UniProtKB - Q5JY90 (Q5JY90_HUMAN)
Protein
Tyrosine-protein kinase
Gene
BTK
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.10.2UniRule annotation
Cofactori
Zn2+ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
- transmembrane receptor protein tyrosine kinase activity Source: RHEA
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- intracellular signal transduction Source: InterPro
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationARBA annotation |
Biological process | Adaptive immunityARBA annotation, Immunity |
Ligand | ATP-bindingUniRule annotation, Metal-binding, Nucleotide-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:BTKImported ORF Names:hCG_20400Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1133, BTK |
VEuPathDBi | HostDB:ENSG00000010671.15 |
PTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
MaxQBi | Q5JY90 |
PRIDEi | Q5JY90 |
ProteomicsDBi | 63487 |
Expressioni
Gene expression databases
Bgeei | ENSG00000010671, Expressed in monocyte and 182 other tissues |
ExpressionAtlasi | Q5JY90, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 133 | PHInterPro annotationAdd BLAST | 131 | |
Domaini | 166 – 479 | Protein kinaseInterPro annotationAdd BLAST | 314 | |
Domaini | 214 – 274 | SH3InterPro annotationAdd BLAST | 61 | |
Domaini | 281 – 349 | SH2InterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 171 – 210 | DisorderedSequence analysisAdd BLAST | 40 |
Sequence similaritiesi
Keywords - Domaini
SH2 domainPROSITE-ProRule annotationARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158469 |
Family and domain databases
CDDi | cd11906, SH3_BTK, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035574, BTK_SH3 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR001562, Znf_Btk_motif |
Pfami | View protein in Pfam PF00779, BTK, 1 hit PF00169, PH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00402, TECBTKDOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00107, BTK, 1 hit SM00233, PH, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit PS51113, ZF_BTK, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q5JY90-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG
60 70 80 90 100
SKKGSIDVEK ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY
110 120 130 140 150
PFQVVYDEGP LYVFSPTEEL RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG
160 170 180 190 200
QYLCCSQTAK NAMGCQILEN RNGSLKPGSS HRKTKKPLPP TPEEDQILKK
210 220 230 240 250
PLPPEPAAAP VSTSELKKVV ALYDYMPMNA NDLQLRKGDE YFILEESNLP
260 270 280 290 300
WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK
310 320 330 340 350
EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAARN
360 370 380 390 400
CLVNDQGVVK VSDFGLSRYV LDDEYTSSVG SKFPVRWSPP EVLMYSKFSS
410 420 430 440 450
KSDIWAFGVL MWEIYSLGKM PYERFTNSET AEHIAQGLRL YRPHLASEKV
460 470 480
YTIMYSCWHE KADERPTFKI LLSNILDVMD EES
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ06187 | BTK_HUMAN | Tyrosine-protein kinase BTK | BTK AGMX1, ATK, BPK | 659 | Annotation score: | ||
U3NG26 | U3NG26_HUMAN | Tyrosine-protein kinase | BTK | 568 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035422 Genomic DNA No translation available. AK057105 mRNA Translation: BAG51864.1 CH471115 Genomic DNA Translation: EAX02857.1 |
RefSeqi | NP_000052.1, NM_000061.2 NP_001274274.1, NM_001287345.1 |
Genome annotation databases
Ensembli | ENST00000372880; ENSP00000361971; ENSG00000010671 |
GeneIDi | 695 |
KEGGi | hsa:695 |
UCSCi | uc010nnn.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL035422 Genomic DNA No translation available. AK057105 mRNA Translation: BAG51864.1 CH471115 Genomic DNA Translation: EAX02857.1 |
RefSeqi | NP_000052.1, NM_000061.2 NP_001274274.1, NM_001287345.1 |
3D structure databases
SMRi | Q5JY90 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q5JY90 |
PRIDEi | Q5JY90 |
ProteomicsDBi | 63487 |
Protocols and materials databases
Antibodypediai | 699, 1248 antibodies |
DNASUi | 695 |
Genome annotation databases
Ensembli | ENST00000372880; ENSP00000361971; ENSG00000010671 |
GeneIDi | 695 |
KEGGi | hsa:695 |
UCSCi | uc010nnn.2, human |
Organism-specific databases
CTDi | 695 |
HGNCi | HGNC:1133, BTK |
OpenTargetsi | ENSG00000010671 |
PharmGKBi | PA25454 |
VEuPathDBi | HostDB:ENSG00000010671.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158469 |
Miscellaneous databases
BioGRID-ORCSi | 695, 7 hits in 650 CRISPR screens |
ChiTaRSi | BTK, human |
GenomeRNAii | 695 |
Gene expression databases
Bgeei | ENSG00000010671, Expressed in monocyte and 182 other tissues |
ExpressionAtlasi | Q5JY90, baseline and differential |
Family and domain databases
CDDi | cd11906, SH3_BTK, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035574, BTK_SH3 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000719, Prot_kinase_dom IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR001562, Znf_Btk_motif |
Pfami | View protein in Pfam PF00779, BTK, 1 hit PF00169, PH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00402, TECBTKDOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00107, BTK, 1 hit SM00233, PH, 1 hit SM00252, SH2, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit PS51113, ZF_BTK, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5JY90_HUMAN | |
Accessioni | Q5JY90Primary (citable) accession number: Q5JY90 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 15, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | April 7, 2021 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |