 |
STRINGi | 10090.ENSMUSP00000072729 |
PTM databases
iPTMneti | Q5KU39 |
PhosphoSitePlusi | Q5KU39 |
Proteomic databases
EPDi | Q5KU39 |
MaxQBi | Q5KU39 |
PaxDbi | Q5KU39 |
PeptideAtlasi | Q5KU39 |
PRIDEi | Q5KU39 |
Protocols and materials databases
Antibodypediai | 13056, 121 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000072961; ENSMUSP00000072729; ENSMUSG00000041236 |
GeneIDi | 218035 |
KEGGi | mmu:218035 |
UCSCi | uc007pok.2, mouse |
Organism-specific databases
CTDi | 27072 |
MGIi | MGI:1929215, Vps41 |
Phylogenomic databases
eggNOGi | KOG2066, Eukaryota |
GeneTreei | ENSGT00390000000481 |
HOGENOMi | CLU_001285_2_2_1 |
InParanoidi | Q5KU39 |
OMAi | RCSLGLI |
OrthoDBi | 722805at2759 |
PhylomeDBi | Q5KU39 |
TreeFami | TF300451 |
Miscellaneous databases
BioGRID-ORCSi | 218035, 7 hits in 19 CRISPR screens |
ChiTaRSi | Vps41, mouse |
PROi | PR:Q5KU39 |
RNActi | Q5KU39, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041236, Expressed in rostral migratory stream and 306 other tissues |
Genevisiblei | Q5KU39, MM |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000547, Clathrin_H-chain/VPS_repeat IPR011990, TPR-like_helical_dom_sf IPR016902, VPS41 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR036322, WD40_repeat_dom_sf IPR001841, Znf_RING |
Pfami | View protein in Pfam PF00637, Clathrin, 1 hit |
PIRSFi | PIRSF028921, VPS41, 1 hit |
SMARTi | View protein in SMART SM00299, CLH, 1 hit |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50236, CHCR, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS41_MOUSE | |
Accessioni | Q5KU39Primary (citable) accession number: Q5KU39 Secondary accession number(s): Q05AE9 Q8CJC3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | February 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families