UniProtKB - Q5JVF3 (PCID2_HUMAN)
PCI domain-containing protein 2
PCID2
Functioni
GO - Molecular functioni
- double-stranded DNA binding Source: GO_Central
- RNA binding Source: GO_Central
GO - Biological processi
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity Source: UniProtKB
- nuclear retention of pre-mRNA at the site of transcription Source: GO_Central
- poly(A)+ mRNA export from nucleus Source: GO_Central
- positive regulation of B cell differentiation Source: Ensembl
- positive regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery Source: GO_Central
- regulation of mRNA stability Source: UniProtKB
- spleen development Source: UniProtKB
- transcription elongation from RNA polymerase II promoter Source: GO_Central
Keywordsi
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q5JVF3 |
Names & Taxonomyi
Protein namesi | Recommended name: PCI domain-containing protein 2Alternative name(s): CSN12-like protein |
Gene namesi | Name:PCID2 ORF Names:HT004 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25653, PCID2 |
MIMi | 613713, gene |
neXtProti | NX_Q5JVF3 |
VEuPathDBi | HostDB:ENSG00000126226.21 |
Subcellular locationi
Nucleus
- nuclear pore complex 1 Publication
Other locations
- Cytoplasm 1 Publication
Nucleus
- nuclear pore nuclear basket Source: UniProtKB
- nucleus Source: UniProtKB
- transcription export complex 2 Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Nuclear pore complex, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55795 |
OpenTargetsi | ENSG00000126226 |
PharmGKBi | PA144596397 |
Miscellaneous databases
Pharosi | Q5JVF3, Tdark |
Genetic variation databases
BioMutai | PCID2 |
DMDMi | 85681034 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000121029 | 2 – 399 | PCI domain-containing protein 2Add BLAST | 398 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Modified residuei | 45 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q5JVF3 |
jPOSTi | Q5JVF3 |
MassIVEi | Q5JVF3 |
MaxQBi | Q5JVF3 |
PaxDbi | Q5JVF3 |
PeptideAtlasi | Q5JVF3 |
PRIDEi | Q5JVF3 |
ProteomicsDBi | 63327 [Q5JVF3-1] 63328 [Q5JVF3-2] 63329 [Q5JVF3-3] 63330 [Q5JVF3-4] |
PTM databases
iPTMneti | Q5JVF3 |
MetOSitei | Q5JVF3 |
PhosphoSitePlusi | Q5JVF3 |
SwissPalmi | Q5JVF3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000126226, Expressed in oocyte and 232 other tissues |
ExpressionAtlasi | Q5JVF3, baseline and differential |
Genevisiblei | Q5JVF3, HS |
Organism-specific databases
HPAi | ENSG00000126226, Low tissue specificity |
Interactioni
Subunit structurei
Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY and with the nucleoporin NUP153 (PubMed:22307388, PubMed:23591820).
Interacts with BRCA2 (PubMed:24896180).
3 PublicationsBinary interactionsi
Hide detailsQ5JVF3
With | #Exp. | IntAct |
---|---|---|
IKZF3 [Q9UKT9] | 3 | EBI-1051701,EBI-747204 |
LENG8 [Q96PV6] | 3 | EBI-1051701,EBI-739546 |
SEM1 [P60896] | 3 | EBI-1051701,EBI-79819 |
Isoform 1 [Q5JVF3-1]
With | #Exp. | IntAct |
---|---|---|
SEM1 [P60896] | 3 | EBI-15970419,EBI-79819 |
Protein-protein interaction databases
BioGRIDi | 120908, 47 interactors |
DIPi | DIP-50497N |
IntActi | Q5JVF3, 24 interactors |
Miscellaneous databases
RNActi | Q5JVF3, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q5JVF3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 210 – 391 | PCIPROSITE-ProRule annotationAdd BLAST | 182 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00390000001101 |
HOGENOMi | CLU_031567_2_0_1 |
InParanoidi | Q5JVF3 |
OMAi | TYLIPCH |
PhylomeDBi | Q5JVF3 |
TreeFami | TF106136 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000717, PCI_dom IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAHITINQYL QQVYEAIDSR DGASCAELVS FKHPHVANPR LQMASPEEKC
60 70 80 90 100
QQVLEPPYDE MFAAHLRCTY AVGNHDFIEA YKCQTVIVQS FLRAFQAHKE
110 120 130 140 150
ENWALPVMYA VALDLRVFAN NADQQLVKKG KSKVGDMLEK AAELLMSCFR
160 170 180 190 200
VCASDTRAGI EDSKKWGMLF LVNQLFKIYF KINKLHLCKP LIRAIDSSNL
210 220 230 240 250
KDDYSTAQRV TYKYYVGRKA MFDSDFKQAE EYLSFAFEHC HRSSQKNKRM
260 270 280 290 300
ILIYLLPVKM LLGHMPTVEL LKKYHLMQFA EVTRAVSEGN LLLLHEALAK
310 320 330 340 350
HEAFFIRCGI FLILEKLKII TYRNLFKKVY LLLKTHQLSL DAFLVALKFM
360 370 380 390
QVEDVDIDEV QCILANLIYM GHVKGYISHQ HQKLVVSKQN PFPPLSTVC
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 74 | N → D in AAH31246 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 87 | I → L in BAA91407 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 106 | P → L in AAG09695 (Ref. 2) Curated | 1 | |
Sequence conflicti | 129 | K → E in AAG09695 (Ref. 2) Curated | 1 | |
Sequence conflicti | 145 | L → M in BAA91407 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 180 | F → I in BAA91611 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 313 | I → T in BAA92118 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016843 | 1 – 12 | MAHIT…QYLQQ → MRLTDVVQQL in isoform 2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_016844 | 89 | Q → QYPLSFMAAVPHRTHAVDYL GLETRKHWASCSFLQLERND SVLEQKLVSALSLGT in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_016845 | 92 – 114 | Missing in isoform 3. 1 PublicationAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000888 mRNA Translation: BAA91407.1 AK001185 mRNA Translation: BAA91542.1 AK001302 mRNA Translation: BAA91611.1 AK002167 mRNA Translation: BAA92118.1 AK023313 mRNA Translation: BAB14521.1 AK024478 mRNA Translation: BAB15768.1 Different initiation. AF183426 mRNA Translation: AAG09695.1 Frameshift. AL136221 Genomic DNA No translation available. AL137002 Genomic DNA No translation available. BC016614 mRNA Translation: AAH16614.1 BC031246 mRNA Translation: AAH31246.1 |
CCDSi | CCDS58301.1 [Q5JVF3-2] CCDS58302.1 [Q5JVF3-4] CCDS9532.2 [Q5JVF3-1] |
RefSeqi | NP_001120674.1, NM_001127202.3 [Q5JVF3-1] NP_001120675.1, NM_001127203.3 [Q5JVF3-1] NP_001245142.1, NM_001258213.2 [Q5JVF3-2] NP_001307584.1, NM_001320655.1 [Q5JVF3-2] NP_001307585.1, NM_001320656.1 [Q5JVF3-4] NP_001307586.1, NM_001320657.1 NP_001307589.1, NM_001320660.1 NP_060856.2, NM_018386.4 [Q5JVF3-1] XP_016876153.1, XM_017020664.1 [Q5JVF3-2] |
Genome annotation databases
Ensembli | ENST00000246505; ENSP00000246505; ENSG00000126226 [Q5JVF3-4] ENST00000337344; ENSP00000337405; ENSG00000126226 [Q5JVF3-1] ENST00000375457; ENSP00000364606; ENSG00000126226 [Q5JVF3-2] ENST00000375459; ENSP00000364608; ENSG00000126226 [Q5JVF3-2] ENST00000375477; ENSP00000364626; ENSG00000126226 [Q5JVF3-1] ENST00000375479; ENSP00000364628; ENSG00000126226 [Q5JVF3-1] ENST00000622406; ENSP00000479494; ENSG00000126226 [Q5JVF3-4] |
GeneIDi | 55795 |
KEGGi | hsa:55795 |
UCSCi | uc058ylr.1, human [Q5JVF3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000888 mRNA Translation: BAA91407.1 AK001185 mRNA Translation: BAA91542.1 AK001302 mRNA Translation: BAA91611.1 AK002167 mRNA Translation: BAA92118.1 AK023313 mRNA Translation: BAB14521.1 AK024478 mRNA Translation: BAB15768.1 Different initiation. AF183426 mRNA Translation: AAG09695.1 Frameshift. AL136221 Genomic DNA No translation available. AL137002 Genomic DNA No translation available. BC016614 mRNA Translation: AAH16614.1 BC031246 mRNA Translation: AAH31246.1 |
CCDSi | CCDS58301.1 [Q5JVF3-2] CCDS58302.1 [Q5JVF3-4] CCDS9532.2 [Q5JVF3-1] |
RefSeqi | NP_001120674.1, NM_001127202.3 [Q5JVF3-1] NP_001120675.1, NM_001127203.3 [Q5JVF3-1] NP_001245142.1, NM_001258213.2 [Q5JVF3-2] NP_001307584.1, NM_001320655.1 [Q5JVF3-2] NP_001307585.1, NM_001320656.1 [Q5JVF3-4] NP_001307586.1, NM_001320657.1 NP_001307589.1, NM_001320660.1 NP_060856.2, NM_018386.4 [Q5JVF3-1] XP_016876153.1, XM_017020664.1 [Q5JVF3-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3T5X | X-ray | 2.12 | A | 201-399 | [»] | |
SMRi | Q5JVF3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120908, 47 interactors |
DIPi | DIP-50497N |
IntActi | Q5JVF3, 24 interactors |
PTM databases
iPTMneti | Q5JVF3 |
MetOSitei | Q5JVF3 |
PhosphoSitePlusi | Q5JVF3 |
SwissPalmi | Q5JVF3 |
Genetic variation databases
BioMutai | PCID2 |
DMDMi | 85681034 |
Proteomic databases
EPDi | Q5JVF3 |
jPOSTi | Q5JVF3 |
MassIVEi | Q5JVF3 |
MaxQBi | Q5JVF3 |
PaxDbi | Q5JVF3 |
PeptideAtlasi | Q5JVF3 |
PRIDEi | Q5JVF3 |
ProteomicsDBi | 63327 [Q5JVF3-1] 63328 [Q5JVF3-2] 63329 [Q5JVF3-3] 63330 [Q5JVF3-4] |
Protocols and materials databases
Antibodypediai | 25858, 88 antibodies |
DNASUi | 55795 |
Genome annotation databases
Organism-specific databases
CTDi | 55795 |
DisGeNETi | 55795 |
GeneCardsi | PCID2 |
HGNCi | HGNC:25653, PCID2 |
HPAi | ENSG00000126226, Low tissue specificity |
MIMi | 613713, gene |
neXtProti | NX_Q5JVF3 |
OpenTargetsi | ENSG00000126226 |
PharmGKBi | PA144596397 |
VEuPathDBi | HostDB:ENSG00000126226.21 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000001101 |
HOGENOMi | CLU_031567_2_0_1 |
InParanoidi | Q5JVF3 |
OMAi | TYLIPCH |
PhylomeDBi | Q5JVF3 |
TreeFami | TF106136 |
Enzyme and pathway databases
PathwayCommonsi | Q5JVF3 |
Miscellaneous databases
BioGRID-ORCSi | 55795, 715 hits in 878 CRISPR screens |
ChiTaRSi | PCID2, human |
GenomeRNAii | 55795 |
Pharosi | Q5JVF3, Tdark |
PROi | PR:Q5JVF3 |
RNActi | Q5JVF3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126226, Expressed in oocyte and 232 other tissues |
ExpressionAtlasi | Q5JVF3, baseline and differential |
Genevisiblei | Q5JVF3, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000717, PCI_dom IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF01399, PCI, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCID2_HUMAN | |
Accessioni | Q5JVF3Primary (citable) accession number: Q5JVF3 Secondary accession number(s): A6NK09 Q9NWH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | January 10, 2006 | |
Last modified: | February 10, 2021 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families