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Protein

Tryptophan synthase

Gene

CNA06290

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Multifunctional tryptophan biosynthesis protein (TRP1)
  2. no protein annotated in this organism
  3. Multifunctional tryptophan biosynthesis protein (TRP1)
  4. Multifunctional tryptophan biosynthesis protein (TRP1)
  5. Tryptophan synthase (CNA06290)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00035;UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthaseUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Ordered Locus Names:CNA06290Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiFungiDB:CNA06290

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiQ5KNJ3

Interactioni

Protein-protein interaction databases

STRINGi214684.XP_566976.1

Structurei

3D structure databases

ProteinModelPortaliQ5KNJ3
SMRiQ5KNJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini364 – 687PALPInterPro annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili328 – 348Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1395 Eukaryota
KOG4175 Eukaryota
COG0133 LUCA
COG0159 LUCA
HOGENOMiHOG000161710
InParanoidiQ5KNJ3
KOiK01694
OMAiCAKFGME
OrthoDBiEOG092C0Y7R

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
cd04724 Tryptophan_synthase_alpha, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00131 Trp_synth_alpha, 1 hit
MF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001926 PLP-dep
IPR011060 RibuloseP-bd_barrel
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR018204 Trp_synthase_alpha_AS
IPR002028 Trp_synthase_suA
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR42882 PTHR42882, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PF00290 Trp_syntA, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
SSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00262 trpA, 1 hit
TIGR00263 trpB, 1 hit
PROSITEiView protein in PROSITE
PS00167 TRP_SYNTHASE_ALPHA, 1 hit
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5KNJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEQLKQVYA DKKAQDQAAF VTFLTAGFPT RDATVPLMLA LEAGGADIIE
60 70 80 90 100
LGVPFSDPVA DGPVIQKANN VAIENNVHYS DCIEYVRQAR AQGLKAPVLF
110 120 130 140 150
MGYYNPIIAY GEERAVKDAR EAGANGYIVV DLPPTEAVDF RNTCTKAGMS
160 170 180 190 200
YIPLVAPSTS IDRVKFLTSI ADSFIYVVSK MGVTGSSSSE NISASLPELV
210 220 230 240 250
KRIRTFTTIP LAVGFGIDNR THFDYVTSSG ADAVVVGSKI IKLIFEHADD
260 270 280 290 300
GLAPKVVEDY CREITLKGQN PPPLGRKNAA APPPANGGDV SPPLPIPSGS
310 320 330 340 350
PLGESQVKVT AAGKLPSRFG LFGGAYVAES LVDCLNELEA AYAEAKEDPA
360 370 380 390 400
FWKEFEDMFG YINRPSELYL AERLTEEMGG ARIWLKREDL NHTGSHKINN
410 420 430 440 450
AVGQILLAKR LGKRRIIAET GAGQHGVATA TVCAKFGMEC DIFMGAEDVR
460 470 480 490 500
RQELNVFRIK MLGGRVIPVT AGSQTLKDAV NEAMRDWVTR LDSTHYLIGS
510 520 530 540 550
AIGPHPFPTI VRDFQRVIGR EIKSQMHEKM GKLPDAVVAC VGGGSNAIGT
560 570 580 590 600
FYDFIEDPSV RLVGVEAGGH GIDTEAHSAT LTKGVMGVVH GAASYIIQSK
610 620 630 640 650
EGQLTPTHSI SAGLDYNSVG PEHSHLKYSG RAEYVVADDL QCLKAFKMCT
660 670 680 690 700
ELEGIIPALE SSHGLWGGMQ LAKSLPKDKD IVICLSGNGA KDVAEVLLTL
710
KNKEWADKLD WHVAQ
Length:715
Mass (Da):76,992
Last modified:February 15, 2005 - v1
Checksum:i9F9391716ED0A494
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017341 Genomic DNA Translation: AAW41157.1
RefSeqiXP_566976.1, XM_566976.1

Genome annotation databases

EnsemblFungiiAAW41157; AAW41157; CNA06290
GeneIDi3253761
KEGGicne:CNA06290

Similar proteinsi

Entry informationi

Entry nameiQ5KNJ3_CRYNJ
AccessioniPrimary (citable) accession number: Q5KNJ3
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: July 18, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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