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UniProtKB - Q5JVE7 (Q5JVE7_HUMAN)
Protein
Submitted name:
Coagulation factor X
Gene
F10
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 276 | Charge relay systemUniRule annotation | 1 | |
Active sitei | 322 | Charge relay systemUniRule annotation | 1 | |
Active sitei | 419 | Charge relay systemUniRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- serine-type endopeptidase activity Source: InterPro
GO - Biological processi
- blood coagulation Source: UniProtKB-KW
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProt
Keywordsi
Molecular function | Hydrolase, Protease, Serine proteaseUniRule annotationARBA annotation |
Biological process | Blood coagulationARBA annotation, Hemostasis |
Ligand | CalciumARBA annotation |
Protein family/group databases
MEROPSi | S01.216 |
Names & Taxonomyi
Protein namesi | Submitted name: Coagulation factor XImportedSubmitted name: Coagulation factor X, isoform CRA_aImportedSubmitted name: cDNA, FLJ94415, Homo sapiens coagulation factor X (F10), mRNAImported |
Gene namesi | Name:F10Imported ORF Names:hCG_27879Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000126218 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: UniProt
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Golgi apparatus
- Golgi lumen Source: UniProt
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_5014309842 | 24 – 488 | Sequence analysisAdd BLAST | 465 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 112 ↔ 121 | PROSITE-ProRule annotation |
Keywords - PTMi
Cleavage on pair of basic residuesARBA annotation, Disulfide bondPROSITE-ProRule annotationARBA annotation, Gamma-carboxyglutamic acidARBA annotation, HydroxylationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000126218, Expressed in right lobe of liver and 146 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 86 | GlaInterPro annotationAdd BLAST | 47 | |
Domaini | 86 – 122 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 235 – 467 | Peptidase S1InterPro annotationAdd BLAST | 233 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_006842_19_5_1 |
OMAi | HCLHQAK |
OrthoDBi | 1314811at2759 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR017857, Coagulation_fac-like_Gla_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00594, Gla, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00069, GLA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5JVE7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRPLHLVLL SASLAGLLLL GESLFIRREQ ANNILARVTR ANSFLEEMKK
60 70 80 90 100
GHLERECMEE TCSYEEAREV FEDSDKTNEF WNKYKDGDQC ETSPCQNQGK
110 120 130 140 150
CKDGLGEYTC TCLEGFEGKN CELFTRKLCS LDNGDCDQFC HEEQNSVVCS
160 170 180 190 200
CARGYTLADN GKACIPTGPY PCGKQTLERR KRSVAQATSS SGEAPDSITW
210 220 230 240 250
KPYDAADLDP TENPFDLLDF NQTQPERGDN NLTRIVGGQE CKDGECPWQA
260 270 280 290 300
LLINEENEGF CGGTILSEFY ILTAAHCLYQ AKRFKVRVGD RNTEQEEGGE
310 320 330 340 350
AVHEVEVVIK HNRFTKETYD FDIAVLRLKT PITFRMNVAP ACLPERDWAE
360 370 380 390 400
STLMTQKTGI VSGFGRTHEK GRQSTRLKML EVPYVDRNSC KLSSSFIITQ
410 420 430 440 450
NMFCAGYDTK QEDACQGDSG GPHVTRFKDT YFVTGIVSWG EGCARKGKYG
460 470 480
IYTKVTAFLK WIDRSMKTRG LPKAKSHAPE VITSSPLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF445049 Genomic DNA Translation: ACA06104.1 AK313798 mRNA Translation: BAG36534.1 CH471085 Genomic DNA Translation: EAX09184.1 |
RefSeqi | NP_000495.1, NM_000504.3 |
Genome annotation databases
GeneIDi | 2159 |
KEGGi | hsa:2159 |
MANE-Selecti | ENST00000375559.8; ENSP00000364709.3; NM_000504.4; NP_000495.1 |
UCSCi | uc001vsx.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF445049 Genomic DNA Translation: ACA06104.1 AK313798 mRNA Translation: BAG36534.1 CH471085 Genomic DNA Translation: EAX09184.1 |
RefSeqi | NP_000495.1, NM_000504.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | S01.216 |
Protocols and materials databases
Antibodypediai | 11687, 683 antibodies from 35 providers |
DNASUi | 2159 |
Genome annotation databases
GeneIDi | 2159 |
KEGGi | hsa:2159 |
MANE-Selecti | ENST00000375559.8; ENSP00000364709.3; NM_000504.4; NP_000495.1 |
UCSCi | uc001vsx.4, human |
Organism-specific databases
CTDi | 2159 |
PharmGKBi | PA27940 |
VEuPathDBi | HostDB:ENSG00000126218 |
Phylogenomic databases
HOGENOMi | CLU_006842_19_5_1 |
OMAi | HCLHQAK |
OrthoDBi | 1314811at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2159, 14 hits in 1076 CRISPR screens |
ChiTaRSi | F10, human |
GenomeRNAii | 2159 |
Gene expression databases
Bgeei | ENSG00000126218, Expressed in right lobe of liver and 146 other tissues |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 4.10.740.10, 1 hit |
InterProi | View protein in InterPro IPR017857, Coagulation_fac-like_Gla_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00594, Gla, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN PR00001, GLABLOOD |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00069, GLA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5JVE7_HUMAN | |
Accessioni | Q5JVE7Primary (citable) accession number: Q5JVE7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | May 25, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |