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Protein
Submitted name:

Engulfment and cell motility protein 2

Gene

ELMO2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Engulfment and cell motility protein 2Imported
Gene namesi
Name:ELMO2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000062598.17
HGNCiHGNC:17233 ELMO2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000062598

PTM / Processingi

Proteomic databases

MaxQBiQ5JVZ4
PeptideAtlasiQ5JVZ4
PRIDEiQ5JVZ4

Expressioni

Gene expression databases

BgeeiENSG00000062598 Expressed in 219 organ(s), highest expression level in cerebellar hemisphere
ExpressionAtlasiQ5JVZ4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5JVZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 272DUF3361InterPro annotationAdd BLAST158

Phylogenomic databases

eggNOGiKOG2999 Eukaryota
ENOG410XPKN LUCA
GeneTreeiENSGT00390000014155
HOGENOMiHOG000230985
HOVERGENiHBG051463

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024574 DUF3361
IPR030713 ELMO2
PANTHERiPTHR12771:SF8 PTHR12771:SF8, 1 hit
PfamiView protein in Pfam
PF11841 DUF3361, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q5JVZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPPSDIVKV AIEWPGANAQ LLEIDQKRPL ASIIKEVCDG WSLPNPEYYT
60 70 80 90 100
LRYADGPQLY ITEQTRSDIK NGTILQLAIS PSRAARQLME RTQSSNMETR
110 120 130 140 150
LDAMKELAKL SADVTFATEF INMDGIIVLT RLVESGTKLL SHYSEMLAFT
160 170 180 190 200
LTAFLELMDH GIVSWDMVSI TFIKQIAGYV SQPMVDVSIL QRSLAILESM
210 220 230 240 250
VLNSQSLYQK IAEEITVGQL ISHLQVSNQE IQTYAIALIN ALFLKAPEDK
260 270 280 290 300
RQDMANAFAQ KHLRSIILNH VIRGNRPIKT EMAHQLYVLQ VLTFNLLEER
310 320 330
MMTKMDPNDQ AQRDIIFELR RIAFDAESDP SNAPGSGT
Length:338
Mass (Da):38,070
Last modified:February 15, 2005 - v1
Checksum:i0F8739B06409FA72
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96JJ3ELMO2_HUMAN
Engulfment and cell motility protei...
ELMO2 CED12A, KIAA1834
720Annotation score:
Q5JVZ5Q5JVZ5_HUMAN
Engulfment and cell motility protei...
ELMO2 hCG_1811050
718Annotation score:
H0YCM7H0YCM7_HUMAN
Engulfment and cell motility protei...
ELMO2
441Annotation score:
Q5JW01Q5JW01_HUMAN
Engulfment and cell motility protei...
ELMO2
283Annotation score:
Q5JVZ8Q5JVZ8_HUMAN
Engulfment and cell motility protei...
ELMO2
267Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei338Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031686 Genomic DNA No translation available.
AL133227 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000450812; ENSP00000416181; ENSG00000062598
UCSCiuc061xmn.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031686 Genomic DNA No translation available.
AL133227 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliQ5JVZ4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ5JVZ4
PeptideAtlasiQ5JVZ4
PRIDEiQ5JVZ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000450812; ENSP00000416181; ENSG00000062598
UCSCiuc061xmn.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000062598.17
HGNCiHGNC:17233 ELMO2
OpenTargetsiENSG00000062598
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2999 Eukaryota
ENOG410XPKN LUCA
GeneTreeiENSGT00390000014155
HOGENOMiHOG000230985
HOVERGENiHBG051463

Miscellaneous databases

ChiTaRSiELMO2 human

Gene expression databases

BgeeiENSG00000062598 Expressed in 219 organ(s), highest expression level in cerebellar hemisphere
ExpressionAtlasiQ5JVZ4 baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR024574 DUF3361
IPR030713 ELMO2
PANTHERiPTHR12771:SF8 PTHR12771:SF8, 1 hit
PfamiView protein in Pfam
PF11841 DUF3361, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5JVZ4_HUMAN
AccessioniPrimary (citable) accession number: Q5JVZ4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 12, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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