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Entry version 120 (10 Feb 2021)
Sequence version 1 (15 Feb 2005)
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Protein

Actin-like protein 10

Gene

ACTL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q5JWF8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q5JWF8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin-like protein 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACTL10
Synonyms:C20orf134
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:16127, ACTL10

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q5JWF8

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000182584.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000182584

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA25676

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q5JWF8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ACTL10

Domain mapping of disease mutations (DMDM)

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DMDMi
74742586

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002328651 – 245Actin-like protein 10Add BLAST245

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5JWF8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q5JWF8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5JWF8

PeptideAtlas

More...
PeptideAtlasi
Q5JWF8

PRoteomics IDEntifications database

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PRIDEi
Q5JWF8

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
63387

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5JWF8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5JWF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182584, Expressed in right testis and 130 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5JWF8, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000182584, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000329647

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5JWF8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0676, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000162922

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_027965_5_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5JWF8

Identification of Orthologs from Complete Genome Data

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OMAi
AGHSWHE

Database of Orthologous Groups

More...
OrthoDBi
649708at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5JWF8

TreeFam database of animal gene trees

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TreeFami
TF300361

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004000, Actin
IPR043129, ATPase_NBD

The PANTHER Classification System

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PANTHERi
PTHR11937, PTHR11937, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00022, Actin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00268, ACTIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53067, SSF53067, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5JWF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTALLALC STGAFSGLAV EAGAGVCHAT PIYAGHSWHQ ATFRLNVAGS
60 70 80 90 100
TLSRYLRDLL VAANPDLLQQ ALPRKAITHL KKRSCYVSLD FEGDLRDPAR
110 120 130 140 150
HHPASFSVGN GCCVCLSSER FRCPEPIFQP GLLGQAEQGL PALAFRALQK
160 170 180 190 200
MPKTLRTRLA DTVVLAGGST LFPGFAERLD KELEAQCRRH GYAALRPHLV
210 220 230 240
AKHGRGMAVW TGGSMVASLH SFQRRWITRA MYQECGSRLL YDVFN
Length:245
Mass (Da):26,751
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06EC6260DF9CC2EE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL121906 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76309.1
BC137111 mRNA Translation: AAI37112.1
BC137114 mRNA Translation: AAI37115.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33463.1

NCBI Reference Sequences

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RefSeqi
NP_001019846.1, NM_001024675.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330271; ENSP00000329647; ENSG00000182584

Database of genes from NCBI RefSeq genomes

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GeneIDi
170487

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:170487

UCSC genome browser

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UCSCi
uc002wzt.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121906 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76309.1
BC137111 mRNA Translation: AAI37112.1
BC137114 mRNA Translation: AAI37115.1
CCDSiCCDS33463.1
RefSeqiNP_001019846.1, NM_001024675.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000329647

PTM databases

iPTMnetiQ5JWF8
PhosphoSitePlusiQ5JWF8

Genetic variation databases

BioMutaiACTL10
DMDMi74742586

Proteomic databases

MassIVEiQ5JWF8
MaxQBiQ5JWF8
PaxDbiQ5JWF8
PeptideAtlasiQ5JWF8
PRIDEiQ5JWF8
ProteomicsDBi63387

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
57049, 13 antibodies

Genome annotation databases

EnsembliENST00000330271; ENSP00000329647; ENSG00000182584
GeneIDi170487
KEGGihsa:170487
UCSCiuc002wzt.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
170487

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ACTL10
HGNCiHGNC:16127, ACTL10
HPAiENSG00000182584, Tissue enriched (testis)
neXtProtiNX_Q5JWF8
OpenTargetsiENSG00000182584
PharmGKBiPA25676
VEuPathDBiHostDB:ENSG00000182584.4

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0676, Eukaryota
GeneTreeiENSGT00940000162922
HOGENOMiCLU_027965_5_2_1
InParanoidiQ5JWF8
OMAiAGHSWHE
OrthoDBi649708at2759
PhylomeDBiQ5JWF8
TreeFamiTF300361

Enzyme and pathway databases

PathwayCommonsiQ5JWF8
SignaLinkiQ5JWF8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
170487, 13 hits in 868 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
170487
PharosiQ5JWF8, Tdark

Protein Ontology

More...
PROi
PR:Q5JWF8
RNActiQ5JWF8, protein

Gene expression databases

BgeeiENSG00000182584, Expressed in right testis and 130 other tissues
GenevisibleiQ5JWF8, HS

Family and domain databases

InterProiView protein in InterPro
IPR004000, Actin
IPR043129, ATPase_NBD
PANTHERiPTHR11937, PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022, Actin, 1 hit
SMARTiView protein in SMART
SM00268, ACTIN, 1 hit
SUPFAMiSSF53067, SSF53067, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACL10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JWF8
Secondary accession number(s): B9EH76
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: February 15, 2005
Last modified: February 10, 2021
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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