Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5'-3' exoribonuclease 1

Gene

CNE03620

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonucleaseUniRule annotationImported, Hydrolase, Nuclease, RNA-bindingUniRule annotation
Biological processNonsense-mediated mRNA decayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
5'-3' exoribonuclease 1UniRule annotation (EC:3.1.13.-UniRule annotation)
Gene namesi
Ordered Locus Names:CNE03620Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:CNE03620

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ5KGH2

Interactioni

Protein-protein interaction databases

STRINGi214684.XP_570931.1

Structurei

3D structure databases

ProteinModelPortaliQ5KGH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 229XRN_NInterPro annotationAdd BLAST229

Sequence similaritiesi

Belongs to the 5'-3' exonuclease family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2044 Eukaryota
COG5049 LUCA
HOGENOMiHOG000160331
InParanoidiQ5KGH2
KOiK12618
OrthoDBiEOG092C068M

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR014722 Rib_L2_dom2
PANTHERiPTHR12341 PTHR12341, 1 hit
PfamiView protein in Pfam
PF03159 XRN_N, 1 hit
PIRSFiPIRSF006743 Exonuclease_Xnr1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5KGH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIPKFFRWI SERYPLTSQL ITPNSIPTFD NLYLDMNGII HNCSHPPSTE
60 70 80 90 100
NDPHFRITEE QMILAIFAYI DHLFTKIKPQ KVFFMAIDGV APRAKMNQQR
110 120 130 140 150
SRRFRAGKDA RDQREKAEKN GEKLPDEKAF DSNAITPGTP FMARLSQHLK
160 170 180 190 200
YYVRKRISED ADWRSIRVIL SGHDVPGEGE HKIQEFIRLN KAQPDYNPNT
210 220 230 240 250
RHCLYGLDAD LIMLGLLSHD PHFCLLREEV TFGRKSRQNT ELANTNFFLL
260 270 280 290 300
HLSLMREYLD LEFSSLQTQI SFEYDLERII DDFILMAIFV GNDFLPHLPD
310 320 330 340 350
LHINEGALER IWGMYKDILP TIDGYINEHG TISLPRLQLL LDKLAEFEVK
360 370 380 390 400
RFEDDLLDQV HFSGNHTRDT MVIEKARKKN RKVITKYQQK VLNQLRSFIE
410 420 430 440 450
KQQNQPNPTH RLELINTQDK RDNAFVQELA DELHLHTTWD EVDDYGQSLI
460 470 480 490 500
VCTFNMEGVS QDGSADGKEE DGDWESDEME DEGKLAVQRV FRNWSKAAVV
510 520 530 540 550
DTYPEDVEKS MDEKLKEAMD DIKRQYYHDK LEINYNDPAQ MQDLVHHYIE
560 570 580 590 600
GLQWILNYYY KGVSSWGWFY KYHYSPRITD LKGVADMKFE FDYGKPFTPF
610 620 630 640 650
QQLMGVLPVD SMDHVPLAYR DLMYEETSPI IDFYPRNFEL DMNGKKQDWE
660 670 680 690 700
AVVKIPFIDQ NRLLKAMAAR DVRLTPEERE RNKSGVLSTQ FVYDPEIDEN
710 720 730 740 750
YPSSFPGVFP ELTRSHCRAS PFNLPVLGGD VQLIFGLVEG VQLGVSALAG
760 770 780 790 800
FPSLDTLPHN GTLDYHGVNV FQSDSKNPSM VITIIGKDEL PKTSEIARNV
810 820 830 840 850
LGQRTFHSWP YLQEGIVAAV SDDMFKYTLQ QVGKSLRVVH MPHQDAVKWR
860 870 880 890 900
RQADHVERHY SRRYGVIIGG VEVLLHIRPL KGLKHLDNGA LVKDYETPEK
910 920 930 940 950
EIVQAYQVAV SQVTFEDERF LERAPPDLKV DFPVGEKVLF LGDMHYGLAA
960 970 980 990 1000
QVSAVNEEAQ TLSVILAYFE EETEETLRFM KAVAHRPAGK WWPSPILSRR
1010 1020 1030 1040 1050
LGISALALSR ITSTLLVQLG DGSKTNIGLS LKFESRGLKV LGYSKRNDRG
1060 1070 1080 1090 1100
WEFSEKTAQV LEAYKKAFPE VFKHLENRGG DLVKSKELCP TAEDPDTVIK
1110 1120 1130 1140 1150
GMKKWLKDEG LNDLESVSLF ADQLEAETCQ IVEKLADDIL SKKTFQSIKK
1160 1170 1180 1190 1200
KRLDNVPRQT LLKPAQAIYR LQGQVFEPGH RVVMVQDPAA GGVPTGMRGV
1210 1220 1230 1240 1250
VVGLGMRTVD VIWDNGFMGG STLQGKCSPY RGSTVPFSSC LNLTRPQFTV
1260 1270 1280 1290 1300
SERAGPKPVP QNVFRPQLGP RPAVPMQHYQ PSVPGRQQTA TTTHHILQKP
1310 1320 1330 1340 1350
KTVHSTQSTT VVGSNGHLKY SGVAKGVRPQ PVQQQPVSHR DQLSNLLGGL
1360 1370 1380 1390 1400
RLGPGPVVND NRDSSHVTHV QAQGNLPVVH SHASVHQAIP TNPPIRGKAQ
1410 1420 1430 1440 1450
NMNNKSGIGA VRGRGAANGA PFAHRGTHNG VPASARGGAP NGGPRGRGGF
1460 1470
RGGSRGFTRG RGVGSGGSAV VEE
Length:1,473
Mass (Da):166,401
Last modified:February 17, 2016 - v2
Checksum:i483C2B25BFFEC1F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017345 Genomic DNA Translation: AAW43624.2
RefSeqiXP_570931.1, XM_570931.1

Genome annotation databases

EnsemblFungiiAAW43624; AAW43624; CNE03620
KEGGicne:CNE03620

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017345 Genomic DNA Translation: AAW43624.2
RefSeqiXP_570931.1, XM_570931.1

3D structure databases

ProteinModelPortaliQ5KGH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi214684.XP_570931.1

Proteomic databases

PaxDbiQ5KGH2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAW43624; AAW43624; CNE03620
KEGGicne:CNE03620

Organism-specific databases

EuPathDBiFungiDB:CNE03620

Phylogenomic databases

eggNOGiKOG2044 Eukaryota
COG5049 LUCA
HOGENOMiHOG000160331
InParanoidiQ5KGH2
KOiK12618
OrthoDBiEOG092C068M

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR014722 Rib_L2_dom2
PANTHERiPTHR12341 PTHR12341, 1 hit
PfamiView protein in Pfam
PF03159 XRN_N, 1 hit
PIRSFiPIRSF006743 Exonuclease_Xnr1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5KGH2_CRYNJ
AccessioniPrimary (citable) accession number: Q5KGH2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 17, 2016
Last modified: July 18, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again