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Entry version 111 (02 Jun 2021)
Sequence version 1 (15 Feb 2005)
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Protein

Leucine-rich repeat-containing protein 73

Gene

LRRC73

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5JTD7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 73
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC73
Synonyms:C6orf154
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:21375, LRRC73

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5JTD7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000204052.4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000204052

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134973511

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5JTD7, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC73

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74742140

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002521591 – 316Leucine-rich repeat-containing protein 73Add BLAST316

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5JTD7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5JTD7

PeptideAtlas

More...
PeptideAtlasi
Q5JTD7

PRoteomics IDEntifications database

More...
PRIDEi
Q5JTD7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63217

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5JTD7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5JTD7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204052, Expressed in testis and 124 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5JTD7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204052, Tissue enhanced (brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
128724, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q5JTD7, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361518

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5JTD7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5JTD7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati57 – 78LRR 1Add BLAST22
Repeati86 – 106LRR 2Add BLAST21
Repeati114 – 137LRR 3Add BLAST24
Repeati145 – 166LRR 4Add BLAST22
Repeati174 – 187LRR 5Add BLAST14
Repeati202 – 223LRR 6Add BLAST22
Repeati231 – 250LRR 7Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni257 – 296DisorderedSequence analysisAdd BLAST40

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QSR8, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003256

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_079918_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5JTD7

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSWMCPG

Database of Orthologous Groups

More...
OrthoDBi
1345365at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5JTD7

TreeFam database of animal gene trees

More...
TreeFami
TF328343

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032675, LRR_dom_sf
IPR039984, LRRC73

The PANTHER Classification System

More...
PANTHERi
PTHR24111:SF2, PTHR24111:SF2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5JTD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPSSIQISG EPLSGAEVRD ICRGLRDNAV RLLSLRGCRL CDRDFGRICR
60 70 80 90 100
ALAGATSLAQ LNLNLGVVSS PSRIKQLAEA LRTNRSIQSL FLHGSPLTDA
110 120 130 140 150
GLALLNPALA LHPALVALDL GDCMLGDEAI NLICGLLPPD GAKSGLKELT
160 170 180 190 200
LSANPGITPK GWSRLAIAVA HSSQVRVLNL DYNPLGDHVA GMLAVAVASS
210 220 230 240 250
RTLEVLDLEG TGLTNQSAQT LLDMVENYPT ALRSLVLAEN SISPELQQQI
260 270 280 290 300
CDLLSEGEEE EEVAGGAGDT QEWERGREPA AHQRGSSSWM CPSDPSSQMV
310
LMTSGLGDSL LAETEM
Length:316
Mass (Da):33,409
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i014D6BD27350EDD2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL355802 Genomic DNA No translation available.
BC108661 mRNA Translation: AAI08662.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34456.1

NCBI Reference Sequences

More...
RefSeqi
NP_001012992.1, NM_001012974.2
NP_001258811.1, NM_001271882.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372441; ENSP00000361518; ENSG00000204052

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
221424

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:221424

UCSC genome browser

More...
UCSCi
uc003ovk.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355802 Genomic DNA No translation available.
BC108661 mRNA Translation: AAI08662.1
CCDSiCCDS34456.1
RefSeqiNP_001012992.1, NM_001012974.2
NP_001258811.1, NM_001271882.1

3D structure databases

SMRiQ5JTD7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128724, 21 interactors
IntActiQ5JTD7, 10 interactors
STRINGi9606.ENSP00000361518

PTM databases

iPTMnetiQ5JTD7
PhosphoSitePlusiQ5JTD7

Genetic variation databases

BioMutaiLRRC73
DMDMi74742140

Proteomic databases

MassIVEiQ5JTD7
PaxDbiQ5JTD7
PeptideAtlasiQ5JTD7
PRIDEiQ5JTD7
ProteomicsDBi63217

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
46004, 77 antibodies

The DNASU plasmid repository

More...
DNASUi
221424

Genome annotation databases

EnsembliENST00000372441; ENSP00000361518; ENSG00000204052
GeneIDi221424
KEGGihsa:221424
UCSCiuc003ovk.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
221424

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRC73
HGNCiHGNC:21375, LRRC73
HPAiENSG00000204052, Tissue enhanced (brain, testis)
neXtProtiNX_Q5JTD7
OpenTargetsiENSG00000204052
PharmGKBiPA134973511
VEuPathDBiHostDB:ENSG00000204052.4

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QSR8, Eukaryota
GeneTreeiENSGT00390000003256
HOGENOMiCLU_079918_0_0_1
InParanoidiQ5JTD7
OMAiSSWMCPG
OrthoDBi1345365at2759
PhylomeDBiQ5JTD7
TreeFamiTF328343

Enzyme and pathway databases

PathwayCommonsiQ5JTD7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
221424, 6 hits in 975 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
221424
PharosiQ5JTD7, Tdark

Protein Ontology

More...
PROi
PR:Q5JTD7
RNActiQ5JTD7, protein

Gene expression databases

BgeeiENSG00000204052, Expressed in testis and 124 other tissues
GenevisibleiQ5JTD7, HS

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR032675, LRR_dom_sf
IPR039984, LRRC73
PANTHERiPTHR24111:SF2, PTHR24111:SF2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC73_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JTD7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 15, 2005
Last modified: June 2, 2021
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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