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Protein

Protein FAM209A

Gene

FAM209A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM209A
Gene namesi
Name:FAM209A
Synonyms:C20orf106
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124103.8
HGNCiHGNC:16100 FAM209A
neXtProtiNX_Q5JX71

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 52ExtracellularSequence analysisAdd BLAST33
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 171CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124103
PharmGKBiPA134974173

Polymorphism and mutation databases

BioMutaiFAM209A
DMDMi74742707

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000026415520 – 171Protein FAM209AAdd BLAST152

Proteomic databases

PaxDbiQ5JX71
PeptideAtlasiQ5JX71
PRIDEiQ5JX71
ProteomicsDBi63432

PTM databases

PhosphoSitePlusiQ5JX71

Expressioni

Gene expression databases

BgeeiENSG00000124103 Expressed in 74 organ(s), highest expression level in right testis
CleanExiHS_C20orf106

Interactioni

Protein-protein interaction databases

BioGridi128313, 1 interactor
IntActiQ5JX71, 225 interactors
STRINGi9606.ENSP00000360379

Structurei

3D structure databases

ProteinModelPortaliQ5JX71
SMRiQ5JX71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili114 – 139Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the FAM209 family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWYA Eukaryota
ENOG4111CPN LUCA
GeneTreeiENSGT00390000005057
HOGENOMiHOG000115798
HOVERGENiHBG056390
InParanoidiQ5JX71
OMAiNKDCAFN
OrthoDBiEOG091G0TAG
PhylomeDBiQ5JX71
TreeFamiTF338191

Family and domain databases

InterProiView protein in InterPro
IPR027943 FAM209
PANTHERiPTHR35157 PTHR35157, 1 hit
PfamiView protein in Pfam
PF15206 FAM209, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JX71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTLKSSLVL LLCLTCSYAF MFSSLRQKTS EPQGKVQYGE HFRIRQNLPE
60 70 80 90 100
HTQGWLGSKW LWLLFVVVPF VILQCQRDSE KNKEQSPPGL RGGQLHSPLK
110 120 130 140 150
KKRNASPNKD CAFNTLMELE VELMKFVSKV RNLKRAMATG SGSNLRLRKS
160 170
EMPADPYHVT ICEIWGEESS S
Length:171
Mass (Da):19,603
Last modified:February 15, 2005 - v1
Checksum:i2CBB21C35AF9623A
GO

Sequence cautioni

The sequence AAH29411 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98P → L in AAH29411 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02962166V → A. Corresponds to variant dbSNP:rs707554Ensembl.1
Natural variantiVAR_03376195L → F. Corresponds to variant dbSNP:rs1054343Ensembl.1
Natural variantiVAR_029622117M → K. Corresponds to variant dbSNP:rs1054349Ensembl.1
Natural variantiVAR_029623135R → G. Corresponds to variant dbSNP:rs1054358Ensembl.1
Natural variantiVAR_029624146R → K. Corresponds to variant dbSNP:rs1054361Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109806 Genomic DNA No translation available.
BC029411 mRNA Translation: AAH29411.1 Sequence problems.
BC107704 mRNA Translation: AAI07705.1
CCDSiCCDS33493.1
RefSeqiNP_001012989.2, NM_001012971.3
UniGeneiHs.504907

Genome annotation databases

EnsembliENST00000371328; ENSP00000360379; ENSG00000124103
GeneIDi200232
KEGGihsa:200232
UCSCiuc002xxx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109806 Genomic DNA No translation available.
BC029411 mRNA Translation: AAH29411.1 Sequence problems.
BC107704 mRNA Translation: AAI07705.1
CCDSiCCDS33493.1
RefSeqiNP_001012989.2, NM_001012971.3
UniGeneiHs.504907

3D structure databases

ProteinModelPortaliQ5JX71
SMRiQ5JX71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128313, 1 interactor
IntActiQ5JX71, 225 interactors
STRINGi9606.ENSP00000360379

PTM databases

PhosphoSitePlusiQ5JX71

Polymorphism and mutation databases

BioMutaiFAM209A
DMDMi74742707

Proteomic databases

PaxDbiQ5JX71
PeptideAtlasiQ5JX71
PRIDEiQ5JX71
ProteomicsDBi63432

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371328; ENSP00000360379; ENSG00000124103
GeneIDi200232
KEGGihsa:200232
UCSCiuc002xxx.4 human

Organism-specific databases

CTDi200232
EuPathDBiHostDB:ENSG00000124103.8
GeneCardsiFAM209A
HGNCiHGNC:16100 FAM209A
neXtProtiNX_Q5JX71
OpenTargetsiENSG00000124103
PharmGKBiPA134974173
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWYA Eukaryota
ENOG4111CPN LUCA
GeneTreeiENSGT00390000005057
HOGENOMiHOG000115798
HOVERGENiHBG056390
InParanoidiQ5JX71
OMAiNKDCAFN
OrthoDBiEOG091G0TAG
PhylomeDBiQ5JX71
TreeFamiTF338191

Miscellaneous databases

GenomeRNAii200232
PROiPR:Q5JX71

Gene expression databases

BgeeiENSG00000124103 Expressed in 74 organ(s), highest expression level in right testis
CleanExiHS_C20orf106

Family and domain databases

InterProiView protein in InterPro
IPR027943 FAM209
PANTHERiPTHR35157 PTHR35157, 1 hit
PfamiView protein in Pfam
PF15206 FAM209, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF209A_HUMAN
AccessioniPrimary (citable) accession number: Q5JX71
Secondary accession number(s): Q05C43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 15, 2005
Last modified: September 12, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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