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UniProtKB - Q5JVG2 (ZN484_HUMAN)

Entry version 145 (11 Dec 2019)
Sequence version 1 (15 Feb 2005)
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Protein

Zinc finger protein 484

Gene

ZNF484

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri223 – 245C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 630C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri664 – 686C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri692 – 714C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri720 – 742C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri776 – 798C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 484
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF484
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000127081.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:23385 ZNF484

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5JVG2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000127081

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134992184

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5JVG2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF484

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762200

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002339861 – 852Zinc finger protein 484Add BLAST852

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki156Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki816Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5JVG2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5JVG2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5JVG2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5JVG2

PeptideAtlas

More...PeptideAtlasi		Q5JVG2

PRoteomics IDEntifications database

More...PRIDEi		Q5JVG2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4953
63331 [Q5JVG2-1]
63332 [Q5JVG2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5JVG2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5JVG2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000127081 Expressed in 95 organ(s), highest expression level in corpus callosum

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA028973

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		123752, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q5JVG2, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000378881

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5JVG2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1852
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5JVG2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q5JVG2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri223 – 245C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri552 – 574C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri580 – 602C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri608 – 630C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri664 – 686C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri692 – 714C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri720 – 742C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri776 – 798C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163284

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5JVG2

KEGG Orthology (KO)

More...KOi		K09228

Identification of Orthologs from Complete Genome Data

More...OMAi		CGKNVSQ

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5JVG2

TreeFam database of animal gene trees

More...TreeFami		TF350810

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5JVG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKSLESVSF KDVTVDFSRD EWQQLDLAQK SLYREVMLEN YFNLISVGCQ 
        60         70         80         90        100
VPKPEVIFSL EQEEPCMLDG EIPSQSRPDG DIGFGPLQQR MSEEVSFQSE 
       110        120        130        140        150
ININLFTRDD PYSILEELWK DDEHTRKCGE NQNKPLSRVV FINKKTLAND 
       160        170        180        190        200
SIFEYKDIGE IVHVNTHLVS SRKRPHNCNS CGKNLEPIIT LYNRNNATEN 
       210        220        230        240        250
SDKTIGDGDI FTHLNSHTEV TACECNQCGK PLHHKQALIQ QQKIHTRESL 
       260        270        280        290        300
YLFSDYVNVF SPKSHAFAHE SICAEEKQHE CHECEAVFTQ KSQLDGSQRV 
       310        320        330        340        350
YAGICTEYEK DFSLKSNRQK TPYEGNYYKC SDYGRAFIQK SDLFRCQRIH 
       360        370        380        390        400
SGEKPYEYSE CEKNLPQNSN LNIHKKIHTG GKHFECTECG KAFTRKSTLS 
       410        420        430        440        450
MHQKIHTGEK PYVCTECGKA FIRKSHFITH ERIHTGEKPY ECSDCGKSFI 
       460        470        480        490        500
KKSQLHVHQR IHTGENPFIC SECGKVFTHK TNLIIHQKIH TGERPYICTV 
       510        520        530        540        550
CGKAFTDRSN LIKHQKIHTG EKPYKCSDCG KSFTWKSRLR IHQKCHTGER 
       560        570        580        590        600
HYECSECGKA FIQKSTLSMH QRIHRGEKPY VCTECGKAFF HKSHFITHER 
       610        620        630        640        650
IHTGEKPYEC SICGKSFTKK SQLHVHQQIH TGEKPYRCAE CGKAFTDRSN 
       660        670        680        690        700
LFTHQKIHTG EKPYKCSDCG KAFTRKSGLH IHQQSHTGER HYECSECGKA 
       710        720        730        740        750
FARKSTLIMH QRIHTGEKPY ICNECGKSFI QKSHLNRHRR IHTGEKPYEC 
       760        770        780        790        800
SDCGKSFIKK SQLHEHHRIH TGEKPYICAE CGKAFTIRSN LIKHQKIHTK 
       810        820        830        840        850
QKPYKCSDLG KALNWKPQLS MPQKSDNGEV ECSMPQLWCG DSEGDQGQLS 

SI
Length:852
Mass (Da):98,221
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98A75F9C12877908
GO
Isoform 2 (identifier: Q5JVG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:816
Mass (Da):93,959
Checksum:iB5383CA9AB13B517
GO
Isoform 3 (identifier: Q5JVG2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MTKSL → MSVLSLP

Show »
Length:854
Mass (Da):98,388
Checksum:iDC702347BB90C166
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033570502G → D. Corresponds to variant dbSNP:rs3739602Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430791 – 36Missing in isoform 2. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0449221 – 5MTKSL → MSVLSLP in isoform 3. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK091203 mRNA Translation: BAG52305.1
AK299274 mRNA Translation: BAG61294.1
AL136981 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62837.1
BC112394 mRNA Translation: AAI12395.1
BC112396 mRNA Translation: AAI12397.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35066.1 [Q5JVG2-1]
CCDS35067.1 [Q5JVG2-2]
CCDS59136.1 [Q5JVG2-3]

NCBI Reference Sequences

More...RefSeqi		NP_001007102.1, NM_001007101.2 [Q5JVG2-2]
NP_001248387.1, NM_001261458.1 [Q5JVG2-3]
NP_001248388.1, NM_001261459.1 [Q5JVG2-2]
NP_001248389.1, NM_001261460.1 [Q5JVG2-2]
NP_113674.1, NM_031486.2 [Q5JVG2-1]
XP_016870670.1, XM_017015181.1 [Q5JVG2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000332591; ENSP00000364646; ENSG00000127081 [Q5JVG2-2]
ENST00000375495; ENSP00000364645; ENSG00000127081 [Q5JVG2-1]
ENST00000395505; ENSP00000378881; ENSG00000127081 [Q5JVG2-3]
ENST00000395506; ENSP00000378882; ENSG00000127081 [Q5JVG2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83744

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83744

UCSC genome browser

More...UCSCi		uc004asu.3 human [Q5JVG2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091203 mRNA Translation: BAG52305.1
AK299274 mRNA Translation: BAG61294.1
AL136981 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62837.1
BC112394 mRNA Translation: AAI12395.1
BC112396 mRNA Translation: AAI12397.1
CCDSiCCDS35066.1 [Q5JVG2-1]
CCDS35067.1 [Q5JVG2-2]
CCDS59136.1 [Q5JVG2-3]
RefSeqiNP_001007102.1, NM_001007101.2 [Q5JVG2-2]
NP_001248387.1, NM_001261458.1 [Q5JVG2-3]
NP_001248388.1, NM_001261459.1 [Q5JVG2-2]
NP_001248389.1, NM_001261460.1 [Q5JVG2-2]
NP_113674.1, NM_031486.2 [Q5JVG2-1]
XP_016870670.1, XM_017015181.1 [Q5JVG2-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EMFNMR-A379-411[»]
2EMGNMR-A463-495[»]
2EMHNMR-A491-523[»]
2EMINMR-A547-579[»]
2EOVNMR-A519-551[»]
2EP1NMR-A435-467[»]
2EP2NMR-A603-635[»]
2EP3NMR-A631-663[»]
2EQWNMR-A409-437[»]
2YTJNMR-A771-803[»]
2YTONMR-A659-691[»]
2YTPNMR-A687-719[»]
2YTSNMR-A715-747[»]
SMRiQ5JVG2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi123752, 2 interactors
IntActiQ5JVG2, 3 interactors
STRINGi9606.ENSP00000378881

PTM databases

iPTMnetiQ5JVG2
PhosphoSitePlusiQ5JVG2

Polymorphism and mutation databases

BioMutaiZNF484
DMDMi74762200

Proteomic databases

jPOSTiQ5JVG2
MassIVEiQ5JVG2
MaxQBiQ5JVG2
PaxDbiQ5JVG2
PeptideAtlasiQ5JVG2
PRIDEiQ5JVG2
ProteomicsDBi4953
63331 [Q5JVG2-1]
63332 [Q5JVG2-2]

Genome annotation databases

EnsembliENST00000332591; ENSP00000364646; ENSG00000127081 [Q5JVG2-2]
ENST00000375495; ENSP00000364645; ENSG00000127081 [Q5JVG2-1]
ENST00000395505; ENSP00000378881; ENSG00000127081 [Q5JVG2-3]
ENST00000395506; ENSP00000378882; ENSG00000127081 [Q5JVG2-2]
GeneIDi83744
KEGGihsa:83744
UCSCiuc004asu.3 human [Q5JVG2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83744
EuPathDBiHostDB:ENSG00000127081.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF484
HGNCiHGNC:23385 ZNF484
HPAiHPA028973
neXtProtiNX_Q5JVG2
OpenTargetsiENSG00000127081
PharmGKBiPA134992184

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163284
HOGENOMiHOG000234617
InParanoidiQ5JVG2
KOiK09228
OMAiCGKNVSQ
OrthoDBi1318335at2759
PhylomeDBiQ5JVG2
TreeFamiTF350810

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF484 human
EvolutionaryTraceiQ5JVG2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83744
PharosiQ5JVG2 Tbio

Protein Ontology

More...PROi		PR:Q5JVG2
RNActiQ5JVG2 protein

Gene expression databases

BgeeiENSG00000127081 Expressed in 95 organ(s), highest expression level in corpus callosum

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN484_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JVG2
Secondary accession number(s): B1AL89, B4DRI2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: February 15, 2005
Last modified: December 11, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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