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Protein

Glycine receptor subunit alpha-4

Gene

GLRA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents.By similarity

Miscellaneous

The alpha subunit binds strychnine.By similarity

Caution

Is shorter at the C-terminus than its mouse ortholog due to the presence of a premature stop codon. As a consequence, it lacks the fourth transmembrane span.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei296Important for obstruction of the ion pore in the closed conformationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine receptor subunit alpha-4
Gene namesi
Name:GLRA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000188828.11
HGNCiHGNC:31715 GLRA4
neXtProtiNX_Q5JXX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 257ExtracellularBy similarityAdd BLAST229
Transmembranei258 – 279Helical; Name=1By similarityAdd BLAST22
Topological domaini280 – 284CytoplasmicBy similarity5
Transmembranei285 – 305Helical; Name=2By similarityAdd BLAST21
Topological domaini306 – 316ExtracellularBy similarityAdd BLAST11
Transmembranei317 – 337Helical; Name=3By similarityAdd BLAST21
Topological domaini338 – 417CytoplasmicBy similarityAdd BLAST80

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188828
PharmGKBiPA142671731

Polymorphism and mutation databases

BioMutaiGLRA4
DMDMi262527577

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000033860929 – 417Glycine receptor subunit alpha-4Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 186By similarity
Disulfide bondi233 ↔ 244By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5JXX5
PRIDEiQ5JXX5
ProteomicsDBi63476

PTM databases

iPTMnetiQ5JXX5
PhosphoSitePlusiQ5JXX5

Expressioni

Tissue specificityi

Detected in trachea smooth muscle.1 Publication

Gene expression databases

BgeeiENSG00000188828 Expressed in 63 organ(s), highest expression level in myometrium
CleanExiHS_GLRA4
ExpressionAtlasiQ5JXX5 baseline and differential

Organism-specific databases

HPAiHPA044759

Interactioni

Subunit structurei

Homopentamer (in vitro). Pentamer composed of alpha and beta subunits.By similarity

Protein-protein interaction databases

BioGridi137537, 1 interactor
STRINGi9606.ENSP00000361700

Structurei

3D structure databases

ProteinModelPortaliQ5JXX5
SMRiQ5JXX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni237 – 242Strychnine-bindingBy similarity6

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231336
HOVERGENiHBG051707
InParanoidiQ5JXX5
KOiK05271
OMAiPRLAYQE
OrthoDBiEOG091G0805
PhylomeDBiQ5JXX5
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008127 Glycine_rcpt_A
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01673 GLYRALPHA
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5JXX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTLVPATLS FLLLWTLPGQ VLLRVALAKE EVKSGTKGSQ PMSPSDFLDK
60 70 80 90 100
LMGRTSGYDA RIRPNFKGPP VNVTCNIFIN SFSSITKTTM DYRVNVFLRQ
110 120 130 140 150
QWNDPRLSYR EYPDDSLDLD PSMLDSIWKP DLFFANEKGA NFHEVTTDNK
160 170 180 190 200
LLRIFKNGNV LYSIRLTLIL SCLMDLKNFP MDIQTCTMQL ESFGYTMKDL
210 220 230 240 250
VFEWLEDAPA VQVAEGLTLP QFILRDEKDL GCCTKHYNTG KFTCIEVKFH
260 270 280 290 300
LERQMGYYLI QMYIPSLLIV ILSWVSFWIN MDAAPARVGL GITTVLTMTT
310 320 330 340 350
QSSGSRASLP KVSYVKAIDI WMAVCLLFVF AALLEYAAIN FVSRQHKEFI
360 370 380 390 400
RLRRRQRRQR LEEDIIQESR FYFRGYGLGH CLQARDGGPM EGSGIYSPQP
410
PAPLLREGET TRKLYVD
Length:417
Mass (Da):47,728
Last modified:November 3, 2009 - v3
Checksum:i7F3B1A5B26B7F0E6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCE1F8WCE1_HUMAN
Glycine receptor subunit alpha-4
GLRA4
44Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93848 Genomic DNA No translation available.
AL049610 Genomic DNA No translation available.
CCDSiCCDS43980.2
RefSeqiNP_001019623.2, NM_001024452.2
UniGeneiHs.533289

Genome annotation databases

EnsembliENST00000372617; ENSP00000361700; ENSG00000188828
GeneIDi441509
KEGGihsa:441509
UCSCiuc011mse.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93848 Genomic DNA No translation available.
AL049610 Genomic DNA No translation available.
CCDSiCCDS43980.2
RefSeqiNP_001019623.2, NM_001024452.2
UniGeneiHs.533289

3D structure databases

ProteinModelPortaliQ5JXX5
SMRiQ5JXX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137537, 1 interactor
STRINGi9606.ENSP00000361700

PTM databases

iPTMnetiQ5JXX5
PhosphoSitePlusiQ5JXX5

Polymorphism and mutation databases

BioMutaiGLRA4
DMDMi262527577

Proteomic databases

PaxDbiQ5JXX5
PRIDEiQ5JXX5
ProteomicsDBi63476

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372617; ENSP00000361700; ENSG00000188828
GeneIDi441509
KEGGihsa:441509
UCSCiuc011mse.3 human

Organism-specific databases

CTDi441509
EuPathDBiHostDB:ENSG00000188828.11
GeneCardsiGLRA4
HGNCiHGNC:31715 GLRA4
HPAiHPA044759
neXtProtiNX_Q5JXX5
OpenTargetsiENSG00000188828
PharmGKBiPA142671731
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231336
HOVERGENiHBG051707
InParanoidiQ5JXX5
KOiK05271
OMAiPRLAYQE
OrthoDBiEOG091G0805
PhylomeDBiQ5JXX5
TreeFamiTF315453

Enzyme and pathway databases

ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission

Miscellaneous databases

ChiTaRSiGLRA4 human
GeneWikiiGLRA4
GenomeRNAii441509
PROiPR:Q5JXX5

Gene expression databases

BgeeiENSG00000188828 Expressed in 63 organ(s), highest expression level in myometrium
CleanExiHS_GLRA4
ExpressionAtlasiQ5JXX5 baseline and differential

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008127 Glycine_rcpt_A
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01673 GLYRALPHA
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLRA4_HUMAN
AccessioniPrimary (citable) accession number: Q5JXX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 3, 2009
Last modified: November 7, 2018
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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