Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q5JZY3 (EPHAA_HUMAN)

Protein

Ephrin type-A receptor 10

Gene

EPHA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • transmembrane-ephrin receptor activity Source: UniProtKB
  • transmembrane receptor protein tyrosine kinase activity Source: GO_Central
  • transmembrane signaling receptor activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-A receptor 10 (EC:2.7.10.1)
Gene namesi
Name:EPHA10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000183317.16
HGNCiHGNC:19987 EPHA10
MIMi611123 gene
neXtProtiNX_Q5JZY3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 565ExtracellularSequence analysisAdd BLAST532
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 1008CytoplasmicSequence analysisAdd BLAST422

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi284656
OpenTargetsiENSG00000183317
PharmGKBiPA134938798

Chemistry databases

ChEMBLiCHEMBL2363043

Polymorphism and mutation databases

BioMutaiEPHA10
DMDMi476007830

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000004215734 – 1008Ephrin type-A receptor 10Add BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi486N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5JZY3
PeptideAtlasiQ5JZY3
PRIDEiQ5JZY3
ProteomicsDBi63538
63539 [Q5JZY3-2]
63540 [Q5JZY3-3]

PTM databases

iPTMnetiQ5JZY3
PhosphoSitePlusiQ5JZY3

Expressioni

Tissue specificityi

Mainly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000183317 Expressed in 113 organ(s), highest expression level in sperm
CleanExiHS_EPHA10
ExpressionAtlasiQ5JZY3 baseline and differential
GenevisibleiQ5JZY3 HS

Organism-specific databases

HPAiHPA027497

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi129927, 5 interactors
IntActiQ5JZY3, 4 interactors
STRINGi9606.ENSP00000362139

Structurei

3D structure databases

ProteinModelPortaliQ5JZY3
SMRiQ5JZY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 216Eph LBDPROSITE-ProRule annotationAdd BLAST182
Domaini340 – 452Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST113
Domaini456 – 554Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini645 – 900Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini933 – 997SAMPROSITE-ProRule annotationAdd BLAST65

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
HOGENOMiHOG000233856
HOVERGENiHBG062180
InParanoidiQ5JZY3
KOiK08897
TreeFamiTF314013

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF00536 SAM_1, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JZY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW 
        60         70         80         90        100
TALPSNGWEE ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR 
       110        120        130        140        150
IFVELQFTLR DCSSIPGAAG TCKETFNVYY LETEADLGRG RPRLGGSRPR 
       160        170        180        190        200
KIDTIAADES FTQGDLGERK MKLNTEVREI GPLSRRGFHL AFQDVGACVA 
       210        220        230        240        250
LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC VAHSEGEPGS 
       260        270        280        290        300
PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS 
       310        320        330        340        350
PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR 
       360        370        380        390        400
SPLVLRLRWL PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP 
       410        420        430        440        450
RQAGLRERAA TLLHLRPGAR YTVRVAALNG VSGPAAAAGT TYAQVTVSTG 
       460        470        480        490        500
PGAPWEEDEI RRDRVEPQSV SLSWREPIPA GAPGANDTEY EIRYYEKGQS 
       510        520        530        540        550
EQTYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA QSFNPSIEVQ 
       560        570        580        590        600
TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG 
       610        620        630        640        650
DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS 
       660        670        680        690        700
LGGGRFGELC CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ 
       710        720        730        740        750
FDHSHIVRLE GVVTRGSTLM IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL 
       760        770        780        790        800
LPGLASAMKY LSEMGYVHRG LAARHVLVSS DLVCKISGFG RGPRDRSEAV 
       810        820        830        840        850
YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM AFGERPYWDM 
       860        870        880        890        900
SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGER PRFSQIHSIL 
       910        920        930        940        950
SKMVQDPEPP KCALTTCPRP PTPLADRAFS TFPSFGSVGA WLEALDLCRY 
       960        970        980        990       1000
KDSFAAAGYG SLEAVAEMTA QDLVSLGISL AEHREALLSG ISALQARVLQ 

LQGQGVQV
Length:1,008
Mass (Da):109,716
Last modified:April 3, 2013 - v2
Checksum:i82D60740B7B6B9BD
GO
Isoform 2 (identifier: Q5JZY3-2) [UniParc]FASTAAdd to basket
Also known as: Epha10s

The sequence of this isoform differs from the canonical sequence as follows:
     284-295: ACPPGFYKVSPR → GIQLAGGRGVGV
     296-1008: Missing.

Show »
Length:295
Mass (Da):32,120
Checksum:iC5818C0D8C4444D1
GO
Isoform 3 (identifier: Q5JZY3-3) [UniParc]FASTAAdd to basket
Also known as: Epha10*

The sequence of this isoform differs from the canonical sequence as follows:
     889-892: ERPR → LPPH
     893-1008: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:892
Mass (Da):97,293
Checksum:iD91B200D8B705F89
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQG3J3KQG3_HUMAN
EPH receptor A10, isoform CRA_b
EPHA10 hCG_1820945
1,014Annotation score:
H0YCC9H0YCC9_HUMAN
Ephrin type-A receptor 10
EPHA10
392Annotation score:
H0YD12H0YD12_HUMAN
Ephrin type-A receptor 10
EPHA10
218Annotation score:
F5GWI2F5GWI2_HUMAN
Ephrin type-A receptor 10
EPHA10
155Annotation score:
H0YER4H0YER4_HUMAN
Ephrin type-A receptor 10
EPHA10
217Annotation score:
H0YEP6H0YEP6_HUMAN
Ephrin type-A receptor 10
EPHA10
92Annotation score:

Sequence cautioni

The sequence AAI12934 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti458D → G in CAI43321 (PubMed:15777695).Curated1
Sequence conflicti503T → A in CAI43321 (PubMed:15777695).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055992103V → L. Corresponds to variant dbSNP:rs34557762Ensembl.1
Natural variantiVAR_042159150R → H in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs771803475Ensembl.1
Natural variantiVAR_042160220T → K1 PublicationCorresponds to variant dbSNP:rs56276182Ensembl.1
Natural variantiVAR_042161281F → I1 PublicationCorresponds to variant dbSNP:rs4653328Ensembl.1
Natural variantiVAR_055993629L → P. Corresponds to variant dbSNP:rs17511304Ensembl.1
Natural variantiVAR_042162630L → P1 Publication1
Natural variantiVAR_055994645V → I. Corresponds to variant dbSNP:rs12405650Ensembl.1
Natural variantiVAR_055995749G → E. Corresponds to variant dbSNP:rs6671088Ensembl.1
Natural variantiVAR_042163775H → R in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_055996807R → Q. Corresponds to variant dbSNP:rs6670599Ensembl.1
Natural variantiVAR_042164956A → T1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015772284 – 295ACPPG…KVSPR → GIQLAGGRGVGV in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_015773296 – 1008Missing in isoform 2. 2 PublicationsAdd BLAST713
Alternative sequenceiVSP_015774889 – 892ERPR → LPPH in isoform 3. 1 Publication4
Alternative sequenceiVSP_015775893 – 1008Missing in isoform 3. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ872185 Genomic DNA Translation: CAI43321.1
AJ781169 mRNA Translation: CAG77605.1
AC104336 Genomic DNA No translation available.
BC067734 mRNA Translation: AAH67734.1
BC112933 mRNA Translation: AAI12934.1 Different initiation.
CCDSiCCDS41305.1 [Q5JZY3-1]
CCDS425.1 [Q5JZY3-2]
RefSeqiNP_001092909.1, NM_001099439.1 [Q5JZY3-1]
NP_775912.2, NM_173641.2 [Q5JZY3-2]
UniGeneiHs.129435

Genome annotation databases

EnsembliENST00000319637; ENSP00000316395; ENSG00000183317 [Q5JZY3-2]
ENST00000373048; ENSP00000362139; ENSG00000183317 [Q5JZY3-1]
GeneIDi284656
KEGGihsa:284656
UCSCiuc001cbw.5 human [Q5JZY3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ872185 Genomic DNA Translation: CAI43321.1
AJ781169 mRNA Translation: CAG77605.1
AC104336 Genomic DNA No translation available.
BC067734 mRNA Translation: AAH67734.1
BC112933 mRNA Translation: AAI12934.1 Different initiation.
CCDSiCCDS41305.1 [Q5JZY3-1]
CCDS425.1 [Q5JZY3-2]
RefSeqiNP_001092909.1, NM_001099439.1 [Q5JZY3-1]
NP_775912.2, NM_173641.2 [Q5JZY3-2]
UniGeneiHs.129435

3D structure databases

ProteinModelPortaliQ5JZY3
SMRiQ5JZY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129927, 5 interactors
IntActiQ5JZY3, 4 interactors
STRINGi9606.ENSP00000362139

Chemistry databases

ChEMBLiCHEMBL2363043

PTM databases

iPTMnetiQ5JZY3
PhosphoSitePlusiQ5JZY3

Polymorphism and mutation databases

BioMutaiEPHA10
DMDMi476007830

Proteomic databases

PaxDbiQ5JZY3
PeptideAtlasiQ5JZY3
PRIDEiQ5JZY3
ProteomicsDBi63538
63539 [Q5JZY3-2]
63540 [Q5JZY3-3]

Protocols and materials databases

DNASUi284656
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319637; ENSP00000316395; ENSG00000183317 [Q5JZY3-2]
ENST00000373048; ENSP00000362139; ENSG00000183317 [Q5JZY3-1]
GeneIDi284656
KEGGihsa:284656
UCSCiuc001cbw.5 human [Q5JZY3-1]

Organism-specific databases

CTDi284656
DisGeNETi284656
EuPathDBiHostDB:ENSG00000183317.16
GeneCardsiEPHA10
HGNCiHGNC:19987 EPHA10
HPAiHPA027497
MIMi611123 gene
neXtProtiNX_Q5JZY3
OpenTargetsiENSG00000183317
PharmGKBiPA134938798
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975
HOGENOMiHOG000233856
HOVERGENiHBG062180
InParanoidiQ5JZY3
KOiK08897
TreeFamiTF314013

Enzyme and pathway databases

ReactomeiR-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928665 EPH-ephrin mediated repulsion of cells

Miscellaneous databases

ChiTaRSiEPHA10 human
GeneWikiiEPHA10
GenomeRNAii284656
PROiPR:Q5JZY3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183317 Expressed in 113 organ(s), highest expression level in sperm
CleanExiHS_EPHA10
ExpressionAtlasiQ5JZY3 baseline and differential
GenevisibleiQ5JZY3 HS

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF00536 SAM_1, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEPHAA_HUMAN
AccessioniPrimary (citable) accession number: Q5JZY3
Secondary accession number(s): A4FU89, J3KPB5, Q6NW42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: April 3, 2013
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again