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UniProtKB - Q5JX71 (F209A_HUMAN)
Protein
Protein FAM209A
Gene
FAM209A
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in sperm acrosome biogenesis.
By similarityMiscellaneous
The primate lineage appears to have undergone gene duplication of FAM209, such that humans contain FAM209A and FAM209B.Curated
Keywordsi
Biological process | Differentiation, Spermatogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q5JX71 |
SignaLinki | Q5JX71 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM209A |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16100, FAM209A |
neXtProti | NX_Q5JX71 |
VEuPathDBi | HostDB:ENSG00000124103 |
Subcellular locationi
Nucleus
- Nucleus inner membrane By similarity; Single-pass type I membrane protein Sequence analysis
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 52 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 74 – 171 | CytoplasmicSequence analysisAdd BLAST | 98 |
Keywords - Cellular componenti
Membrane, NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000124103 |
PharmGKBi | PA134974173 |
Miscellaneous databases
Pharosi | Q5JX71, Tdark |
Genetic variation databases
BioMutai | FAM209A |
DMDMi | 74742707 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000264155 | 20 – 171 | Protein FAM209AAdd BLAST | 152 |
Proteomic databases
MassIVEi | Q5JX71 |
PaxDbi | Q5JX71 |
PeptideAtlasi | Q5JX71 |
PRIDEi | Q5JX71 |
ProteomicsDBi | 63432 |
PTM databases
PhosphoSitePlusi | Q5JX71 |
Expressioni
Gene expression databases
Bgeei | ENSG00000124103, Expressed in right testis and 96 other tissues |
Organism-specific databases
HPAi | ENSG00000124103, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Q5JX71
Protein-protein interaction databases
BioGRIDi | 128313, 233 interactors |
IntActi | Q5JX71, 227 interactors |
STRINGi | 9606.ENSP00000360379 |
Miscellaneous databases
RNActi | Q5JX71, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 81 – 107 | DisorderedSequence analysisAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 114 – 139 | Sequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the FAM209 family.Curated
Keywords - Domaini
Coiled coil, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SQY6, Eukaryota |
GeneTreei | ENSGT00390000005057 |
HOGENOMi | CLU_1585866_0_0_1 |
InParanoidi | Q5JX71 |
OMAi | TICEIWG |
OrthoDBi | 1258912at2759 |
PhylomeDBi | Q5JX71 |
TreeFami | TF338191 |
Family and domain databases
InterProi | View protein in InterPro IPR027943, FAM209 |
PANTHERi | PTHR35157, PTHR35157, 1 hit |
Pfami | View protein in Pfam PF15206, FAM209, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5JX71-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWTLKSSLVL LLCLTCSYAF MFSSLRQKTS EPQGKVQYGE HFRIRQNLPE
60 70 80 90 100
HTQGWLGSKW LWLLFVVVPF VILQCQRDSE KNKEQSPPGL RGGQLHSPLK
110 120 130 140 150
KKRNASPNKD CAFNTLMELE VELMKFVSKV RNLKRAMATG SGSNLRLRKS
160 170
EMPADPYHVT ICEIWGEESS S
Sequence cautioni
The sequence AAH29411 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 98 | P → L in AAH29411 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029621 | 66 | V → A. Corresponds to variant dbSNP:rs707554Ensembl. | 1 | |
Natural variantiVAR_033761 | 95 | L → F. Corresponds to variant dbSNP:rs1054343Ensembl. | 1 | |
Natural variantiVAR_029622 | 117 | M → K. Corresponds to variant dbSNP:rs1054349Ensembl. | 1 | |
Natural variantiVAR_029623 | 135 | R → G. Corresponds to variant dbSNP:rs1054358Ensembl. | 1 | |
Natural variantiVAR_029624 | 146 | R → K. Corresponds to variant dbSNP:rs1054361Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL109806 Genomic DNA No translation available. BC029411 mRNA Translation: AAH29411.1 Sequence problems. BC107704 mRNA Translation: AAI07705.1 |
CCDSi | CCDS33493.1 |
RefSeqi | NP_001012989.2, NM_001012971.3 |
Genome annotation databases
Ensembli | ENST00000371328; ENSP00000360379; ENSG00000124103 |
GeneIDi | 200232 |
KEGGi | hsa:200232 |
MANE-Selecti | ENST00000371328.5; ENSP00000360379.4; NM_001012971.4; NP_001012989.2 |
UCSCi | uc002xxx.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL109806 Genomic DNA No translation available. BC029411 mRNA Translation: AAH29411.1 Sequence problems. BC107704 mRNA Translation: AAI07705.1 |
CCDSi | CCDS33493.1 |
RefSeqi | NP_001012989.2, NM_001012971.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 128313, 233 interactors |
IntActi | Q5JX71, 227 interactors |
STRINGi | 9606.ENSP00000360379 |
PTM databases
PhosphoSitePlusi | Q5JX71 |
Genetic variation databases
BioMutai | FAM209A |
DMDMi | 74742707 |
Proteomic databases
MassIVEi | Q5JX71 |
PaxDbi | Q5JX71 |
PeptideAtlasi | Q5JX71 |
PRIDEi | Q5JX71 |
ProteomicsDBi | 63432 |
Protocols and materials databases
Antibodypediai | 52593, 31 antibodies from 4 providers |
DNASUi | 200232 |
Genome annotation databases
Ensembli | ENST00000371328; ENSP00000360379; ENSG00000124103 |
GeneIDi | 200232 |
KEGGi | hsa:200232 |
MANE-Selecti | ENST00000371328.5; ENSP00000360379.4; NM_001012971.4; NP_001012989.2 |
UCSCi | uc002xxx.4, human |
Organism-specific databases
CTDi | 200232 |
GeneCardsi | FAM209A |
HGNCi | HGNC:16100, FAM209A |
HPAi | ENSG00000124103, Tissue enriched (testis) |
neXtProti | NX_Q5JX71 |
OpenTargetsi | ENSG00000124103 |
PharmGKBi | PA134974173 |
VEuPathDBi | HostDB:ENSG00000124103 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SQY6, Eukaryota |
GeneTreei | ENSGT00390000005057 |
HOGENOMi | CLU_1585866_0_0_1 |
InParanoidi | Q5JX71 |
OMAi | TICEIWG |
OrthoDBi | 1258912at2759 |
PhylomeDBi | Q5JX71 |
TreeFami | TF338191 |
Enzyme and pathway databases
PathwayCommonsi | Q5JX71 |
SignaLinki | Q5JX71 |
Miscellaneous databases
BioGRID-ORCSi | 200232, 6 hits in 983 CRISPR screens |
ChiTaRSi | FAM209A, human |
GenomeRNAii | 200232 |
Pharosi | Q5JX71, Tdark |
PROi | PR:Q5JX71 |
RNActi | Q5JX71, protein |
Gene expression databases
Bgeei | ENSG00000124103, Expressed in right testis and 96 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR027943, FAM209 |
PANTHERi | PTHR35157, PTHR35157, 1 hit |
Pfami | View protein in Pfam PF15206, FAM209, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F209A_HUMAN | |
Accessioni | Q5JX71Primary (citable) accession number: Q5JX71 Secondary accession number(s): Q05C43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | February 15, 2005 | |
Last modified: | February 23, 2022 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families