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Entry version 101 (05 Jun 2019)
Sequence version 2 (17 Feb 2016)
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Protein
Submitted name:

MYO2-related

Gene

CND05780

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi198 – 205ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationSAAS annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MYO2-relatedImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:CND05780Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri214684 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002149 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CND05780

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5KHP4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5207.AAW42813

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 807Myosin motorInterPro annotationAdd BLAST713
Domaini1287 – 1570DiluteInterPro annotationAdd BLAST284

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni685 – 707Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili980 – 1007Sequence analysisAdd BLAST28
Coiled coili1032 – 1052Sequence analysisAdd BLAST21
Coiled coili1095 – 1115Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0161 Eukaryota
COG5022 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000171839

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5KHP4

Database of Orthologous Groups

More...
OrthoDBi
311886at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01380 MYSc_Myo5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 5 hits
PF00063 Myosin_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5KHP4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLYSKGTL VWISQPSSGW VAGTVESLDL PTDGDSSSEV VMIVSHDSDP
60 70 80 90 100
TTNETLKFPL SALQSATTDP TSLRTTTSSL GQDYLPALRN PPALETAEDL
110 120 130 140 150
ANLSNLNEPS VLHAMATRYM QHYPYTYSGI VLLSMNPFTP LNIYETAFVK
160 170 180 190 200
LYAGQKKGER EPHVFAIAEE ALDSMRRGDG GGGVDPTGAG DQTIIVSGES
210 220 230 240 250
GAGKTVAAKY ILKYFASAHH DSSTQSTVVG EDGMSEIEKQ ILASNPIMEA
260 270 280 290 300
FGNAKTTRND NSSRFGKYIE ILFNRTNEIT GARIRTYLLE RSRLTYQPIS
310 320 330 340 350
ERNYHIFYQL LAGAPSKERK DLSLSMAPRD FGYLAGGGPT STSIPGVDDS
360 370 380 390 400
KEFAVTQSAL STVGISIERQ WHIFRLLAAL LHLGNIKITQ IRTDAALADD
410 420 430 440 450
DSALNIATDL LGIPLSDFKK WIIKKQLTTR NEKIVTSLGS TQALVVRDSV
460 470 480 490 500
AKFIYSSLFQ WLVCVVNDSL GGNNGGRSNA TKFIGVLDIY GFEHFTKNSF
510 520 530 540 550
EQFCINWANE KLQQEFYAHV FKLEQEEYVR EQISWKFIEF ADNQACIDII
560 570 580 590 600
EGKMGVLALL DEESRLPGGS DTSFATKLHQ QLVQPWQKQV FKKPRFQQGA
610 620 630 640 650
FTITHYAHEV TYDVEGFVEK NRDSVPEEHL SLLKSSANGF LCEVLAFALK
660 670 680 690 700
PSEAPSQQNF KTPLVMSKRV TPRKQTLGSM FKNSLTSLMD TINNTNVHYI
710 720 730 740 750
RCIKPNEAKK AWELDSHQVL SQLRACGVLE TIRISCNGYP SRWEYAQFAE
760 770 780 790 800
RYHLMLHSKE WNQGLDLKQL CSLILQKTLD NDDRYQLGLT KIFFRAGTLA
810 820 830 840 850
FLESLRSRRQ YELATTIQKY IRRRLAYKHY SQLKSGAIVI QNWWRGVLSR
860 870 880 890 900
KKLVELKKLK VTLWIQSTAR GHLSRKRYIQ EKENVVRLQT VARRHLARKR
910 920 930 940 950
ANEMRELTAA VTLQCLFRSC AARREYQTQV RRIVVLQSQW RRKLAVRELV
960 970 980 990 1000
SLKIEAKSAT KLKEISYQLE NKVVELTQAL QKRLSENKDL VSRVAALERE
1010 1020 1030 1040 1050
TAVLNQRNNE LLIGRQELEQ RLSIALAESG NYKSLVAQKE QVESELRRKT
1060 1070 1080 1090 1100
DKDIEQREEI RLLTAQLDAA LCSTEETKAS LDLANSQSVG DKATIDQLRT
1110 1120 1130 1140 1150
ELSHVREQLS RTNTLNALTK GNRSREVPSS PSTGQGFRHF ENTIGLGTAP
1160 1170 1180 1190 1200
DQIPLARRRN RRHSMTAGSL LVGGGNQDAN QIVKLNPRAA STIYTQDISL
1210 1220 1230 1240 1250
HLRDSQDLPF SPSLANTSDE ITRLLEDEVS LDDDVLQGLI YQLKIPNPSL
1260 1270 1280 1290 1300
HAPPTAKDVL FPAHLISLVS NEMWKRHMRS ESERFLAVVM SAVQRHVVEF
1310 1320 1330 1340 1350
KGEDIIIPGI FWLSNIQEIL SFISFAEDEE SKGYVPGYDF SNGHDSDWRG
1360 1370 1380 1390 1400
YIRLLGVVKH DLDSLEYNIY HTFMLEIKKK LSKMVVPALI ESQSLPGFIT
1410 1420 1430 1440 1450
SEGSGVFSKM LGGIGGAQQP AAKMDDILNL LNKVWKCLKI YYMEESVTHQ
1460 1470 1480 1490 1500
VMTELLKLIG QLSFNDLLMR RNFSSWKRAM QIQYNVTRIE EWCKAHDMPE
1510 1520 1530 1540 1550
GLLQLEHLLQ ATKLLQLKKA TLNDIDILFD VCWILSPAQV QKLISQYHTA
1560 1570 1580 1590 1600
DYEAPLNAEI LRAVAARVKP EDKNDQLLLA PETDDVGPYQ LPPPREIVNL
1610 1620
ETYVPAWLNI PTVRRLAALV A
Length:1,621
Mass (Da):182,925
Last modified:February 17, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A07299FB1EA2BFC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE017344 Genomic DNA Translation: AAW42813.2

NCBI Reference Sequences

More...
RefSeqi
XP_570120.1, XM_570120.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AAW42813; AAW42813; CND05780

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017344 Genomic DNA Translation: AAW42813.2
RefSeqiXP_570120.1, XM_570120.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5207.AAW42813

Proteomic databases

PaxDbiQ5KHP4

Genome annotation databases

EnsemblFungiiAAW42813; AAW42813; CND05780

Organism-specific databases

EuPathDBiFungiDB:CND05780

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
HOGENOMiHOG000171839
InParanoidiQ5KHP4
OrthoDBi311886at2759

Family and domain databases

CDDicd01380 MYSc_Myo5, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 5 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 4 hits
PS51456 MYOSIN_MOTOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5KHP4_CRYNJ
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5KHP4
Secondary accession number(s): Q55UP7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 17, 2016
Last modified: June 5, 2019
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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