FAM209A

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM209A
Gene namesⁱ	Name:FAM209A Synonyms:C20orf106
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000124103.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16100 FAM209A
neXtProtⁱ	NX_Q5JX71

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 52	ExtracellularSequence analysisAdd BLAST	33
Transmembraneⁱ	53 – 73	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	74 – 171	CytoplasmicSequence analysisAdd BLAST	98

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000124103
PharmGKBⁱ	PA134974173

Polymorphism and mutation databases

BioMutaⁱ	FAM209A
DMDMⁱ	74742707

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000264155	20 – 171	Protein FAM209AAdd BLAST		152

Proteomic databases

PaxDbⁱ	Q5JX71
PeptideAtlas More...PeptideAtlasⁱ	Q5JX71
PRIDEⁱ	Q5JX71
ProteomicsDBⁱ	63432

PTM databases

PhosphoSitePlusⁱ	Q5JX71

PhosphoSitePlusⁱ

Q5JX71

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000124103 Expressed in 74 organ(s), highest expression level in right testis
CleanExⁱ	HS_C20orf106

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	128313, 1 interactor
IntActⁱ	Q5JX71, 225 interactors
STRINGⁱ	9606.ENSP00000360379

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5JX71
SMRⁱ	Q5JX71
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	114 – 139	Sequence analysisAdd BLAST		26

Sequence similaritiesⁱ

Belongs to the FAM209 family.Curated

Keywords - Domainⁱ

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IWYA Eukaryota ENOG4111CPN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005057
HOGENOMⁱ	HOG000115798
HOVERGENⁱ	HBG056390
InParanoidⁱ	Q5JX71
OMAⁱ	NKDCAFN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TAG
PhylomeDBⁱ	Q5JX71
TreeFamⁱ	TF338191

Family and domain databases

InterProⁱ	View protein in InterPro IPR027943 FAM209
PANTHERⁱ	PTHR35157 PTHR35157, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15206 FAM209, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q5JX71-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWTLKSSLVL LLCLTCSYAF MFSSLRQKTS EPQGKVQYGE HFRIRQNLPE 
        60         70         80         90        100
HTQGWLGSKW LWLLFVVVPF VILQCQRDSE KNKEQSPPGL RGGQLHSPLK 
       110        120        130        140        150
KKRNASPNKD CAFNTLMELE VELMKFVSKV RNLKRAMATG SGSNLRLRKS 
       160        170 
EMPADPYHVT ICEIWGEESS S

Length:171

Mass (Da):19,603

Last modified:February 15, 2005 - v1

Checksum:ⁱ2CBB21C35AF9623A

GO

Sequence cautionⁱ

The sequence AAH29411 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	98	P → L in AAH29411 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_029621	66	V → A. Corresponds to variant dbSNP:rs707554Ensembl.	1
Natural variantⁱVAR_033761	95	L → F. Corresponds to variant dbSNP:rs1054343Ensembl.	1
Natural variantⁱVAR_029622	117	M → K. Corresponds to variant dbSNP:rs1054349Ensembl.	1
Natural variantⁱVAR_029623	135	R → G. Corresponds to variant dbSNP:rs1054358Ensembl.	1
Natural variantⁱVAR_029624	146	R → K. Corresponds to variant dbSNP:rs1054361Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL109806 Genomic DNA No translation available. BC029411 mRNA Translation: AAH29411.1 Sequence problems. BC107704 mRNA Translation: AAI07705.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33493.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001012989.2, NM_001012971.3
UniGeneⁱ	Hs.504907

Genome annotation databases

Ensemblⁱ	ENST00000371328; ENSP00000360379; ENSG00000124103
GeneIDⁱ	200232
KEGGⁱ	hsa:200232
UCSC genome browser More...UCSCⁱ	uc002xxx.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5JX71	Family with sequence similarity 209 member A		GORGO		171	UniRef90_Q5JX71
Uncharacterized protein		PANPA		170

Protein	Similar proteins		Species	Score	Length	Source
Q5JX71	Family with sequence similarity 209 member A		GORGO		171	UniRef50_Q5JX71
Uncharacterized protein		PANPA		170
Uncharacterized protein		RABIT		168
Uncharacterized protein		TUPCH		169
Uncharacterized protein		ICTTR		170
+47

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL109806 Genomic DNA No translation available. BC029411 mRNA Translation: AAH29411.1 Sequence problems. BC107704 mRNA Translation: AAI07705.1
CCDSⁱ	CCDS33493.1
RefSeqⁱ	NP_001012989.2, NM_001012971.3
UniGeneⁱ	Hs.504907

3D structure databases

ProteinModelPortalⁱ	Q5JX71
SMRⁱ	Q5JX71
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128313, 1 interactor
IntActⁱ	Q5JX71, 225 interactors
STRINGⁱ	9606.ENSP00000360379

PTM databases

PhosphoSitePlusⁱ	Q5JX71

PhosphoSitePlusⁱ

Q5JX71

Polymorphism and mutation databases

BioMutaⁱ	FAM209A
DMDMⁱ	74742707

Proteomic databases

PaxDbⁱ	Q5JX71
PeptideAtlasⁱ	Q5JX71
PRIDEⁱ	Q5JX71
ProteomicsDBⁱ	63432

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000371328; ENSP00000360379; ENSG00000124103
GeneIDⁱ	200232
KEGGⁱ	hsa:200232
UCSCⁱ	uc002xxx.4 human

Organism-specific databases

CTDⁱ	200232
EuPathDBⁱ	HostDB:ENSG00000124103.8
GeneCardsⁱ	FAM209A
HGNCⁱ	HGNC:16100 FAM209A
neXtProtⁱ	NX_Q5JX71
OpenTargetsⁱ	ENSG00000124103
PharmGKBⁱ	PA134974173
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWYA Eukaryota ENOG4111CPN LUCA
GeneTreeⁱ	ENSGT00390000005057
HOGENOMⁱ	HOG000115798
HOVERGENⁱ	HBG056390
InParanoidⁱ	Q5JX71
OMAⁱ	NKDCAFN
OrthoDBⁱ	EOG091G0TAG
PhylomeDBⁱ	Q5JX71
TreeFamⁱ	TF338191

Miscellaneous databases

GenomeRNAiⁱ	200232
Protein Ontology More...PROⁱ	PR:Q5JX71

Gene expression databases

Bgeeⁱ	ENSG00000124103 Expressed in 74 organ(s), highest expression level in right testis
CleanExⁱ	HS_C20orf106

Family and domain databases

InterProⁱ	View protein in InterPro IPR027943 FAM209
PANTHERⁱ	PTHR35157 PTHR35157, 1 hit
Pfamⁱ	View protein in Pfam PF15206 FAM209, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F209A_HUMAN
Accessionⁱ	Q5JX71Primary (citable) accession number: Q5JX71 Secondary accession number(s): Q05C43
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	February 15, 2005
	Last modified:	September 12, 2018
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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Supporting data

UniProtKB - Q5JX71 (F209A_HUMAN)

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Protein FAM209A

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Nucleus

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ