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UniProtKB - Q5JZY3 (EPHAA_HUMAN)

Entry version 160 (07 Apr 2021)
Sequence version 2 (03 Apr 2013)
Previous versions | rss
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Protein

Ephrin type-A receptor 10

Gene

EPHA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5JZY3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2682334, EPH-Ephrin signaling
R-HSA-3928663, EPHA-mediated growth cone collapse
R-HSA-3928665, EPH-ephrin mediated repulsion of cells

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ephrin type-A receptor 10 (EC:2.7.10.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPHA10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19987, EPHA10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611123, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5JZY3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000183317.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini34 – 565ExtracellularSequence analysisAdd BLAST532
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 1008CytoplasmicSequence analysisAdd BLAST422

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		284656

Open Targets

More...OpenTargetsi		ENSG00000183317

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134938798

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5JZY3, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2363043

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EPHA10

Domain mapping of disease mutations (DMDM)

More...DMDMi		476007830

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004215734 – 1008Ephrin type-A receptor 10Add BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi486N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5JZY3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5JZY3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5JZY3

PeptideAtlas

More...PeptideAtlasi		Q5JZY3

PRoteomics IDEntifications database

More...PRIDEi		Q5JZY3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		63538 [Q5JZY3-1]
63539 [Q5JZY3-2]
63540 [Q5JZY3-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q5JZY3, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5JZY3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5JZY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183317, Expressed in sperm and 130 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5JZY3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5JZY3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183317, Tissue enhanced (brain, intestine, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129927, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q5JZY3, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362139

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5JZY3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5JZY3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 216Eph LBDPROSITE-ProRule annotationAdd BLAST182
Domaini340 – 452Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST113
Domaini456 – 554Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini645 – 900Protein kinasePROSITE-ProRule annotationAdd BLAST256
Domaini933 – 997SAMPROSITE-ProRule annotationAdd BLAST65

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain is predicted to be catalytically inactive.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0196, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160752

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_141_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5JZY3

TreeFam database of animal gene trees

More...TreeFami		TF314013

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit
2.60.120.260, 1 hit
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027936, Eph_TM
IPR001090, Ephrin_rcpt_lig-bd_dom
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR008979, Galactose-bd-like_sf
IPR013783, Ig-like_fold
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR016257, Tyr_kinase_ephrin_rcpt
IPR001426, Tyr_kinase_rcpt_V_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14575, EphA2_TM, 1 hit
PF01404, Ephrin_lbd, 1 hit
PF00041, fn3, 2 hits
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF00536, SAM_1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000666, TyrPK_ephrin_receptor, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00615, EPH_lbd, 1 hit
SM00060, FN3, 2 hits
SM00454, SAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit
SSF49265, SSF49265, 1 hit
SSF49785, SSF49785, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01186, EGF_2, 1 hit
PS51550, EPH_LBD, 1 hit
PS50853, FN3, 2 hits
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105, SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JZY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METCAGPHPL RLFLCRMQLC LALLLGPWRP GTAEEVILLD SKASQAELGW 
        60         70         80         90        100
TALPSNGWEE ISGVDEHDRP IRTYQVCNVL EPNQDNWLQT GWISRGRGQR 
       110        120        130        140        150
IFVELQFTLR DCSSIPGAAG TCKETFNVYY LETEADLGRG RPRLGGSRPR 
       160        170        180        190        200
KIDTIAADES FTQGDLGERK MKLNTEVREI GPLSRRGFHL AFQDVGACVA 
       210        220        230        240        250
LVSVRVYYKQ CRATVRGLAT FPATAAESAF STLVEVAGTC VAHSEGEPGS 
       260        270        280        290        300
PPRMHCGADG EWLVPVGRCS CSAGFQERGD FCEACPPGFY KVSPRRPLCS 
       310        320        330        340        350
PCPEHSRALE NASTFCVCQD SYARSPTDPP SASCTRPPSA PRDLQYSLSR 
       360        370        380        390        400
SPLVLRLRWL PPADSGGRSD VTYSLLCLRC GREGPAGACE PCGPRVAFLP 
       410        420        430        440        450
RQAGLRERAA TLLHLRPGAR YTVRVAALNG VSGPAAAAGT TYAQVTVSTG 
       460        470        480        490        500
PGAPWEEDEI RRDRVEPQSV SLSWREPIPA GAPGANDTEY EIRYYEKGQS 
       510        520        530        540        550
EQTYSMVKTG APTVTVTNLK PATRYVFQIR AASPGPSWEA QSFNPSIEVQ 
       560        570        580        590        600
TLGEAASGSR DQSPAIVVTV VTISALLVLG SVMSVLAIWR RPCSYGKGGG 
       610        620        630        640        650
DAHDEEELYF HFKVPTRRTF LDPQSCGDLL QAVHLFAKEL DAKSVTLERS 
       660        670        680        690        700
LGGGRFGELC CGCLQLPGRQ ELLVAVHMLR DSASDSQRLG FLAEALTLGQ 
       710        720        730        740        750
FDHSHIVRLE GVVTRGSTLM IVTEYMSHGA LDGFLRRHEG QLVAGQLMGL 
       760        770        780        790        800
LPGLASAMKY LSEMGYVHRG LAARHVLVSS DLVCKISGFG RGPRDRSEAV 
       810        820        830        840        850
YTTMSGRSPA LWAAPETLQF GHFSSASDVW SFGIIMWEVM AFGERPYWDM 
       860        870        880        890        900
SGQDVIKAVE DGFRLPPPRN CPNLLHRLML DCWQKDPGER PRFSQIHSIL 
       910        920        930        940        950
SKMVQDPEPP KCALTTCPRP PTPLADRAFS TFPSFGSVGA WLEALDLCRY 
       960        970        980        990       1000
KDSFAAAGYG SLEAVAEMTA QDLVSLGISL AEHREALLSG ISALQARVLQ 

LQGQGVQV
Length:1,008
Mass (Da):109,716
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82D60740B7B6B9BD
GO
Isoform 2 (identifier: Q5JZY3-2) [UniParc]FASTAAdd to basket
Also known as: Epha10s

The sequence of this isoform differs from the canonical sequence as follows:
     284-295: ACPPGFYKVSPR → GIQLAGGRGVGV
     296-1008: Missing.

Show »
Length:295
Mass (Da):32,120
Checksum:iC5818C0D8C4444D1
GO
Isoform 3 (identifier: Q5JZY3-3) [UniParc]FASTAAdd to basket
Also known as: Epha10*

The sequence of this isoform differs from the canonical sequence as follows:
     889-892: ERPR → LPPH
     893-1008: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:892
Mass (Da):97,293
Checksum:iD91B200D8B705F89
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQG3J3KQG3_HUMAN
EPH receptor A10, isoform CRA_b
EPHA10 hCG_1820945
1,014Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCC9H0YCC9_HUMAN
Ephrin type-A receptor 10
EPHA10
392Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD12H0YD12_HUMAN
Ephrin type-A receptor 10
EPHA10
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWI2F5GWI2_HUMAN
Ephrin type-A receptor 10
EPHA10
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YER4H0YER4_HUMAN
Ephrin type-A receptor 10
EPHA10
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEP6H0YEP6_HUMAN
Ephrin type-A receptor 10
EPHA10
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI12934 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti458D → G in CAI43321 (PubMed:15777695).Curated1
Sequence conflicti503T → A in CAI43321 (PubMed:15777695).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055992103V → L. Corresponds to variant dbSNP:rs34557762Ensembl.1
Natural variantiVAR_042159150R → H in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs771803475Ensembl.1
Natural variantiVAR_042160220T → K1 PublicationCorresponds to variant dbSNP:rs56276182Ensembl.1
Natural variantiVAR_042161281F → I1 PublicationCorresponds to variant dbSNP:rs4653328Ensembl.1
Natural variantiVAR_055993629L → P. Corresponds to variant dbSNP:rs17511304Ensembl.1
Natural variantiVAR_042162630L → P1 Publication1
Natural variantiVAR_055994645V → I. Corresponds to variant dbSNP:rs12405650Ensembl.1
Natural variantiVAR_055995749G → E. Corresponds to variant dbSNP:rs6671088Ensembl.1
Natural variantiVAR_042163775H → R in a breast infiltrating ductal carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_055996807R → Q. Corresponds to variant dbSNP:rs6670599Ensembl.1
Natural variantiVAR_042164956A → T1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015772284 – 295ACPPG…KVSPR → GIQLAGGRGVGV in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_015773296 – 1008Missing in isoform 2. 2 PublicationsAdd BLAST713
Alternative sequenceiVSP_015774889 – 892ERPR → LPPH in isoform 3. 1 Publication4
Alternative sequenceiVSP_015775893 – 1008Missing in isoform 3. 1 PublicationAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ872185 Genomic DNA Translation: CAI43321.1
AJ781169 mRNA Translation: CAG77605.1
AC104336 Genomic DNA No translation available.
BC067734 mRNA Translation: AAH67734.1
BC112933 mRNA Translation: AAI12934.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41305.1 [Q5JZY3-1]
CCDS425.1 [Q5JZY3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001092909.1, NM_001099439.1 [Q5JZY3-1]
NP_775912.2, NM_173641.2 [Q5JZY3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000319637; ENSP00000316395; ENSG00000183317 [Q5JZY3-2]
ENST00000373048; ENSP00000362139; ENSG00000183317 [Q5JZY3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		284656

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:284656

UCSC genome browser

More...UCSCi		uc001cbw.5, human [Q5JZY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ872185 Genomic DNA Translation: CAI43321.1
AJ781169 mRNA Translation: CAG77605.1
AC104336 Genomic DNA No translation available.
BC067734 mRNA Translation: AAH67734.1
BC112933 mRNA Translation: AAI12934.1 Different initiation.
CCDSiCCDS41305.1 [Q5JZY3-1]
CCDS425.1 [Q5JZY3-2]
RefSeqiNP_001092909.1, NM_001099439.1 [Q5JZY3-1]
NP_775912.2, NM_173641.2 [Q5JZY3-2]

3D structure databases

SMRiQ5JZY3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129927, 5 interactors
IntActiQ5JZY3, 5 interactors
STRINGi9606.ENSP00000362139

Chemistry databases

ChEMBLiCHEMBL2363043

PTM databases

GlyGeniQ5JZY3, 2 sites
iPTMnetiQ5JZY3
PhosphoSitePlusiQ5JZY3

Genetic variation databases

BioMutaiEPHA10
DMDMi476007830

Proteomic databases

jPOSTiQ5JZY3
MassIVEiQ5JZY3
PaxDbiQ5JZY3
PeptideAtlasiQ5JZY3
PRIDEiQ5JZY3
ProteomicsDBi63538 [Q5JZY3-1]
63539 [Q5JZY3-2]
63540 [Q5JZY3-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51311, 269 antibodies

The DNASU plasmid repository

More...DNASUi		284656

Genome annotation databases

EnsembliENST00000319637; ENSP00000316395; ENSG00000183317 [Q5JZY3-2]
ENST00000373048; ENSP00000362139; ENSG00000183317 [Q5JZY3-1]
GeneIDi284656
KEGGihsa:284656
UCSCiuc001cbw.5, human [Q5JZY3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		284656
DisGeNETi284656

GeneCards: human genes, protein and diseases

More...GeneCardsi		EPHA10
HGNCiHGNC:19987, EPHA10
HPAiENSG00000183317, Tissue enhanced (brain, intestine, testis)
MIMi611123, gene
neXtProtiNX_Q5JZY3
OpenTargetsiENSG00000183317
PharmGKBiPA134938798
VEuPathDBiHostDB:ENSG00000183317.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0196, Eukaryota
GeneTreeiENSGT00940000160752
HOGENOMiCLU_000288_141_4_1
InParanoidiQ5JZY3
TreeFamiTF314013

Enzyme and pathway databases

PathwayCommonsiQ5JZY3
ReactomeiR-HSA-2682334, EPH-Ephrin signaling
R-HSA-3928663, EPHA-mediated growth cone collapse
R-HSA-3928665, EPH-ephrin mediated repulsion of cells

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		284656, 6 hits in 1021 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		EPHA10, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		EPHA10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		284656
PharosiQ5JZY3, Tbio

Protein Ontology

More...PROi		PR:Q5JZY3
RNActiQ5JZY3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000183317, Expressed in sperm and 130 other tissues
ExpressionAtlasiQ5JZY3, baseline and differential
GenevisibleiQ5JZY3, HS

Family and domain databases

CDDicd00063, FN3, 2 hits
Gene3Di1.10.150.50, 1 hit
2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936, Eph_TM
IPR001090, Ephrin_rcpt_lig-bd_dom
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR008979, Galactose-bd-like_sf
IPR013783, Ig-like_fold
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR016257, Tyr_kinase_ephrin_rcpt
IPR001426, Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575, EphA2_TM, 1 hit
PF01404, Ephrin_lbd, 1 hit
PF00041, fn3, 2 hits
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF00536, SAM_1, 1 hit
PIRSFiPIRSF000666, TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109, TYRKINASE
SMARTiView protein in SMART
SM00615, EPH_lbd, 1 hit
SM00060, FN3, 2 hits
SM00454, SAM, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
SSF49265, SSF49265, 1 hit
SSF49785, SSF49785, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01186, EGF_2, 1 hit
PS51550, EPH_LBD, 1 hit
PS50853, FN3, 2 hits
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00790, RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791, RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105, SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEPHAA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JZY3
Secondary accession number(s): A4FU89, J3KPB5, Q6NW42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: April 3, 2013
Last modified: April 7, 2021
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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