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Protein

Methyltransferase-like protein 24

Gene

METTL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 24 (EC:2.1.1.-)
Gene namesi
Name:METTL24
Synonyms:C6orf186
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000053328.8
HGNCiHGNC:21566 METTL24
neXtProtiNX_Q5JXM2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000053328
PharmGKBiPA134906793

Polymorphism and mutation databases

BioMutaiMETTL24
DMDMi205830266

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000034374330 – 366Methyltransferase-like protein 24Add BLAST337

Proteomic databases

EPDiQ5JXM2
PaxDbiQ5JXM2
PeptideAtlasiQ5JXM2
PRIDEiQ5JXM2
ProteomicsDBi63463

PTM databases

PhosphoSitePlusiQ5JXM2

Expressioni

Gene expression databases

BgeeiENSG00000053328 Expressed in 87 organ(s), highest expression level in kidney

Organism-specific databases

HPAiHPA037441
HPA037442

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344071

Structurei

3D structure databases

ProteinModelPortaliQ5JXM2
SMRiQ5JXM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHCM Eukaryota
ENOG410Y3P7 LUCA
GeneTreeiENSGT00390000002881
HOGENOMiHOG000111577
HOVERGENiHBG107658
InParanoidiQ5JXM2
OMAiPRWHIDL
OrthoDBiEOG091G08NE
PhylomeDBiQ5JXM2
TreeFamiTF330614

Family and domain databases

InterProiView protein in InterPro
IPR025714 Methyltranfer_dom
IPR026913 METTL24
PANTHERiPTHR32026 PTHR32026, 1 hit
PfamiView protein in Pfam
PF13383 Methyltransf_22, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JXM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARERPPGRG CGVLRRCLLG AVLLFGLRLC AELRRAGPGS PTRSAPPGPA
60 70 80 90 100
WRPPGPHLPP APGQPRGASR RQVTYVRSGR RAPPGGGGSG TPEPGCCAPR
110 120 130 140 150
GRPRRKGPRW HIDLQPWAGS AQSLDEEAWR FLRYISTTQI ACNHMNTDSL
160 170 180 190 200
ATDSSPTHKP WSVCLDDRFN LAHQIRNKQC RLYSLGLGSD DTHFEVSMAN
210 220 230 240 250
NGCEVHRFDP SVKSAHILES QHLWYHRLSI DWRDPHPAVA AQKPHSNTRK
260 270 280 290 300
LGSILNEFGH HKIDVLKADL ESAEWKVLEN LILEDVLEQI GQLIFEIHLH
310 320 330 340 350
WPGFEVSGSD SSVVRFWYSL LKELEQKDFR LFHSYKDLSK PQLFLKKDIF
360
NASSCYTLSW VNTRWK
Length:366
Mass (Da):41,330
Last modified:February 5, 2008 - v1
Checksum:i8B9A3DCE659A846D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308G → V in BAC86851 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044502281L → F. Corresponds to variant dbSNP:rs2334321Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445068 Genomic DNA No translation available.
AL050350 Genomic DNA No translation available.
AK127146 mRNA Translation: BAC86851.1
CCDSiCCDS43489.1
RefSeqiNP_001116836.1, NM_001123364.1
UniGeneiHs.634429

Genome annotation databases

EnsembliENST00000338882; ENSP00000344071; ENSG00000053328
GeneIDi728464
KEGGihsa:728464
UCSCiuc010kdu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445068 Genomic DNA No translation available.
AL050350 Genomic DNA No translation available.
AK127146 mRNA Translation: BAC86851.1
CCDSiCCDS43489.1
RefSeqiNP_001116836.1, NM_001123364.1
UniGeneiHs.634429

3D structure databases

ProteinModelPortaliQ5JXM2
SMRiQ5JXM2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344071

PTM databases

PhosphoSitePlusiQ5JXM2

Polymorphism and mutation databases

BioMutaiMETTL24
DMDMi205830266

Proteomic databases

EPDiQ5JXM2
PaxDbiQ5JXM2
PeptideAtlasiQ5JXM2
PRIDEiQ5JXM2
ProteomicsDBi63463

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338882; ENSP00000344071; ENSG00000053328
GeneIDi728464
KEGGihsa:728464
UCSCiuc010kdu.2 human

Organism-specific databases

CTDi728464
EuPathDBiHostDB:ENSG00000053328.8
GeneCardsiMETTL24
HGNCiHGNC:21566 METTL24
HPAiHPA037441
HPA037442
neXtProtiNX_Q5JXM2
OpenTargetsiENSG00000053328
PharmGKBiPA134906793
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHCM Eukaryota
ENOG410Y3P7 LUCA
GeneTreeiENSGT00390000002881
HOGENOMiHOG000111577
HOVERGENiHBG107658
InParanoidiQ5JXM2
OMAiPRWHIDL
OrthoDBiEOG091G08NE
PhylomeDBiQ5JXM2
TreeFamiTF330614

Miscellaneous databases

ChiTaRSiMETTL24 human
GenomeRNAii728464
PROiPR:Q5JXM2

Gene expression databases

BgeeiENSG00000053328 Expressed in 87 organ(s), highest expression level in kidney

Family and domain databases

InterProiView protein in InterPro
IPR025714 Methyltranfer_dom
IPR026913 METTL24
PANTHERiPTHR32026 PTHR32026, 1 hit
PfamiView protein in Pfam
PF13383 Methyltransf_22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMET24_HUMAN
AccessioniPrimary (citable) accession number: Q5JXM2
Secondary accession number(s): Q6ZSU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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