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Protein

Krueppel-like factor 17

Gene

KLF17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri283 – 307C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri313 – 337C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri343 – 365C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 17
Alternative name(s):
Zinc finger protein 393
Gene namesi
Name:KLF17
Synonyms:ZNF393
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171872.4
HGNCiHGNC:18830 KLF17
MIMi609602 gene
neXtProtiNX_Q5JT82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi128209
OpenTargetsiENSG00000171872
PharmGKBiPA134877071

Polymorphism and mutation databases

BioMutaiKLF17
DMDMi74762198

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475551 – 389Krueppel-like factor 17Add BLAST389

Proteomic databases

PaxDbiQ5JT82
PeptideAtlasiQ5JT82
PRIDEiQ5JT82
ProteomicsDBi63203

PTM databases

iPTMnetiQ5JT82
PhosphoSitePlusiQ5JT82

Expressioni

Gene expression databases

BgeeiENSG00000171872 Expressed in 43 organ(s), highest expression level in testis
CleanExiHS_KLF17
ExpressionAtlasiQ5JT82 baseline and differential
GenevisibleiQ5JT82 HS

Organism-specific databases

HPAiHPA024629

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CIB3Q96Q775EBI-10292791,EBI-10292696

Protein-protein interaction databases

BioGridi126099, 1 interactor
IntActiQ5JT82, 1 interactor
STRINGi9606.ENSP00000361373

Structurei

3D structure databases

ProteinModelPortaliQ5JT82
SMRiQ5JT82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri283 – 307C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri313 – 337C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri343 – 365C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000049152
HOVERGENiHBG080136
InParanoidiQ5JT82
KOiK09211
OMAiWSFFRSD
OrthoDBiEOG091G0GDE
PhylomeDBiQ5JT82
TreeFamiTF315506

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5JT82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYGRPQAEME QEAGELSRWQ AAHQAAQDNE NSAPILNMSS SSGSSGVHTS
60 70 80 90 100
WNQGLPSIQH FPHSAEMLGS PLVSVEAPGQ NVNEGGPQFS MPLPERGMSY
110 120 130 140 150
CPQATLTPSR MIYCQRMSPP QQEMTIFSGP QLMPVGEPNI PRVARPFGGN
160 170 180 190 200
LRMPPNGLPV SASTGIPIMS HTGNPPVPYP GLSTVPSDET LLGPTVPSTE
210 220 230 240 250
AQAVLPSMAQ MLPPQDAHDL GMPPAESQSL LVLGSQDSLV SQPDSQEGPF
260 270 280 290 300
LPEQPGPAPQ TVEKNSRPQE GTGRRGSSEA RPYCCNYENC GKAYTKRSHL
310 320 330 340 350
VSHQRKHTGE RPYSCNWESC SWSFFRSDEL RRHMRVHTRY RPYKCDQCSR
360 370 380
EFMRSDHLKQ HQKTHRPGPS DPQANNNNGE QDSPPAAGP
Length:389
Mass (Da):42,577
Last modified:February 15, 2005 - v1
Checksum:i0AA451DB23C2580A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RR65A0A0U1RR65_HUMAN
Krueppel-like factor 17
KLF17
115Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05271935I → N1 PublicationCorresponds to variant dbSNP:rs11210969Ensembl.1
Natural variantiVAR_05272057S → T2 PublicationsCorresponds to variant dbSNP:rs2429051Ensembl.1
Natural variantiVAR_05272180Q → H. Corresponds to variant dbSNP:rs6656945Ensembl.1
Natural variantiVAR_026198156N → S1 PublicationCorresponds to variant dbSNP:rs2485652Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097479 mRNA Translation: BAC05070.1
AL356653 Genomic DNA No translation available.
BC049844 mRNA Translation: AAH49844.1
CCDSiCCDS508.1
RefSeqiNP_775755.3, NM_173484.3
UniGeneiHs.567674
Hs.647667

Genome annotation databases

EnsembliENST00000372299; ENSP00000361373; ENSG00000171872
GeneIDi128209
KEGGihsa:128209
UCSCiuc001clp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097479 mRNA Translation: BAC05070.1
AL356653 Genomic DNA No translation available.
BC049844 mRNA Translation: AAH49844.1
CCDSiCCDS508.1
RefSeqiNP_775755.3, NM_173484.3
UniGeneiHs.567674
Hs.647667

3D structure databases

ProteinModelPortaliQ5JT82
SMRiQ5JT82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126099, 1 interactor
IntActiQ5JT82, 1 interactor
STRINGi9606.ENSP00000361373

PTM databases

iPTMnetiQ5JT82
PhosphoSitePlusiQ5JT82

Polymorphism and mutation databases

BioMutaiKLF17
DMDMi74762198

Proteomic databases

PaxDbiQ5JT82
PeptideAtlasiQ5JT82
PRIDEiQ5JT82
ProteomicsDBi63203

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372299; ENSP00000361373; ENSG00000171872
GeneIDi128209
KEGGihsa:128209
UCSCiuc001clp.4 human

Organism-specific databases

CTDi128209
DisGeNETi128209
EuPathDBiHostDB:ENSG00000171872.4
GeneCardsiKLF17
HGNCiHGNC:18830 KLF17
HPAiHPA024629
MIMi609602 gene
neXtProtiNX_Q5JT82
OpenTargetsiENSG00000171872
PharmGKBiPA134877071
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000049152
HOVERGENiHBG080136
InParanoidiQ5JT82
KOiK09211
OMAiWSFFRSD
OrthoDBiEOG091G0GDE
PhylomeDBiQ5JT82
TreeFamiTF315506

Miscellaneous databases

ChiTaRSiKLF17 human
GeneWikiiKLF17
GenomeRNAii128209
PROiPR:Q5JT82
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171872 Expressed in 43 organ(s), highest expression level in testis
CleanExiHS_KLF17
ExpressionAtlasiQ5JT82 baseline and differential
GenevisibleiQ5JT82 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF17_HUMAN
AccessioniPrimary (citable) accession number: Q5JT82
Secondary accession number(s): Q86VQ7, Q8N805
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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