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UniProtKB - Q5KTQ9 (CAX1C_ORYSJ)
Protein
Vacuolar cation/proton exchanger 1c
Gene
CAX1c
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Vacuolar cation/proton exchanger (CAX). Translocates Ca2+ and other metal ions into vacuoles using the proton gradient formed by H+-ATPase and H+-pyrophosphatase.
1 PublicationGO - Molecular functioni
- calcium:proton antiporter activity Source: GO_Central
GO - Biological processi
- calcium ion transmembrane transport Source: GO_Central
- cellular calcium ion homeostasis Source: GO_Central
Keywordsi
Biological process | Antiport, Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar cation/proton exchanger 1cAlternative name(s): Ca(2+)/H(+) exchanger 1c OsCAX1c |
Gene namesi | Name:CAX1c Ordered Locus Names:Os02g0314300, Os02g0314400, Os02g0314100, LOC_Os02g21009 ORF Names:P0705A04.26 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
Subcellular locationi
Vacuole
- Vacuole membrane Curated; Multi-pass membrane protein Curated
Note: Tonoplast.
Vacuole
- plant-type vacuole membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 73 | CytoplasmicSequence analysisAdd BLAST | 73 | |
Transmembranei | 74 – 94 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 95 – 101 | ExtracellularSequence analysis | 7 | |
Transmembranei | 102 – 122 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 123 – 134 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 135 – 155 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 156 – 170 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 171 – 191 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 192 – 201 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 202 – 222 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 223 – 239 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 240 – 260 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 261 – 287 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 288 – 308 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 309 – 331 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 332 – 352 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 353 – 360 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 361 – 381 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 382 – 385 | ExtracellularSequence analysis | 4 | |
Transmembranei | 386 – 406 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 407 – 424 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 425 – 445 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 446 – 450 | ExtracellularSequence analysis | 5 |
Keywords - Cellular componenti
Membrane, VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209499 | 1 – 450 | Vacuolar cation/proton exchanger 1cAdd BLAST | 450 |
Proteomic databases
PaxDbi | Q5KTQ9 |
Expressioni
Tissue specificityi
Expressed in leaf blades.1 Publication
Gene expression databases
Genevisiblei | Q5KTQ9, OS |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 28 – 52 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 143 – 178 | Cation selectionSequence analysisAdd BLAST | 36 | |
Regioni | 339 – 374 | Cation selectionSequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/proton exchanger (CAX) subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1397, Eukaryota |
HOGENOMi | CLU_008721_2_0_1 |
InParanoidi | Q5KTQ9 |
OMAi | SAMVWLI |
OrthoDBi | 727723at2759 |
Family and domain databases
Gene3Di | 1.20.1420.30, 2 hits |
InterProi | View protein in InterPro IPR004713, CaH_exchang IPR004798, CAX-like IPR004837, NaCa_Exmemb IPR044880, NCX_ion-bd_dom_sf |
PANTHERi | PTHR31503, PTHR31503, 1 hit |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
TIGRFAMsi | TIGR00378, cax, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5KTQ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPPESSHHH LLESGLLEVS KAPSAAVAAE EEEKKEAAAW TPSSSSSMTG
60 70 80 90 100
RKIKSEASPL LRRLLGGPAA QLQEVLLGTK LYPLFSAVPL AVAAESLRLG
110 120 130 140 150
RVWVFAFSLI GLAPLAERVS FLSEHIANTV GPTAGGIMNA TCGNVPELII
160 170 180 190 200
ALFALHKNKM EILKWSLLGS ILSNLLLVLG SSLLFGGIVN IGKERPLDKR
210 220 230 240 250
QADVSIGLLL LGVLCHIATL VSKYTSSTGD SINSSSVMQL SRSCAIVMLI
260 270 280 290 300
AYFGSLMFQL KTHRQIFELE EDSSDSSSSE DDATDKSVIG FASAMVWLIG
310 320 330 340 350
MAVVTAMLSS YVVTTIEEAS ESMGIPVRFI SIILLPIVGN AAEHAGAIIF
360 370 380 390 400
AFKNKIDISL GITLGSATQI SMLVVPVILI VSWVNAIPMD LDFNLLETGS
410 420 430 440 450
LAMAVITTAF TLQDDKWHYL KGLNLVFSYI VIAVCFFVMK ALPTLKKEDD
Sequence cautioni
The sequence BAD15983 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB112771 mRNA Translation: BAD83661.1 AP004891 Genomic DNA Translation: BAD15983.1 Sequence problems. AP008208 Genomic DNA Translation: BAH91649.1 AP014958 Genomic DNA Translation: BAS78336.1 |
RefSeqi | XP_015622639.1, XM_015767153.1 |
Genome annotation databases
EnsemblPlantsi | Os02t0314300-00; Os02t0314300-00; Os02g0314300 |
GeneIDi | 9269067 |
Gramenei | Os02t0314300-00; Os02t0314300-00; Os02g0314300 |
KEGGi | osa:9269067 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB112771 mRNA Translation: BAD83661.1 AP004891 Genomic DNA Translation: BAD15983.1 Sequence problems. AP008208 Genomic DNA Translation: BAH91649.1 AP014958 Genomic DNA Translation: BAS78336.1 |
RefSeqi | XP_015622639.1, XM_015767153.1 |
3D structure databases
AlphaFoldDBi | Q5KTQ9 |
SMRi | Q5KTQ9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4530.OS02T0314300-00 |
Proteomic databases
PaxDbi | Q5KTQ9 |
Genome annotation databases
EnsemblPlantsi | Os02t0314300-00; Os02t0314300-00; Os02g0314300 |
GeneIDi | 9269067 |
Gramenei | Os02t0314300-00; Os02t0314300-00; Os02g0314300 |
KEGGi | osa:9269067 |
Phylogenomic databases
eggNOGi | KOG1397, Eukaryota |
HOGENOMi | CLU_008721_2_0_1 |
InParanoidi | Q5KTQ9 |
OMAi | SAMVWLI |
OrthoDBi | 727723at2759 |
Gene expression databases
Genevisiblei | Q5KTQ9, OS |
Family and domain databases
Gene3Di | 1.20.1420.30, 2 hits |
InterProi | View protein in InterPro IPR004713, CaH_exchang IPR004798, CAX-like IPR004837, NaCa_Exmemb IPR044880, NCX_ion-bd_dom_sf |
PANTHERi | PTHR31503, PTHR31503, 1 hit |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
TIGRFAMsi | TIGR00378, cax, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CAX1C_ORYSJ | |
Accessioni | Q5KTQ9Primary (citable) accession number: Q5KTQ9 Secondary accession number(s): A0A0P0VI98, C7IY34, Q6Z6R2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | May 25, 2022 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Oryza sativa (rice)
Index of Oryza sativa entries and their corresponding gene designations - SIMILARITY comments
Index of protein domains and families