UniProtKB - Q5JWE9 (Q5JWE9_HUMAN)
Protein
Submitted name:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Gene
GNAS
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G-protein beta/gamma-subunit complex binding Source: InterPro
- GTPase activity Source: InterPro
- GTP binding Source: InterPro
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | TransducerARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortImported |
Gene namesi | Name:GNASImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4392, GNAS |
VEuPathDBi | HostDB:ENSG00000087460.23 |
PTM / Processingi
Proteomic databases
MaxQBi | Q5JWE9 |
PeptideAtlasi | Q5JWE9 |
PRIDEi | Q5JWE9 |
ProteomicsDBi | 63383 |
Expressioni
Gene expression databases
Bgeei | ENSG00000087460, Expressed in type B pancreatic cell and 264 other tissues |
ExpressionAtlasi | Q5JWE9, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156300 |
HOGENOMi | CLU_014184_6_1_1 |
Family and domain databases
Gene3Di | 1.10.400.10, 1 hit |
InterProi | View protein in InterPro IPR000367, Gprotein_alpha_S IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00443, GPROTEINAS |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 41 potential isoforms that are computationally mapped.Show allAlign All
Q5JWE9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVRNCLYGN NMSGQRDIPP EIGEQPEQPP LEAPGAAAPG AGPSPAEEME
60 70 80 90 100
TEPPHNEPIP VENDGEACGP PEVSRPNFQV LNPAFREAGA HGSYSPPPEE
110 120 130 140 150
AMPFEAEQPS LGGFWPTLEQ PGFPSGVHAG LEAFGPALME PGAFSGARPG
160 170 180 190 200
LGGYSPPPEE AMPFEFDQPA QRGCSQLLLQ VPDLAPGGPG AAGVPGAPPE
210 220 230 240 250
EPQALRPAKA GSRGGYSPPP EETMPFELDG EGFGDDSPPP GLSRVIAQVD
260 270 280 290 300
GSSQFAAVAA SSAVRLTPAA NAPPLWVPGA IGSPSQEAVR PPSNFTGSSP
310 320 330 340 350
WMEISGPPFE IGSAPAGVDD TPVNMDSPPI ALDGPPIKVS GAPDKRERAE
360 370 380 390 400
RPPVEEEAAE MEGAADAAEG GKVPSPGYGS PAAGAASADT AARAAPAAPA
410 420 430 440 450
DPDSGATPED PDSGTAPADP DSGAFAADPD SGAAPAAPAD PDSGAAPDAP
460 470 480 490 500
ADPDSGAAPD APADPDAGAA PEAPAAPAAA ETRAAHVAPA APDAGAPTAP
510 520 530 540 550
AASATRAAQV RRAASAAPAS GARRKIHLRP PSPEIQAADP PTPRPTRASA
560 570 580 590 600
WRGKSESSRG RRVYYDEGVA SSDDDSSGDE SDDGTSGCLR WFQHRRNRRR
610 620 630 640 650
RKPQRNLLRN FLVQAFGGCF GRSESPQPKA SRSLKVKKVP LAEKRRQMRK
660 670 680 690 700
EALEKRAQKR AEKKRSKLID KQLQDEKMGY MCTHRLLLLG AGESGKSTIV
710 720 730 740 750
KQMRILHVNG FNGDEKATKV QDIKNNLKEA IETIVAAMSN LVPPVELANP
760 770 780 790 800
ENQFRVDYIL SVMNVPDFDF PPEFYEHAKA LWEDEGVRAC YERSNEYQLI
810
DCAQYFLDKI DV
Computationally mapped potential isoform sequencesi
There are 41 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP63092 | GNAS2_HUMAN | Guanine nucleotide-binding protein ... | GNAS GNAS1, GSP | 394 | Annotation score: | ||
Q5JWF2 | GNAS1_HUMAN | Guanine nucleotide-binding protein ... | GNAS GNAS1 | 1,037 | Annotation score: | ||
P84996 | ALEX_HUMAN | Protein ALEX | GNAS GNAS1 | 626 | Annotation score: | ||
O95467 | GNAS3_HUMAN | Neuroendocrine secretory protein 55 | GNAS GNAS1 | 245 | Annotation score: | ||
B0AZR9 | B0AZR9_HUMAN | GNAS complex locus, isoform CRA_b | GNAS hCG_1788380 | 335 | Annotation score: | ||
A0A0A0MR13 | A0A0A0MR13_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 362 | Annotation score: | ||
S4R3E3 | S4R3E3_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 160 | Annotation score: | ||
S4R3V9 | S4R3V9_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 120 | Annotation score: | ||
A0A590UJ58 | A0A590UJ58_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 351 | Annotation score: | ||
A0A590UJI6 | A0A590UJI6_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 228 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 812 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL109840 Genomic DNA No translation available. AL121917 Genomic DNA No translation available. AL132655 Genomic DNA No translation available. KF456967 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000349036; ENSP00000265621; ENSG00000087460 |
UCSCi | uc061ycb.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL109840 Genomic DNA No translation available. AL121917 Genomic DNA No translation available. AL132655 Genomic DNA No translation available. KF456967 Genomic DNA No translation available. |
3D structure databases
SMRi | Q5JWE9 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q5JWE9 |
PeptideAtlasi | Q5JWE9 |
PRIDEi | Q5JWE9 |
ProteomicsDBi | 63383 |
Protocols and materials databases
Antibodypediai | 4152, 770 antibodies |
Genome annotation databases
Ensembli | ENST00000349036; ENSP00000265621; ENSG00000087460 |
UCSCi | uc061ycb.1, human |
Organism-specific databases
HGNCi | HGNC:4392, GNAS |
OpenTargetsi | ENSG00000087460 |
VEuPathDBi | HostDB:ENSG00000087460.23 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156300 |
HOGENOMi | CLU_014184_6_1_1 |
Miscellaneous databases
ChiTaRSi | GNAS, human |
Gene expression databases
Bgeei | ENSG00000087460, Expressed in type B pancreatic cell and 264 other tissues |
ExpressionAtlasi | Q5JWE9, baseline and differential |
Family and domain databases
Gene3Di | 1.10.400.10, 1 hit |
InterProi | View protein in InterPro IPR000367, Gprotein_alpha_S IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00443, GPROTEINAS |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5JWE9_HUMAN | |
Accessioni | Q5JWE9Primary (citable) accession number: Q5JWE9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 15, 2005 |
Last sequence update: | April 7, 2021 | |
Last modified: | April 7, 2021 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |