F10

Functionⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	276	Charge relay systemUniRule annotation	1
Active siteⁱ	322	Charge relay systemUniRule annotation	1
Active siteⁱ	419	Charge relay systemUniRule annotation	1

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
serine-type endopeptidase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Serine proteaseUniRule annotation

Molecular function

Hydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Coagulation factor X, isoform CRA_aImported Submitted name: cDNA, FLJ94415, Homo sapiens coagulation factor X (F10), mRNAImported
Gene namesⁱ	Name:F10Imported ORF Names:hCG_27879Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000126218.11

EuPathDBⁱ

HostDB:ENSG00000126218.11

Keywords - Cellular componentⁱ

SecretedSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA27940

PharmGKBⁱ

PA27940

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_5014309842	24 – 488	Sequence analysisAdd BLAST		465

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	112 ↔ 121	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5JVE7
PRIDEⁱ	Q5JVE7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000126218
ExpressionAtlasⁱ	Q5JVE7 baseline and differential

Structureⁱ

3D structure databases

SMRⁱ	Q5JVE7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	40 – 86	GlaInterPro annotationAdd BLAST	47
Domainⁱ	86 – 122	EGF-likeInterPro annotationAdd BLAST	37
Domainⁱ	235 – 467	Peptidase S1InterPro annotationAdd BLAST	233

Sequence similaritiesⁱ

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domainⁱ

EGF-like domainPROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IGPV Eukaryota COG5640 LUCA
HOVERGENⁱ	HBG013304
KEGG Orthology (KO) More...KOⁱ	K01314
OMAⁱ	NFLKWID
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AH5

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	4.10.740.10, 1 hit
InterProⁱ	View protein in InterPro IPR017857 Coagulation_fac-like_Gla_dom IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR035972 GLA-like_dom_SF IPR000294 GLA_domain IPR012224 Pept_S1A_FX IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00008 EGF, 1 hit PF00594 Gla, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF001143 Factor_X, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN PR00001 GLABLOOD
SMARTⁱ	View protein in SMART SM00181 EGF, 2 hits SM00179 EGF_CA, 1 hit SM00069 GLA, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 2 hits SSF57630 SSF57630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS00022 EGF_1, 1 hit PS01186 EGF_2, 1 hit PS50026 EGF_3, 1 hit PS01187 EGF_CA, 1 hit PS00011 GLA_1, 1 hit PS50998 GLA_2, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5JVE7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGRPLHLVLL SASLAGLLLL GESLFIRREQ ANNILARVTR ANSFLEEMKK 
        60         70         80         90        100
GHLERECMEE TCSYEEAREV FEDSDKTNEF WNKYKDGDQC ETSPCQNQGK 
       110        120        130        140        150
CKDGLGEYTC TCLEGFEGKN CELFTRKLCS LDNGDCDQFC HEEQNSVVCS 
       160        170        180        190        200
CARGYTLADN GKACIPTGPY PCGKQTLERR KRSVAQATSS SGEAPDSITW 
       210        220        230        240        250
KPYDAADLDP TENPFDLLDF NQTQPERGDN NLTRIVGGQE CKDGECPWQA 
       260        270        280        290        300
LLINEENEGF CGGTILSEFY ILTAAHCLYQ AKRFKVRVGD RNTEQEEGGE 
       310        320        330        340        350
AVHEVEVVIK HNRFTKETYD FDIAVLRLKT PITFRMNVAP ACLPERDWAE 
       360        370        380        390        400
STLMTQKTGI VSGFGRTHEK GRQSTRLKML EVPYVDRNSC KLSSSFIITQ 
       410        420        430        440        450
NMFCAGYDTK QEDACQGDSG GPHVTRFKDT YFVTGIVSWG EGCARKGKYG 
       460        470        480 
IYTKVTAFLK WIDRSMKTRG LPKAKSHAPE VITSSPLK

Length:488

Mass (Da):54,732

Last modified:May 10, 2005 - v1

Checksum:ⁱF81D5746AF4797AF

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF445049 Genomic DNA Translation: ACA06104.1 AK313798 mRNA Translation: BAG36534.1 CH471085 Genomic DNA Translation: EAX09184.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000495.1, NM_000504.3
UniGeneⁱ	Hs.361463

Genome annotation databases

GeneIDⁱ	2159
KEGGⁱ	hsa:2159
UCSC genome browser More...UCSCⁱ	uc001vsx.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q5JVE7	Coagulation factor X	)	HUMAN		488
Coagulation factor X		PANTR		488
Coagulation factor X		PANPA		488
UPI0000683559		HUMAN		95
UPI0000112F2F		HUMAN		235
+13

Protein	Similar proteins		Species	Score	Length
Q5JVE7	Coagulation factor X	)	HUMAN		488
Coagulation factor X		PANTR		488
Coagulation factor X		PANPA		488
Coagulation factor X precursor		MACMU		489
Coagulation factor X (Predicted)		PAPAN		488
+45

Protein	Similar proteins		Species	Score	Length
Q5JVE7	Coagulation factor X	)	HUMAN		488
Coagulation factor X		PANTR		488
Coagulation factor X		PANPA		488
Coagulation factor X precursor		MACMU		489
Coagulation factor X		CHLSB		488
+77

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EF445049 Genomic DNA Translation: ACA06104.1 AK313798 mRNA Translation: BAG36534.1 CH471085 Genomic DNA Translation: EAX09184.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000495.1, NM_000504.3
UniGeneⁱ	Hs.361463

3D structure databases

SMRⁱ	Q5JVE7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5JVE7
PRIDEⁱ	Q5JVE7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	2159
KEGGⁱ	hsa:2159
UCSC genome browser More...UCSCⁱ	uc001vsx.4 human

Organism-specific databases

CTDⁱ	2159
EuPathDBⁱ	HostDB:ENSG00000126218.11
PharmGKBⁱ	PA27940

Phylogenomic databases

eggNOGⁱ	ENOG410IGPV Eukaryota COG5640 LUCA
HOVERGENⁱ	HBG013304
KEGG Orthology (KO) More...KOⁱ	K01314
OMAⁱ	NFLKWID
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AH5

Miscellaneous databases

ChiTaRSⁱ	F10 human
GenomeRNAiⁱ	2159

Gene expression databases

Bgeeⁱ	ENSG00000126218
ExpressionAtlasⁱ	Q5JVE7 baseline and differential

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	4.10.740.10, 1 hit
InterProⁱ	View protein in InterPro IPR017857 Coagulation_fac-like_Gla_dom IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR035972 GLA-like_dom_SF IPR000294 GLA_domain IPR012224 Pept_S1A_FX IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00008 EGF, 1 hit PF00594 Gla, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF001143 Factor_X, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN PR00001 GLABLOOD
SMARTⁱ	View protein in SMART SM00181 EGF, 2 hits SM00179 EGF_CA, 1 hit SM00069 GLA, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 2 hits SSF57630 SSF57630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS00022 EGF_1, 1 hit PS01186 EGF_2, 1 hit PS50026 EGF_3, 1 hit PS01187 EGF_CA, 1 hit PS00011 GLA_1, 1 hit PS50998 GLA_2, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5JVE7_HUMAN
Accessionⁱ	Q5JVE7Primary (citable) accession number: Q5JVE7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	June 20, 2018
	This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q5JVE7 (Q5JVE7_HUMAN)

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Coagulation factor X, isoform CRA_a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ