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Protein
Submitted name:

Four and a half LIM domains protein 1

Gene

FHL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Four and a half LIM domains protein 1Imported
Gene namesi
Name:FHL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000022267.16
HGNCiHGNC:3702 FHL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000022267

PTM / Processingi

Proteomic databases

MaxQBiQ5JXI2
PeptideAtlasiQ5JXI2
PRIDEiQ5JXI2

Expressioni

Gene expression databases

BgeeiENSG00000022267 Expressed in 243 organ(s), highest expression level in biceps brachii
ExpressionAtlasiQ5JXI2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5JXI2
SMRiQ5JXI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 114LIM zinc-bindingInterPro annotationAdd BLAST61
Domaini115 – 176LIM zinc-bindingInterPro annotationAdd BLAST62

Keywords - Domaini

LIM domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118910
HOGENOMiHOG000231075
HOVERGENiHBG074526

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All

Q5JXI2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASHRHSGPS SYKVGTMAEK FDCHYCRDPL QGKKYVQKDG HHCCLKCFDK
60 70 80 90 100
FCANTCVECR KPIGADSKEV HYKNRFWHDT CFRCAKCLHP LANETFVAKD
110 120 130 140 150
NKILCNKCTT REDSPKCKGC FKAIVAGDQN VEYKGTVWHK DCFTCSNCKQ
160 170 180 190 200
VIGTGSFFPK GEDFYCVTCH ETKFAKHCVK CNKGLVKAPV WWPMKDNPGT
210
TTASTAKNAP
Length:210
Mass (Da):23,701
Last modified:February 15, 2005 - v1
Checksum:i2C54446BBABB394B
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q13642FHL1_HUMAN
Four and a half LIM domains protein...
FHL1 SLIM1
323Annotation score:
Q5JXH7Q5JXH7_HUMAN
Four and a half LIM domains protein...
FHL1
205Annotation score:
Q5JXI8Q5JXI8_HUMAN
Four and a half LIM domains protein...
FHL1
257Annotation score:
Q5JXH8Q5JXH8_HUMAN
Four and a half LIM domains protein...
FHL1
204Annotation score:
Q5JXI0Q5JXI0_HUMAN
Four and a half LIM domains protein...
FHL1
141Annotation score:
Q5JXH9Q5JXH9_HUMAN
Four and a half LIM domains protein...
FHL1
155Annotation score:
Q5JXI3Q5JXI3_HUMAN
Four and a half LIM domains protein...
FHL1
207Annotation score:
A0A0D9SFZ9A0A0D9SFZ9_HUMAN
Four and a half LIM domains protein...
FHL1
175Annotation score:
A0A0D9SG53A0A0D9SG53_HUMAN
Four and a half LIM domains protein...
FHL1
130Annotation score:
A0A0D9SFI6A0A0D9SFI6_HUMAN
Four and a half LIM domains protein...
FHL1
147Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078638 Genomic DNA No translation available.
RefSeqiNP_001317588.1, NM_001330659.1
UniGeneiHs.435369

Genome annotation databases

EnsembliENST00000370676; ENSP00000359710; ENSG00000022267
GeneIDi2273
UCSCiuc065bhi.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078638 Genomic DNA No translation available.
RefSeqiNP_001317588.1, NM_001330659.1
UniGeneiHs.435369

3D structure databases

ProteinModelPortaliQ5JXI2
SMRiQ5JXI2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ5JXI2
PeptideAtlasiQ5JXI2
PRIDEiQ5JXI2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370676; ENSP00000359710; ENSG00000022267
GeneIDi2273
UCSCiuc065bhi.1 human

Organism-specific databases

CTDi2273
EuPathDBiHostDB:ENSG00000022267.16
HGNCiHGNC:3702 FHL1
OpenTargetsiENSG00000022267
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118910
HOGENOMiHOG000231075
HOVERGENiHBG074526

Miscellaneous databases

ChiTaRSiFHL1 human
GenomeRNAii2273

Gene expression databases

BgeeiENSG00000022267 Expressed in 243 organ(s), highest expression level in biceps brachii
ExpressionAtlasiQ5JXI2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ5JXI2_HUMAN
AccessioniPrimary (citable) accession number: Q5JXI2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 12, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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