UniProtKB - Q5JUY5 (Q5JUY5_HUMAN)
Protein
Submitted name:
Thrombopoietin receptor
Gene
MPL
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Thrombopoietin receptorImported |
Gene namesi | Name:MPLImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7217, MPL |
VEuPathDBi | HostDB:ENSG00000117400.14 |
Subcellular locationi
Nucleus
- nuclear membrane Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 483 – 506 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5010702610 | 22 – 628 | Sequence analysisAdd BLAST | 607 |
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | Q5JUY5 |
PRIDEi | Q5JUY5 |
ProteomicsDBi | 63304 |
Expressioni
Gene expression databases
Bgeei | ENSG00000117400, Expressed in monocyte and 88 other tissues |
ExpressionAtlasi | Q5JUY5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 165 – 274 | Fibronectin type-IIIInterPro annotationAdd BLAST | 110 | |
Domaini | 385 – 479 | Fibronectin type-IIIInterPro annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 198 – 225 | DisorderedSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000161225 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR015152, Growth/epo_recpt_lig-bind IPR013783, Ig-like_fold IPR003528, Long_hematopoietin_rcpt_CS |
Pfami | View protein in Pfam PF09067, EpoR_lig-bind, 1 hit PF00041, fn3, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 2 hits |
SUPFAMi | SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01352, HEMATOPO_REC_L_F1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q5JUY5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSWALFMVT SCLLLAPQNL AQVSSQDSEP LKCFSRTFED LTCFWDEEEA
60 70 80 90 100
APSGTYQLLY AYPREKPRAC PLSSQSMPHF GTRYVCQFPD QEEVRLFFPL
110 120 130 140 150
HLWVKNVFLN QTRTQRVLFV DSVGLPAPPS IIKAMGGSQP GELQISWEEP
160 170 180 190 200
APEISDFLRY ELRYGPRDPK NSTGPTVIQL IATETCCPAL QRPHSASALD
210 220 230 240 250
QSPCAQPTMP WQDGPKQTSP SREASALTAE GGSCLISGLQ PGNSYWLQLR
260 270 280 290 300
SEPDGISLGG SWGSWSLPVT VDLPGDAVAL GLQCFTLDLK NVTCQWQQQD
310 320 330 340 350
HASSQGFFYH SRARCCPRDR YPIWENCEEE EKTNPGLQTP QFSRCHFKSR
360 370 380 390 400
NDSIIHILVE VTTAPGTVHS YLGSPFWIHQ AVRLPTPNLH WREISSGHLE
410 420 430 440 450
LEWQHPSSWA AQETCYQLRY TGEGHQDWKV LEPPLGARGG TLELRPRSRY
460 470 480 490 500
RLQLRARLNG PTYQGPWSSW SDPTRVETAT ETAWISLVTA LHLVLGLSAV
510 520 530 540 550
LGLLLLRWQF PAHYRRLRHA LWPSLPDLHR VLGQYLRDTA ALSPPKATVS
560 570 580 590 600
DTCEEVEPSL LEILPKSSER TPLPLCSSQA QMDYRRLQPS CLGTMPLSVC
610 620
PPMAESGSCC TTHIANHSYL PLSYWQQP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP40238 | TPOR_HUMAN | Thrombopoietin receptor | MPL TPOR | 635 | Annotation score: | ||
A0A2R8YE13 | A0A2R8YE13_HUMAN | Thrombopoietin receptor | MPL | 177 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL139289 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000413998; ENSP00000414004; ENSG00000117400 |
UCSCi | uc001civ.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL139289 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q5JUY5 |
PRIDEi | Q5JUY5 |
ProteomicsDBi | 63304 |
Protocols and materials databases
Antibodypediai | 2379, 333 antibodies |
Genome annotation databases
Ensembli | ENST00000413998; ENSP00000414004; ENSG00000117400 |
UCSCi | uc001civ.4, human |
Organism-specific databases
HGNCi | HGNC:7217, MPL |
OpenTargetsi | ENSG00000117400 |
VEuPathDBi | HostDB:ENSG00000117400.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161225 |
Miscellaneous databases
ChiTaRSi | MPL, human |
Gene expression databases
Bgeei | ENSG00000117400, Expressed in monocyte and 88 other tissues |
ExpressionAtlasi | Q5JUY5, baseline and differential |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR015152, Growth/epo_recpt_lig-bind IPR013783, Ig-like_fold IPR003528, Long_hematopoietin_rcpt_CS |
Pfami | View protein in Pfam PF09067, EpoR_lig-bind, 1 hit PF00041, fn3, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 2 hits |
SUPFAMi | SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01352, HEMATOPO_REC_L_F1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5JUY5_HUMAN | |
Accessioni | Q5JUY5Primary (citable) accession number: Q5JUY5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 15, 2005 |
Last sequence update: | June 7, 2017 | |
Last modified: | February 10, 2021 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |