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Entry version 96 (18 Sep 2019)
Sequence version 1 (15 Feb 2005)
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Protein

Protein FAM78A

Gene

FAM78A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM78A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM78A
Synonyms:C9orf59
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25465 FAM78A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5JUQ0

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000126882

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134970135

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5JUQ0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM78A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74742326

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002651121 – 283Protein FAM78AAdd BLAST283

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5JUQ0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5JUQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5JUQ0

PeptideAtlas

More...
PeptideAtlasi
Q5JUQ0

PRoteomics IDEntifications database

More...
PRIDEi
Q5JUQ0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63285

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5JUQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5JUQ0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5JUQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126882 Expressed in 192 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5JUQ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5JUQ0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021472
HPA023914

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130355, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q5JUQ0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361345

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM78 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGXQ Eukaryota
ENOG410YZF1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018059

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231929

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5JUQ0

Identification of Orthologs from Complete Genome Data

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OMAi
IQSISCK

Database of Orthologous Groups

More...
OrthoDBi
958650at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5JUQ0

TreeFam database of animal gene trees

More...
TreeFami
TF329533

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029638 FAM78
IPR029640 FAM78A

The PANTHER Classification System

More...
PANTHERi
PTHR31655 PTHR31655, 1 hit
PTHR31655:SF3 PTHR31655:SF3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5JUQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGFFCDCWP SLEIRALLYA MGCIQSIGGK ARVFREGITV IDVKASIDPV
60 70 80 90 100
PTSIDESSSV VLRYRTPHFR ASAQVVMPPI PKKETWVVGW IQACSHMEFY
110 120 130 140 150
NQYGEQGMSS WELPDLQEGK IQAISDSDGV NYPWYGNTTE TCTIVGPTKR
160 170 180 190 200
DSKFIISMND NFYPSVTWAV PVSESNVAKL TNIYRDQSFT TWLVATNTST
210 220 230 240 250
NDMIILQTLH WRMQLSIEVN PNRPLGQRAR LREPIAQDQP KILSKNEPIP
260 270 280
PSALVKPNAN DAQVLMWRPK YGQPLVVIPP KHR
Length:283
Mass (Da):31,968
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45EF1D53B5E7EE4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JUQ2Q5JUQ2_HUMAN
Protein FAM78A
FAM78A
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JUQ1Q5JUQ1_HUMAN
Protein FAM78A
FAM78A
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH49388 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL157938 Genomic DNA No translation available.
BC049388 mRNA Translation: AAH49388.1 Different initiation.
AK024434 mRNA Translation: BAB15724.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6941.2

NCBI Reference Sequences

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RefSeqi
NP_203745.2, NM_033387.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372271; ENSP00000361345; ENSG00000126882

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
286336

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:286336

UCSC genome browser

More...
UCSCi
uc004cak.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157938 Genomic DNA No translation available.
BC049388 mRNA Translation: AAH49388.1 Different initiation.
AK024434 mRNA Translation: BAB15724.1
CCDSiCCDS6941.2
RefSeqiNP_203745.2, NM_033387.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi130355, 4 interactors
IntActiQ5JUQ0, 1 interactor
STRINGi9606.ENSP00000361345

PTM databases

iPTMnetiQ5JUQ0
PhosphoSitePlusiQ5JUQ0
SwissPalmiQ5JUQ0

Polymorphism and mutation databases

BioMutaiFAM78A
DMDMi74742326

Proteomic databases

EPDiQ5JUQ0
MassIVEiQ5JUQ0
PaxDbiQ5JUQ0
PeptideAtlasiQ5JUQ0
PRIDEiQ5JUQ0
ProteomicsDBi63285

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
286336

Genome annotation databases

EnsembliENST00000372271; ENSP00000361345; ENSG00000126882
GeneIDi286336
KEGGihsa:286336
UCSCiuc004cak.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
286336

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM78A
HGNCiHGNC:25465 FAM78A
HPAiHPA021472
HPA023914
neXtProtiNX_Q5JUQ0
OpenTargetsiENSG00000126882
PharmGKBiPA134970135

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGXQ Eukaryota
ENOG410YZF1 LUCA
GeneTreeiENSGT00390000018059
HOGENOMiHOG000231929
InParanoidiQ5JUQ0
OMAiIQSISCK
OrthoDBi958650at2759
PhylomeDBiQ5JUQ0
TreeFamiTF329533

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM78A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
286336
PharosiQ5JUQ0

Protein Ontology

More...
PROi
PR:Q5JUQ0

Gene expression databases

BgeeiENSG00000126882 Expressed in 192 organ(s), highest expression level in leukocyte
ExpressionAtlasiQ5JUQ0 baseline and differential
GenevisibleiQ5JUQ0 HS

Family and domain databases

InterProiView protein in InterPro
IPR029638 FAM78
IPR029640 FAM78A
PANTHERiPTHR31655 PTHR31655, 1 hit
PTHR31655:SF3 PTHR31655:SF3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA78A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JUQ0
Secondary accession number(s): Q86VQ9, Q9H7P4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: February 15, 2005
Last modified: September 18, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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