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Entry version 114 (31 Jul 2019)
Sequence version 1 (15 Feb 2005)
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Protein
Submitted name:

Xenobiotic-transporting ATPase, putative

Gene

CNB05770

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi895 – 902ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransportSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Xenobiotic-transporting ATPase, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:CNB05770Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri214684 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002149 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CNB05770

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei525 – 542HelicalSequence analysisAdd BLAST18
Transmembranei554 – 576HelicalSequence analysisAdd BLAST23
Transmembranei596 – 619HelicalSequence analysisAdd BLAST24
Transmembranei631 – 650HelicalSequence analysisAdd BLAST20
Transmembranei662 – 683HelicalSequence analysisAdd BLAST22
Transmembranei771 – 788HelicalSequence analysisAdd BLAST18
Transmembranei1207 – 1227HelicalSequence analysisAdd BLAST21
Transmembranei1239 – 1258HelicalSequence analysisAdd BLAST20
Transmembranei1278 – 1306HelicalSequence analysisAdd BLAST29
Transmembranei1327 – 1351HelicalSequence analysisAdd BLAST25
Transmembranei1357 – 1375HelicalSequence analysisAdd BLAST19
Transmembranei1387 – 1407HelicalSequence analysisAdd BLAST21
Transmembranei1481 – 1500HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5KLC4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini159 – 409ABC transporterInterPro annotationAdd BLAST251
Domaini859 – 1102ABC transporterInterPro annotationAdd BLAST244

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 48DisorderedSequence analysisAdd BLAST22
Regioni816 – 837DisorderedSequence analysisAdd BLAST22
Regioni1150 – 1169DisorderedSequence analysisAdd BLAST20
Regioni1506 – 1536DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili446 – 466Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 46PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1511 – 1536PolyampholyteSequence analysisAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. [View classification]SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0065 Eukaryota
COG0842 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000162078

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5KLC4

KEGG Orthology (KO)

More...
KOi
K08711

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITHFFFI

Database of Orthologous Groups

More...
OrthoDBi
37708at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR010929 PDR_CDR_ABC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF06422 PDR_CDR, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5KLC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFAGVGAMG PYDRTEHSAG AALNRTTSRS HYYDDHPNDN LPSPTDEYRN
60 70 80 90 100
RELGQLARSW SRRSQTGALG PGFSQAPQGE SIAEELTGDV FTYQKDSDLD
110 120 130 140 150
PFSSNFNPKK WTKLMFRAHE TTSPPRKAGL SFKNLGVFGY GSDADYQKTV
160 170 180 190 200
GNLALAGLGA LRDLIGNRKR KVQILNGIDG VIEAGEMLVV LGPPGSGCST
210 220 230 240 250
MLKTIAGEMN GIYIDESSEL NYRGITPKQM YGQFRGEAIY TAEVDVHFPN
260 270 280 290 300
LTVGQTLSFA AEARAPRHTP NGIPKKDYAK HLRDVVMSVF GITHTLNTIV
310 320 330 340 350
GNDFVRGVSG GERKRVTIAE AALAGAPLQC WDNSTRGLDS ANAIEFCKNL
360 370 380 390 400
RINADYMDIS SVVAIYQAPQ RAYDLFDKVS VLYEGEQIFF GKCTEAKQFF
410 420 430 440 450
VDMGFHCPSQ QTVPDFLTSL TSASERTPRE GFEGKVPTTP QEFAAAWKKS
460 470 480 490 500
NKYAELQEQI AQFEQKYPVH GENYDKFLES RRAQQSKHLR AKSPYTLSYG
510 520 530 540 550
GQVKLCLRRG FQRLRADPSL TLTQLFGNFI MALIVGSVFY NMPSNTTSFY
560 570 580 590 600
SRGALLFFAI LMSAFGSALE ILILYAQRGI VEKHSRYAFY HPSTEAIASA
610 620 630 640 650
LTDIPYKVLN CICFNLALYF MANLRREPGP FFFFMLISFT LTMVMSMFFR
660 670 680 690 700
SIASLSRSLT QALAPAAIMI LALVIYTGFA INVQNMRGWA RWINYLDPIA
710 720 730 740 750
YGFESLMINE FHDREYACSV FVPTGPGYEG ATGEERVCST VGSVAGSSVV
760 770 780 790 800
NGDAYINGSY EYYHAHKWRN FGILIGFFLF LTAVYLLATE LITAKKSKGE
810 820 830 840 850
ILVFPRGKIP RTLLAQSTAS HNSDDPEPGK YAGGGNVQTK VTGADRADAG
860 870 880 890 900
IIQRQTAIFS WKDVVYDIKI KKEQRRILDH VDGWVKPGTL TALMGVSGAG
910 920 930 940 950
KTTLLDVLAT RVTMGVVTGE MLVDGQQRDI SFQRKTGYVQ QQDLHLETST
960 970 980 990 1000
VREALRFSVL LRQPNHISKE EKFEYVEEVL KLLEMDAYAD AVVGVPGTGL
1010 1020 1030 1040 1050
NVEQRKRLTI GVELVAKPAL LLFLDEPTSG LDSQTSWNIL LLLRKLTEHG
1060 1070 1080 1090 1100
QAILCTIHQP SAMLFEQFDR LLFLAKGGKT VYFGEVGKES RTLINYFERN
1110 1120 1130 1140 1150
GAEKCPPGEN PAEWMLSAIG ASPGSQCTTD WHQTWLNSPE REEVRRELAR
1160 1170 1180 1190 1200
IKETNGGKGD AAKQDKTQEK SKAEIKAEYA EFAAPLWKQF IIVVWRVWQQ
1210 1220 1230 1240 1250
HWRTPSYIWA KAALCIGSGL FIGFSFFKSG TSQQGLQNQL FSVFMLFTIF
1260 1270 1280 1290 1300
GQLVQQMLPN FVTQRSLYEV RERPSKTYSW KVFIMSNVIA EIPWSILMGV
1310 1320 1330 1340 1350
VIYFTWYYPI GYYRNAIPTD AVHLRGALMF LYIEMFMLFT STFAIMIVAG
1360 1370 1380 1390 1400
IDTAETAGNI ANLLFLMCLI FCGVLATKET FPHFWIFMYR VSPFTYLVEG
1410 1420 1430 1440 1450
MLGVAIANTN IVCADNELLT FNPPSGRTCG QYMSNYIAAA GGYLTNEDAT
1460 1470 1480 1490 1500
TGCSFCSMSE TNAFLAQFDI YYSHKWRDFG LLWIFVIFNA VAAVAIYYVA
1510 1520 1530
RVPKNTGKEQ ASEPEQLEKS AGLETTEKRS RRSEST
Length:1,536
Mass (Da):171,523
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3C4F1DC3B013577
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE017342 Genomic DNA Translation: AAW41688.1

NCBI Reference Sequences

More...
RefSeqi
XP_568995.1, XM_568995.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AAW41688; AAW41688; CNB05770

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3255549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cne:CNB05770

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017342 Genomic DNA Translation: AAW41688.1
RefSeqiXP_568995.1, XM_568995.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiQ5KLC4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAW41688; AAW41688; CNB05770
GeneIDi3255549
KEGGicne:CNB05770

Organism-specific databases

EuPathDBiFungiDB:CNB05770

Phylogenomic databases

eggNOGiKOG0065 Eukaryota
COG0842 LUCA
HOGENOMiHOG000162078
InParanoidiQ5KLC4
KOiK08711
OMAiITHFFFI
OrthoDBi37708at2759

Family and domain databases

CDDicd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR010929 PDR_CDR_ABC
PfamiView protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF06422 PDR_CDR, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5KLC4_CRYNJ
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5KLC4
Secondary accession number(s): Q55YL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: July 31, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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