Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Migration and invasion-inhibitory protein

Gene

MIIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Migration and invasion-inhibitory protein
Alternative name(s):
IGFBP2-binding protein
Invasion-inhibitory protein 45
Short name:
IIp45
Gene namesi
Name:MIIP
Synonyms:IIP45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116691.10
HGNCiHGNC:25715 MIIP
MIMi608772 gene
neXtProtiNX_Q5JXC2

Pathology & Biotechi

Organism-specific databases

DisGeNETi60672
OpenTargetsiENSG00000116691
PharmGKBiPA165751598

Polymorphism and mutation databases

BioMutaiMIIP
DMDMi296439302

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003243221 – 388Migration and invasion-inhibitory proteinAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141PhosphothreonineCombined sources1
Modified residuei303PhosphoserineCombined sources1

Post-translational modificationi

Isoform 2 is degraded by the ubiquitin-proteasome pathway.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5JXC2
MaxQBiQ5JXC2
PaxDbiQ5JXC2
PeptideAtlasiQ5JXC2
PRIDEiQ5JXC2
ProteomicsDBi63443
63444 [Q5JXC2-2]

PTM databases

iPTMnetiQ5JXC2
PhosphoSitePlusiQ5JXC2

Expressioni

Tissue specificityi

Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells.1 Publication

Inductioni

Up-regulated by IGFBP2.1 Publication

Gene expression databases

BgeeiENSG00000116691
GenevisibleiQ5JXC2 HS

Organism-specific databases

HPAiHPA044948

Interactioni

Subunit structurei

Interacts with IGFBP2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
STK16O757163EBI-2801965,EBI-749295

Protein-protein interaction databases

BioGridi121947, 8 interactors
IntActiQ5JXC2, 20 interactors
STRINGi9606.ENSP00000235332

Structurei

3D structure databases

ProteinModelPortaliQ5JXC2
SMRiQ5JXC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni239 – 282Interaction with IGFBP21 PublicationAdd BLAST44

Phylogenomic databases

eggNOGiENOG410II0C Eukaryota
ENOG4111PRQ LUCA
GeneTreeiENSGT00390000003768
HOGENOMiHOG000095519
InParanoidiQ5JXC2
OMAiTPCRLCR
OrthoDBiEOG091G0B37
PhylomeDBiQ5JXC2
TreeFamiTF335829

Family and domain databases

InterProiView protein in InterPro
IPR031466 MIIP
PANTHERiPTHR34831 PTHR34831, 1 hit
PfamiView protein in Pfam
PF15734 MIIP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JXC2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEAEELAQL RLLNLELLRQ LWVGQDAVRR SVARAASESS LESSSSYNSE
60 70 80 90 100
TPSTPETSST SLSTSCPRGR SSVWGPPDAC RGDLRDVARS GVASLPPAKC
110 120 130 140 150
QHQESLGRPR PHSAPSLGTS SLRDPEPSGR LGDPGPQEAQ TPRSILAQQS
160 170 180 190 200
KLSKPRVTFS EESAVPKRSW RLRPYLGYDW IAGSLDTSSS ITSQPEAFFS
210 220 230 240 250
KLQEFRETNK EECICSHPEP QLPGLRESSG SGVEEDHECV YCYRVNRRLF
260 270 280 290 300
PVPVDPGTPC RLCRTPRDQQ GPGTLAQPAH VRVSIPLSIL EPPHRYHIHR
310 320 330 340 350
RKSFDASDTL ALPRHCLLGW DIFPPKSEKS SAPRNLDLWS SVSAEAQHQK
360 370 380
LSGTSSPFHP ASPMQMLPPT PTWSVPQVPR PHVPRQKP
Length:388
Mass (Da):42,824
Last modified:May 18, 2010 - v3
Checksum:i31854F9B1669B00C
GO
Isoform 2 (identifier: Q5JXC2-2) [UniParc]FASTAAdd to basket
Also known as: IIP45S

The sequence of this isoform differs from the canonical sequence as follows:
     282-388: RVSIPLSILE...PRPHVPRQKP → STACWAGTFF...PTSHGRSPED

Show »
Length:359
Mass (Da):39,292
Checksum:i68EB9BA04ECACF33
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183G → V in BAB14062 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03972999K → N3 PublicationsCorresponds to variant dbSNP:rs11553925Ensembl.1
Natural variantiVAR_039730142P → S1 PublicationCorresponds to variant dbSNP:rs11588712Ensembl.1
Natural variantiVAR_039731167K → E4 PublicationsCorresponds to variant dbSNP:rs2295283Ensembl.1
Natural variantiVAR_059688247R → W. Corresponds to variant dbSNP:rs2295289Ensembl.1
Natural variantiVAR_059689288S → L. Corresponds to variant dbSNP:rs35317667Ensembl.1
Natural variantiVAR_059690381P → S. Corresponds to variant dbSNP:rs34874602Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032214282 – 388RVSIP…PRQKP → STACWAGTFFLRSLRKAQPP GTWTSGPLYPLRPSTRSCPA PAQALFTRPHQCRCCPRPRP GQCPRSLGPTSHGRSPED in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ618905 mRNA Translation: ACM90320.1
AK022500 mRNA Translation: BAB14062.1
AK024020 mRNA Translation: BAB14781.1
AL096840 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71729.1
BC008068 mRNA Translation: AAH08068.1
CCDSiCCDS143.1 [Q5JXC2-1]
RefSeqiNP_068752.2, NM_021933.3 [Q5JXC2-1]
XP_011540197.1, XM_011541895.1 [Q5JXC2-1]
XP_011540198.1, XM_011541896.1 [Q5JXC2-1]
UniGeneiHs.8595

Genome annotation databases

EnsembliENST00000235332; ENSP00000235332; ENSG00000116691 [Q5JXC2-1]
GeneIDi60672
KEGGihsa:60672
UCSCiuc001ato.3 human [Q5JXC2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMIIP_HUMAN
AccessioniPrimary (citable) accession number: Q5JXC2
Secondary accession number(s): C0KL22
, Q96HU6, Q9H839, Q9HA00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health