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UniProtKB - Q5JVG2 (ZN484_HUMAN)
Protein
Zinc finger protein 484
Gene
ZNF484
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 223 – 245 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 328 – 350 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 468 – 490 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 496 – 518 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 524 – 546 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 552 – 574 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 580 – 602 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 608 – 630 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 636 – 658 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 664 – 686 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 692 – 714 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 720 – 742 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 748 – 770 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 776 – 798 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q5JVG2 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q5JVG2 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 484 |
Gene namesi | Name:ZNF484 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23385, ZNF484 |
neXtProti | NX_Q5JVG2 |
VEuPathDBi | HostDB:ENSG00000127081 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 83744 |
OpenTargetsi | ENSG00000127081 |
PharmGKBi | PA134992184 |
Miscellaneous databases
Pharosi | Q5JVG2, Tbio |
Genetic variation databases
BioMutai | ZNF484 |
DMDMi | 74762200 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233986 | 1 – 852 | Zinc finger protein 484Add BLAST | 852 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 156 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 816 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | Q5JVG2 |
MassIVEi | Q5JVG2 |
MaxQBi | Q5JVG2 |
PaxDbi | Q5JVG2 |
PeptideAtlasi | Q5JVG2 |
PRIDEi | Q5JVG2 |
ProteomicsDBi | 4953 63331 [Q5JVG2-1] 63332 [Q5JVG2-2] |
PTM databases
iPTMneti | Q5JVG2 |
PhosphoSitePlusi | Q5JVG2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127081, Expressed in corpus callosum and 120 other tissues |
Organism-specific databases
HPAi | ENSG00000127081, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123752, 12 interactors |
IntActi | Q5JVG2, 4 interactors |
Miscellaneous databases
RNActi | Q5JVG2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q5JVG2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q5JVG2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 78 | KRABPROSITE-ProRule annotationAdd BLAST | 71 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 223 – 245 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 328 – 350 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 356 – 378 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 468 – 490 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 496 – 518 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 524 – 546 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 552 – 574 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 580 – 602 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 608 – 630 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 636 – 658 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 664 – 686 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 692 – 714 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 720 – 742 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 748 – 770 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 776 – 798 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163284 |
HOGENOMi | CLU_002678_35_1_1 |
InParanoidi | Q5JVG2 |
OMAi | CGKNVSQ |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5JVG2 |
TreeFami | TF350810 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 17 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 11 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 18 hits |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5JVG2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTKSLESVSF KDVTVDFSRD EWQQLDLAQK SLYREVMLEN YFNLISVGCQ
60 70 80 90 100
VPKPEVIFSL EQEEPCMLDG EIPSQSRPDG DIGFGPLQQR MSEEVSFQSE
110 120 130 140 150
ININLFTRDD PYSILEELWK DDEHTRKCGE NQNKPLSRVV FINKKTLAND
160 170 180 190 200
SIFEYKDIGE IVHVNTHLVS SRKRPHNCNS CGKNLEPIIT LYNRNNATEN
210 220 230 240 250
SDKTIGDGDI FTHLNSHTEV TACECNQCGK PLHHKQALIQ QQKIHTRESL
260 270 280 290 300
YLFSDYVNVF SPKSHAFAHE SICAEEKQHE CHECEAVFTQ KSQLDGSQRV
310 320 330 340 350
YAGICTEYEK DFSLKSNRQK TPYEGNYYKC SDYGRAFIQK SDLFRCQRIH
360 370 380 390 400
SGEKPYEYSE CEKNLPQNSN LNIHKKIHTG GKHFECTECG KAFTRKSTLS
410 420 430 440 450
MHQKIHTGEK PYVCTECGKA FIRKSHFITH ERIHTGEKPY ECSDCGKSFI
460 470 480 490 500
KKSQLHVHQR IHTGENPFIC SECGKVFTHK TNLIIHQKIH TGERPYICTV
510 520 530 540 550
CGKAFTDRSN LIKHQKIHTG EKPYKCSDCG KSFTWKSRLR IHQKCHTGER
560 570 580 590 600
HYECSECGKA FIQKSTLSMH QRIHRGEKPY VCTECGKAFF HKSHFITHER
610 620 630 640 650
IHTGEKPYEC SICGKSFTKK SQLHVHQQIH TGEKPYRCAE CGKAFTDRSN
660 670 680 690 700
LFTHQKIHTG EKPYKCSDCG KAFTRKSGLH IHQQSHTGER HYECSECGKA
710 720 730 740 750
FARKSTLIMH QRIHTGEKPY ICNECGKSFI QKSHLNRHRR IHTGEKPYEC
760 770 780 790 800
SDCGKSFIKK SQLHEHHRIH TGEKPYICAE CGKAFTIRSN LIKHQKIHTK
810 820 830 840 850
QKPYKCSDLG KALNWKPQLS MPQKSDNGEV ECSMPQLWCG DSEGDQGQLS
SI
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033570 | 502 | G → D. Corresponds to variant dbSNP:rs3739602Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043079 | 1 – 36 | Missing in isoform 2. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_044922 | 1 – 5 | MTKSL → MSVLSLP in isoform 3. 1 Publication | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091203 mRNA Translation: BAG52305.1 AK299274 mRNA Translation: BAG61294.1 AL136981 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62837.1 BC112394 mRNA Translation: AAI12395.1 BC112396 mRNA Translation: AAI12397.1 |
CCDSi | CCDS35066.1 [Q5JVG2-1] CCDS35067.1 [Q5JVG2-2] CCDS59136.1 [Q5JVG2-3] |
RefSeqi | NP_001007102.1, NM_001007101.2 [Q5JVG2-2] NP_001248387.1, NM_001261458.1 [Q5JVG2-3] NP_001248388.1, NM_001261459.1 [Q5JVG2-2] NP_001248389.1, NM_001261460.1 [Q5JVG2-2] NP_113674.1, NM_031486.2 [Q5JVG2-1] XP_016870670.1, XM_017015181.1 [Q5JVG2-2] |
Genome annotation databases
Ensembli | ENST00000332591; ENSP00000364646; ENSG00000127081 [Q5JVG2-2] ENST00000375495; ENSP00000364645; ENSG00000127081 ENST00000395505; ENSP00000378881; ENSG00000127081 [Q5JVG2-3] ENST00000395506; ENSP00000378882; ENSG00000127081 [Q5JVG2-2] |
GeneIDi | 83744 |
KEGGi | hsa:83744 |
MANE-Selecti | ENST00000375495.8; ENSP00000364645.3; NM_031486.4; NP_113674.1 |
UCSCi | uc004asu.3, human [Q5JVG2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091203 mRNA Translation: BAG52305.1 AK299274 mRNA Translation: BAG61294.1 AL136981 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62837.1 BC112394 mRNA Translation: AAI12395.1 BC112396 mRNA Translation: AAI12397.1 |
CCDSi | CCDS35066.1 [Q5JVG2-1] CCDS35067.1 [Q5JVG2-2] CCDS59136.1 [Q5JVG2-3] |
RefSeqi | NP_001007102.1, NM_001007101.2 [Q5JVG2-2] NP_001248387.1, NM_001261458.1 [Q5JVG2-3] NP_001248388.1, NM_001261459.1 [Q5JVG2-2] NP_001248389.1, NM_001261460.1 [Q5JVG2-2] NP_113674.1, NM_031486.2 [Q5JVG2-1] XP_016870670.1, XM_017015181.1 [Q5JVG2-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EMF | NMR | - | A | 379-411 | [»] | |
2EMG | NMR | - | A | 463-495 | [»] | |
2EMH | NMR | - | A | 491-523 | [»] | |
2EMI | NMR | - | A | 547-579 | [»] | |
2EOV | NMR | - | A | 519-551 | [»] | |
2EP1 | NMR | - | A | 435-467 | [»] | |
2EP2 | NMR | - | A | 603-635 | [»] | |
2EP3 | NMR | - | A | 631-663 | [»] | |
2EQW | NMR | - | A | 409-437 | [»] | |
2YTJ | NMR | - | A | 771-803 | [»] | |
2YTO | NMR | - | A | 659-691 | [»] | |
2YTP | NMR | - | A | 687-719 | [»] | |
2YTS | NMR | - | A | 715-747 | [»] | |
SMRi | Q5JVG2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123752, 12 interactors |
IntActi | Q5JVG2, 4 interactors |
PTM databases
iPTMneti | Q5JVG2 |
PhosphoSitePlusi | Q5JVG2 |
Genetic variation databases
BioMutai | ZNF484 |
DMDMi | 74762200 |
Proteomic databases
jPOSTi | Q5JVG2 |
MassIVEi | Q5JVG2 |
MaxQBi | Q5JVG2 |
PaxDbi | Q5JVG2 |
PeptideAtlasi | Q5JVG2 |
PRIDEi | Q5JVG2 |
ProteomicsDBi | 4953 63331 [Q5JVG2-1] 63332 [Q5JVG2-2] |
Protocols and materials databases
Antibodypediai | 28320, 100 antibodies from 16 providers |
DNASUi | 83744 |
Genome annotation databases
Ensembli | ENST00000332591; ENSP00000364646; ENSG00000127081 [Q5JVG2-2] ENST00000375495; ENSP00000364645; ENSG00000127081 ENST00000395505; ENSP00000378881; ENSG00000127081 [Q5JVG2-3] ENST00000395506; ENSP00000378882; ENSG00000127081 [Q5JVG2-2] |
GeneIDi | 83744 |
KEGGi | hsa:83744 |
MANE-Selecti | ENST00000375495.8; ENSP00000364645.3; NM_031486.4; NP_113674.1 |
UCSCi | uc004asu.3, human [Q5JVG2-1] |
Organism-specific databases
CTDi | 83744 |
DisGeNETi | 83744 |
GeneCardsi | ZNF484 |
HGNCi | HGNC:23385, ZNF484 |
HPAi | ENSG00000127081, Low tissue specificity |
neXtProti | NX_Q5JVG2 |
OpenTargetsi | ENSG00000127081 |
PharmGKBi | PA134992184 |
VEuPathDBi | HostDB:ENSG00000127081 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163284 |
HOGENOMi | CLU_002678_35_1_1 |
InParanoidi | Q5JVG2 |
OMAi | CGKNVSQ |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5JVG2 |
TreeFami | TF350810 |
Enzyme and pathway databases
PathwayCommonsi | Q5JVG2 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q5JVG2 |
Miscellaneous databases
BioGRID-ORCSi | 83744, 16 hits in 1057 CRISPR screens |
ChiTaRSi | ZNF484, human |
EvolutionaryTracei | Q5JVG2 |
GenomeRNAii | 83744 |
Pharosi | Q5JVG2, Tbio |
PROi | PR:Q5JVG2 |
RNActi | Q5JVG2, protein |
Gene expression databases
Bgeei | ENSG00000127081, Expressed in corpus callosum and 120 other tissues |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 17 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 11 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 18 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN484_HUMAN | |
Accessioni | Q5JVG2Primary (citable) accession number: Q5JVG2 Secondary accession number(s): B1AL89, B4DRI2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | February 15, 2005 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families