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Protein

Cilia- and flagella-associated protein 157

Gene

CFAP157

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 157Curated
Gene namesi
Name:CFAP157Imported
Synonyms:C9orf117Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000160401.14
HGNCiHGNC:27843 CFAP157
neXtProtiNX_Q5JU67

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160401
PharmGKBiPA134929148

Polymorphism and mutation databases

BioMutaiC9orf117
DMDMi74742270

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003072241 – 520Cilia- and flagella-associated protein 157Add BLAST520

Proteomic databases

EPDiQ5JU67
PaxDbiQ5JU67
PeptideAtlasiQ5JU67
PRIDEiQ5JU67
ProteomicsDBi63255
63256 [Q5JU67-2]

PTM databases

iPTMnetiQ5JU67
PhosphoSitePlusiQ5JU67

Expressioni

Gene expression databases

BgeeiENSG00000160401 Expressed in 122 organ(s), highest expression level in right uterine tube
CleanExiHS_C9orf117
ExpressionAtlasiQ5JU67 baseline and differential
GenevisibleiQ5JU67 HS

Organism-specific databases

HPAiHPA021474
HPA021786

Interactioni

Subunit structurei

Interacts with TUBB and TUBA4A. Interacts with CEP350.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130334, 1 interactor
IntActiQ5JU67, 1 interactor
MINTiQ5JU67
STRINGi9606.ENSP00000362392

Structurei

3D structure databases

ProteinModelPortaliQ5JU67
SMRiQ5JU67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili33 – 189Sequence analysisAdd BLAST157
Coiled coili236 – 372Sequence analysisAdd BLAST137

Sequence similaritiesi

Belongs to the CFAP157 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE36 Eukaryota
ENOG410YBVK LUCA
GeneTreeiENSGT00730000111240
HOGENOMiHOG000098302
HOVERGENiHBG107684
InParanoidiQ5JU67
OMAiKWDELAV
OrthoDBiEOG091G08D6
PhylomeDBiQ5JU67
TreeFamiTF329637

Family and domain databases

InterProiView protein in InterPro
IPR038844 CFAP157
PANTHERiPTHR31954 PTHR31954, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JU67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPKKSVSKA GKELEVKKKG GKKEPVVAVE PPLAKEMKEF YHIQIRDLED
60 70 80 90 100
RLARYQRKWD ELAVQEKMFR QEFEQLANNK KEIVAFLKRT LNQQVDEITD
110 120 130 140 150
LNEQLQNLQL AKEMEKDAFE AQLAQVRHEF QETKDQLTTE NIILGGKLAA
160 170 180 190 200
LEEFRLQKEE VTDKFTLLEE QVRKQENEFR DYAYNLEKKS VLDKDRLRKE
210 220 230 240 250
IIQRVNLVAN EFHKVTTNRM WETTKRAIKE NNGITLQMAR VSQQGMKLLQ
260 270 280 290 300
ENEQLKGRQN NLCKQLELLE NTQKVMARHK RGHQKIILML TKKCQEQQQD
310 320 330 340 350
TKEAEELRLL LSQLEQRSLQ LQVDNQALKS QRDQLSLQLE QQQVDLQRLQ
360 370 380 390 400
QELANEQKVR ASLEAALVQA TSFLQNILQM HRDEEDSDVD VTFQPWHKEM
410 420 430 440 450
LQQLLVMLSS TVATRPQKAA CPHQESQSHG PPKESRPSIQ LPRTGSLLPQ
460 470 480 490 500
LSDITPYQPG DLGLVPRQVH IPPNPQDLRL LSYITRVGTF RAHSSPEMRA
510 520
PGSLKRLEKF SLPEVPLRPK
Length:520
Mass (Da):60,533
Last modified:February 15, 2005 - v1
Checksum:iF9197B78E37615EA
GO
Isoform 2 (identifier: Q5JU67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-425: MHRDEEDSDV...PQKAACPHQE → TGKTSWKWAL...TAMKRTVTLT
     426-520: Missing.

Note: No experimental confirmation available.
Show »
Length:425
Mass (Da):49,868
Checksum:i9E63FB8FB7035825
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LP78A0A096LP78_HUMAN
Cilia- and flagella-associated prot...
CFAP157
137Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050845483Y → S. Corresponds to variant dbSNP:rs497632Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028641380 – 425MHRDE…CPHQE → TGKTSWKWALRLEFPGRGWV LGPLWACCHPTLTNRCTAMK RTVTLT in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_028642426 – 520Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162426 Genomic DNA No translation available.
BC141809 mRNA Translation: AAI41810.1
CCDSiCCDS43878.1 [Q5JU67-1]
RefSeqiNP_001012520.2, NM_001012502.2 [Q5JU67-1]
UniGeneiHs.652519

Genome annotation databases

EnsembliENST00000373295; ENSP00000362392; ENSG00000160401 [Q5JU67-1]
ENST00000614677; ENSP00000478313; ENSG00000160401 [Q5JU67-2]
GeneIDi286207
KEGGihsa:286207
UCSCiuc004brn.2 human [Q5JU67-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162426 Genomic DNA No translation available.
BC141809 mRNA Translation: AAI41810.1
CCDSiCCDS43878.1 [Q5JU67-1]
RefSeqiNP_001012520.2, NM_001012502.2 [Q5JU67-1]
UniGeneiHs.652519

3D structure databases

ProteinModelPortaliQ5JU67
SMRiQ5JU67
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130334, 1 interactor
IntActiQ5JU67, 1 interactor
MINTiQ5JU67
STRINGi9606.ENSP00000362392

PTM databases

iPTMnetiQ5JU67
PhosphoSitePlusiQ5JU67

Polymorphism and mutation databases

BioMutaiC9orf117
DMDMi74742270

Proteomic databases

EPDiQ5JU67
PaxDbiQ5JU67
PeptideAtlasiQ5JU67
PRIDEiQ5JU67
ProteomicsDBi63255
63256 [Q5JU67-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373295; ENSP00000362392; ENSG00000160401 [Q5JU67-1]
ENST00000614677; ENSP00000478313; ENSG00000160401 [Q5JU67-2]
GeneIDi286207
KEGGihsa:286207
UCSCiuc004brn.2 human [Q5JU67-1]

Organism-specific databases

CTDi286207
EuPathDBiHostDB:ENSG00000160401.14
GeneCardsiCFAP157
HGNCiHGNC:27843 CFAP157
HPAiHPA021474
HPA021786
neXtProtiNX_Q5JU67
OpenTargetsiENSG00000160401
PharmGKBiPA134929148
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE36 Eukaryota
ENOG410YBVK LUCA
GeneTreeiENSGT00730000111240
HOGENOMiHOG000098302
HOVERGENiHBG107684
InParanoidiQ5JU67
OMAiKWDELAV
OrthoDBiEOG091G08D6
PhylomeDBiQ5JU67
TreeFamiTF329637

Miscellaneous databases

GenomeRNAii286207
PROiPR:Q5JU67

Gene expression databases

BgeeiENSG00000160401 Expressed in 122 organ(s), highest expression level in right uterine tube
CleanExiHS_C9orf117
ExpressionAtlasiQ5JU67 baseline and differential
GenevisibleiQ5JU67 HS

Family and domain databases

InterProiView protein in InterPro
IPR038844 CFAP157
PANTHERiPTHR31954 PTHR31954, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCF157_HUMAN
AccessioniPrimary (citable) accession number: Q5JU67
Secondary accession number(s): A5D8T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 15, 2005
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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