UniProtKB - Q5JZY3 (EPHAA_HUMAN)
Protein
Ephrin type-A receptor 10
Gene
EPHA10
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.1 Publication
Catalytic activityi
- EC:2.7.10.1
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- transmembrane-ephrin receptor activity Source: UniProtKB
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- axon guidance Source: GO_Central
- ephrin receptor signaling pathway Source: Reactome
- multicellular organism development Source: GO_Central
- positive regulation of kinase activity Source: GO_Central
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q5JZY3 |
Reactomei | R-HSA-2682334, EPH-Ephrin signaling R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-3928665, EPH-ephrin mediated repulsion of cells |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:EPHA10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19987, EPHA10 |
MIMi | 611123, gene |
neXtProti | NX_Q5JZY3 |
VEuPathDBi | HostDB:ENSG00000183317.16 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB
- neuron projection Source: GO_Central
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 34 – 565 | ExtracellularSequence analysisAdd BLAST | 532 | |
Transmembranei | 566 – 586 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 587 – 1008 | CytoplasmicSequence analysisAdd BLAST | 422 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 284656 |
OpenTargetsi | ENSG00000183317 |
PharmGKBi | PA134938798 |
Miscellaneous databases
Pharosi | Q5JZY3, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2363043 |
Genetic variation databases
BioMutai | EPHA10 |
DMDMi | 476007830 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
ChainiPRO_0000042157 | 34 – 1008 | Ephrin type-A receptor 10Add BLAST | 975 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 311 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 486 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q5JZY3 |
MassIVEi | Q5JZY3 |
PaxDbi | Q5JZY3 |
PeptideAtlasi | Q5JZY3 |
PRIDEi | Q5JZY3 |
ProteomicsDBi | 63538 [Q5JZY3-1] 63539 [Q5JZY3-2] 63540 [Q5JZY3-3] |
PTM databases
GlyGeni | Q5JZY3, 2 sites |
iPTMneti | Q5JZY3 |
PhosphoSitePlusi | Q5JZY3 |
Expressioni
Tissue specificityi
Mainly expressed in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000183317, Expressed in sperm and 130 other tissues |
ExpressionAtlasi | Q5JZY3, baseline and differential |
Genevisiblei | Q5JZY3, HS |
Organism-specific databases
HPAi | ENSG00000183317, Tissue enhanced (brain, intestine, testis) |
Interactioni
Binary interactionsi
Hide detailsIsoform 3 [Q5JZY3-3]
With | #Exp. | IntAct |
---|---|---|
BANP [Q8N9N5] | 3 | EBI-10244652,EBI-744695 |
CAMK2D [Q13557] | 3 | EBI-10244652,EBI-351018 |
FHL3 [Q13643] | 3 | EBI-10244652,EBI-741101 |
TFCP2 [Q12800] | 3 | EBI-10244652,EBI-717422 |
Protein-protein interaction databases
BioGRIDi | 129927, 5 interactors |
IntActi | Q5JZY3, 5 interactors |
STRINGi | 9606.ENSP00000362139 |
Miscellaneous databases
RNActi | Q5JZY3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 216 | Eph LBDPROSITE-ProRule annotationAdd BLAST | 182 | |
Domaini | 340 – 452 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 113 | |
Domaini | 456 – 554 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 645 – 900 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 256 | |
Domaini | 933 – 997 | SAMPROSITE-ProRule annotationAdd BLAST | 65 |
Domaini
The protein kinase domain is predicted to be catalytically inactive.
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000160752 |
HOGENOMi | CLU_000288_141_4_1 |
InParanoidi | Q5JZY3 |
TreeFami | TF314013 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS50011, PROTEIN_KINASE_DOM, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5JZY3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW
60 70 80 90 100
TALPSNGWEE ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR
110 120 130 140 150
IFVELQFTLR DCSSIPGAAG TCKETFNVYY LETEADLGRG RPRLGGSRPR
160 170 180 190 200
KIDTIAADES FTQGDLGERK MKLNTEVREI GPLSRRGFHL AFQDVGACVA
210 220 230 240 250
LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC VAHSEGEPGS
260 270 280 290 300
PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS
310 320 330 340 350
PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR
360 370 380 390 400
SPLVLRLRWL PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP
410 420 430 440 450
RQAGLRERAA TLLHLRPGAR YTVRVAALNG VSGPAAAAGT TYAQVTVSTG
460 470 480 490 500
PGAPWEEDEI RRDRVEPQSV SLSWREPIPA GAPGANDTEY EIRYYEKGQS
510 520 530 540 550
EQTYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA QSFNPSIEVQ
560 570 580 590 600
TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG
610 620 630 640 650
DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS
660 670 680 690 700
LGGGRFGELC CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ
710 720 730 740 750
FDHSHIVRLE GVVTRGSTLM IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL
760 770 780 790 800
LPGLASAMKY LSEMGYVHRG LAARHVLVSS DLVCKISGFG RGPRDRSEAV
810 820 830 840 850
YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM AFGERPYWDM
860 870 880 890 900
SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGER PRFSQIHSIL
910 920 930 940 950
SKMVQDPEPP KCALTTCPRP PTPLADRAFS TFPSFGSVGA WLEALDLCRY
960 970 980 990 1000
KDSFAAAGYG SLEAVAEMTA QDLVSLGISL AEHREALLSG ISALQARVLQ
LQGQGVQV
Isoform 3 (identifier: Q5JZY3-3) [UniParc]FASTAAdd to basket
Also known as: Epha10*
The sequence of this isoform differs from the canonical sequence as follows:
889-892: ERPR → LPPH
893-1008: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KQG3 | J3KQG3_HUMAN | EPH receptor A10, isoform CRA_b | EPHA10 hCG_1820945 | 1,014 | Annotation score: | ||
H0YCC9 | H0YCC9_HUMAN | Ephrin type-A receptor 10 | EPHA10 | 392 | Annotation score: | ||
H0YD12 | H0YD12_HUMAN | Ephrin type-A receptor 10 | EPHA10 | 218 | Annotation score: | ||
F5GWI2 | F5GWI2_HUMAN | Ephrin type-A receptor 10 | EPHA10 | 155 | Annotation score: | ||
H0YER4 | H0YER4_HUMAN | Ephrin type-A receptor 10 | EPHA10 | 217 | Annotation score: | ||
H0YEP6 | H0YEP6_HUMAN | Ephrin type-A receptor 10 | EPHA10 | 92 | Annotation score: |
Sequence cautioni
The sequence AAI12934 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 458 | D → G in CAI43321 (PubMed:15777695).Curated | 1 | |
Sequence conflicti | 503 | T → A in CAI43321 (PubMed:15777695).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055992 | 103 | V → L. Corresponds to variant dbSNP:rs34557762Ensembl. | 1 | |
Natural variantiVAR_042159 | 150 | R → H in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs771803475Ensembl. | 1 | |
Natural variantiVAR_042160 | 220 | T → K1 PublicationCorresponds to variant dbSNP:rs56276182Ensembl. | 1 | |
Natural variantiVAR_042161 | 281 | F → I1 PublicationCorresponds to variant dbSNP:rs4653328Ensembl. | 1 | |
Natural variantiVAR_055993 | 629 | L → P. Corresponds to variant dbSNP:rs17511304Ensembl. | 1 | |
Natural variantiVAR_042162 | 630 | L → P1 Publication | 1 | |
Natural variantiVAR_055994 | 645 | V → I. Corresponds to variant dbSNP:rs12405650Ensembl. | 1 | |
Natural variantiVAR_055995 | 749 | G → E. Corresponds to variant dbSNP:rs6671088Ensembl. | 1 | |
Natural variantiVAR_042163 | 775 | H → R in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_055996 | 807 | R → Q. Corresponds to variant dbSNP:rs6670599Ensembl. | 1 | |
Natural variantiVAR_042164 | 956 | A → T1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015772 | 284 – 295 | ACPPG…KVSPR → GIQLAGGRGVGV in isoform 2. 2 PublicationsAdd BLAST | 12 | |
Alternative sequenceiVSP_015773 | 296 – 1008 | Missing in isoform 2. 2 PublicationsAdd BLAST | 713 | |
Alternative sequenceiVSP_015774 | 889 – 892 | ERPR → LPPH in isoform 3. 1 Publication | 4 | |
Alternative sequenceiVSP_015775 | 893 – 1008 | Missing in isoform 3. 1 PublicationAdd BLAST | 116 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ872185 Genomic DNA Translation: CAI43321.1 AJ781169 mRNA Translation: CAG77605.1 AC104336 Genomic DNA No translation available. BC067734 mRNA Translation: AAH67734.1 BC112933 mRNA Translation: AAI12934.1 Different initiation. |
CCDSi | CCDS41305.1 [Q5JZY3-1] CCDS425.1 [Q5JZY3-2] |
RefSeqi | NP_001092909.1, NM_001099439.1 [Q5JZY3-1] NP_775912.2, NM_173641.2 [Q5JZY3-2] |
Genome annotation databases
Ensembli | ENST00000319637; ENSP00000316395; ENSG00000183317 [Q5JZY3-2] ENST00000373048; ENSP00000362139; ENSG00000183317 [Q5JZY3-1] |
GeneIDi | 284656 |
KEGGi | hsa:284656 |
UCSCi | uc001cbw.5, human [Q5JZY3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ872185 Genomic DNA Translation: CAI43321.1 AJ781169 mRNA Translation: CAG77605.1 AC104336 Genomic DNA No translation available. BC067734 mRNA Translation: AAH67734.1 BC112933 mRNA Translation: AAI12934.1 Different initiation. |
CCDSi | CCDS41305.1 [Q5JZY3-1] CCDS425.1 [Q5JZY3-2] |
RefSeqi | NP_001092909.1, NM_001099439.1 [Q5JZY3-1] NP_775912.2, NM_173641.2 [Q5JZY3-2] |
3D structure databases
SMRi | Q5JZY3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129927, 5 interactors |
IntActi | Q5JZY3, 5 interactors |
STRINGi | 9606.ENSP00000362139 |
Chemistry databases
ChEMBLi | CHEMBL2363043 |
PTM databases
GlyGeni | Q5JZY3, 2 sites |
iPTMneti | Q5JZY3 |
PhosphoSitePlusi | Q5JZY3 |
Genetic variation databases
BioMutai | EPHA10 |
DMDMi | 476007830 |
Proteomic databases
jPOSTi | Q5JZY3 |
MassIVEi | Q5JZY3 |
PaxDbi | Q5JZY3 |
PeptideAtlasi | Q5JZY3 |
PRIDEi | Q5JZY3 |
ProteomicsDBi | 63538 [Q5JZY3-1] 63539 [Q5JZY3-2] 63540 [Q5JZY3-3] |
Protocols and materials databases
Antibodypediai | 51311, 269 antibodies |
DNASUi | 284656 |
Genome annotation databases
Ensembli | ENST00000319637; ENSP00000316395; ENSG00000183317 [Q5JZY3-2] ENST00000373048; ENSP00000362139; ENSG00000183317 [Q5JZY3-1] |
GeneIDi | 284656 |
KEGGi | hsa:284656 |
UCSCi | uc001cbw.5, human [Q5JZY3-1] |
Organism-specific databases
CTDi | 284656 |
DisGeNETi | 284656 |
GeneCardsi | EPHA10 |
HGNCi | HGNC:19987, EPHA10 |
HPAi | ENSG00000183317, Tissue enhanced (brain, intestine, testis) |
MIMi | 611123, gene |
neXtProti | NX_Q5JZY3 |
OpenTargetsi | ENSG00000183317 |
PharmGKBi | PA134938798 |
VEuPathDBi | HostDB:ENSG00000183317.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0196, Eukaryota |
GeneTreei | ENSGT00940000160752 |
HOGENOMi | CLU_000288_141_4_1 |
InParanoidi | Q5JZY3 |
TreeFami | TF314013 |
Enzyme and pathway databases
PathwayCommonsi | Q5JZY3 |
Reactomei | R-HSA-2682334, EPH-Ephrin signaling R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-3928665, EPH-ephrin mediated repulsion of cells |
Miscellaneous databases
BioGRID-ORCSi | 284656, 6 hits in 1021 CRISPR screens |
ChiTaRSi | EPHA10, human |
GeneWikii | EPHA10 |
GenomeRNAii | 284656 |
Pharosi | Q5JZY3, Tbio |
PROi | PR:Q5JZY3 |
RNActi | Q5JZY3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183317, Expressed in sperm and 130 other tissues |
ExpressionAtlasi | Q5JZY3, baseline and differential |
Genevisiblei | Q5JZY3, HS |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 1.10.150.50, 1 hit 2.60.120.260, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR027936, Eph_TM IPR001090, Ephrin_rcpt_lig-bd_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR008979, Galactose-bd-like_sf IPR013783, Ig-like_fold IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR016257, Tyr_kinase_ephrin_rcpt IPR001426, Tyr_kinase_rcpt_V_CS |
Pfami | View protein in Pfam PF14575, EphA2_TM, 1 hit PF01404, Ephrin_lbd, 1 hit PF00041, fn3, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF00536, SAM_1, 1 hit |
PIRSFi | PIRSF000666, TyrPK_ephrin_receptor, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00615, EPH_lbd, 1 hit SM00060, FN3, 2 hits SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF49265, SSF49265, 1 hit SSF49785, SSF49785, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS51550, EPH_LBD, 1 hit PS50853, FN3, 2 hits PS50011, PROTEIN_KINASE_DOM, 1 hit PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EPHAA_HUMAN | |
Accessioni | Q5JZY3Primary (citable) accession number: Q5JZY3 Secondary accession number(s): A4FU89, J3KPB5, Q6NW42 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | April 3, 2013 | |
Last modified: | April 7, 2021 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families