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Protein

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

Gene

GNAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity).By similarity

Miscellaneous

This protein is produced by a bicistronic gene which also produces the ALEX protein from an overlapping reading frame.By similarity
The GNAS locus is imprinted in a complex manner, giving rise to distinct paternally, maternally and biallelically expressed proteins. The XLas isoforms are paternally derived, the Gnas isoforms are biallelically derived and the Nesp55 isoforms are maternally derived.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi697MagnesiumBy similarity1
Metal bindingi847MagnesiumBy similarity1
Binding sitei1009GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi690 – 698GTPBy similarity9
Nucleotide bindingi840 – 847GTPBy similarity8
Nucleotide bindingi866 – 870GTPBy similarity5
Nucleotide bindingi935 – 938GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-164378 PKA activation in glucagon signalling
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5610787 Hedgehog 'off' state
SIGNORiQ5JWF2

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Alternative name(s):
Adenylate cyclase-stimulating G alpha protein
Extra large alphas protein
Short name:
XLalphas
Gene namesi
Name:GNAS
Synonyms:GNAS11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000087460.23
HGNCiHGNC:4392 GNAS
MIMi139320 gene+phenotype
neXtProtiNX_Q5JWF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

GNAS hyperfunction (GNASHYP)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionThis condition is characterized by increased trauma-related bleeding tendency, prolonged bleeding time, brachydactyly and mental retardation. Both the XLas isoforms and the ALEX protein are mutated which strongly reduces the interaction between them and this may allow unimpeded activation of the XLas isoforms.
See also OMIM:139320
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028777436A → D in GNASHYP. 2 PublicationsCorresponds to variant dbSNP:rs61749698Ensembl.1
Natural variantiVAR_028779459P → R in GNASHYP. 2 PublicationsCorresponds to variant dbSNP:rs148033592Ensembl.1
ACTH-independent macronodular adrenal hyperplasia 1 (AIMAH1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare adrenal defect characterized by multiple, bilateral, non-pigmented, benign, adrenocortical nodules. It results in excessive production of cortisol leading to ACTH-independent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
See also OMIM:219080
Pseudohypoparathyroidism 1B (PHP1B)7 Publications
The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed.
Disease descriptionA disorder characterized by end-organ resistance to parathyroid hormone, hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH.
See also OMIM:603233
Pseudohypoparathyroidism 1C (PHP1C)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by end-organ resistance to parathyroid hormone, hypocalcemia and hyperphosphatemia. It is commonly associated with Albright hereditary osteodystrophy whose features are short stature, obesity, round facies, short metacarpals and ectopic calcification.
See also OMIM:612462

Keywords - Diseasei

Cushing syndrome, Disease mutation

Organism-specific databases

DisGeNETi2778
MalaCardsiGNAS
MIMi139320 gene+phenotype
219080 phenotype
603233 phenotype
612462 phenotype
OpenTargetsiENSG00000087460
PharmGKBiPA175

Polymorphism and mutation databases

DMDMi116248089

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002539841 – 1037Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLasAdd BLAST1037

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei844ADP-ribosylarginine; by cholera toxinBy similarity1
Modified residuei995PhosphoserineCombined sources1

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Proteomic databases

EPDiQ5JWF2
MaxQBiQ5JWF2
PaxDbiQ5JWF2
PeptideAtlasiQ5JWF2
PRIDEiQ5JWF2
ProteomicsDBi63384
63385 [Q5JWF2-2]
63386 [Q5JWF2-3]

PTM databases

iPTMnetiQ5JWF2
SwissPalmiQ5JWF2

Expressioni

Gene expression databases

BgeeiENSG00000087460 Expressed in 252 organ(s), highest expression level in telencephalon
CleanExiHS_GNAS
ExpressionAtlasiQ5JWF2 baseline and differential
GenevisibleiQ5JWF2 HS

Organism-specific databases

HPAiCAB010337
HPA027478
HPA028386

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts through its N-terminal region with ALEX which is produced from the same locus in a different open reading frame. This interaction may inhibit its adenylyl cyclase-stimulating activity (By similarity). Interacts with MAGED2 (PubMed:27120771).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARRB1P494075EBI-4400880,EBI-743313

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109040, 95 interactors
IntActiQ5JWF2, 10 interactors
MINTiQ5JWF2
STRINGi9606.ENSP00000360141

Structurei

3D structure databases

ProteinModelPortaliQ5JWF2
SMRiQ5JWF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili641 – 667Sequence analysisAdd BLAST27
Coiled coili730 – 756Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi358 – 522Ala-richSequence analysisAdd BLAST165

Sequence similaritiesi

Belongs to the G-alpha family. G(s) subfamily.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0099 Eukaryota
ENOG410XPC4 LUCA
GeneTreeiENSGT00910000144108
HOVERGENiHBG079975
InParanoidiQ5JWF2
OrthoDBiEOG091G0CAY
PhylomeDBiQ5JWF2
TreeFamiTF300673

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000367 Gprotein_alpha_S
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00443 GPROTEINAS
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform XLas-1 (identifier: Q5JWF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVRNCLYGN NMSGQRDIPP EIGEQPEQPP LEAPGAAAPG AGPSPAEEME
60 70 80 90 100
TEPPHNEPIP VENDGEACGP PEVSRPNFQV LNPAFREAGA HGSYSPPPEE
110 120 130 140 150
AMPFEAEQPS LGGFWPTLEQ PGFPSGVHAG LEAFGPALME PGAFSGARPG
160 170 180 190 200
LGGYSPPPEE AMPFEFDQPA QRGCSQLLLQ VPDLAPGGPG AAGVPGAPPE
210 220 230 240 250
EPQALRPAKA GSRGGYSPPP EETMPFELDG EGFGDDSPPP GLSRVIAQVD
260 270 280 290 300
GSSQFAAVAA SSAVRLTPAA NAPPLWVPGA IGSPSQEAVR PPSNFTGSSP
310 320 330 340 350
WMEISGPPFE IGSAPAGVDD TPVNMDSPPI ALDGPPIKVS GAPDKRERAE
360 370 380 390 400
RPPVEEEAAE MEGAADAAEG GKVPSPGYGS PAAGAASADT AARAAPAAPA
410 420 430 440 450
DPDSGATPED PDSGTAPADP DSGAFAADPD SGAAPAAPAD PDSGAAPDAP
460 470 480 490 500
ADPDSGAAPD APADPDAGAA PEAPAAPAAA ETRAAHVAPA APDAGAPTAP
510 520 530 540 550
AASATRAAQV RRAASAAPAS GARRKIHLRP PSPEIQAADP PTPRPTRASA
560 570 580 590 600
WRGKSESSRG RRVYYDEGVA SSDDDSSGDE SDDGTSGCLR WFQHRRNRRR
610 620 630 640 650
RKPQRNLLRN FLVQAFGGCF GRSESPQPKA SRSLKVKKVP LAEKRRQMRK
660 670 680 690 700
EALEKRAQKR AEKKRSKLID KQLQDEKMGY MCTHRLLLLG AGESGKSTIV
710 720 730 740 750
KQMRILHVNG FNGEGGEEDP QAARSNSDGE KATKVQDIKN NLKEAIETIV
760 770 780 790 800
AAMSNLVPPV ELANPENQFR VDYILSVMNV PDFDFPPEFY EHAKALWEDE
810 820 830 840 850
GVRACYERSN EYQLIDCAQY FLDKIDVIKQ ADYVPSDQDL LRCRVLTSGI
860 870 880 890 900
FETKFQVDKV NFHMFDVGGQ RDERRKWIQC FNDVTAIIFV VASSSYNMVI
910 920 930 940 950
REDNQTNRLQ EALNLFKSIW NNRWLRTISV ILFLNKQDLL AEKVLAGKSK
960 970 980 990 1000
IEDYFPEFAR YTTPEDATPE PGEDPRVTRA KYFIRDEFLR ISTASGDGRH
1010 1020 1030
YCYPHFTCAV DTENIRRVFN DCRDIIQRMH LRQYELL
Note: Gene prediction confirmed by EST data.Curated
Length:1,037
Mass (Da):111,025
Last modified:October 17, 2006 - v2
Checksum:i02CB52383015E75D
GO
Isoform XLas-2 (identifier: Q5JWF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     714-729: EGGEEDPQAARSNSDG → DS

Note: Gene prediction confirmed by EST data.Curated
Show »
Length:1,023
Mass (Da):109,626
Checksum:i22DBCF510AEF25D6
GO
Isoform XLas-3 (identifier: Q5JWF2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     691-752: AGESGKSTIV...KEAIETIVAA → RKVVPSDTEG...VLENLVKAPL
     753-1037: Missing.

Show »
Length:752
Mass (Da):77,643
Checksum:i65A9202D681E861F
GO
Isoform Gnas-1Curated (identifier: P63092-1) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Alpha-S2Curated, GNASlCurated, Alpha-S-longCurated
The sequence of this isoform can be found in the external entry P63092.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:394
Mass (Da):45,665
GO
Isoform 3 (identifier: P63092-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P63092.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:379
Mass (Da):44,179
GO
Isoform Gnas-2Curated (identifier: P63092-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Alpha-S1Curated, GNASsCurated, Alpha-S-shortCurated
The sequence of this isoform can be found in the external entry P63092.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:380
Mass (Da):44,266
GO
Isoform Nesp55Curated (identifier: O95467-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry O95467.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Shares no sequence similarity with other isoforms due to a novel first exon containing the entire reading frame spliced to shared exon 2 so that exons 2-13 make up the 3'-UTR.
Length:245
Mass (Da):28,029
GO
Isoform 4 (identifier: P63092-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P63092.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Gene prediction based on EST data.
Length:395
Mass (Da):45,752
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P84996ALEX_HUMAN
Protein ALEX
GNAS GNAS1
626Annotation score:
Q5JWE9Q5JWE9_HUMAN
Guanine nucleotide-binding protein ...
GNAS
193Annotation score:
Q5JWD1Q5JWD1_HUMAN
Guanine nucleotide-binding protein ...
GNAS
87Annotation score:
S4R3E3S4R3E3_HUMAN
Guanine nucleotide-binding protein ...
GNAS
160Annotation score:
H0Y7F4H0Y7F4_HUMAN
Guanine nucleotide-binding protein ...
GNAS
199Annotation score:
A0A0A0MR13A0A0A0MR13_HUMAN
Guanine nucleotide-binding protein ...
GNAS
158Annotation score:
S4R3V9S4R3V9_HUMAN
Guanine nucleotide-binding protein ...
GNAS
120Annotation score:
H0Y7E8H0Y7E8_HUMAN
Guanine nucleotide-binding protein ...
GNAS
93Annotation score:
A2A2R6A2A2R6_HUMAN
Guanine nucleotide-binding protein ...
GNAS
61Annotation score:
A2A2S1A2A2S1_HUMAN
Guanine nucleotide-binding protein ...
GNAS
166Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence CAB83215 differs from that shown. Reason: Frameshift at position 40.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15Q → E in CAB83215 (PubMed:10749992).Curated1
Sequence conflicti46A → S in CAB83215 (PubMed:10749992).Curated1
Sequence conflicti132E → A in CAB83215 (PubMed:10749992).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028777436A → D in GNASHYP. 2 PublicationsCorresponds to variant dbSNP:rs61749698Ensembl.1
Natural variantiVAR_028778437A → APADPDSGAAPDA in GNAS hyperfunction. 2 Publications1
Natural variantiVAR_028779459P → R in GNASHYP. 2 PublicationsCorresponds to variant dbSNP:rs148033592Ensembl.1
Natural variantiVAR_0596561023R → L. Corresponds to variant dbSNP:rs8986Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052173691 – 752AGESG…TIVAA → RKVVPSDTEGRFRLDRPAPA TVSWTGRGFSVSSLLIRSPN PPAFTVEKPDTQVLENLVKA PL in isoform XLas-3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_052174714 – 729EGGEE…SNSDG → DS in isoform XLas-2. CuratedAdd BLAST16
Alternative sequenceiVSP_052175753 – 1037Missing in isoform XLas-3. 1 PublicationAdd BLAST285

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109840 Genomic DNA No translation available.
AL121917 Genomic DNA No translation available.
AL132655 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75462.1
CH471077 Genomic DNA Translation: EAW75469.1
AJ251760 Genomic DNA Translation: CAB83215.1 Frameshift.
AJ224867 mRNA Translation: CAA12164.1
AJ224868 Genomic DNA Translation: CAA12165.1
AY898804 Genomic DNA Translation: AAX51890.1
CCDSiCCDS46622.1 [Q5JWF2-1]
RefSeqiNP_001296812.1, NM_001309883.1
NP_536350.2, NM_080425.3 [Q5JWF2-1]
XP_016883302.1, XM_017027813.1 [Q5JWF2-2]
UniGeneiHs.125898

Genome annotation databases

EnsembliENST00000371100; ENSP00000360141; ENSG00000087460 [Q5JWF2-1]
ENST00000371102; ENSP00000360143; ENSG00000087460 [Q5JWF2-2]
GeneIDi2778
UCSCiuc002xzw.4 human [Q5JWF2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109840 Genomic DNA No translation available.
AL121917 Genomic DNA No translation available.
AL132655 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75462.1
CH471077 Genomic DNA Translation: EAW75469.1
AJ251760 Genomic DNA Translation: CAB83215.1 Frameshift.
AJ224867 mRNA Translation: CAA12164.1
AJ224868 Genomic DNA Translation: CAA12165.1
AY898804 Genomic DNA Translation: AAX51890.1
CCDSiCCDS46622.1 [Q5JWF2-1]
RefSeqiNP_001296812.1, NM_001309883.1
NP_536350.2, NM_080425.3 [Q5JWF2-1]
XP_016883302.1, XM_017027813.1 [Q5JWF2-2]
UniGeneiHs.125898

3D structure databases

ProteinModelPortaliQ5JWF2
SMRiQ5JWF2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109040, 95 interactors
IntActiQ5JWF2, 10 interactors
MINTiQ5JWF2
STRINGi9606.ENSP00000360141

PTM databases

iPTMnetiQ5JWF2
SwissPalmiQ5JWF2

Polymorphism and mutation databases

DMDMi116248089

Proteomic databases

EPDiQ5JWF2
MaxQBiQ5JWF2
PaxDbiQ5JWF2
PeptideAtlasiQ5JWF2
PRIDEiQ5JWF2
ProteomicsDBi63384
63385 [Q5JWF2-2]
63386 [Q5JWF2-3]

Protocols and materials databases

DNASUi2778
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371100; ENSP00000360141; ENSG00000087460 [Q5JWF2-1]
ENST00000371102; ENSP00000360143; ENSG00000087460 [Q5JWF2-2]
GeneIDi2778
UCSCiuc002xzw.4 human [Q5JWF2-1]

Organism-specific databases

CTDi2778
DisGeNETi2778
EuPathDBiHostDB:ENSG00000087460.23
GeneCardsiGNAS
HGNCiHGNC:4392 GNAS
HPAiCAB010337
HPA027478
HPA028386
MalaCardsiGNAS
MIMi139320 gene+phenotype
219080 phenotype
603233 phenotype
612462 phenotype
neXtProtiNX_Q5JWF2
OpenTargetsiENSG00000087460
PharmGKBiPA175
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0099 Eukaryota
ENOG410XPC4 LUCA
GeneTreeiENSGT00910000144108
HOVERGENiHBG079975
InParanoidiQ5JWF2
OrthoDBiEOG091G0CAY
PhylomeDBiQ5JWF2
TreeFamiTF300673

Enzyme and pathway databases

ReactomeiR-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-164378 PKA activation in glucagon signalling
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5610787 Hedgehog 'off' state
SIGNORiQ5JWF2

Miscellaneous databases

ChiTaRSiGNAS human
GenomeRNAii2778
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087460 Expressed in 252 organ(s), highest expression level in telencephalon
CleanExiHS_GNAS
ExpressionAtlasiQ5JWF2 baseline and differential
GenevisibleiQ5JWF2 HS

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000367 Gprotein_alpha_S
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00443 GPROTEINAS
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGNAS1_HUMAN
AccessioniPrimary (citable) accession number: Q5JWF2
Secondary accession number(s): A2A2S3
, E1P5G3, O75684, O75685, Q5JW67, Q5JWF1, Q9NY42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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