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Protein

Intracellular hyaluronan-binding protein 4

Gene

HABP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594). Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation (PubMed:19523114). Binds (via C-terminus) to poly(U) RNA (PubMed:19523114). Involved in mRNA translation regulation, probably at the initiation step (PubMed:21771594).By similarity4 Publications

Miscellaneous

Able to bind hyaluronan. However, its intracellular localization suggests that this interaction may not be relevant in vivo.Curated
The interaction with RACK1 is abolished upon activation of L540 tumor cells with PMA, which results in phosphorylation and exit of HABP4 from the nucleus.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
SIGNORiQ5JVS0

Names & Taxonomyi

Protein namesi
Recommended name:
Intracellular hyaluronan-binding protein 41 Publication
Short name:
IHABP-41 Publication
Short name:
IHABP41 Publication
Alternative name(s):
Hyaluronan-binding protein 4Imported
Ki-1/57 intracellular antigen1 Publication
Gene namesi
Name:HABP4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000130956.13
HGNCiHGNC:17062 HABP4
MIMi617369 gene
neXtProtiNX_Q5JVS0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22927
OpenTargetsiENSG00000130956
PharmGKBiPA38434

Chemistry databases

DrugBankiDB08818 Hyaluronic acid

Polymorphism and mutation databases

BioMutaiHABP4
DMDMi74742472

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002579721 – 413Intracellular hyaluronan-binding protein 4Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei70Omega-N-methylarginineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei354Phosphothreonine; by PKC1 Publication1
Modified residuei375Phosphothreonine; by PKC1 Publication1

Post-translational modificationi

Methylated (PubMed:16879614). Methylation is decreased by phorbol 12-myristate 13-acetate (PMA)-activated PKC, in vitro (PubMed:16879614).1 Publication
Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ5JVS0
MaxQBiQ5JVS0
PaxDbiQ5JVS0
PeptideAtlasiQ5JVS0
PRIDEiQ5JVS0
ProteomicsDBi63346
63347 [Q5JVS0-2]

PTM databases

iPTMnetiQ5JVS0
PhosphoSitePlusiQ5JVS0

Expressioni

Tissue specificityi

Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes.2 Publications

Gene expression databases

BgeeiENSG00000130956 Expressed in 229 organ(s), highest expression level in endothelial cell
CleanExiHS_HABP4
GenevisibleiQ5JVS0 HS

Organism-specific databases

HPAiHPA055969

Interactioni

Subunit structurei

Associates with polysomes (PubMed:21771594). Interacts with FMR1 (PubMed:21771594). Interacts with FXR1 and FXR2 (PubMed:21771594). Interacts with CHD3 (via C-terminus) (PubMed:12505151). Interacts (via C-terminus) with RACK1 (PubMed:14699138). Interacts with p53/TP53 (PubMed:16455055). Interacts (via N-terminus) with SRSF9; this interaction is direct (PubMed:19523114). Interacts with SYNCRIP; this interaction is direct (PubMed:19523114). Interacts with MEF2C (via N-terminus); this interaction decreases DNA-binding activity of MEF2C in myocardial cells in response to mechanical stress (PubMed:15862299). Interacts with PRMT1 (via N-terminus) (PubMed:16879614). Interacts with SPIN1 (By similarity).By similarity1 Publication7 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi116587, 23 interactors
IntActiQ5JVS0, 19 interactors
MINTiQ5JVS0
STRINGi9606.ENSP00000364398

Structurei

3D structure databases

ProteinModelPortaliQ5JVS0
SMRiQ5JVS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 64Sequence analysisAdd BLAST25

Domaini

The C-terminal region is necessary for nucleus and cytoplasmic localization (PubMed:19523114). The N-terminal region is necessary for nucleus and nuclear bodies localization (PubMed:19523114). Regions containing Arg-Gly-Gly repeats (RGG/RXR-box) may be preferentially methylated by PRMT1 (PubMed:16879614).2 Publications

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2945 Eukaryota
ENOG410YBHR LUCA
GeneTreeiENSGT00520000055591
HOGENOMiHOG000220826
HOVERGENiHBG056357
InParanoidiQ5JVS0
KOiK19019
OMAiRTEDNMG
OrthoDBiEOG091G0UA9
PhylomeDBiQ5JVS0
TreeFamiTF318374

Family and domain databases

InterProiView protein in InterPro
IPR039764 HABP4/SERBP1
IPR006861 HABP4_PAIRBP1-bd
IPR032381 IHABP4_N
PANTHERiPTHR12299 PTHR12299, 1 hit
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF16174 IHABP4_N, 1 hit
SMARTiView protein in SMART
SM01233 HABP4_PAI-RBP1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 12 Publications (identifier: Q5JVS0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGALGSPVA AAGAAMQESF GCVVANRFHQ LLDDESDPFD ILREAERRRQ
60 70 80 90 100
QQLQRKRRDE AAAAAGAGPR GGRSPAGASG HRAGAGGRRE SQKERKSLPA
110 120 130 140 150
PVAQRPDSPG GGLQAPGQKR TPRRGEQQGW NDSRGPEGML ERAERRSYRE
160 170 180 190 200
YRPYETERQA DFTAEKFPDE KPGDRFDRDR PLRGRGGPRG GMRGRGRGGP
210 220 230 240 250
GNRVFDAFDQ RGKREFERYG GNDKIAVRTE DNMGGCGVRT WGSGKDTSDV
260 270 280 290 300
EPTAPMEEPT VVEESQGTPE EESPAKVPEL EVEEETQVQE MTLDEWKNLQ
310 320 330 340 350
EQTRPKPEFN IRKPESTVPS KAVVIHKSKY RDDMVKDDYE DDSHVFRKPA
360 370 380 390 400
NDITSQLEIN FGNLPRPGRG ARGGTRGGRG RIRRAENYGP RAEVVMQDVA
410
PNPDDPEDFP ALS
Length:413
Mass (Da):45,785
Last modified:February 15, 2005 - v1
Checksum:i98749EEC5CB92155
GO
Isoform 21 Publication (identifier: Q5JVS0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-276: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:308
Mass (Da):34,365
Checksum:iCFA9C86A34BF5514
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104Q → H in AAF62546 (PubMed:10887182).Curated1
Sequence conflicti115A → S in AAC31117 (PubMed:9523163).Curated1
Sequence conflicti388 – 389YG → NY in AAF62546 (PubMed:10887182).Curated2
Sequence conflicti388 – 389YG → NY in AAC31117 (PubMed:9523163).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052194172 – 276Missing in isoform 2. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241831 mRNA Translation: AAF62546.1
AL133477 Genomic DNA No translation available.
BC018788 mRNA Translation: AAH18788.1
U77327 mRNA Translation: AAC31117.1
CCDSiCCDS6719.1 [Q5JVS0-1]
RefSeqiNP_055097.2, NM_014282.3 [Q5JVS0-1]
UniGeneiHs.494567

Genome annotation databases

EnsembliENST00000375249; ENSP00000364398; ENSG00000130956 [Q5JVS0-1]
ENST00000375251; ENSP00000364400; ENSG00000130956 [Q5JVS0-2]
GeneIDi22927
KEGGihsa:22927
UCSCiuc010msg.5 human [Q5JVS0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF241831 mRNA Translation: AAF62546.1
AL133477 Genomic DNA No translation available.
BC018788 mRNA Translation: AAH18788.1
U77327 mRNA Translation: AAC31117.1
CCDSiCCDS6719.1 [Q5JVS0-1]
RefSeqiNP_055097.2, NM_014282.3 [Q5JVS0-1]
UniGeneiHs.494567

3D structure databases

ProteinModelPortaliQ5JVS0
SMRiQ5JVS0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116587, 23 interactors
IntActiQ5JVS0, 19 interactors
MINTiQ5JVS0
STRINGi9606.ENSP00000364398

Chemistry databases

DrugBankiDB08818 Hyaluronic acid

PTM databases

iPTMnetiQ5JVS0
PhosphoSitePlusiQ5JVS0

Polymorphism and mutation databases

BioMutaiHABP4
DMDMi74742472

Proteomic databases

EPDiQ5JVS0
MaxQBiQ5JVS0
PaxDbiQ5JVS0
PeptideAtlasiQ5JVS0
PRIDEiQ5JVS0
ProteomicsDBi63346
63347 [Q5JVS0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375249; ENSP00000364398; ENSG00000130956 [Q5JVS0-1]
ENST00000375251; ENSP00000364400; ENSG00000130956 [Q5JVS0-2]
GeneIDi22927
KEGGihsa:22927
UCSCiuc010msg.5 human [Q5JVS0-1]

Organism-specific databases

CTDi22927
DisGeNETi22927
EuPathDBiHostDB:ENSG00000130956.13
GeneCardsiHABP4
HGNCiHGNC:17062 HABP4
HPAiHPA055969
MIMi617369 gene
neXtProtiNX_Q5JVS0
OpenTargetsiENSG00000130956
PharmGKBiPA38434
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2945 Eukaryota
ENOG410YBHR LUCA
GeneTreeiENSGT00520000055591
HOGENOMiHOG000220826
HOVERGENiHBG056357
InParanoidiQ5JVS0
KOiK19019
OMAiRTEDNMG
OrthoDBiEOG091G0UA9
PhylomeDBiQ5JVS0
TreeFamiTF318374

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
SIGNORiQ5JVS0

Miscellaneous databases

ChiTaRSiHABP4 human
GeneWikiiHABP4
GenomeRNAii22927
PROiPR:Q5JVS0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130956 Expressed in 229 organ(s), highest expression level in endothelial cell
CleanExiHS_HABP4
GenevisibleiQ5JVS0 HS

Family and domain databases

InterProiView protein in InterPro
IPR039764 HABP4/SERBP1
IPR006861 HABP4_PAIRBP1-bd
IPR032381 IHABP4_N
PANTHERiPTHR12299 PTHR12299, 1 hit
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF16174 IHABP4_N, 1 hit
SMARTiView protein in SMART
SM01233 HABP4_PAI-RBP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHABP4_HUMAN
AccessioniPrimary (citable) accession number: Q5JVS0
Secondary accession number(s): O75804, Q8WV33, Q9NYJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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