Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RRP12-like protein

Gene

RRP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
RRP12-like protein
Gene namesi
Name:RRP12
Synonyms:KIAA0690
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000052749.13
HGNCiHGNC:29100 RRP12
MIMi617723 gene
neXtProtiNX_Q5JTH9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei903 – 923HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23223
OpenTargetsiENSG00000052749
PharmGKBiPA162402122

Polymorphism and mutation databases

BioMutaiRRP12
DMDMi71153787

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507681 – 1297RRP12-like proteinAdd BLAST1297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Cross-linki71Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei72PhosphoserineCombined sources1
Modified residuei77PhosphothreonineCombined sources1
Modified residuei88PhosphothreonineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei1049PhosphoserineCombined sources1
Modified residuei1072PhosphoserineCombined sources1
Modified residuei1080PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5JTH9
MaxQBiQ5JTH9
PaxDbiQ5JTH9
PeptideAtlasiQ5JTH9
PRIDEiQ5JTH9
ProteomicsDBi63219
63220 [Q5JTH9-2]

2D gel databases

SWISS-2DPAGEiQ5JTH9

PTM databases

CarbonylDBiQ5JTH9
iPTMnetiQ5JTH9
PhosphoSitePlusiQ5JTH9
SwissPalmiQ5JTH9

Expressioni

Tissue specificityi

Weakly expressed. Expressed at intermediate level in testis and ovary.1 Publication

Gene expression databases

BgeeiENSG00000052749 Expressed in 186 organ(s), highest expression level in left coronary artery
CleanExiHS_RRP12
ExpressionAtlasiQ5JTH9 baseline and differential
GenevisibleiQ5JTH9 HS

Organism-specific databases

HPAiHPA049945

Interactioni

Protein-protein interaction databases

BioGridi116829, 93 interactors
IntActiQ5JTH9, 38 interactors
MINTiQ5JTH9
STRINGi9606.ENSP00000360031

Structurei

3D structure databases

ProteinModelPortaliQ5JTH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1054 – 1090Glu-richAdd BLAST37

Sequence similaritiesi

Belongs to the RRP12 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1248 Eukaryota
ENOG410XQ3D LUCA
GeneTreeiENSGT00390000013106
HOGENOMiHOG000006643
HOVERGENiHBG080767
InParanoidiQ5JTH9
KOiK14794
OMAiLQWQIWT
OrthoDBiEOG091G00MA
PhylomeDBiQ5JTH9
TreeFamiTF300780

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR012978 Uncharacterised_NUC173
PfamiView protein in Pfam
PF08161 NUC173, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JTH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRSGKLPSG VSAKLKRWKK GHSSDSNPAI CRHRQAARSR FFSRPSGRSD
60 70 80 90 100
LTVDAVKLHN ELQSGSLRLG KSEAPETPME EEAELVLTEK SSGTFLSGLS
110 120 130 140 150
DCTNVTFSKV QRFWESNSAA HKEICAVLAA VTEVIRSQGG KETETEYFAA
160 170 180 190 200
LMTTMEAVES PESLAAVAYL LNLVLKRVPS PVLIKKFSDT SKAFMDIMSA
210 220 230 240 250
QASSGSTSVL RWVLSCLATL LRKQDLEAWG YPVTLQVYHG LLSFTVHPKP
260 270 280 290 300
KIRKAAQHGV CSVLKGSEFM FEKAPAHHPA AISTAKFCIQ EIEKSGGSKE
310 320 330 340 350
ATTTLHMLTL LKDLLPCFPE GLVKSCSETL LRVMTLSHVL VTACAMQAFH
360 370 380 390 400
SLFHARPGLS TLSAELNAQI ITALYDYVPS ENDLQPLLAW LKVMEKAHIN
410 420 430 440 450
LVRLQWDLGL GHLPRFFGTA VTCLLSPHSQ VLTAATQSLK EILKECVAPH
460 470 480 490 500
MADIGSVTSS ASGPAQSVAK MFRAVEEGLT YKFHAAWSSV LQLLCVFFEA
510 520 530 540 550
CGRQAHPVMR KCLQSLCDLR LSPHFPHTAA LDQAVGAAVT SMGPEVVLQA
560 570 580 590 600
VPLEIDGSEE TLDFPRSWLL PVIRDHVQET RLGFFTTYFL PLANTLKSKA
610 620 630 640 650
MDLAQAGSTV ESKIYDTLQW QMWTLLPGFC TRPTDVAISF KGLARTLGMA
660 670 680 690 700
ISERPDLRVT VCQALRTLIT KGCQAEADRA EVSRFAKNFL PILFNLYGQP
710 720 730 740 750
VAAGDTPAPR RAVLETIRTY LTITDTQLVN SLLEKASEKV LDPASSDFTR
760 770 780 790 800
LSVLDLVVAL APCADEAAIS KLYSTIRPYL ESKAHGVQKK AYRVLEEVCA
810 820 830 840 850
SPQGPGALFV QSHLEDLKKT LLDSLRSTSS PAKRPRLKCL LHIVRKLSAE
860 870 880 890 900
HKEFITALIP EVILCTKEVS VGARKNAFAL LVEMGHAFLR FGSNQEEALQ
910 920 930 940 950
CYLVLIYPGL VGAVTMVSCS ILALTHLLFE FKGLMGTSTV EQLLENVCLL
960 970 980 990 1000
LASRTRDVVK SALGFIKVAV TVMDVAHLAK HVQLVMEAIG KLSDDMRRHF
1010 1020 1030 1040 1050
RMKLRNLFTK FIRKFGFELV KRLLPEEYHR VLVNIRKAEA RAKRHRALSQ
1060 1070 1080 1090 1100
AAVEEEEEEE EEEEPAQGKG DSIEEILADS EDEEDNEEEE RSRGKEQRKL
1110 1120 1130 1140 1150
ARQRSRAWLK EGGGDEPLNF LDPKVAQRVL ATQPGPGRGR KKDHGFKVSA
1160 1170 1180 1190 1200
DGRLIIREEA DGNKMEEEEG AKGEDEEMAD PMEDVIIRNK KHQKLKHQKE
1210 1220 1230 1240 1250
AEEEELEIPP QYQAGGSGIH RPVAKKAMPG AEYKAKKAKG DVKKKGRPDP
1260 1270 1280 1290
YAYIPLNRSK LNRRKKMKLQ GQFKGLVKAA RRGSQVGHKN RRKDRRP
Length:1,297
Mass (Da):143,702
Last modified:July 19, 2005 - v2
Checksum:i23A203CBFB7C46D3
GO
Isoform 2 (identifier: Q5JTH9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-251: Missing.

Note: No experimental confirmation available.
Show »
Length:1,197
Mass (Da):132,709
Checksum:i6FBE0C051493D000
GO
Isoform 3 (identifier: Q5JTH9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-212: Missing.

Note: No experimental confirmation available.
Show »
Length:1,236
Mass (Da):137,114
Checksum:i39277064AC555FB5
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1M8H7C1M8_HUMAN
RRP12-like protein
RRP12
64Annotation score:
A0A087X1U8A0A087X1U8_HUMAN
RRP12-like protein
RRP12
176Annotation score:
A0A087X0G0A0A087X0G0_HUMAN
RRP12-like protein
RRP12
106Annotation score:
A0A087WYW2A0A087WYW2_HUMAN
RRP12-like protein
RRP12
32Annotation score:

Sequence cautioni

The sequence BAA31665 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249K → R in BAG59012 (PubMed:14702039).Curated1
Sequence conflicti818K → R in BAG59012 (PubMed:14702039).Curated1
Sequence conflicti1196K → R in BAG59012 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0577561145G → S3 PublicationsCorresponds to variant dbSNP:rs2275580Ensembl.1
Natural variantiVAR_0577571281R → Q2 PublicationsCorresponds to variant dbSNP:rs1048445Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014798152 – 251Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_045674152 – 212Missing in isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014590 mRNA Translation: BAA31665.1 Different initiation.
AK296315 mRNA Translation: BAG59012.1
AL355490 Genomic DNA No translation available.
BC002621 mRNA Translation: AAH02621.3
BC012745 mRNA Translation: AAH12745.1
AL832924 mRNA Translation: CAH10606.1
CCDSiCCDS44467.1 [Q5JTH9-3]
CCDS60605.1 [Q5JTH9-2]
CCDS7457.1 [Q5JTH9-1]
PIRiT00356
RefSeqiNP_001138586.1, NM_001145114.1 [Q5JTH9-3]
NP_001271266.1, NM_001284337.1 [Q5JTH9-2]
NP_055994.2, NM_015179.3 [Q5JTH9-1]
UniGeneiHs.434251

Genome annotation databases

EnsembliENST00000315563; ENSP00000324315; ENSG00000052749 [Q5JTH9-2]
ENST00000370992; ENSP00000360031; ENSG00000052749 [Q5JTH9-1]
ENST00000414986; ENSP00000414863; ENSG00000052749 [Q5JTH9-3]
ENST00000536831; ENSP00000446184; ENSG00000052749 [Q5JTH9-1]
GeneIDi23223
KEGGihsa:23223
UCSCiuc001knf.4 human [Q5JTH9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014590 mRNA Translation: BAA31665.1 Different initiation.
AK296315 mRNA Translation: BAG59012.1
AL355490 Genomic DNA No translation available.
BC002621 mRNA Translation: AAH02621.3
BC012745 mRNA Translation: AAH12745.1
AL832924 mRNA Translation: CAH10606.1
CCDSiCCDS44467.1 [Q5JTH9-3]
CCDS60605.1 [Q5JTH9-2]
CCDS7457.1 [Q5JTH9-1]
PIRiT00356
RefSeqiNP_001138586.1, NM_001145114.1 [Q5JTH9-3]
NP_001271266.1, NM_001284337.1 [Q5JTH9-2]
NP_055994.2, NM_015179.3 [Q5JTH9-1]
UniGeneiHs.434251

3D structure databases

ProteinModelPortaliQ5JTH9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116829, 93 interactors
IntActiQ5JTH9, 38 interactors
MINTiQ5JTH9
STRINGi9606.ENSP00000360031

PTM databases

CarbonylDBiQ5JTH9
iPTMnetiQ5JTH9
PhosphoSitePlusiQ5JTH9
SwissPalmiQ5JTH9

Polymorphism and mutation databases

BioMutaiRRP12
DMDMi71153787

2D gel databases

SWISS-2DPAGEiQ5JTH9

Proteomic databases

EPDiQ5JTH9
MaxQBiQ5JTH9
PaxDbiQ5JTH9
PeptideAtlasiQ5JTH9
PRIDEiQ5JTH9
ProteomicsDBi63219
63220 [Q5JTH9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315563; ENSP00000324315; ENSG00000052749 [Q5JTH9-2]
ENST00000370992; ENSP00000360031; ENSG00000052749 [Q5JTH9-1]
ENST00000414986; ENSP00000414863; ENSG00000052749 [Q5JTH9-3]
ENST00000536831; ENSP00000446184; ENSG00000052749 [Q5JTH9-1]
GeneIDi23223
KEGGihsa:23223
UCSCiuc001knf.4 human [Q5JTH9-1]

Organism-specific databases

CTDi23223
DisGeNETi23223
EuPathDBiHostDB:ENSG00000052749.13
GeneCardsiRRP12
H-InvDBiHIX0009088
HGNCiHGNC:29100 RRP12
HPAiHPA049945
MIMi617723 gene
neXtProtiNX_Q5JTH9
OpenTargetsiENSG00000052749
PharmGKBiPA162402122
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1248 Eukaryota
ENOG410XQ3D LUCA
GeneTreeiENSGT00390000013106
HOGENOMiHOG000006643
HOVERGENiHBG080767
InParanoidiQ5JTH9
KOiK14794
OMAiLQWQIWT
OrthoDBiEOG091G00MA
PhylomeDBiQ5JTH9
TreeFamiTF300780

Miscellaneous databases

ChiTaRSiRRP12 human
GeneWikiiRRP12
GenomeRNAii23223
PROiPR:Q5JTH9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000052749 Expressed in 186 organ(s), highest expression level in left coronary artery
CleanExiHS_RRP12
ExpressionAtlasiQ5JTH9 baseline and differential
GenevisibleiQ5JTH9 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR012978 Uncharacterised_NUC173
PfamiView protein in Pfam
PF08161 NUC173, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRRP12_HUMAN
AccessioniPrimary (citable) accession number: Q5JTH9
Secondary accession number(s): B4DK00
, E9PCK7, Q5JTH8, Q69YK4, Q96E87, Q9BUH3, Q9Y4C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again