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Entry version 89 (31 Jul 2019)
Sequence version 1 (15 Feb 2005)
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Protein
Submitted name:

Importin beta-4 subunit, putative

Gene

CNF00890

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Importin beta-4 subunit, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:CNF00890Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri214684 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002149 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CNF00890

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5KFR0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5207.AAW44196

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 98Importin N-terminalInterPro annotationAdd BLAST72
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati517 – 555HEATPROSITE-ProRule annotationAdd BLAST39

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQKY Eukaryota
ENOG410XP2Z LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5KFR0

KEGG Orthology (KO)

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KOi
K20221

Identification of Orthologs from Complete Genome Data

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OMAi
FENISTM

Database of Orthologous Groups

More...
OrthoDBi
331433at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR001494 Importin-beta_N
IPR040122 Importin_beta
IPR034085 TOG

The PANTHER Classification System

More...
PANTHERi
PTHR10527 PTHR10527, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03810 IBN_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00913 IBN_N, 1 hit
SM01349 TOG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit
PS50166 IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5KFR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPNYISTLR QLLEASIAPD TSLIKAATTQ LNTQFYKDPN CIPSLYEVSC
60 70 80 90 100
TSENPAIRQL AAVELRKRIS AGDGKMWKKN PQQLRDQIKE SLLQRLTSET
110 120 130 140 150
SSIVRHAQAQ AVAAIADIEL TVTPPQWPTL MPGLYQAAGS ADKAHRETAI
160 170 180 190 200
YVLFSILDTV AESFESHLQS LFKVFSVSLV DPESAEVRVT TLRALAKVAE
210 220 230 240 250
YIEPSDKHDI KAFQDLIVPM LKVLEQAIKD GDDEGVKHGY DAFETFLILE
260 270 280 290 300
APLVSKHVAE LVQFFLGAAS NKEVEDEMRC GALNVLSWVI RYKKSKVQAL
310 320 330 340 350
GLAKPIIEGL LPIGCEDDPE DVDEDSPSRL AFRTLDNLAQ VLPPQQVFPV
360 370 380 390 400
LTQQLQVYMS SGDARMRKSA LMAFGVSVEG CSEYIRPHVD QLWPVIEGGL
410 420 430 440 450
QDGEVIVRKA ACIALGCLCE WLAEECATRH SVIVPILFNL IVDPATQKNA
460 470 480 490 500
CTCLDSYLEI LGDDIVNYLT LLMERLLVLL ENGTVAVKIT VTGAIGSAAH
510 520 530 540 550
AAKEKFIPYF GQTIQRLVPF LELNENDEQN DLRGVATDTI GTIADAVGAD
560 570 580 590 600
VFRPYFQPLM KAAFEALTMD NSRLRESSFI FFGIMAQVFT GEFAQYLPQC
610 620 630 640 650
VPALVASCQQ SEVSEELDEE GNSNPAQLAE AFSMAAGSSK NAGELLDDEE
660 670 680 690 700
DDTDLAALDD MFSKVNSAVA IEKEVAADTI GELFAATKSA FMPYVEETVK
710 720 730 740 750
VLIDLLDHYY EGIRKSAVGA LFQYIKTMYE LSEAPEWQPG AKIAIPLHEH
760 770 780 790 800
VKSIVNLVLP PIFETWKTED DQSVVIFMCS ELADTMNKCG PAVIEGYLDE
810 820 830 840 850
VATFAIEILE KKSLCQQDPD GDDEGAAEAD SSEYEAALVS NAADVFGAMA
860 870 880 890 900
TVLGPDFQQA FGQVLPLIAK YTESKRTNTE RSMAIGSLGE IIVGLKSGVT
910 920 930 940 950
QFTEPLFQVI SRGIVDEDPD VRSNAAFASG VLIENSDADL SSHYPALLHA
960 970 980 990 1000
LHPLFTPPEH APPALYNARD NAAGSVARMI TKNAAALPLA DVVAVIVSVL
1010 1020 1030 1040 1050
PLRFDPLENR AVYKALFQLF RTQPDLVMAH IDHLLQAFAY VLLDPSHADD
1060 1070 1080
TTDETKAELK ALVEHLKSQV PDKVAAAGFA
Length:1,080
Mass (Da):118,049
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0383E1FEF65C5CF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE017346 Genomic DNA Translation: AAW44196.1

NCBI Reference Sequences

More...
RefSeqi
XP_571503.1, XM_571503.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AAW44196; AAW44196; CNF00890

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3258174

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cne:CNF00890

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017346 Genomic DNA Translation: AAW44196.1
RefSeqiXP_571503.1, XM_571503.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5207.AAW44196

Proteomic databases

PaxDbiQ5KFR0

Genome annotation databases

EnsemblFungiiAAW44196; AAW44196; CNF00890
GeneIDi3258174
KEGGicne:CNF00890

Organism-specific databases

EuPathDBiFungiDB:CNF00890

Phylogenomic databases

eggNOGiENOG410IQKY Eukaryota
ENOG410XP2Z LUCA
InParanoidiQ5KFR0
KOiK20221
OMAiFENISTM
OrthoDBi331433at2759

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR021133 HEAT_type_2
IPR001494 Importin-beta_N
IPR040122 Importin_beta
IPR034085 TOG
PANTHERiPTHR10527 PTHR10527, 1 hit
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SM01349 TOG, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit
PS50166 IMPORTIN_B_NT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5KFR0_CRYNJ
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5KFR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: July 31, 2019
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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