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Protein

Long-chain fatty acid transport protein 3

Gene

SLC27A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-48 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi332 – 343AMPSequence analysisAdd BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandNucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs

Protein family/group databases

TCDBi4.C.1.1.12 the fatty acid transporter (fat) family

Chemistry databases

SwissLipidsiSLP:000001267

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 3 (EC:6.2.1.-)
Short name:
FATP-3
Short name:
Fatty acid transport protein 3
Alternative name(s):
Solute carrier family 27 member 3
Very long-chain acyl-CoA synthetase homolog 3
Short name:
VLCS-3
Gene namesi
Name:SLC27A3
Synonyms:ACSVL3, FATP3
ORF Names:PSEC0067, UNQ367/PRO703
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143554.13
HGNCiHGNC:10997 SLC27A3
MIMi604193 gene
neXtProtiNX_Q5K4L6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi11000
OpenTargetsiENSG00000143554
PharmGKBiPA35871

Polymorphism and mutation databases

BioMutaiSLC27A3
DMDMi215274206

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001932071 – 730Long-chain fatty acid transport protein 3Add BLAST730

Proteomic databases

EPDiQ5K4L6
MaxQBiQ5K4L6
PaxDbiQ5K4L6
PeptideAtlasiQ5K4L6
PRIDEiQ5K4L6
ProteomicsDBi63544
63545 [Q5K4L6-2]
63546 [Q5K4L6-3]

PTM databases

iPTMnetiQ5K4L6
PhosphoSitePlusiQ5K4L6

Expressioni

Gene expression databases

BgeeiENSG00000143554 Expressed in 182 organ(s), highest expression level in body of stomach
ExpressionAtlasiQ5K4L6 baseline and differential
GenevisibleiQ5K4L6 HS

Organism-specific databases

HPAiHPA006935
HPA067508

Interactioni

Protein-protein interaction databases

BioGridi116193, 34 interactors
IntActiQ5K4L6, 1 interactor
MINTiQ5K4L6
STRINGi9606.ENSP00000357650

Structurei

3D structure databases

ProteinModelPortaliQ5K4L6
SMRiQ5K4L6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1179 Eukaryota
ENOG410XQ8T LUCA
GeneTreeiENSGT00550000074420
HOVERGENiHBG005642
InParanoidiQ5K4L6
KOiK08772
PhylomeDBiQ5K4L6
TreeFamiTF313430

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR030307 FATP3
PANTHERiPTHR43107:SF12 PTHR43107:SF12, 1 hit
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5K4L6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVCQRTRAP WKEKSQLERA ALGFRKGGSG MFASGWNQTV PIEEAGSMAA
60 70 80 90 100
LLLLPLLLLL PLLLLKLHLW PQLRWLPADL AFAVRALCCK RALRARALAA
110 120 130 140 150
AAADPEGPEG GCSLAWRLAE LAQQRAAHTF LIHGSRRFSY SEAERESNRA
160 170 180 190 200
ARAFLRALGW DWGPDGGDSG EGSAGEGERA APGAGDAAAG SGAEFAGGDG
210 220 230 240 250
AARGGGAAAP LSPGATVALL LPAGPEFLWL WFGLAKAGLR TAFVPTALRR
260 270 280 290 300
GPLLHCLRSC GARALVLAPE FLESLEPDLP ALRAMGLHLW AAGPGTHPAG
310 320 330 340 350
ISDLLAEVSA EVDGPVPGYL SSPQSITDTC LYIFTSGTTG LPKAARISHL
360 370 380 390 400
KILQCQGFYQ LCGVHQEDVI YLALPLYHMS GSLLGIVGCM GIGATVVLKS
410 420 430 440 450
KFSAGQFWED CQQHRVTVFQ YIGELCRYLV NQPPSKAERG HKVRLAVGSG
460 470 480 490 500
LRPDTWERFV RRFGPLQVLE TYGLTEGNVA TINYTGQRGA VGRASWLYKH
510 520 530 540 550
IFPFSLIRYD VTTGEPIRDP QGHCMATSPG EPGLLVAPVS QQSPFLGYAG
560 570 580 590 600
GPELAQGKLL KDVFRPGDVF FNTGDLLVCD DQGFLRFHDR TGDTFRWKGE
610 620 630 640 650
NVATTEVAEV FEALDFLQEV NVYGVTVPGH EGRAGMAALV LRPPHALDLM
660 670 680 690 700
QLYTHVSENL PPYARPRFLR LQESLATTET FKQQKVRMAN EGFDPSTLSD
710 720 730
PLYVLDQAVG AYLPLTTARY SALLAGNLRI
Length:730
Mass (Da):78,644
Last modified:November 25, 2008 - v3
Checksum:iE8CC4E9463A534A0
GO
Isoform 2 (identifier: Q5K4L6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     673-707: Missing.

Show »
Length:695
Mass (Da):74,702
Checksum:iC92234E76758019E
GO
Isoform 3 (identifier: Q5K4L6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     270-276: EFLESLE → GKAGAPN
     277-730: Missing.

Show »
Length:276
Mass (Da):28,670
Checksum:i7FC81638A981ED34
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R3N0X6R3N0_HUMAN
Long-chain fatty acid transport pro...
SLC27A3 hCG_19279
811Annotation score:
H7BZH4H7BZH4_HUMAN
Long-chain fatty acid transport pro...
SLC27A3
400Annotation score:
H0YDP0H0YDP0_HUMAN
Long-chain fatty acid transport pro...
SLC27A3
152Annotation score:
H0YDM5H0YDM5_HUMAN
Long-chain fatty acid transport pro...
SLC27A3
144Annotation score:

Sequence cautioni

The sequence AAH29792 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55156 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB84960 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86050 differs from that shown. Reason: Frameshift at position 540.Curated
The sequence BAC86050 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAE12159 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12K → E in BAB55156 (PubMed:14702039).Curated1
Sequence conflicti66K → M in CAE12159 (Ref. 1) Curated1
Sequence conflicti472Y → F in AAH03654 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048241110G → A. Corresponds to variant dbSNP:rs34527123Ensembl.1
Natural variantiVAR_048242439R → H. Corresponds to variant dbSNP:rs35102232Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036534270 – 276EFLESLE → GKAGAPN in isoform 3. 1 Publication7
Alternative sequenceiVSP_036535277 – 730Missing in isoform 3. 1 PublicationAdd BLAST454
Alternative sequenceiVSP_016218673 – 707Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ577572 mRNA Translation: CAE12159.1 Different initiation.
AK074134 mRNA Translation: BAB84960.1 Different initiation.
AY358409 mRNA Translation: AAQ88775.1
AK027499 mRNA Translation: BAB55156.1 Different initiation.
AK075377 mRNA Translation: BAC11578.1
AK125102 mRNA Translation: BAC86050.1 Sequence problems.
AL513523 Genomic DNA No translation available.
BC003041 mRNA Translation: AAH03041.1
BC003654 mRNA Translation: AAH03654.2
BC009916 mRNA Translation: AAH09916.1
BC029792 mRNA Translation: AAH29792.1 Different initiation.
RefSeqiNP_001304858.2, NM_001317929.2
NP_077306.2, NM_024330.2
UniGeneiHs.438723

Genome annotation databases

EnsembliENST00000368661; ENSP00000357650; ENSG00000143554 [Q5K4L6-1]
ENST00000623839; ENSP00000485585; ENSG00000263163 [Q5K4L6-1]
ENST00000624995; ENSP00000485061; ENSG00000143554 [Q5K4L6-1]
GeneIDi11000
KEGGihsa:11000
UCSCiuc001fcz.3 human [Q5K4L6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ577572 mRNA Translation: CAE12159.1 Different initiation.
AK074134 mRNA Translation: BAB84960.1 Different initiation.
AY358409 mRNA Translation: AAQ88775.1
AK027499 mRNA Translation: BAB55156.1 Different initiation.
AK075377 mRNA Translation: BAC11578.1
AK125102 mRNA Translation: BAC86050.1 Sequence problems.
AL513523 Genomic DNA No translation available.
BC003041 mRNA Translation: AAH03041.1
BC003654 mRNA Translation: AAH03654.2
BC009916 mRNA Translation: AAH09916.1
BC029792 mRNA Translation: AAH29792.1 Different initiation.
RefSeqiNP_001304858.2, NM_001317929.2
NP_077306.2, NM_024330.2
UniGeneiHs.438723

3D structure databases

ProteinModelPortaliQ5K4L6
SMRiQ5K4L6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116193, 34 interactors
IntActiQ5K4L6, 1 interactor
MINTiQ5K4L6
STRINGi9606.ENSP00000357650

Chemistry databases

SwissLipidsiSLP:000001267

Protein family/group databases

TCDBi4.C.1.1.12 the fatty acid transporter (fat) family

PTM databases

iPTMnetiQ5K4L6
PhosphoSitePlusiQ5K4L6

Polymorphism and mutation databases

BioMutaiSLC27A3
DMDMi215274206

Proteomic databases

EPDiQ5K4L6
MaxQBiQ5K4L6
PaxDbiQ5K4L6
PeptideAtlasiQ5K4L6
PRIDEiQ5K4L6
ProteomicsDBi63544
63545 [Q5K4L6-2]
63546 [Q5K4L6-3]

Protocols and materials databases

DNASUi11000
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368661; ENSP00000357650; ENSG00000143554 [Q5K4L6-1]
ENST00000623839; ENSP00000485585; ENSG00000263163 [Q5K4L6-1]
ENST00000624995; ENSP00000485061; ENSG00000143554 [Q5K4L6-1]
GeneIDi11000
KEGGihsa:11000
UCSCiuc001fcz.3 human [Q5K4L6-1]

Organism-specific databases

CTDi11000
DisGeNETi11000
EuPathDBiHostDB:ENSG00000143554.13
GeneCardsiSLC27A3
HGNCiHGNC:10997 SLC27A3
HPAiHPA006935
HPA067508
MIMi604193 gene
neXtProtiNX_Q5K4L6
OpenTargetsiENSG00000143554
PharmGKBiPA35871
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1179 Eukaryota
ENOG410XQ8T LUCA
GeneTreeiENSGT00550000074420
HOVERGENiHBG005642
InParanoidiQ5K4L6
KOiK08772
PhylomeDBiQ5K4L6
TreeFamiTF313430

Enzyme and pathway databases

ReactomeiR-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs

Miscellaneous databases

ChiTaRSiSLC27A3 human
GeneWikiiSLC27A3
GenomeRNAii11000
PROiPR:Q5K4L6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143554 Expressed in 182 organ(s), highest expression level in body of stomach
ExpressionAtlasiQ5K4L6 baseline and differential
GenevisibleiQ5K4L6 HS

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR030307 FATP3
PANTHERiPTHR43107:SF12 PTHR43107:SF12, 1 hit
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS27A3_HUMAN
AccessioniPrimary (citable) accession number: Q5K4L6
Secondary accession number(s): Q5VUQ7
, Q5VUQ8, Q5VUR3, Q6ZV16, Q8N2X7, Q8TEJ0, Q96SW5, Q9BTJ5, Q9BTY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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