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Protein

Signal-regulatory protein beta-2

Gene

SIRPB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-regulatory protein beta-2
Short name:
SIRP-beta-2
Alternative name(s):
Protein tyrosine phosphatase non-receptor type substrate 1-like 3
Protein tyrosine phosphatase non-receptor type substrate protein
Gene namesi
Name:SIRPB2
Synonyms:PTPN1L, PTPNS1L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000196209.12
HGNCiHGNC:16247 SIRPB2
neXtProtiNX_Q5JXA9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 287ExtracellularSequence analysisAdd BLAST255
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309 – 342CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196209
PharmGKBiPA164742382

Polymorphism and mutation databases

BioMutaiSIRPB2
DMDMi74762205

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000033862933 – 342Signal-regulatory protein beta-2Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 127PROSITE-ProRule annotation
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi180 ↔ 242PROSITE-ProRule annotation
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5JXA9
PeptideAtlasiQ5JXA9
PRIDEiQ5JXA9
ProteomicsDBi63437
63438 [Q5JXA9-2]

PTM databases

iPTMnetiQ5JXA9
PhosphoSitePlusiQ5JXA9

Expressioni

Gene expression databases

BgeeiENSG00000196209
ExpressionAtlasiQ5JXA9 baseline and differential
GenevisibleiQ5JXA9 HS

Organism-specific databases

HPAiHPA011548
HPA048032

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352849

Structurei

3D structure databases

ProteinModelPortaliQ5JXA9
SMRiQ5JXA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 143Ig-like V-type 1Add BLAST111
Domaini157 – 258Ig-like V-type 2Add BLAST102

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0R4 Eukaryota
ENOG410ZC9B LUCA
GeneTreeiENSGT00440000033339
HOGENOMiHOG000154328
HOVERGENiHBG102811
InParanoidiQ5JXA9
KOiK16826
OMAiEHTGTYH
OrthoDBiEOG091G0ASC
PhylomeDBiQ5JXA9
TreeFamiTF341862

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JXA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCSTMSAPTC LAHLPPCFLL LALVLVPSDA SGQSSRNDWQ VLQPEGPMLV
60 70 80 90 100
AEGETLLLRC MVVGSCTDGM IKWVKVSTQD QQEIYNFKRG SFPGVMPMIQ
110 120 130 140 150
RTSEPLNCDY SIYIHNVTRE HTGTYHCVRF DGLSEHSEMK SDEGTSVLVK
160 170 180 190 200
GAGDPEPDLW IIQPQELVLG TTGDTVFLNC TVLGDGPPGP IRWFQGAGLS
210 220 230 240 250
REAIYNFGGI SHPKETAVQA SNNDFSILLQ NVSSEDAGTY YCVKFQRKPN
260 270 280 290 300
RQYLSGQGTS LKVKAKSTSS KEAEFTSEPA TEMSPTGLLV VFAPVVLGLK
310 320 330 340
AITLAALLLA LATSRRSPGQ EDVKTTGPAG AMNTLAWSKG QE
Length:342
Mass (Da):36,968
Last modified:February 15, 2005 - v1
Checksum:i5D0B35E6FD8E29B9
GO
Isoform 2 (identifier: Q5JXA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-150: Missing.
     290-342: Missing.

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):20,435
Checksum:i2AFCF082F1DD42D8
GO
Isoform 3 (identifier: Q5JXA9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-150: Missing.

Note: No experimental confirmation available.
Show »
Length:244
Mass (Da):25,837
Checksum:iC51D91A02EC4826E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289L → Q in AAR04783 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043814153G → E. Corresponds to variant dbSNP:rs6033876Ensembl.1
Natural variantiVAR_043815215E → A2 PublicationsCorresponds to variant dbSNP:rs6042507Ensembl.1
Natural variantiVAR_043816304L → F. Corresponds to variant dbSNP:rs8119290Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03406553 – 150Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST98
Alternative sequenceiVSP_034066290 – 342Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424277 mRNA Translation: AAR04783.1
AK297072 mRNA Translation: BAG59591.1
AL109658 Genomic DNA No translation available.
CCDSiCCDS42849.1 [Q5JXA9-1]
CCDS46570.1 [Q5JXA9-3]
RefSeqiNP_001116434.1, NM_001122962.1 [Q5JXA9-1]
NP_001128308.1, NM_001134836.1 [Q5JXA9-3]
UniGeneiHs.721685

Genome annotation databases

EnsembliENST00000359801; ENSP00000352849; ENSG00000196209 [Q5JXA9-1]
ENST00000444444; ENSP00000402438; ENSG00000196209 [Q5JXA9-3]
GeneIDi284759
KEGGihsa:284759
UCSCiuc002wfg.3 human [Q5JXA9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSIRB2_HUMAN
AccessioniPrimary (citable) accession number: Q5JXA9
Secondary accession number(s): B4DLM9, E9PCW6, Q6TCH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 15, 2005
Last modified: June 20, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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