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Entry version 130 (10 Feb 2021)
Sequence version 1 (15 Feb 2005)
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Protein

Centrosomal protein of 78 kDa

Gene

CEP78

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242). May play a role in cilium biogenesis (PubMed:27588451).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5JTW2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-8854518, AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 78 kDa
Short name:
Cep78
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP78
Synonyms:C9orf81
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25740, CEP78

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617110, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5JTW2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000148019.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cone-rod dystrophy and hearing loss 1 (CRDHL1)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease defined by the association of progressive cone-rod dystrophy with sensorineural hearing loss. Cone-rod dystrophy is characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors.
Related information in OMIM

Keywords - Diseasei

Ciliopathy, Cone-rod dystrophy, Deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
84131

MalaCards human disease database

More...
MalaCardsi
CEP78
MIMi617236, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000148019

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
231183, Usher syndrome type 3

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134937066

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5JTW2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CEP78

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74742229

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002919521 – 689Centrosomal protein of 78 kDaAdd BLAST689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei325PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5JTW2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5JTW2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5JTW2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5JTW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5JTW2

PeptideAtlas

More...
PeptideAtlasi
Q5JTW2

PRoteomics IDEntifications database

More...
PRIDEi
Q5JTW2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20620
63235 [Q5JTW2-1]
63236 [Q5JTW2-2]
63237 [Q5JTW2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5JTW2

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q5JTW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5JTW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:27588451, PubMed:27588452). Expressed in different retinal cell types with higher expression in cone compared to rod cells (at protein level) (PubMed:27588452).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is cell cycle-dependent, with low levels in mitosis. The expression starts to increase during late G1 until the S/G2 transition (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148019, Expressed in secondary oocyte and 195 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5JTW2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5JTW2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000148019, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PLK4 (PubMed:27246242).

Interacts with FAM161A (PubMed:27588451).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123903, 49 interactors

Protein interaction database and analysis system

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IntActi
Q5JTW2, 26 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365782

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5JTW2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili450 – 505Sequence analysisAdd BLAST56

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP78 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4308, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000013287

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021273_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5JTW2

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSKDMTF

Database of Orthologous Groups

More...
OrthoDBi
982225at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5JTW2

TreeFam database of animal gene trees

More...
TreeFami
TF328928

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026212, Cep78
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516, LRR_6, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02062, CENTROSOME78

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JTW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIDSVKLRRD SAADFFSHYE YLCALQNSVP LPAVRACLRE GVLDFNADRL
60 70 80 90 100
RGVDWAPLLS TLKINKDLPL VSIKSFFQPW LGDTGSDMNK FCRSRVPAIR
110 120 130 140 150
YKDVTFQLCK ALKGCLSISS VLKNLELNGL ILRERDLTIL AKGLNKSASL
160 170 180 190 200
VHLSLANCPI GDGGLEIICQ GIKSSITLKT VNFTGCNLTW QGADHMAKIL
210 220 230 240 250
KYQTMRRHEE TWAESLRYRR PDLDCMAGLR RITLNCNTLI GDLGACAFAD
260 270 280 290 300
SLSEDLWLRA LDLQQCGLTN EGAKALLEAL ETNTTLVVLD IRKNPLIDHS
310 320 330 340 350
MMKAVIKKVL QNGRSAKSEY QWITSPSVKE PSKTAKQKRR TIILGSGHKG
360 370 380 390 400
KATIRIGLAT KKPVSSGRKH SLGKEYYAPA PLPPGVSGFL PWRTAERAKR
410 420 430 440 450
HRGFPLIKTR DICNQLQQPG FPVTVTVESP SSSEVEEVDD SSESVHEVPE
460 470 480 490 500
KTSIEQEALQ EKLEECLKQL KEERVIRLKV DKRVSELEHE NAQLRNINFS
510 520 530 540 550
LSEALHAQSL TNMILDDEGV LGSIENSFQK FHAFLDLLKD AGLGQLATMA
560 570 580 590 600
GIDQSDFQLL GHPQMTSTVS NPPKEEKKAL EDEKPEPKQN ALGQMQNIQF
610 620 630 640 650
QKITGDARIP LPLDSFPVPV STPEGLGTSS NNLGVPATEQ RQESFEGFIA
660 670 680
RMCSPSPDAT SGTGSQRKEE ELSRNSRSSS EKKTKTESH
Length:689
Mass (Da):76,396
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FEEE6542F8E4F5F
GO
Isoform 2 (identifier: Q5JTW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-356: I → IV
     599-599: Q → QVSICMQSAYNEGTLMK
     687-689: ESH → GEYTKKHSDKQHPGKDLHS

Show »
Length:722
Mass (Da):80,074
Checksum:i747ACCD87DB5D60E
GO
Isoform 3 (identifier: Q5JTW2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     599-599: Q → QVSICMQSAYNEGTLMK

Show »
Length:705
Mass (Da):78,153
Checksum:i96D85522FD74506A
GO
Isoform 4 (identifier: Q5JTW2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-356: I → IV
     687-689: ESH → GEYTKKHSDKQHPGKDLHS

Show »
Length:706
Mass (Da):78,317
Checksum:i4D194C3FE5E69CB7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MST6A8MST6_HUMAN
Centrosomal protein of 78 kDa
CEP78
705Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y432A0A2R8Y432_HUMAN
Centrosomal protein of 78 kDa
CEP78
717Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4C1A0A2R8Y4C1_HUMAN
Centrosomal protein of 78 kDa
CEP78
685Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y589A0A2R8Y589_HUMAN
Centrosomal protein of 78 kDa
CEP78
673Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5W6A0A2R8Y5W6_HUMAN
Centrosomal protein of 78 kDa
CEP78
711Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7A4A0A2R8Y7A4_HUMAN
Centrosomal protein of 78 kDa
CEP78
727Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7U5A0A2R8Y7U5_HUMAN
Centrosomal protein of 78 kDa
CEP78
696Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCP0A0A2R8YCP0_HUMAN
Centrosomal protein of 78 kDa
CEP78
721Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TZI9A0A2U3TZI9_HUMAN
Centrosomal protein of 78 kDa
CEP78
711Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFB0A0A2R8YFB0_HUMAN
Centrosomal protein of 78 kDa
CEP78
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH91515 differs from that shown. Probable intron retention.Curated
The sequence AAH91515 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49R → G in AAI28059 (PubMed:15489334).Curated1
Sequence conflicti173K → R in AAI28059 (PubMed:15489334).Curated1
Sequence conflicti236 – 237CN → GY in BAB14190 (PubMed:14702039).Curated2
Sequence conflicti451K → R in BAB14190 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_026321356I → IV in isoform 2 and isoform 4. 1 Publication1
Alternative sequenceiVSP_026322599Q → QVSICMQSAYNEGTLMK in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_026323687 – 689ESH → GEYTKKHSDKQHPGKDLHS in isoform 2 and isoform 4. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL353705 Genomic DNA No translation available.
BC091515 mRNA Translation: AAH91515.1 Sequence problems.
BC128058 mRNA Translation: AAI28059.1
AK022705 mRNA Translation: BAB14190.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47984.1 [Q5JTW2-2]
CCDS47985.1 [Q5JTW2-5]
CCDS83376.1 [Q5JTW2-3]
CCDS83377.1 [Q5JTW2-1]

NCBI Reference Sequences

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RefSeqi
NP_001092272.1, NM_001098802.1 [Q5JTW2-2]
NP_001317620.1, NM_001330691.1 [Q5JTW2-3]
NP_001317622.1, NM_001330693.1 [Q5JTW2-1]
NP_001317623.1, NM_001330694.1
NP_115547.1, NM_032171.1 [Q5JTW2-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000376597; ENSP00000365782; ENSG00000148019 [Q5JTW2-2]
ENST00000415759; ENSP00000399286; ENSG00000148019 [Q5JTW2-5]
ENST00000424347; ENSP00000411284; ENSG00000148019 [Q5JTW2-1]
ENST00000642669; ENSP00000495681; ENSG00000148019 [Q5JTW2-5]
ENST00000643273; ENSP00000496423; ENSG00000148019 [Q5JTW2-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84131

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84131

UCSC genome browser

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UCSCi
uc004akx.3, human [Q5JTW2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353705 Genomic DNA No translation available.
BC091515 mRNA Translation: AAH91515.1 Sequence problems.
BC128058 mRNA Translation: AAI28059.1
AK022705 mRNA Translation: BAB14190.1
CCDSiCCDS47984.1 [Q5JTW2-2]
CCDS47985.1 [Q5JTW2-5]
CCDS83376.1 [Q5JTW2-3]
CCDS83377.1 [Q5JTW2-1]
RefSeqiNP_001092272.1, NM_001098802.1 [Q5JTW2-2]
NP_001317620.1, NM_001330691.1 [Q5JTW2-3]
NP_001317622.1, NM_001330693.1 [Q5JTW2-1]
NP_001317623.1, NM_001330694.1
NP_115547.1, NM_032171.1 [Q5JTW2-5]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123903, 49 interactors
IntActiQ5JTW2, 26 interactors
STRINGi9606.ENSP00000365782

PTM databases

iPTMnetiQ5JTW2
MetOSiteiQ5JTW2
PhosphoSitePlusiQ5JTW2

Genetic variation databases

BioMutaiCEP78
DMDMi74742229

Proteomic databases

EPDiQ5JTW2
jPOSTiQ5JTW2
MassIVEiQ5JTW2
MaxQBiQ5JTW2
PaxDbiQ5JTW2
PeptideAtlasiQ5JTW2
PRIDEiQ5JTW2
ProteomicsDBi20620
63235 [Q5JTW2-1]
63236 [Q5JTW2-2]
63237 [Q5JTW2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27392, 79 antibodies

Genome annotation databases

EnsembliENST00000376597; ENSP00000365782; ENSG00000148019 [Q5JTW2-2]
ENST00000415759; ENSP00000399286; ENSG00000148019 [Q5JTW2-5]
ENST00000424347; ENSP00000411284; ENSG00000148019 [Q5JTW2-1]
ENST00000642669; ENSP00000495681; ENSG00000148019 [Q5JTW2-5]
ENST00000643273; ENSP00000496423; ENSG00000148019 [Q5JTW2-3]
GeneIDi84131
KEGGihsa:84131
UCSCiuc004akx.3, human [Q5JTW2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84131
DisGeNETi84131

GeneCards: human genes, protein and diseases

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GeneCardsi
CEP78
HGNCiHGNC:25740, CEP78
HPAiENSG00000148019, Low tissue specificity
MalaCardsiCEP78
MIMi617110, gene
617236, phenotype
neXtProtiNX_Q5JTW2
OpenTargetsiENSG00000148019
Orphaneti231183, Usher syndrome type 3
PharmGKBiPA134937066
VEuPathDBiHostDB:ENSG00000148019.12

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4308, Eukaryota
GeneTreeiENSGT00390000013287
HOGENOMiCLU_021273_0_0_1
InParanoidiQ5JTW2
OMAiRSKDMTF
OrthoDBi982225at2759
PhylomeDBiQ5JTW2
TreeFamiTF328928

Enzyme and pathway databases

PathwayCommonsiQ5JTW2
ReactomeiR-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-8854518, AURKA Activation by TPX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84131, 6 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CEP78, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CEP78

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84131
PharosiQ5JTW2, Tbio

Protein Ontology

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PROi
PR:Q5JTW2
RNActiQ5JTW2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148019, Expressed in secondary oocyte and 195 other tissues
ExpressionAtlasiQ5JTW2, baseline and differential
GenevisibleiQ5JTW2, HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR026212, Cep78
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
PfamiView protein in Pfam
PF13516, LRR_6, 2 hits
PRINTSiPR02062, CENTROSOME78

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEP78_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JTW2
Secondary accession number(s): A1A4S8
, E9PHX5, Q5BJE3, Q5JTW0, Q5JTW1, Q9H9N3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: February 15, 2005
Last modified: February 10, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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