PCID2

Functionⁱ

Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.By similarity2 Publications

GO - Molecular functionⁱ

double-stranded DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20870947
negative regulation of cysteine-type endopeptidase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20870947
nuclear retention of pre-mRNA at the site of transcription
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
poly(A)+ mRNA export from nucleus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of B cell differentiation Source: Ensembl
positive regulation of mitotic cell cycle spindle assembly checkpoint
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20870947
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20870947
posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of mRNA stability
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20870947
spleen development Source: UniProtKB
transcription elongation from RNA polymerase II promoter
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PCI domain-containing protein 2 Alternative name(s): CSN12-like protein
Gene namesⁱ	Name:PCID2 ORF Names:HT004
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000126226.21
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25653 PCID2
MIMⁱ	613713 gene
neXtProtⁱ	NX_Q5JVF3

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55795
Open Targets More...OpenTargetsⁱ	ENSG00000126226
PharmGKBⁱ	PA144596397

Polymorphism and mutation databases

BioMutaⁱ	PCID2
DMDMⁱ	85681034

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000121029	2 – 399	PCI domain-containing protein 2Add BLAST		398

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanine1 Publication		1
Modified residueⁱ	45	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q5JVF3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5JVF3
PaxDbⁱ	Q5JVF3
PeptideAtlas More...PeptideAtlasⁱ	Q5JVF3
PRIDEⁱ	Q5JVF3
ProteomicsDBⁱ	63327 63328 [Q5JVF3-2] 63329 [Q5JVF3-3] 63330 [Q5JVF3-4]

PTM databases

iPTMnetⁱ	Q5JVF3
PhosphoSitePlusⁱ	Q5JVF3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000126226 Expressed in 218 organ(s), highest expression level in oocyte
CleanExⁱ	HS_PCID2
ExpressionAtlasⁱ	Q5JVF3 baseline and differential
Genevisibleⁱ	Q5JVF3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA069107 HPA073074

HPAⁱ

HPA069107
HPA073074

Interactionⁱ

Subunit structureⁱ

Belongs to the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). Interacts with BRCA2.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IKZF3	Q9UKT9	3	EBI-1051701,EBI-747204
SEM1	P60896	3	EBI-15970419,EBI-79819

Protein-protein interaction databases

BioGridⁱ	120908, 29 interactors
Database of interacting proteins More...DIPⁱ	DIP-50497N
IntActⁱ	Q5JVF3, 20 interactors
STRINGⁱ	9606.ENSP00000337405

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	206 – 222	Combined sources	17
Helixⁱ	226 – 239	Combined sources	14
Helixⁱ	245 – 261	Combined sources	17
Helixⁱ	268 – 273	Combined sources	6
Helixⁱ	277 – 279	Combined sources	3
Helixⁱ	280 – 288	Combined sources	9
Helixⁱ	291 – 300	Combined sources	10
Helixⁱ	302 – 307	Combined sources	6
Helixⁱ	311 – 315	Combined sources	5
Helixⁱ	317 – 333	Combined sources	17
Beta strandⁱ	336 – 339	Combined sources	4
Helixⁱ	340 – 349	Combined sources	10
Helixⁱ	357 – 369	Combined sources	13
Beta strandⁱ	375 – 378	Combined sources	4
Turnⁱ	379 – 382	Combined sources	4
Beta strandⁱ	383 – 386	Combined sources	4
Helixⁱ	395 – 397	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q5JVF3
SMRⁱ	Q5JVF3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	210 – 391	PCIPROSITE-ProRule annotationAdd BLAST		182

Sequence similaritiesⁱ

Belongs to the CSN12 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2688 Eukaryota COG5600 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001101
HOVERGENⁱ	HBG055800
InParanoidⁱ	Q5JVF3
OMAⁱ	SRKWGIY
PhylomeDBⁱ	Q5JVF3
TreeFamⁱ	TF106136

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000717 PCI_dom IPR036388 WH-like_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q5JVF3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHITINQYL QQVYEAIDSR DGASCAELVS FKHPHVANPR LQMASPEEKC 
        60         70         80         90        100
QQVLEPPYDE MFAAHLRCTY AVGNHDFIEA YKCQTVIVQS FLRAFQAHKE 
       110        120        130        140        150
ENWALPVMYA VALDLRVFAN NADQQLVKKG KSKVGDMLEK AAELLMSCFR 
       160        170        180        190        200
VCASDTRAGI EDSKKWGMLF LVNQLFKIYF KINKLHLCKP LIRAIDSSNL 
       210        220        230        240        250
KDDYSTAQRV TYKYYVGRKA MFDSDFKQAE EYLSFAFEHC HRSSQKNKRM 
       260        270        280        290        300
ILIYLLPVKM LLGHMPTVEL LKKYHLMQFA EVTRAVSEGN LLLLHEALAK 
       310        320        330        340        350
HEAFFIRCGI FLILEKLKII TYRNLFKKVY LLLKTHQLSL DAFLVALKFM 
       360        370        380        390 
QVEDVDIDEV QCILANLIYM GHVKGYISHQ HQKLVVSKQN PFPPLSTVC

Length:399

Mass (Da):46,030

Last modified:January 10, 2006 - v2

Checksum:ⁱ8D23273361F00E18

GO

Isoform 2 (identifier: Q5JVF3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-12: MAHITINQYLQQ → MRLTDVVQQL

« Hide

        10         20         30         40         50
MRLTDVVQQL VYEAIDSRDG ASCAELVSFK HPHVANPRLQ MASPEEKCQQ 
        60         70         80         90        100
VLEPPYDEMF AAHLRCTYAV GNHDFIEAYK CQTVIVQSFL RAFQAHKEEN 
       110        120        130        140        150
WALPVMYAVA LDLRVFANNA DQQLVKKGKS KVGDMLEKAA ELLMSCFRVC 
       160        170        180        190        200
ASDTRAGIED SKKWGMLFLV NQLFKIYFKI NKLHLCKPLI RAIDSSNLKD 
       210        220        230        240        250
DYSTAQRVTY KYYVGRKAMF DSDFKQAEEY LSFAFEHCHR SSQKNKRMIL 
       260        270        280        290        300
IYLLPVKMLL GHMPTVELLK KYHLMQFAEV TRAVSEGNLL LLHEALAKHE 
       310        320        330        340        350
AFFIRCGIFL ILEKLKIITY RNLFKKVYLL LKTHQLSLDA FLVALKFMQV 
       360        370        380        390 
EDVDIDEVQC ILANLIYMGH VKGYISHQHQ KLVVSKQNPF PPLSTVC

Note: No experimental confirmation available.

Show »

Length:397

Mass (Da):45,773

Checksum:ⁱ785FD46B5D72AF70

GO

Isoform 3 (identifier: Q5JVF3-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
92-114: Missing.

« Hide

        10         20         30         40         50
MAHITINQYL QQVYEAIDSR DGASCAELVS FKHPHVANPR LQMASPEEKC 
        60         70         80         90        100
QQVLEPPYDE MFAAHLRCTY AVGNHDFIEA YKCQTVIVQS FLRVFANNAD 
       110        120        130        140        150
QQLVKKGKSK VGDMLEKAAE LLMSCFRVCA SDTRAGIEDS KKWGMLFLVN 
       160        170        180        190        200
QLFKIYFKIN KLHLCKPLIR AIDSSNLKDD YSTAQRVTYK YYVGRKAMFD 
       210        220        230        240        250
SDFKQAEEYL SFAFEHCHRS SQKNKRMILI YLLPVKMLLG HMPTVELLKK 
       260        270        280        290        300
YHLMQFAEVT RAVSEGNLLL LHEALAKHEA FFIRCGIFLI LEKLKIITYR 
       310        320        330        340        350
NLFKKVYLLL KTHQLSLDAF LVALKFMQVE DVDIDEVQCI LANLIYMGHV 
       360        370 
KGYISHQHQK LVVSKQNPFP PLSTVC

Note: No experimental confirmation available.

Show »

Length:376

Mass (Da):43,375

Checksum:ⁱ039E8F8B8192F3C1

GO

Isoform 4 (identifier: Q5JVF3-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
89-89: Q → QYPLSFMAAVPHRTHAVDYLGLETRKHWASCSFLQLERNDSVLEQKLVSALSLGT

« Hide

        10         20         30         40         50
MAHITINQYL QQVYEAIDSR DGASCAELVS FKHPHVANPR LQMASPEEKC 
        60         70         80         90        100
QQVLEPPYDE MFAAHLRCTY AVGNHDFIEA YKCQTVIVQY PLSFMAAVPH 
       110        120        130        140        150
RTHAVDYLGL ETRKHWASCS FLQLERNDSV LEQKLVSALS LGTSFLRAFQ 
       160        170        180        190        200
AHKEENWALP VMYAVALDLR VFANNADQQL VKKGKSKVGD MLEKAAELLM 
       210        220        230        240        250
SCFRVCASDT RAGIEDSKKW GMLFLVNQLF KIYFKINKLH LCKPLIRAID 
       260        270        280        290        300
SSNLKDDYST AQRVTYKYYV GRKAMFDSDF KQAEEYLSFA FEHCHRSSQK 
       310        320        330        340        350
NKRMILIYLL PVKMLLGHMP TVELLKKYHL MQFAEVTRAV SEGNLLLLHE 
       360        370        380        390        400
ALAKHEAFFI RCGIFLILEK LKIITYRNLF KKVYLLLKTH QLSLDAFLVA 
       410        420        430        440        450
LKFMQVEDVD IDEVQCILAN LIYMGHVKGY ISHQHQKLVV SKQNPFPPLS 

TVC

Note: No experimental confirmation available.

Show »

Length:453

Mass (Da):52,100

Checksum:ⁱ57BB6C3A1E85A059

GO

Sequence cautionⁱ

The sequence AAG09695 differs from that shown. Reason: Frameshift at position 48.Curated

The sequence BAB15768 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	74	N → D in AAH31246 (PubMed:15489334).Curated	1
Sequence conflictⁱ	87	I → L in BAA91407 (PubMed:14702039).Curated	1
Sequence conflictⁱ	106	P → L in AAG09695 (Ref. 2) Curated	1
Sequence conflictⁱ	129	K → E in AAG09695 (Ref. 2) Curated	1
Sequence conflictⁱ	145	L → M in BAA91407 (PubMed:14702039).Curated	1
Sequence conflictⁱ	180	F → I in BAA91611 (PubMed:14702039).Curated	1
Sequence conflictⁱ	313	I → T in BAA92118 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_016843	1 – 12	MAHIT…QYLQQ → MRLTDVVQQL in isoform 2. 1 PublicationAdd BLAST	12
Alternative sequenceⁱVSP_016844	89	Q → QYPLSFMAAVPHRTHAVDYL GLETRKHWASCSFLQLERND SVLEQKLVSALSLGT in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_016845	92 – 114	Missing in isoform 3. 1 PublicationAdd BLAST	23

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000888 mRNA Translation: BAA91407.1 AK001185 mRNA Translation: BAA91542.1 AK001302 mRNA Translation: BAA91611.1 AK002167 mRNA Translation: BAA92118.1 AK023313 mRNA Translation: BAB14521.1 AK024478 mRNA Translation: BAB15768.1 Different initiation. AF183426 mRNA Translation: AAG09695.1 Frameshift. AL136221 Genomic DNA No translation available. AL137002 Genomic DNA No translation available. BC016614 mRNA Translation: AAH16614.1 BC031246 mRNA Translation: AAH31246.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58301.1 [Q5JVF3-2] CCDS58302.1 [Q5JVF3-4] CCDS9532.2 [Q5JVF3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001120674.1, NM_001127202.3 [Q5JVF3-1] NP_001120675.1, NM_001127203.3 [Q5JVF3-1] NP_001245142.1, NM_001258213.2 [Q5JVF3-2] NP_001307584.1, NM_001320655.1 [Q5JVF3-2] NP_001307585.1, NM_001320656.1 [Q5JVF3-4] NP_001307586.1, NM_001320657.1 NP_001307589.1, NM_001320660.1 NP_060856.2, NM_018386.4 [Q5JVF3-1] XP_016876153.1, XM_017020664.1 [Q5JVF3-2]
UniGeneⁱ	Hs.508769

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q5JVF3	PCI domain containing 2		PANTR		399	UniRef100_Q5JVF3
UPI0007DC4DA0		HUMAN		357
Q5JVF3-4	Uncharacterized protein		HUMAN		453	UniRef100_A0A024RE04
PCID2 isoform 1		PANTR		453
Uncharacterized protein		HUMAN		292
UPI0000EE5331		HUMAN		232

Protein	Similar proteins		Species	Score	Length	Source
Q5JVF3	PCI domain-containing protein 2		MOUSE		399	UniRef90_Q5JVF3
PCI domain containing 2		PANTR		399
PCI domain containing 2		AILME		401
PCI domain-containing protein 2 isoform X1		BALAS		399
Uncharacterized protein		AOTNA		399
+92
Q5JVF3-2	Uncharacterized protein		MACMU		403	UniRef90_Q5JVF3-2
Uncharacterized protein		MACFA		401
PCI domain-containing protein 2		TARSY		399
PCI domain containing 2		PANTR		397
Uncharacterized protein		PANPA		397
+38
Q5JVF3-3	PCI domain-containing protein 2 isoform X2		NEOSC		378	UniRef90_Q5JVF3-3
PCI domain containing 2 (Predicted)		PAPAN		378
PCI domain containing 2 (Predicted)		OTOGA		363
PCI domain-containing protein 2 isoform X2		BALAS		363
PCI domain-containing protein 2		AMAAE		363
+16
Q5JVF3-4	Uncharacterized protein		NOMLE		453	UniRef90_G1QIL0
Uncharacterized protein		HUMAN		453
PCID2 isoform 1		PANTR		453
PCI domain containing 2 (Predicted)		CALJA		453
Uncharacterized protein		MACMU		453
+11

Protein	Similar proteins		Species	Score	Length	Source
Q5JVF3	PCI domain-containing protein 2		MOUSE		399	UniRef50_Q5JVF3
PCI domain-containing protein 2		DANRE		399
PCI domain-containing protein 2		XENLA		399
PCI domain-containing protein 2		BOVIN		408
PCI domain containing 2		PANTR		399
+509
Q5JVF3-3	PCI domain containing 2 (Predicted)		PAPAN		378	UniRef50_Q5JVF3-3
PCI domain-containing protein 2 isoform X2		NEOSC		378
PCI domain-containing protein 2 isoform X2		BALAS		363
PCI domain-containing protein 2		AMAAE		363
PCI domain containing 2 (Predicted)		OTOGA		363
+102

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000888 mRNA Translation: BAA91407.1 AK001185 mRNA Translation: BAA91542.1 AK001302 mRNA Translation: BAA91611.1 AK002167 mRNA Translation: BAA92118.1 AK023313 mRNA Translation: BAB14521.1 AK024478 mRNA Translation: BAB15768.1 Different initiation. AF183426 mRNA Translation: AAG09695.1 Frameshift. AL136221 Genomic DNA No translation available. AL137002 Genomic DNA No translation available. BC016614 mRNA Translation: AAH16614.1 BC031246 mRNA Translation: AAH31246.1
CCDSⁱ	CCDS58301.1 [Q5JVF3-2] CCDS58302.1 [Q5JVF3-4] CCDS9532.2 [Q5JVF3-1]
RefSeqⁱ	NP_001120674.1, NM_001127202.3 [Q5JVF3-1] NP_001120675.1, NM_001127203.3 [Q5JVF3-1] NP_001245142.1, NM_001258213.2 [Q5JVF3-2] NP_001307584.1, NM_001320655.1 [Q5JVF3-2] NP_001307585.1, NM_001320656.1 [Q5JVF3-4] NP_001307586.1, NM_001320657.1 NP_001307589.1, NM_001320660.1 NP_060856.2, NM_018386.4 [Q5JVF3-1] XP_016876153.1, XM_017020664.1 [Q5JVF3-2]
UniGeneⁱ	Hs.508769

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3T5X	X-ray	2.12	A	201-399	[»]
ProteinModelPortalⁱ	Q5JVF3
SMRⁱ	Q5JVF3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120908, 29 interactors
DIPⁱ	DIP-50497N
IntActⁱ	Q5JVF3, 20 interactors
STRINGⁱ	9606.ENSP00000337405

PTM databases

iPTMnetⁱ	Q5JVF3
PhosphoSitePlusⁱ	Q5JVF3

Polymorphism and mutation databases

BioMutaⁱ	PCID2
DMDMⁱ	85681034

Proteomic databases

EPDⁱ	Q5JVF3
MaxQBⁱ	Q5JVF3
PaxDbⁱ	Q5JVF3
PeptideAtlasⁱ	Q5JVF3
PRIDEⁱ	Q5JVF3
ProteomicsDBⁱ	63327 63328 [Q5JVF3-2] 63329 [Q5JVF3-3] 63330 [Q5JVF3-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55795
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000246505; ENSP00000246505; ENSG00000126226 [Q5JVF3-4] ENST00000337344; ENSP00000337405; ENSG00000126226 [Q5JVF3-1] ENST00000375457; ENSP00000364606; ENSG00000126226 [Q5JVF3-2] ENST00000375459; ENSP00000364608; ENSG00000126226 [Q5JVF3-2] ENST00000375477; ENSP00000364626; ENSG00000126226 [Q5JVF3-1] ENST00000375479; ENSP00000364628; ENSG00000126226 [Q5JVF3-1] ENST00000622406; ENSP00000479494; ENSG00000126226 [Q5JVF3-4]
GeneIDⁱ	55795
KEGGⁱ	hsa:55795
UCSCⁱ	uc058ylr.1 human [Q5JVF3-1]

Organism-specific databases

CTDⁱ	55795
DisGeNETⁱ	55795
EuPathDBⁱ	HostDB:ENSG00000126226.21
GeneCardsⁱ	PCID2
H-InvDBⁱ	HIX0130585
HGNCⁱ	HGNC:25653 PCID2
HPAⁱ	HPA069107 HPA073074
MIMⁱ	613713 gene
neXtProtⁱ	NX_Q5JVF3
OpenTargetsⁱ	ENSG00000126226
PharmGKBⁱ	PA144596397
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2688 Eukaryota COG5600 LUCA
GeneTreeⁱ	ENSGT00390000001101
HOVERGENⁱ	HBG055800
InParanoidⁱ	Q5JVF3
OMAⁱ	SRKWGIY
PhylomeDBⁱ	Q5JVF3
TreeFamⁱ	TF106136

Miscellaneous databases

ChiTaRSⁱ	PCID2 human
GenomeRNAiⁱ	55795
Protein Ontology More...PROⁱ	PR:Q5JVF3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000126226 Expressed in 218 organ(s), highest expression level in oocyte
CleanExⁱ	HS_PCID2
ExpressionAtlasⁱ	Q5JVF3 baseline and differential
Genevisibleⁱ	Q5JVF3 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000717 PCI_dom IPR036388 WH-like_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PCID2_HUMAN
Accessionⁱ	Q5JVF3Primary (citable) accession number: Q5JVF3 Secondary accession number(s): A6NK09 Q9NWH3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
	Last sequence update:	January 10, 2006
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5JVF3 (PCID2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

PCI domain-containing protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ