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Protein

Calcium homeostasis modulator protein 4

Gene

CALHM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Pore-forming subunit of a voltage-gated ion channel.By similarity

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.84.1.5 the calcium homeostasis modulator ca(2+) channel (calhm-c) family

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium homeostasis modulator protein 4
Alternative name(s):
Protein FAM26D
Gene namesi
Name:CALHM4Imported
Synonyms:C6orf78, FAM26D
ORF Names:UNQ6481/PRO21277
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164451.13
HGNCiHGNC:21094 CALHM4
neXtProtiNX_Q5JW98

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164451
PharmGKBiPA162387625

Polymorphism and mutation databases

BioMutaiFAM26D
DMDMi67460441

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001867241 – 314Calcium homeostasis modulator protein 4Add BLAST314

Proteomic databases

PaxDbiQ5JW98
PeptideAtlasiQ5JW98
PRIDEiQ5JW98
ProteomicsDBi63378
63379 [Q5JW98-2]
63380 [Q5JW98-3]

PTM databases

PhosphoSitePlusiQ5JW98

Expressioni

Gene expression databases

BgeeiENSG00000164451 Expressed in 31 organ(s), highest expression level in placenta
CleanExiHS_FAM26D
ExpressionAtlasiQ5JW98 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi128707, 20 interactors
STRINGi9606.ENSP00000357586

Structurei

3D structure databases

ProteinModelPortaliQ5JW98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CALHM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCWY Eukaryota
ENOG4110NTE LUCA
GeneTreeiENSGT00530000062796
HOGENOMiHOG000070099
HOVERGENiHBG099442
InParanoidiQ5JW98
OMAiFASVDHY
OrthoDBiEOG091G0BN1
PhylomeDBiQ5JW98

Family and domain databases

InterProiView protein in InterPro
IPR029569 CALHM
IPR029574 CALHM4
PANTHERiPTHR32261 PTHR32261, 1 hit
PTHR32261:SF5 PTHR32261:SF5, 1 hit
PfamiView protein in Pfam
PF14798 Ca_hom_mod, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JW98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCPTLNNIVS SLQRNGIFIN SLIAALTIGG QQLFSSSTFS CPCQVGKNFY
60 70 80 90 100
YGSAFLVIPA LILLVAGFAL RSQMWTITGE YCCSCAPPYR RISPLECKLA
110 120 130 140 150
CLRFFSITGR AVIAPLTWLA VTLLTGTYYE CAASEFASVD HYPMFDNVSA
160 170 180 190 200
SKREEILAGF PCCRSAPSDV ILVRDEIALL HRYQSQMLGW ILITLATIAA
210 220 230 240 250
LVSCCVAKCC SPLTSLQHCY WTSHLQNERE LFEQAAEQHS RLLMMHRIKK
260 270 280 290 300
LFGFIPGSED VKHIRIPSCQ DWKDISVPTL LCMGDDLQGH YSFLGNRVDE
310
DNEEDRSRGI ELKP
Length:314
Mass (Da):35,060
Last modified:February 15, 2005 - v1
Checksum:i2CF5DB1741A2E64E
GO
Isoform 2 (identifier: Q5JW98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.

Show »
Length:128
Mass (Da):14,630
Checksum:iA311918A8255050E
GO
Isoform 3 (identifier: Q5JW98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Show »
Length:171
Mass (Da):19,478
Checksum:i9EB1F62C7AF6ACA9
GO
Isoform 4 (identifier: Q5JW98-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: MCPTLNNIVS...EILAGFPCCR → MAPRSAKETFRINPNVAANL

Show »
Length:170
Mass (Da):19,305
Checksum:i78873AC1E830269E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QZ26B0QZ26_HUMAN
Calcium homeostasis modulator prote...
CALHM4
123Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0138171 – 186Missing in isoform 2. 2 PublicationsAdd BLAST186
Alternative sequenceiVSP_0452161 – 164MCPTL…FPCCR → MAPRSAKETFRINPNVAANL in isoform 4. 1 PublicationAdd BLAST164
Alternative sequenceiVSP_0182521 – 143Missing in isoform 3. 1 PublicationAdd BLAST143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358252 mRNA Translation: AAQ88619.1
AK056801 mRNA Translation: BAB71288.1
AK300309 mRNA Translation: BAG62062.1
AL121953 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48223.1
CH471051 Genomic DNA Translation: EAW48224.1
BC057769 mRNA Translation: AAH57769.2
CCDSiCCDS5109.1 [Q5JW98-2]
CCDS59031.1 [Q5JW98-4]
CCDS59032.1 [Q5JW98-3]
RefSeqiNP_001243816.1, NM_001256887.2 [Q5JW98-3]
NP_001243817.1, NM_001256888.2 [Q5JW98-4]
NP_001243818.1, NM_001256889.2 [Q5JW98-2]
NP_694581.1, NM_153036.4 [Q5JW98-2]
XP_005266917.1, XM_005266860.3 [Q5JW98-1]
UniGeneiHs.350750

Genome annotation databases

EnsembliENST00000368596; ENSP00000357585; ENSG00000164451 [Q5JW98-1]
ENST00000368597; ENSP00000357586; ENSG00000164451 [Q5JW98-2]
ENST00000405399; ENSP00000385836; ENSG00000164451 [Q5JW98-3]
ENST00000628083; ENSP00000487169; ENSG00000164451 [Q5JW98-4]
GeneIDi221301
KEGGihsa:221301
UCSCiuc003pwz.5 human [Q5JW98-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358252 mRNA Translation: AAQ88619.1
AK056801 mRNA Translation: BAB71288.1
AK300309 mRNA Translation: BAG62062.1
AL121953 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48223.1
CH471051 Genomic DNA Translation: EAW48224.1
BC057769 mRNA Translation: AAH57769.2
CCDSiCCDS5109.1 [Q5JW98-2]
CCDS59031.1 [Q5JW98-4]
CCDS59032.1 [Q5JW98-3]
RefSeqiNP_001243816.1, NM_001256887.2 [Q5JW98-3]
NP_001243817.1, NM_001256888.2 [Q5JW98-4]
NP_001243818.1, NM_001256889.2 [Q5JW98-2]
NP_694581.1, NM_153036.4 [Q5JW98-2]
XP_005266917.1, XM_005266860.3 [Q5JW98-1]
UniGeneiHs.350750

3D structure databases

ProteinModelPortaliQ5JW98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128707, 20 interactors
STRINGi9606.ENSP00000357586

Protein family/group databases

TCDBi1.A.84.1.5 the calcium homeostasis modulator ca(2+) channel (calhm-c) family

PTM databases

PhosphoSitePlusiQ5JW98

Polymorphism and mutation databases

BioMutaiFAM26D
DMDMi67460441

Proteomic databases

PaxDbiQ5JW98
PeptideAtlasiQ5JW98
PRIDEiQ5JW98
ProteomicsDBi63378
63379 [Q5JW98-2]
63380 [Q5JW98-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368596; ENSP00000357585; ENSG00000164451 [Q5JW98-1]
ENST00000368597; ENSP00000357586; ENSG00000164451 [Q5JW98-2]
ENST00000405399; ENSP00000385836; ENSG00000164451 [Q5JW98-3]
ENST00000628083; ENSP00000487169; ENSG00000164451 [Q5JW98-4]
GeneIDi221301
KEGGihsa:221301
UCSCiuc003pwz.5 human [Q5JW98-1]

Organism-specific databases

CTDi221301
EuPathDBiHostDB:ENSG00000164451.13
GeneCardsiCALHM4
H-InvDBiHIX0200851
HGNCiHGNC:21094 CALHM4
neXtProtiNX_Q5JW98
OpenTargetsiENSG00000164451
PharmGKBiPA162387625
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCWY Eukaryota
ENOG4110NTE LUCA
GeneTreeiENSGT00530000062796
HOGENOMiHOG000070099
HOVERGENiHBG099442
InParanoidiQ5JW98
OMAiFASVDHY
OrthoDBiEOG091G0BN1
PhylomeDBiQ5JW98

Miscellaneous databases

GenomeRNAii221301
PROiPR:Q5JW98

Gene expression databases

BgeeiENSG00000164451 Expressed in 31 organ(s), highest expression level in placenta
CleanExiHS_FAM26D
ExpressionAtlasiQ5JW98 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR029569 CALHM
IPR029574 CALHM4
PANTHERiPTHR32261 PTHR32261, 1 hit
PTHR32261:SF5 PTHR32261:SF5, 1 hit
PfamiView protein in Pfam
PF14798 Ca_hom_mod, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAHM4_HUMAN
AccessioniPrimary (citable) accession number: Q5JW98
Secondary accession number(s): B0QZ25
, B0QZ27, B4DTQ0, Q96MK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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