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Protein

KRAB domain-containing protein 4

Gene

KRBOX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Despite its name, it does not contain a canonical C2H2-type zinc-finger, seems to be a partial inverted duplication of ZNF674.Curated

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
KRAB domain-containing protein 4
Alternative name(s):
KRAB box domain-containing protein 4
Gene namesi
Name:KRBOX4
Synonyms:ZNF673
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147121.15
HGNCiHGNC:26007 KRBOX4
MIMi300585 gene
neXtProtiNX_Q5JUW0

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi55634
OpenTargetsiENSG00000147121
PharmGKBiPA142670474

Polymorphism and mutation databases

BioMutaiKRBOX4
DMDMi74742348

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339941 – 171KRAB domain-containing protein 4Add BLAST171

Proteomic databases

MaxQBiQ5JUW0
PaxDbiQ5JUW0
PeptideAtlasiQ5JUW0
PRIDEiQ5JUW0
ProteomicsDBi63298
63299 [Q5JUW0-2]
63300 [Q5JUW0-3]

PTM databases

iPTMnetiQ5JUW0
PhosphoSitePlusiQ5JUW0

Expressioni

Tissue specificityi

Expressed in brain, ovary, testis, prostate, tonsil, heart, bone marrow, colon, breast and kidney.1 Publication

Gene expression databases

BgeeiENSG00000147121
CleanExiHS_ZNF673
ExpressionAtlasiQ5JUW0 baseline and differential
GenevisibleiQ5JUW0 HS

Organism-specific databases

HPAiHPA065295

Interactioni

Protein-protein interaction databases

BioGridi120773, 15 interactors
IntActiQ5JUW0, 16 interactors
STRINGi9606.ENSP00000345797

Structurei

3D structure databases

ProteinModelPortaliQ5JUW0
SMRiQ5JUW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149096
HOGENOMiHOG000231475
HOVERGENiHBG067759
InParanoidiQ5JUW0
OrthoDBiEOG091G0P6J
PhylomeDBiQ5JUW0
TreeFamiTF342644

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SUPFAMiSSF109640 SSF109640, 1 hit
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5JUW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMSQESLTF KDVFVDFTLE EWQQLDSAQK NLYRDVMLEN YSHLVSVGYL
60 70 80 90 100
VAKPDVIFRL GPGEESWMAD GGTPVRTCAG EDRPEVWQVD EQIDHYKESQ
110 120 130 140 150
DKLPWQAAFI GKETLKDESG QESRTCRKSI YLSTEFDSVR QRLPKYYSWE
160 170
KAFKTSFKLS WSKWKLCKKE R
Note: Gene prediction based on EST data.
Length:171
Mass (Da):20,100
Last modified:February 15, 2005 - v1
Checksum:iEA51AFEFDB5CEE9F
GO
Isoform 2 (identifier: Q5JUW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     80-84: Missing.

Show »
Length:166
Mass (Da):19,545
Checksum:i0A378FF50E0C8458
GO
Isoform 3 (identifier: Q5JUW0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-98: EVWQVDEQIDHYKE → DVSIFASCILKCCY
     99-171: Missing.

Note: No experimental confirmation available.
Show »
Length:98
Mass (Da):11,065
Checksum:i68DA07E408A8D7D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64E → G in BAA91104 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01816380 – 84Missing in isoform 2. 2 Publications5
Alternative sequenceiVSP_01816485 – 98EVWQV…DHYKE → DVSIFASCILKCCY in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_01816599 – 171Missing in isoform 3. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000351 mRNA Translation: BAA91104.1
AK096413 mRNA Translation: BAG53284.1
AK289703 mRNA Translation: BAF82392.1
AL139811 Genomic DNA No translation available.
CH471164 Genomic DNA Translation: EAW59263.1
BC012569 mRNA Translation: AAH12569.1
CCDSiCCDS14267.1 [Q5JUW0-2]
CCDS48097.1 [Q5JUW0-1]
CCDS48098.1 [Q5JUW0-3]
RefSeqiNP_001123370.1, NM_001129898.1 [Q5JUW0-1]
NP_001123371.1, NM_001129899.1 [Q5JUW0-3]
NP_001123372.1, NM_001129900.1
NP_060246.2, NM_017776.2 [Q5JUW0-2]
UniGeneiHs.632800

Genome annotation databases

EnsembliENST00000298190; ENSP00000298190; ENSG00000147121 [Q5JUW0-2]
ENST00000344302; ENSP00000345797; ENSG00000147121 [Q5JUW0-1]
ENST00000377919; ENSP00000367152; ENSG00000147121 [Q5JUW0-3]
ENST00000487081; ENSP00000418076; ENSG00000147121 [Q5JUW0-3]
GeneIDi55634
KEGGihsa:55634
UCSCiuc004dgm.5 human [Q5JUW0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKRBX4_HUMAN
AccessioniPrimary (citable) accession number: Q5JUW0
Secondary accession number(s): A8K0Y8
, B3KU22, Q96EA3, Q9NXB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: February 15, 2005
Last modified: June 20, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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