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Protein

Potassium channel subfamily T member 1

Gene

KCNT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandCalcium, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily T member 1
Alternative name(s):
KCa4.1
Gene namesi
Name:KCNT1
Synonyms:KIAA1422
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107147.11
HGNCiHGNC:18865 KCNT1
MIMi608167 gene
neXtProtiNX_Q5JUK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 97CytoplasmicSequence analysisAdd BLAST97
Transmembranei98 – 118Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini119 – 155ExtracellularSequence analysisAdd BLAST37
Transmembranei156 – 176Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini177 – 187CytoplasmicSequence analysisAdd BLAST11
Transmembranei188 – 208Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini209 – 213ExtracellularSequence analysis5
Transmembranei214 – 226Helical; Name=Segment S4Sequence analysisAdd BLAST13
Topological domaini227 – 251CytoplasmicSequence analysisAdd BLAST25
Transmembranei252 – 272Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini273 – 281ExtracellularSequence analysis9
Intramembranei282 – 302Pore-formingSequence analysisAdd BLAST21
Topological domaini303 – 304ExtracellularSequence analysis2
Transmembranei305 – 325Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini326 – 1230CytoplasmicSequence analysisAdd BLAST905

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Epileptic encephalopathy, early infantile, 14 (EIEE14)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare epileptic encephalopathy of infancy that combines pharmacoresistant seizures with developmental delay. This severe neurologic disorder is characterized by onset in the first 6 months of life of refractory focal seizures and arrest of psychomotor development. Ictal EEG shows discharges that arise randomly from various areas of both hemispheres and migrate from one brain region to another.
See also OMIM:614959
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078683269G → S in EIEE14. 2 PublicationsCorresponds to variant dbSNP:rs587777264Ensembl.1
Natural variantiVAR_069312409R → Q in EIEE14; gain-of-function mutation. 1 PublicationCorresponds to variant dbSNP:rs397515402Ensembl.1
Natural variantiVAR_069313455R → H in EIEE14. 1 PublicationCorresponds to variant dbSNP:rs397515404Ensembl.1
Natural variantiVAR_078214497M → V in EIEE14. 1 PublicationCorresponds to variant dbSNP:rs886041691Ensembl.1
Natural variantiVAR_078641562T → I in EIEE14; unknown pathological significance. 1 Publication1
Natural variantiVAR_069314741I → M in EIEE14. 1 PublicationCorresponds to variant dbSNP:rs370521183Ensembl.1
Natural variantiVAR_078684877M → K in EIEE14; unknown pathological significance. 1 Publication1
Natural variantiVAR_069318915A → T in EIEE14; gain-of-function mutation. 2 PublicationsCorresponds to variant dbSNP:rs397515403Ensembl.1
Natural variantiVAR_078215928K → E in EIEE14. 1 PublicationCorresponds to variant dbSNP:rs1057519544Ensembl.1
Natural variantiVAR_078685947A → T in EIEE14; variant homologue in rat has increased channel activity upon positive potentials. 1 Publication1
Natural variantiVAR_0786421088R → Q in EIEE14; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs758311066Ensembl.1
Epilepsy, nocturnal frontal lobe, 5 (ENFL5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant focal epilepsy syndrome characterized by childhood onset of clusters of motor seizures during sleep. Some patients may develop behavioral or psychiatric manifestations and/or intellectual disability. The phenotype is more severe than observed in other genetic forms of nocturnal frontal lobe epilepsy.
See also OMIM:615005
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069311379R → Q in ENFL5. 1 PublicationCorresponds to variant dbSNP:rs397515407Ensembl.1
Natural variantiVAR_069315777Y → H in ENFL5. 1 PublicationCorresponds to variant dbSNP:rs397515406Ensembl.1
Natural variantiVAR_069316877M → I in ENFL5. 1 PublicationCorresponds to variant dbSNP:rs797044544Ensembl.1
Natural variantiVAR_069317909R → C in ENFL5. 1 PublicationCorresponds to variant dbSNP:rs397515405Ensembl.1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNETi57582
MalaCardsiKCNT1
MIMi614959 phenotype
615005 phenotype
OpenTargetsiENSG00000107147
Orphaneti98784 Autosomal dominant nocturnal frontal lobe epilepsy
293181 Malignant migrating partial seizures of infancy
PharmGKBiPA38725

Chemistry databases

GuidetoPHARMACOLOGYi385

Polymorphism and mutation databases

BioMutaiKCNT1
DMDMi73920089

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540901 – 1230Potassium channel subfamily T member 1Add BLAST1230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5JUK3
PeptideAtlasiQ5JUK3
PRIDEiQ5JUK3
ProteomicsDBi63278
63279 [Q5JUK3-2]

PTM databases

iPTMnetiQ5JUK3
PhosphoSitePlusiQ5JUK3

Expressioni

Tissue specificityi

Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000107147 Expressed in 100 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_KCNT1
ExpressionAtlasiQ5JUK3 baseline and differential
GenevisibleiQ5JUK3 HS

Organism-specific databases

HPAiHPA059880

Interactioni

Subunit structurei

Interacts (via C-terminus) with FMR1; this interaction alters gating properties of KCNT1 (PubMed:20512134). Interacts with CRBN via its cytoplasmic C-terminus (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000360822

Structurei

3D structure databases

ProteinModelPortaliQ5JUK3
SMRiQ5JUK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini475 – 596RCK N-terminalAdd BLAST122

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3193 Eukaryota
ENOG410XSMA LUCA
GeneTreeiENSGT00530000063026
HOGENOMiHOG000231460
HOVERGENiHBG055190
InParanoidiQ5JUK3
KOiK04946
OMAiCFPMVYF
OrthoDBiEOG091G011O
PhylomeDBiQ5JUK3
TreeFamiTF314283

Family and domain databases

InterProiView protein in InterPro
IPR003929 K_chnl_BK_asu
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF07885 Ion_trans_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JUK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARAKLPRSP SEGKAGPGGA PAGAAAPEEP HGLSPLLPAR GGGSVGSDVG
60 70 80 90 100
QRLPVEDFSL DSSLSQVQVE FYVNENTFKE RLKLFFIKNQ RSSLRIRLFN
110 120 130 140 150
FSLKLLTCLL YIVRVLLDDP ALGIGCWGCP KQNYSFNDSS SEINWAPILW
160 170 180 190 200
VERKMTLWAI QVIVAIISFL ETMLLIYLSY KGNIWEQIFR VSFVLEMINT
210 220 230 240 250
LPFIITIFWP PLRNLFIPVF LNCWLAKHAL ENMINDFHRA ILRTQSAMFN
260 270 280 290 300
QVLILFCTLL CLVFTGTCGI QHLERAGENL SLLTSFYFCI VTFSTVGYGD
310 320 330 340 350
VTPKIWPSQL LVVIMICVAL VVLPLQFEEL VYLWMERQKS GGNYSRHRAQ
360 370 380 390 400
TEKHVVLCVS SLKIDLLMDF LNEFYAHPRL QDYYVVILCP TEMDVQVRRV
410 420 430 440 450
LQIPLWSQRV IYLQGSALKD QDLMRAKMDN GEACFILSSR NEVDRTAADH
460 470 480 490 500
QTILRAWAVK DFAPNCPLYV QILKPENKFH VKFADHVVCE EECKYAMLAL
510 520 530 540 550
NCICPATSTL ITLLVHTSRG QEGQESPEQW QRMYGRCSGN EVYHIRMGDS
560 570 580 590 600
KFFREYEGKS FTYAAFHAHK KYGVCLIGLK REDNKSILLN PGPRHILAAS
610 620 630 640 650
DTCFYINITK EENSAFIFKQ EEKRKKRAFS GQGLHEGPAR LPVHSIIASM
660 670 680 690 700
GTVAMDLQGT EHRPTQSGGG GGGSKLALPT ENGSGSRRPS IAPVLELADS
710 720 730 740 750
SALLPCDLLS DQSEDEVTPS DDEGLSVVEY VKGYPPNSPY IGSSPTLCHL
760 770 780 790 800
LPVKAPFCCL RLDKGCKHNS YEDAKAYGFK NKLIIVSAET AGNGLYNFIV
810 820 830 840 850
PLRAYYRSRK ELNPIVLLLD NKPDHHFLEA ICCFPMVYYM EGSVDNLDSL
860 870 880 890 900
LQCGIIYADN LVVVDKESTM SAEEDYMADA KTIVNVQTMF RLFPSLSITT
910 920 930 940 950
ELTHPSNMRF MQFRAKDSYS LALSKLEKRE RENGSNLAFM FRLPFAAGRV
960 970 980 990 1000
FSISMLDTLL YQSFVKDYMI TITRLLLGLD TTPGSGYLCA MKITEGDLWI
1010 1020 1030 1040 1050
RTYGRLFQKL CSSSAEIPIG IYRTESHVFS TSESQISVNV EDCEDTREVK
1060 1070 1080 1090 1100
GPWGSRAGTG GSSQGRHTGG GDPAEHPLLR RKSLQWARRL SRKAPKQAGR
1110 1120 1130 1140 1150
AAAAEWISQQ RLSLYRRSER QELSELVKNR MKHLGLPTTG YEDVANLTAS
1160 1170 1180 1190 1200
DVMNRVNLGY LQDEMNDHQN TLSYVLINPP PDTRLEPSDI VYLIRSDPLA
1210 1220 1230
HVASSSQSRK SSCSHKLSSC NPETRDETQL
Note: No experimental confirmation available.
Length:1,230
Mass (Da):138,343
Last modified:August 30, 2005 - v2
Checksum:i482D70015434493E
GO
Isoform 2 (identifier: Q5JUK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MARAKLPRSP...DFSLDSSLSQ → MPLPDGARTP...GDPSFQNDDR
     1033-1033: E → EPHDLRAQ

Note: No experimental confirmation available.
Show »
Length:1,256
Mass (Da):142,004
Checksum:iD6F9FCC8D1383EE6
GO
Isoform 3 (identifier: Q5JUK3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MARAKLPRSP...DFSLDSSLSQ → MPLPDGARTP...GDPSFQNDDR
     1033-1033: E → EPHDLRAQ
     1142-1162: Missing.

Note: No experimental confirmation available.
Show »
Length:1,235
Mass (Da):139,700
Checksum:iAACACE2A0A39A693
GO
Isoform 4 (identifier: Q5JUK3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: MARAKLPRSP...DFSLDSSLSQ → MPLPDGARTP...EFDDGQCAPR
     266-266: G → GGCR
     1033-1033: E → EPHDLRAQ

Note: No experimental confirmation available.
Show »
Length:1,211
Mass (Da):136,987
Checksum:i781214BF3727177C
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J9Y7C9J9Y7_HUMAN
Potassium channel subfamily T membe...
KCNT1
1,217Annotation score:
C9JAX7C9JAX7_HUMAN
Potassium channel subfamily T membe...
KCNT1
1,235Annotation score:
C9JYL2C9JYL2_HUMAN
Potassium channel subfamily T membe...
KCNT1
1,216Annotation score:
A0A0R4J2E0A0A0R4J2E0_HUMAN
Potassium channel subfamily T membe...
KCNT1
1,223Annotation score:
A0A0D9SEY3A0A0D9SEY3_HUMAN
Potassium channel subfamily T membe...
KCNT1
1,237Annotation score:
A0A0D9SFC8A0A0D9SFC8_HUMAN
Potassium channel subfamily T membe...
KCNT1
1,201Annotation score:
C9JBV2C9JBV2_HUMAN
Potassium channel subfamily T membe...
KCNT1
285Annotation score:
F8WC49F8WC49_HUMAN
Potassium channel subfamily T membe...
KCNT1
122Annotation score:
A0A0D9SFR1A0A0D9SFR1_HUMAN
Potassium channel subfamily T membe...
KCNT1
177Annotation score:
A0A1B0GWC7A0A1B0GWC7_HUMAN
Potassium channel subfamily T membe...
KCNT1
53Annotation score:
There is more potential isoformShow all

Sequence cautioni

The sequence BAA92660 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107T → I in BAG54469 (PubMed:14702039).Curated1
Sequence conflicti498L → P in BAG54469 (PubMed:14702039).Curated1
Sequence conflicti615A → V in AAI71770 (PubMed:15489334).Curated1
Sequence conflicti822K → E in BAG54469 (PubMed:14702039).Curated1
Sequence conflicti969M → K in BAG54469 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078683269G → S in EIEE14. 2 PublicationsCorresponds to variant dbSNP:rs587777264Ensembl.1
Natural variantiVAR_069311379R → Q in ENFL5. 1 PublicationCorresponds to variant dbSNP:rs397515407Ensembl.1
Natural variantiVAR_069312409R → Q in EIEE14; gain-of-function mutation. 1 PublicationCorresponds to variant dbSNP:rs397515402Ensembl.1
Natural variantiVAR_069313455R → H in EIEE14. 1 PublicationCorresponds to variant dbSNP:rs397515404Ensembl.1
Natural variantiVAR_078214497M → V in EIEE14. 1 PublicationCorresponds to variant dbSNP:rs886041691Ensembl.1
Natural variantiVAR_078641562T → I in EIEE14; unknown pathological significance. 1 Publication1
Natural variantiVAR_069314741I → M in EIEE14. 1 PublicationCorresponds to variant dbSNP:rs370521183Ensembl.1
Natural variantiVAR_069315777Y → H in ENFL5. 1 PublicationCorresponds to variant dbSNP:rs397515406Ensembl.1
Natural variantiVAR_069316877M → I in ENFL5. 1 PublicationCorresponds to variant dbSNP:rs797044544Ensembl.1
Natural variantiVAR_078684877M → K in EIEE14; unknown pathological significance. 1 Publication1
Natural variantiVAR_069317909R → C in ENFL5. 1 PublicationCorresponds to variant dbSNP:rs397515405Ensembl.1
Natural variantiVAR_069318915A → T in EIEE14; gain-of-function mutation. 2 PublicationsCorresponds to variant dbSNP:rs397515403Ensembl.1
Natural variantiVAR_078215928K → E in EIEE14. 1 PublicationCorresponds to variant dbSNP:rs1057519544Ensembl.1
Natural variantiVAR_078685947A → T in EIEE14; variant homologue in rat has increased channel activity upon positive potentials. 1 Publication1
Natural variantiVAR_0786421088R → Q in EIEE14; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs758311066Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0154701 – 66MARAK…SSLSQ → MPLPDGARTPGGVCREARGG GYTNRTFEFDDGQCAPRRPC AGDGALLDTAGFKMSDLDSE VLPLPPRYRFRDLLLGDPSF QNDDR in isoform 2 and isoform 3. 2 PublicationsAdd BLAST66
Alternative sequenceiVSP_0557001 – 66MARAK…SSLSQ → MPLPDGARTPGGVCREARGG GYTNRTFEFDDGQCAPR in isoform 4. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_055701266G → GGCR in isoform 4. 1 Publication1
Alternative sequenceiVSP_0154711033E → EPHDLRAQ in isoform 2, isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_0444761142 – 1162Missing in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127272 mRNA Translation: BAG54469.1
AL158822 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88180.1
BC136618 mRNA Translation: AAI36619.1
BC171770 mRNA Translation: AAI71770.1
AB037843 mRNA Translation: BAA92660.1 Different initiation.
CCDSiCCDS35175.2 [Q5JUK3-3]
CCDS65188.1 [Q5JUK3-4]
RefSeqiNP_001258932.1, NM_001272003.1 [Q5JUK3-4]
NP_065873.2, NM_020822.2 [Q5JUK3-3]
UniGeneiHs.104950

Genome annotation databases

EnsembliENST00000371757; ENSP00000360822; ENSG00000107147 [Q5JUK3-3]
ENST00000487664; ENSP00000417851; ENSG00000107147 [Q5JUK3-2]
ENST00000488444; ENSP00000419007; ENSG00000107147 [Q5JUK3-1]
ENST00000628528; ENSP00000486374; ENSG00000107147 [Q5JUK3-4]
GeneIDi57582
KEGGihsa:57582
UCSCiuc011mdq.3 human [Q5JUK3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127272 mRNA Translation: BAG54469.1
AL158822 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88180.1
BC136618 mRNA Translation: AAI36619.1
BC171770 mRNA Translation: AAI71770.1
AB037843 mRNA Translation: BAA92660.1 Different initiation.
CCDSiCCDS35175.2 [Q5JUK3-3]
CCDS65188.1 [Q5JUK3-4]
RefSeqiNP_001258932.1, NM_001272003.1 [Q5JUK3-4]
NP_065873.2, NM_020822.2 [Q5JUK3-3]
UniGeneiHs.104950

3D structure databases

ProteinModelPortaliQ5JUK3
SMRiQ5JUK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360822

Chemistry databases

GuidetoPHARMACOLOGYi385

PTM databases

iPTMnetiQ5JUK3
PhosphoSitePlusiQ5JUK3

Polymorphism and mutation databases

BioMutaiKCNT1
DMDMi73920089

Proteomic databases

PaxDbiQ5JUK3
PeptideAtlasiQ5JUK3
PRIDEiQ5JUK3
ProteomicsDBi63278
63279 [Q5JUK3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371757; ENSP00000360822; ENSG00000107147 [Q5JUK3-3]
ENST00000487664; ENSP00000417851; ENSG00000107147 [Q5JUK3-2]
ENST00000488444; ENSP00000419007; ENSG00000107147 [Q5JUK3-1]
ENST00000628528; ENSP00000486374; ENSG00000107147 [Q5JUK3-4]
GeneIDi57582
KEGGihsa:57582
UCSCiuc011mdq.3 human [Q5JUK3-1]

Organism-specific databases

CTDi57582
DisGeNETi57582
EuPathDBiHostDB:ENSG00000107147.11
GeneCardsiKCNT1
HGNCiHGNC:18865 KCNT1
HPAiHPA059880
MalaCardsiKCNT1
MIMi608167 gene
614959 phenotype
615005 phenotype
neXtProtiNX_Q5JUK3
OpenTargetsiENSG00000107147
Orphaneti98784 Autosomal dominant nocturnal frontal lobe epilepsy
293181 Malignant migrating partial seizures of infancy
PharmGKBiPA38725
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3193 Eukaryota
ENOG410XSMA LUCA
GeneTreeiENSGT00530000063026
HOGENOMiHOG000231460
HOVERGENiHBG055190
InParanoidiQ5JUK3
KOiK04946
OMAiCFPMVYF
OrthoDBiEOG091G011O
PhylomeDBiQ5JUK3
TreeFamiTF314283

Miscellaneous databases

ChiTaRSiKCNT1 human
GeneWikiiKCNT1
GenomeRNAii57582
PROiPR:Q5JUK3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107147 Expressed in 100 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_KCNT1
ExpressionAtlasiQ5JUK3 baseline and differential
GenevisibleiQ5JUK3 HS

Family and domain databases

InterProiView protein in InterPro
IPR003929 K_chnl_BK_asu
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF07885 Ion_trans_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNT1_HUMAN
AccessioniPrimary (citable) accession number: Q5JUK3
Secondary accession number(s): B3KXF7
, B7ZVY4, B9EGP2, G5E9V0, Q9P2C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: September 12, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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