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Entry version 100 (17 Jun 2020)
Sequence version 1 (15 Feb 2005)
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Protein

Protein FAM209A

Gene

FAM209A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM209A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM209A
Synonyms:C20orf106
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000124103.8

Human Gene Nomenclature Database

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HGNCi
HGNC:16100 FAM209A

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q5JX71

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 52ExtracellularSequence analysisAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 171CytoplasmicSequence analysisAdd BLAST98

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000124103

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134974173

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q5JX71 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FAM209A

Domain mapping of disease mutations (DMDM)

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DMDMi
74742707

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000026415520 – 171Protein FAM209AAdd BLAST152

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5JX71

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5JX71

PeptideAtlas

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PeptideAtlasi
Q5JX71

PRoteomics IDEntifications database

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PRIDEi
Q5JX71

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
63432

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5JX71

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000124103 Expressed in right testis and 73 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000124103 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q5JX71
With#Exp.IntAct
ADGRE2 [Q9UHX3]3EBI-18304435,EBI-11277970
ADIPOQ [Q15848]3EBI-18304435,EBI-10827839
AGTRAP - isoform 2 [Q6RW13-2]3EBI-18304435,EBI-11522760
AIG1 - isoform 2 [Q9NVV5-2]3EBI-18304435,EBI-11957045
ALG8 [Q9BVK2]3EBI-18304435,EBI-3921603
ANKRD46 - isoform 2 [Q86W74-2]3EBI-18304435,EBI-12109402
APMAP [Q9HDC9]3EBI-18304435,EBI-723950
APOC3 [P02656]3EBI-18304435,EBI-1220113
APOD [P05090]3EBI-18304435,EBI-715495
APOL2 [Q9BQE5]3EBI-18304435,EBI-4290634
AQP1 [P29972]3EBI-18304435,EBI-745213
AQP2 [P41181]3EBI-18304435,EBI-12701138
AQP3 [Q92482]3EBI-18304435,EBI-2808854
ARV1 [Q9H2C2]3EBI-18304435,EBI-11724186
ASGR1 [P07306]3EBI-18304435,EBI-1172335
ASNA1 [O43681]3EBI-18304435,EBI-2515857
ATP13A1 - isoform C [Q9HD20-3]3EBI-18304435,EBI-12069500
B4GALNT2 [Q8NHY0]3EBI-18304435,EBI-1042940
BDNF - isoform 2 [P23560-2]3EBI-18304435,EBI-12275524
BET1 [O15155]3EBI-18304435,EBI-749204
BIK [Q13323]3EBI-18304435,EBI-700794
BMP10 [O95393]3EBI-18304435,EBI-3922513
BNIP2 [Q12982]3EBI-18304435,EBI-752094
BNIP3 [Q12983]3EBI-18304435,EBI-749464
BTN2A2 [Q8WVV5]3EBI-18304435,EBI-8648738
C11orf24 [Q96F05]3EBI-18304435,EBI-2836238
C16orf58 [Q96GQ5]3EBI-18304435,EBI-8636004
C2 [P06681]3EBI-18304435,EBI-2835920
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-18304435,EBI-12003442
CANT1 [Q8WVQ1]3EBI-18304435,EBI-16770554
CCL4L2 [Q8NHW4]3EBI-18304435,EBI-10271156
CD53 [P19397]3EBI-18304435,EBI-6657396
CD59 [P13987]3EBI-18304435,EBI-297972
CD81 [P60033]3EBI-18304435,EBI-712921
CDIPT [O14735]3EBI-18304435,EBI-358858
CDS1 [Q92903]3EBI-18304435,EBI-13295305
CDS2 [O95674]3EBI-18304435,EBI-3913685
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-18304435,EBI-12256978
CLDN2 [P57739]3EBI-18304435,EBI-751440
CLDN4 [O14493]3EBI-18304435,EBI-9316372
CLDND2 [Q8NHS1]3EBI-18304435,EBI-11959453
CLEC4G [Q6UXB4]3EBI-18304435,EBI-2114729
CLN6 [Q9NWW5]3EBI-18304435,EBI-6165897
CMTM7 [Q96FZ5]3EBI-18304435,EBI-2807956
CNIH1 [O95406]3EBI-18304435,EBI-12172273
CNPY3 [Q9BT09]3EBI-18304435,EBI-2835965
COL4A5 - isoform 2 [P29400-2]3EBI-18304435,EBI-12211159
COL8A2 [Q4VAQ0]3EBI-18304435,EBI-10241815
COMT [P21964]3EBI-18304435,EBI-372265
CTRL [P40313]3EBI-18304435,EBI-7883667
CTXN3 [Q4LDR2]3EBI-18304435,EBI-12019274
CYB561D2 [O14569]3EBI-18304435,EBI-717654
CYB5B [O43169]3EBI-18304435,EBI-1058710
CYBC1 [Q9BQA9]3EBI-18304435,EBI-2680384
DEFB121 [Q5J5C9]3EBI-18304435,EBI-10244198
DEFB128 [Q7Z7B8]3EBI-18304435,EBI-18310688
DNAJC30 [Q96LL9]3EBI-18304435,EBI-8639143
DOLK [Q9UPQ8]3EBI-18304435,EBI-8645574
EBP [Q15125]3EBI-18304435,EBI-3915253
EMC6 [Q9BV81]3EBI-18304435,EBI-2820492
EMD [P50402]3EBI-18304435,EBI-489887
ENTPD3 - isoform 2 [O75355-2]3EBI-18304435,EBI-12279764
EOGT - isoform 3 [Q5NDL2-3]3EBI-18304435,EBI-13052900
ERG28 [Q9UKR5]3EBI-18304435,EBI-711490
ERMP1 [Q7Z2K6]3EBI-18304435,EBI-10976398
FA2H [Q7L5A8]3EBI-18304435,EBI-11337888
FAM20B [O75063]3EBI-18304435,EBI-11090967
FAM3C [Q92520]3EBI-18304435,EBI-2876774
FATE1 [Q969F0]3EBI-18304435,EBI-743099
FDFT1 [P37268]3EBI-18304435,EBI-714550
FIS1 [Q9Y3D6]3EBI-18304435,EBI-3385283
FXYD3 - isoform 3 [Q14802-3]3EBI-18304435,EBI-12175685
GAST [P01350]3EBI-18304435,EBI-3436637
GHITM [Q9H3K2]3EBI-18304435,EBI-2868909
GIMAP1 [Q8WWP7]3EBI-18304435,EBI-11991950
GJB2 [P29033]3EBI-18304435,EBI-3905204
GKN1 [Q9NS71]3EBI-18304435,EBI-3933251
GKN2 [Q86XP6]3EBI-18304435,EBI-13380976
GOSR2 [O14653]3EBI-18304435,EBI-4401517
GPR108 [Q9NPR9]3EBI-18304435,EBI-11343451
GPR151 [Q8TDV0]3EBI-18304435,EBI-11955647
GPR37L1 [O60883]3EBI-18304435,EBI-2927498
GYPA [P02724]3EBI-18304435,EBI-702665
HACD2 [Q6Y1H2]3EBI-18304435,EBI-530257
HHATL [Q9HCP6]3EBI-18304435,EBI-5916693
HMOX1 [P09601]3EBI-18304435,EBI-2806151
HMOX2 [P30519]3EBI-18304435,EBI-712096
HTATIP2 - isoform 3 [Q9BUP3-3]3EBI-18304435,EBI-12937691
IGFBP5 [P24593]3EBI-18304435,EBI-720480
INSIG2 [Q9Y5U4]3EBI-18304435,EBI-8503746
JAGN1 [Q8N5M9]3EBI-18304435,EBI-10266796
KIR2DL3 [P43628]3EBI-18304435,EBI-8632435
LHFPL5 [Q8TAF8]3EBI-18304435,EBI-2820517
LPAR3 [Q9UBY5]3EBI-18304435,EBI-12033434
LRP10 [Q7Z4F1]3EBI-18304435,EBI-2830349
MAL [P21145]3EBI-18304435,EBI-3932027
MARCHF2 [Q9P0N8]3EBI-18304435,EBI-10317612
MFF - isoform 5 [Q9GZY8-5]3EBI-18304435,EBI-11956541
MGLL [A0A0C4DFN3]3EBI-18304435,EBI-12866138
MIP [P30301]3EBI-18304435,EBI-8449636
MMD [Q15546]3EBI-18304435,EBI-17873222
MMD2 - isoform 2 [Q8IY49-2]3EBI-18304435,EBI-13349813
MS4A1 [P11836]3EBI-18304435,EBI-2808234
MS4A13 [Q5J8X5]3EBI-18304435,EBI-12070086
MYADM [Q96S97]3EBI-18304435,EBI-13301517
MYADML2 [A6NDP7]3EBI-18304435,EBI-17641390
NAPB [Q9H115]3EBI-18304435,EBI-3921185
NAT8 [Q9UHE5]3EBI-18304435,EBI-2863634
NCR3 [O14931]3EBI-18304435,EBI-14989262
NINJ2 [Q9NZG7]3EBI-18304435,EBI-10317425
NRAC [Q8N912]3EBI-18304435,EBI-12051377
NRM [Q8IXM6]3EBI-18304435,EBI-10262547
NXPE3 [Q969Y0]3EBI-18304435,EBI-17973370
OLFM4 [Q6UX06]3EBI-18304435,EBI-2804156
ORMDL3 [Q8N138]3EBI-18304435,EBI-721750
OTOR [Q9NRC9]3EBI-18304435,EBI-18311020
PAQR7 [Q86WK9]3EBI-18304435,EBI-10694587
PGAP2 - isoform 5 [Q9UHJ9-5]3EBI-18304435,EBI-12092917
PGLYRP3 [Q96LB9]3EBI-18304435,EBI-12339509
PLN [P26678]3EBI-18304435,EBI-692836
PLP1 - isoform DM-20 [P60201-2]3EBI-18304435,EBI-12188331
PLP2 [Q04941]3EBI-18304435,EBI-608347
PLPP4 [Q5VZY2]3EBI-18304435,EBI-10485931
PLPP6 [Q8IY26]3EBI-18304435,EBI-11721828
PMP22 [Q01453]3EBI-18304435,EBI-2845982
PNLIPRP1 [P54315]3EBI-18304435,EBI-8652812
PPGB [Q59EV6]3EBI-18304435,EBI-14210385
PRB1 [A5D903]3EBI-18304435,EBI-10173935
PTCH1 - isoform M [Q13635-3]3EBI-18304435,EBI-14199621
RHAG [Q02094]3EBI-18304435,EBI-14772355
RPRM [Q9NS64]3EBI-18304435,EBI-1052363
RTP2 [Q5QGT7]3EBI-18304435,EBI-10244780
S100A2 [P29034]3EBI-18304435,EBI-752230
SCARF1 [Q14162]3EBI-18304435,EBI-12056025
SCGB1D1 [O95968]3EBI-18304435,EBI-12825395
SCRG1 [O75711]3EBI-18304435,EBI-10189029
SEC22A [Q96IW7]3EBI-18304435,EBI-8652744
SEC22B [O75396]3EBI-18304435,EBI-1058865
SEC61G [P60059]3EBI-18304435,EBI-4402709
SELENOK [Q9Y6D0]3EBI-18304435,EBI-9679163
SEMA6C [Q1RMY5]3EBI-18304435,EBI-18310377
SERP1 [Q9Y6X1]3EBI-18304435,EBI-10329948
SFTPC [P11686]3EBI-18304435,EBI-10197617
SLC13A3 [Q8WWT9]3EBI-18304435,EBI-12938720
SLC1A1 [P43005]3EBI-18304435,EBI-745376
SLC30A8 [Q8IWU4]3EBI-18304435,EBI-10262251
SLC35A1 [P78382]3EBI-18304435,EBI-12870360
SLC35A4 [Q96G79]3EBI-18304435,EBI-12363689
SLC35B4 [Q969S0]3EBI-18304435,EBI-10281213
SLC35E3 [Q7Z769]3EBI-18304435,EBI-13389236
SLC35G2 [Q8TBE7]3EBI-18304435,EBI-727304
SLC38A7 [Q9NVC3]3EBI-18304435,EBI-10314552
SLC52A2 [Q9HAB3]3EBI-18304435,EBI-10309896
SLC7A14 [Q8TBB6]3EBI-18304435,EBI-5235586
SMCO4 [Q9NRQ5]3EBI-18304435,EBI-8640191
SMIM1 [B2RUZ4]3EBI-18304435,EBI-12188413
SNORC [Q6UX34]3EBI-18304435,EBI-11957067
STATH [P02808]3EBI-18304435,EBI-738687
STX1B [P61266]3EBI-18304435,EBI-9071709
STX3 [Q13277]3EBI-18304435,EBI-1394295
STX5 [Q13190]3EBI-18304435,EBI-714206
STX8 [Q9UNK0]3EBI-18304435,EBI-727240
SYNGR1 - isoform 1B [O43759-2]3EBI-18304435,EBI-12187159
SYT15 - isoform 2 [Q9BQS2-2]3EBI-18304435,EBI-13373352
TECR [Q9NZ01]3EBI-18304435,EBI-2877718
TEX264 [Q9Y6I9]3EBI-18304435,EBI-10329860
TFRC [P02786]3EBI-18304435,EBI-355727
THBD [P07204]3EBI-18304435,EBI-941422
THSD7B [C9JKN6]3EBI-18304435,EBI-17192156
TM6SF2 [Q9BZW4]3EBI-18304435,EBI-13082040
TMBIM6 [P55061]3EBI-18304435,EBI-1045825
TMEM100 [Q9NV29]3EBI-18304435,EBI-8644968
TMEM107 [Q6UX40]3EBI-18304435,EBI-12845616
TMEM11 [P17152]3EBI-18304435,EBI-723946
TMEM120A [Q9BXJ8]3EBI-18304435,EBI-727322
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-18304435,EBI-10694905
TMEM140 [Q9NV12]3EBI-18304435,EBI-2844246
TMEM141 [Q96I45]3EBI-18304435,EBI-17681263
TMEM14B [Q9NUH8]3EBI-18304435,EBI-8638294
TMEM14C [Q9P0S9]3EBI-18304435,EBI-2339195
TMEM189-UBE2V1 [I3L0A0]3EBI-18304435,EBI-12213001
TMEM203 [Q969S6]3EBI-18304435,EBI-12274070
TMEM208 [Q9BTX3]3EBI-18304435,EBI-12876824
TMEM218 [A2RU14]3EBI-18304435,EBI-10173151
TMEM222 [Q9H0R3]3EBI-18304435,EBI-347385
TMEM229B [Q8NBD8]3EBI-18304435,EBI-12195227
TMEM236 [Q5W0B7]3EBI-18304435,EBI-13378608
TMEM243 [Q9BU79]3EBI-18304435,EBI-12887458
TMEM254 [Q8TBM7]3EBI-18304435,EBI-11956809
TMEM42 [Q69YG0]3EBI-18304435,EBI-12038591
TMEM43 [Q9BTV4]3EBI-18304435,EBI-721293
TMEM47 [Q9BQJ4]3EBI-18304435,EBI-13370320
TMEM50B [P56557]3EBI-18304435,EBI-12366453
TMEM60 [Q9H2L4]3EBI-18304435,EBI-2852148
TMEM65 [Q6PI78]3EBI-18304435,EBI-6656213
TMEM72 [A0PK05]3EBI-18304435,EBI-12878352
TMEM79 [Q9BSE2]3EBI-18304435,EBI-8649725
TMEM86A [Q8N2M4]3EBI-18304435,EBI-12015604
TMEM86B [Q8N661]3EBI-18304435,EBI-2548832
TMEM97 [Q5BJF2]3EBI-18304435,EBI-12111910
TMPRSS4 [Q9NRS4]3EBI-18304435,EBI-10313040
TMUB2 [Q71RG4]3EBI-18304435,EBI-2820477
TNF [P01375]3EBI-18304435,EBI-359977
TNFRSF10C [O14798]3EBI-18304435,EBI-717441
TNMD - isoform 2 [Q9H2S6-2]3EBI-18304435,EBI-12003398
TRAF3IP3 [Q9Y228]3EBI-18304435,EBI-765817
TRAM1L1 [Q8N609]3EBI-18304435,EBI-11996766
TSPAN2 [O60636]3EBI-18304435,EBI-3914288
TSPAN33 [Q86UF1]3EBI-18304435,EBI-12045841
TSPAN7 [P41732]3EBI-18304435,EBI-1042779
TSPO [P30536]3EBI-18304435,EBI-6623146
TTMP [Q5BVD1]3EBI-18304435,EBI-10243654
TWSG1 [Q9GZX9]3EBI-18304435,EBI-10304067
UBE2J1 [Q9Y385]3EBI-18304435,EBI-988826
UBIAD1 [Q9Y5Z9]3EBI-18304435,EBI-2819725
UNC50 [Q53HI1]3EBI-18304435,EBI-7601760
UPK1B [O75841]3EBI-18304435,EBI-12237619
VAMP3 [Q15836]3EBI-18304435,EBI-722343
VAMP4 [O75379]3EBI-18304435,EBI-744953
VAMP5 [O95183]3EBI-18304435,EBI-10191195
VKORC1 [Q9BQB6]3EBI-18304435,EBI-6256462
VMP1 [Q96GC9]3EBI-18304435,EBI-2800296
WFDC2 [Q14508]3EBI-18304435,EBI-723529
WFS1 [O76024]3EBI-18304435,EBI-720609
YIPF6 [Q96EC8]3EBI-18304435,EBI-751210
ZFPL1 [O95159]3EBI-18304435,EBI-718439

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128313, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q5JX71, 227 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360379

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5JX71 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5JX71

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili114 – 139Sequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM209 family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWYA Eukaryota
ENOG4111CPN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005057

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1585866_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5JX71

Identification of Orthologs from Complete Genome Data

More...
OMAi
TICEIWG

Database of Orthologous Groups

More...
OrthoDBi
1258912at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5JX71

TreeFam database of animal gene trees

More...
TreeFami
TF338191

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027943 FAM209

The PANTHER Classification System

More...
PANTHERi
PTHR35157 PTHR35157, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15206 FAM209, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q5JX71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTLKSSLVL LLCLTCSYAF MFSSLRQKTS EPQGKVQYGE HFRIRQNLPE
60 70 80 90 100
HTQGWLGSKW LWLLFVVVPF VILQCQRDSE KNKEQSPPGL RGGQLHSPLK
110 120 130 140 150
KKRNASPNKD CAFNTLMELE VELMKFVSKV RNLKRAMATG SGSNLRLRKS
160 170
EMPADPYHVT ICEIWGEESS S
Length:171
Mass (Da):19,603
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CBB21C35AF9623A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH29411 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti98P → L in AAH29411 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02962166V → A. Corresponds to variant dbSNP:rs707554Ensembl.1
Natural variantiVAR_03376195L → F. Corresponds to variant dbSNP:rs1054343Ensembl.1
Natural variantiVAR_029622117M → K. Corresponds to variant dbSNP:rs1054349Ensembl.1
Natural variantiVAR_029623135R → G. Corresponds to variant dbSNP:rs1054358Ensembl.1
Natural variantiVAR_029624146R → K. Corresponds to variant dbSNP:rs1054361Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL109806 Genomic DNA No translation available.
BC029411 mRNA Translation: AAH29411.1 Sequence problems.
BC107704 mRNA Translation: AAI07705.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33493.1

NCBI Reference Sequences

More...
RefSeqi
NP_001012989.2, NM_001012971.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371328; ENSP00000360379; ENSG00000124103

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
200232

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:200232

UCSC genome browser

More...
UCSCi
uc002xxx.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109806 Genomic DNA No translation available.
BC029411 mRNA Translation: AAH29411.1 Sequence problems.
BC107704 mRNA Translation: AAI07705.1
CCDSiCCDS33493.1
RefSeqiNP_001012989.2, NM_001012971.3

3D structure databases

SMRiQ5JX71
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128313, 1 interactor
IntActiQ5JX71, 227 interactors
STRINGi9606.ENSP00000360379

PTM databases

PhosphoSitePlusiQ5JX71

Polymorphism and mutation databases

BioMutaiFAM209A
DMDMi74742707

Proteomic databases

MassIVEiQ5JX71
PaxDbiQ5JX71
PeptideAtlasiQ5JX71
PRIDEiQ5JX71
ProteomicsDBi63432

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
52593 31 antibodies

Genome annotation databases

EnsembliENST00000371328; ENSP00000360379; ENSG00000124103
GeneIDi200232
KEGGihsa:200232
UCSCiuc002xxx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
200232
EuPathDBiHostDB:ENSG00000124103.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM209A
HGNCiHGNC:16100 FAM209A
HPAiENSG00000124103 Tissue enriched (testis)
neXtProtiNX_Q5JX71
OpenTargetsiENSG00000124103
PharmGKBiPA134974173

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWYA Eukaryota
ENOG4111CPN LUCA
GeneTreeiENSGT00390000005057
HOGENOMiCLU_1585866_0_0_1
InParanoidiQ5JX71
OMAiTICEIWG
OrthoDBi1258912at2759
PhylomeDBiQ5JX71
TreeFamiTF338191

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
200232 3 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM209A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
200232
PharosiQ5JX71 Tdark

Protein Ontology

More...
PROi
PR:Q5JX71
RNActiQ5JX71 protein

Gene expression databases

BgeeiENSG00000124103 Expressed in right testis and 73 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR027943 FAM209
PANTHERiPTHR35157 PTHR35157, 1 hit
PfamiView protein in Pfam
PF15206 FAM209, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF209A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JX71
Secondary accession number(s): Q05C43
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 15, 2005
Last modified: June 17, 2020
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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