UniProtKB - Q5JU00 (DRC5_HUMAN)
Protein
Dynein regulatory complex subunit 5
Gene
TCTE1
Organism
Homo sapiens (Human)
Status
Functioni
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.By similarity
GO - Biological processi
- flagellated sperm motility Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q5JU00 |
Names & Taxonomyi
Protein namesi | Recommended name: Dynein regulatory complex subunit 5By similarityAlternative name(s): T-complex-associated testis-expressed protein 1 Short name: Tcte-1 |
Gene namesi | Name:TCTE1 Synonyms:DRC5By similarity |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000146221.9 |
HGNCi | HGNC:11693, TCTE1 |
MIMi | 186975, gene |
neXtProti | NX_Q5JU00 |
Subcellular locationi
Cytoskeleton
- flagellum axoneme By similarity
Other locations
- flagellum By similarity
Note: Detected along the length of the sperm flagellum.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-KW
Other locations
- cytoplasm Source: UniProtKB-KW
- sperm flagellum Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, FlagellumPathology & Biotechi
Organism-specific databases
DisGeNETi | 202500 |
OpenTargetsi | ENSG00000146221 |
PharmGKBi | PA36413 |
Miscellaneous databases
Pharosi | Q5JU00, Tdark |
Polymorphism and mutation databases
BioMutai | TCTE1 |
DMDMi | 74755678 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000326525 | 1 – 501 | Dynein regulatory complex subunit 5Add BLAST | 501 |
Proteomic databases
MassIVEi | Q5JU00 |
PaxDbi | Q5JU00 |
PeptideAtlasi | Q5JU00 |
PRIDEi | Q5JU00 |
ProteomicsDBi | 63246 |
PTM databases
iPTMneti | Q5JU00 |
PhosphoSitePlusi | Q5JU00 |
Expressioni
Gene expression databases
Bgeei | ENSG00000146221, Expressed in testis and 81 other tissues |
ExpressionAtlasi | Q5JU00, baseline and differential |
Genevisiblei | Q5JU00, HS |
Organism-specific databases
HPAi | ENSG00000146221, Group enriched (fallopian tube, testis) |
Interactioni
Subunit structurei
Component of the nexin-dynein regulatory complex (N-DRC).
Interacts with FBXL13/DRC6, DRC3 and DRC7.
By similarityProtein-protein interaction databases
IntActi | Q5JU00, 80 interactors |
STRINGi | 9606.ENSP00000360560 |
Miscellaneous databases
RNActi | Q5JU00, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 308 – 321 | LRR 1Add BLAST | 14 | |
Repeati | 335 – 355 | LRR 2Add BLAST | 21 | |
Repeati | 363 – 383 | LRR 3Add BLAST | 21 | |
Repeati | 391 – 411 | LRR 4Add BLAST | 21 | |
Repeati | 419 – 439 | LRR 5Add BLAST | 21 |
Sequence similaritiesi
Belongs to the DRC5 family.Curated
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000159341 |
HOGENOMi | CLU_029623_1_0_1 |
InParanoidi | Q5JU00 |
OMAi | LFMMLIC |
OrthoDBi | 519026at2759 |
PhylomeDBi | Q5JU00 |
TreeFami | TF325870 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13516, LRR_6, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5JU00-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQDTVTTSAL LDPSHSSVST QDNSSTGGHT SSTSPQLSKP SITPVPAKSR
60 70 80 90 100
NPHPRANIRR MRRIIAEDPE WSLAIVPLLT ELCIQHIIRN FQKNPILKQM
110 120 130 140 150
LPEHQQKVLN HLSPDLPLAV TANLIDSENY WLRCCMHRWP VCHVAHHGGS
160 170 180 190 200
WKRMFFERHL ENLLKHFIPG TTDPAVILDL LPLCRNYVRR VHVDQFLPPV
210 220 230 240 250
QLPAQLRPGD QSDSGSEGEM EEPTVDHYQL GDLVAGLSHL EELDLVYDVK
260 270 280 290 300
DCGMNFEWNL FLFTYRDCLS LAAAIKACHT LKIFKLTRSK VDDDKARIII
310 320 330 340 350
RSLLDHPVLE ELDLSQNLIG DRGARGAAKL LSHSRLRVLN LANNQVRAPG
360 370 380 390 400
AQSLAHALAH NTNLISLNLR LNCIEDEGGQ ALAHALQTNK CLTTLHLGGN
410 420 430 440 450
ELSEPTATLL SQVLAINTTL TSINLSCNHI GLDGGKQLLE GMSDNKTLLE
460 470 480 490 500
FDLRLSDVAQ ESEYLIGQAL YANREAARQR ALNPSHFMST ITANGPENSV
G
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5JU01 | Q5JU01_HUMAN | Dynein regulatory complex subunit 5 | TCTE1 | 198 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040073 | 35 | P → L2 PublicationsCorresponds to variant dbSNP:rs324146Ensembl. | 1 | |
Natural variantiVAR_040074 | 53 | H → R1 PublicationCorresponds to variant dbSNP:rs17853373Ensembl. | 1 | |
Natural variantiVAR_040075 | 261 | F → S. Corresponds to variant dbSNP:rs2297336Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK301825 mRNA Translation: BAG63271.1 AL353588 Genomic DNA No translation available. BC035022 mRNA Translation: AAH35022.1 |
CCDSi | CCDS4910.1 |
RefSeqi | NP_872345.2, NM_182539.3 XP_005248929.1, XM_005248872.1 XP_011512638.1, XM_011514336.2 XP_011512640.1, XM_011514338.2 |
Genome annotation databases
Ensembli | ENST00000371505; ENSP00000360560; ENSG00000146221 |
GeneIDi | 202500 |
KEGGi | hsa:202500 |
UCSCi | uc003oxi.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK301825 mRNA Translation: BAG63271.1 AL353588 Genomic DNA No translation available. BC035022 mRNA Translation: AAH35022.1 |
CCDSi | CCDS4910.1 |
RefSeqi | NP_872345.2, NM_182539.3 XP_005248929.1, XM_005248872.1 XP_011512638.1, XM_011514336.2 XP_011512640.1, XM_011514338.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q5JU00, 80 interactors |
STRINGi | 9606.ENSP00000360560 |
PTM databases
iPTMneti | Q5JU00 |
PhosphoSitePlusi | Q5JU00 |
Polymorphism and mutation databases
BioMutai | TCTE1 |
DMDMi | 74755678 |
Proteomic databases
MassIVEi | Q5JU00 |
PaxDbi | Q5JU00 |
PeptideAtlasi | Q5JU00 |
PRIDEi | Q5JU00 |
ProteomicsDBi | 63246 |
Protocols and materials databases
Antibodypediai | 30669, 72 antibodies |
DNASUi | 202500 |
Genome annotation databases
Ensembli | ENST00000371505; ENSP00000360560; ENSG00000146221 |
GeneIDi | 202500 |
KEGGi | hsa:202500 |
UCSCi | uc003oxi.3, human |
Organism-specific databases
CTDi | 202500 |
DisGeNETi | 202500 |
EuPathDBi | HostDB:ENSG00000146221.9 |
GeneCardsi | TCTE1 |
HGNCi | HGNC:11693, TCTE1 |
HPAi | ENSG00000146221, Group enriched (fallopian tube, testis) |
MIMi | 186975, gene |
neXtProti | NX_Q5JU00 |
OpenTargetsi | ENSG00000146221 |
PharmGKBi | PA36413 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000159341 |
HOGENOMi | CLU_029623_1_0_1 |
InParanoidi | Q5JU00 |
OMAi | LFMMLIC |
OrthoDBi | 519026at2759 |
PhylomeDBi | Q5JU00 |
TreeFami | TF325870 |
Enzyme and pathway databases
PathwayCommonsi | Q5JU00 |
Miscellaneous databases
BioGRID-ORCSi | 202500, 18 hits in 840 CRISPR screens |
GenomeRNAii | 202500 |
Pharosi | Q5JU00, Tdark |
PROi | PR:Q5JU00 |
RNActi | Q5JU00, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000146221, Expressed in testis and 81 other tissues |
ExpressionAtlasi | Q5JU00, baseline and differential |
Genevisiblei | Q5JU00, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF13516, LRR_6, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DRC5_HUMAN | |
Accessioni | Q5JU00Primary (citable) accession number: Q5JU00 Secondary accession number(s): B4DX59, Q8IYS6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | February 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations