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Entry version 126 (16 Oct 2019)
Sequence version 2 (05 Oct 2010)
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Protein

Protein PRRC2B

Gene

PRRC2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PRRC2B
Alternative name(s):
HLA-B-associated transcript 2-like 1
Proline-rich coiled-coil protein 2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRRC2B
Synonyms:BAT2L, BAT2L1, KIAA0515
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28121 PRRC2B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5JSZ5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000130723

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165585468

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5JSZ5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRRC2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153415

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002744811 – 2229Protein PRRC2BAdd BLAST2229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei166PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei222PhosphoserineBy similarity1
Modified residuei226PhosphoserineCombined sources1
Modified residuei228PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki251Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei388PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei556PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Cross-linki734Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei736PhosphothreonineCombined sources1
Modified residuei740PhosphoserineCombined sources1
Modified residuei745PhosphoserineCombined sources1
Modified residuei765PhosphoserineCombined sources1
Cross-linki963Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1132PhosphoserineCombined sources1
Modified residuei1231PhosphoserineCombined sources1
Modified residuei1470PhosphoserineCombined sources1
Modified residuei1507PhosphoserineCombined sources1
Modified residuei1754PhosphoserineCombined sources1
Modified residuei1843PhosphoserineCombined sources1
Isoform 1 (identifier: Q5JSZ5-5)
Modified residuei776PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5JSZ5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5JSZ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5JSZ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5JSZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5JSZ5

PeptideAtlas

More...
PeptideAtlasi
Q5JSZ5

PRoteomics IDEntifications database

More...
PRIDEi
Q5JSZ5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63178 [Q5JSZ5-1]
63179 [Q5JSZ5-2]
63180 [Q5JSZ5-3]
63181 [Q5JSZ5-4]
63182 [Q5JSZ5-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5JSZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5JSZ5

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q5JSZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130723 Expressed in 232 organ(s), highest expression level in cerebral cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5JSZ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5JSZ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021022
HPA064301

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124226, 51 interactors

Protein interaction database and analysis system

More...
IntActi
Q5JSZ5, 40 interactors

Molecular INTeraction database

More...
MINTi
Q5JSZ5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349856

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5JSZ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili495 – 553Sequence analysisAdd BLAST59
Coiled coili1563 – 1587Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi391 – 395Poly-Glu5
Compositional biasi616 – 647Gln-richAdd BLAST32
Compositional biasi1953 – 1956Poly-Ala4

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4817 Eukaryota
ENOG4110ERT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183161

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5JSZ5

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRMTQGR

Database of Orthologous Groups

More...
OrthoDBi
17901at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5JSZ5

TreeFam database of animal gene trees

More...
TreeFami
TF328738

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009738 BAT2_N
IPR033184 PRRC2

The PANTHER Classification System

More...
PANTHERi
PTHR14038 PTHR14038, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07001 BAT2_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 5 (identifier: Q5JSZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDRLGQITK GKDGKSKYST LSLFDKYKGK SVDAIRSSVI PRHGLQSLGK
60 70 80 90 100
VAAARRMPPP ANLPSLKSEN KGNDPNIVIV PKDGTGWANK QDQQDPKSSS
110 120 130 140 150
ATASQPPESL PQPGLQKSVS NLQKPTQSIS QENTNSVPGG PKSWAQLNGK
160 170 180 190 200
PVGHEGGLRG SSRLLSFSPE EFPTLKAAGG QDKAGKEKGV LDLSYGPGPS
210 220 230 240 250
LRPQNVTSWR EGGGRHIISA TSLSTSPTEL GSRNSSTGDG APSSACTSDS
260 270 280 290 300
KDPSLRPAQP VRKGASQFMG NVYHPPTYHD MLPAFMCSPK SSENQGTVER
310 320 330 340 350
GSFPLPQLRL EPRVPFRQFQ MNDQDGKENR LGLSRPLRPL RQLVERAPRP
360 370 380 390 400
TIINAENLKG LDDLDADADD GWAGLHEEVD YSEKLKFSDD EEEEEVVKDG
410 420 430 440 450
RPKWNSWDPR RQRQLSMSSA DSADAKRTRE EGKDWAEAVG ASRVVRKAPD
460 470 480 490 500
PQPPPRKLHG WAPGPDYQKS SMGSMFRQQS IEDKEDKPPP RQKFIQSEMS
510 520 530 540 550
EAVERARKRR EEEERRAREE RLAACAAKLK QLDQKCKQAR KAGEARKQAE
560 570 580 590 600
KEVPWSPSAE KASPQENGPA VHKGSPEFPA QETPTTFPEE APTVSPAVAQ
610 620 630 640 650
SNSSEEEARE AGSPAQEFKY QKSLPPRFQR QQQQQQQEQL YKMQHWQPVY
660 670 680 690 700
PPPSHPQRTF YPHHPQMLGF DPRWMMMPSY MDPRITPTRT PVDFYPSALH
710 720 730 740 750
PSGLMKPMMP QESLNGTGCR SEDQNCVPPL QERKVTPIDS PPVWSPEGYM
760 770 780 790 800
ALQSKGYPLP HPKSSDTLAM DMRVRNESSF SASLGRAGGV SAQRDLFEER
810 820 830 840 850
GEEYLSAFDK KAQADFDSCI SSQRIGQELL FPPQENVQDA GAPGGHTQNL
860 870 880 890 900
RCSPLEPDFV PDEKKPECGS WDVSHQPETA DTAHGVERET PREGTAFNIS
910 920 930 940 950
SWDKNGSPNK QPSSEPEWTP EPRSSSSQHP EQTGRTRRSG PIKKPVLKAL
960 970 980 990 1000
KVEDKEKELE KIKQELGEES TRLAKEKEQS PTAEKDEDEE NDASLANSST
1010 1020 1030 1040 1050
TTLEDKGPGH ATFGREATKF EEEEKPDKAW EARPPRESSD VPPMKRNNWI
1060 1070 1080 1090 1100
FIDEEQAFGV RGQARGRGRG FREFTFRGRP AGGNGSGLCG GGVLGARSIY
1110 1120 1130 1140 1150
CSSQRSGRGR GLREFARPED CPRAKPRRRV ASETHSEGSE YEELPKRRRQ
1160 1170 1180 1190 1200
RGSENGNEGS LLEREESTLK KGDCRDSWRS NKGCSEDHSG LDAKSRGPRA
1210 1220 1230 1240 1250
FGRALPPRLS NCGYGRRTFV SKESPHWQSK SPGSSWQEYG PSDTCGSRRP
1260 1270 1280 1290 1300
TDRDYVPDSY RHPDAFGGRG FEDSRAEDKR SFFQDEHVAD SENAENRPFR
1310 1320 1330 1340 1350
RRRPPRQDKP PRFRRLRQER ESLGLWGPEE EPHLLAGQWP GRPKLCSGDK
1360 1370 1380 1390 1400
SGTVGRRSPE LSYQNSSDHA NEEWETASES SDFSERRERR EGPGSEPDSQ
1410 1420 1430 1440 1450
VDGGLSGASL GEKKELAKRS FSSQRPVVDR QSRKLEPGGF GEKPVRPGGG
1460 1470 1480 1490 1500
DTSPRYESQQ NGTPLKVKRS PDEALPGGLS GCSSGSGHSP YALERAAHAS
1510 1520 1530 1540 1550
ADLPEASSKK AEKEAKLAAP RAGEQGEAMK QFDLNYGSAI IENCGSSPGE
1560 1570 1580 1590 1600
ESEVGSMVGE GFIEVLTKKQ RRLLEEERRK KEQAVQVPVK GRGLSSRIPP
1610 1620 1630 1640 1650
RFAKKQNNLC LEQGDVTVPG SSLGTEIWES SSQALPVQAP ANDSWRKAVT
1660 1670 1680 1690 1700
AFSSTETGSA EQGFKSSQGD SGVDLSAESR ESSATSSQRS SPYGTLKPEE
1710 1720 1730 1740 1750
MSGPGLAEPK ADSHKEQAPK PSEQKDSEQG SGQSKEHRPG PIGNERSLKN
1760 1770 1780 1790 1800
RKGSEGAERL QGAVVPPVNG VEIHVDSVLP VPPIEFGVSP KDSDFSLPPG
1810 1820 1830 1840 1850
SASGPTGSPV VKLQDALASN AGLTQSIPIL RRDHHIQRAI GLSPMSFPTA
1860 1870 1880 1890 1900
DLTLKMESAR KAWENSPSLP EQSSPGGAGS GIQPPSSVGA SSGVNYSSFG
1910 1920 1930 1940 1950
GVSMPPMPVA SVAPSASMPG SHLPPLYLDG HVFASQPRLV PQTIPQQQSY
1960 1970 1980 1990 2000
QQAAAAQQIP ISLHTSLQAQ AQLGLRGGLP VSQSQEIFSS LQPFRSQVYM
2010 2020 2030 2040 2050
HPSLSPPSTM ILSGGTALKP PYSAFPGMQP LEMVKPQSGS PYQPMSGNQA
2060 2070 2080 2090 2100
LVYEGQLSQA AGLGASQMLD SQLPQLTMPL PRYGSGQQPL ILPQSIQLPP
2110 2120 2130 2140 2150
GQSLSVGAPR RIPPPGSQPP VLNTSREPSQ MEMKGFHFAD SKQNVPSGGP
2160 2170 2180 2190 2200
VPSPQTYRPS SASPSGKPSG SAVNMGSVQG HYVQQAKQRV DEKPSLGAVK
2210 2220
LQEAPSAASQ MKRTGAIKPR AVKVEESKA
Length:2,229
Mass (Da):242,967
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F5F13DAC0217A6D
GO
Isoform 2 (identifier: Q5JSZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1903: Missing.

Show »
Length:326
Mass (Da):34,382
Checksum:i8173024F1E23876D
GO
Isoform 3 (identifier: Q5JSZ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1903: Missing.
     2075-2075: Q → QQ

Show »
Length:327
Mass (Da):34,510
Checksum:iB4A913AB7ADD9BFE
GO
Isoform 4 (identifier: Q5JSZ5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1903: Missing.
     2159-2229: PSSASPSGKP...RAVKVEESKA → QNNEWMRNPAWEP

Show »
Length:268
Mass (Da):28,737
Checksum:iFF58D2A53BC14113
GO
Isoform 1 (identifier: Q5JSZ5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     775-1468: Missing.

Show »
Length:1,535
Mass (Da):165,527
Checksum:iE0BACA25A0E75CF2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y412H0Y412_HUMAN
Protein PRRC2B
PRRC2B
588Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C065A0A494C065_HUMAN
Protein PRRC2B
PRRC2B
877Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0D3A0A494C0D3_HUMAN
Protein PRRC2B
PRRC2B
1,461Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JT00Q5JT00_HUMAN
Protein PRRC2B
PRRC2B
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLU0H3BLU0_HUMAN
Protein PRRC2B
PRRC2B
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQP5A0A1W2PQP5_HUMAN
Protein PRRC2B
PRRC2B
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YET3A0A2R8YET3_HUMAN
Protein PRRC2B
PRRC2B
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAH18678 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti936T → S in CAH18678 (PubMed:17974005).Curated1
Sequence conflicti981P → L in CAH18678 (PubMed:17974005).Curated1
Sequence conflicti1044M → T in CAH18678 (PubMed:17974005).Curated1
Sequence conflicti1276A → V in CAH18678 (PubMed:17974005).Curated1
Sequence conflicti1933F → L in AAU10087 (Ref. 2) Curated1
Sequence conflicti1985Q → R in AAU10087 (Ref. 2) Curated1
Sequence conflicti2069L → S in AAU10087 (Ref. 2) Curated1
Sequence conflicti2135G → S in AAU10087 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057735417M → V. Corresponds to variant dbSNP:rs34553878Ensembl.1
Natural variantiVAR_0302891630S → T. Corresponds to variant dbSNP:rs10736851Ensembl.1
Natural variantiVAR_0302901675L → P. Corresponds to variant dbSNP:rs10751478Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0227601 – 1903Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST1903
Alternative sequenceiVSP_039905775 – 1468Missing in isoform 1. CuratedAdd BLAST694
Alternative sequenceiVSP_0227612075Q → QQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_0227622159 – 2229PSSAS…EESKA → QNNEWMRNPAWEP in isoform 4. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK026162 mRNA Translation: BAB15380.1
AY700780 mRNA Translation: AAU10087.1
AL358781 Genomic DNA No translation available.
BC012289 mRNA Translation: AAH12289.1
CR749818 mRNA Translation: CAH18678.1 Sequence problems.
AB011087 mRNA Translation: BAA25441.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS48044.1 [Q5JSZ5-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00083

NCBI Reference Sequences

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RefSeqi
NP_037450.2, NM_013318.3 [Q5JSZ5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000357304; ENSP00000349856; ENSG00000130723 [Q5JSZ5-1]
ENST00000405995; ENSP00000384606; ENSG00000130723 [Q5JSZ5-5]
ENST00000458550; ENSP00000398853; ENSG00000130723 [Q5JSZ5-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84726

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84726

UCSC genome browser

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UCSCi
uc004cam.2 human [Q5JSZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026162 mRNA Translation: BAB15380.1
AY700780 mRNA Translation: AAU10087.1
AL358781 Genomic DNA No translation available.
BC012289 mRNA Translation: AAH12289.1
CR749818 mRNA Translation: CAH18678.1 Sequence problems.
AB011087 mRNA Translation: BAA25441.1
CCDSiCCDS48044.1 [Q5JSZ5-1]
PIRiT00083
RefSeqiNP_037450.2, NM_013318.3 [Q5JSZ5-1]

3D structure databases

SMRiQ5JSZ5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124226, 51 interactors
IntActiQ5JSZ5, 40 interactors
MINTiQ5JSZ5
STRINGi9606.ENSP00000349856

PTM databases

iPTMnetiQ5JSZ5
PhosphoSitePlusiQ5JSZ5

Polymorphism and mutation databases

BioMutaiPRRC2B
DMDMi308153415

Proteomic databases

EPDiQ5JSZ5
jPOSTiQ5JSZ5
MassIVEiQ5JSZ5
MaxQBiQ5JSZ5
PaxDbiQ5JSZ5
PeptideAtlasiQ5JSZ5
PRIDEiQ5JSZ5
ProteomicsDBi63178 [Q5JSZ5-1]
63179 [Q5JSZ5-2]
63180 [Q5JSZ5-3]
63181 [Q5JSZ5-4]
63182 [Q5JSZ5-5]

Genome annotation databases

EnsembliENST00000357304; ENSP00000349856; ENSG00000130723 [Q5JSZ5-1]
ENST00000405995; ENSP00000384606; ENSG00000130723 [Q5JSZ5-5]
ENST00000458550; ENSP00000398853; ENSG00000130723 [Q5JSZ5-4]
GeneIDi84726
KEGGihsa:84726
UCSCiuc004cam.2 human [Q5JSZ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84726

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRRC2B
HGNCiHGNC:28121 PRRC2B
HPAiHPA021022
HPA064301
neXtProtiNX_Q5JSZ5
OpenTargetsiENSG00000130723
PharmGKBiPA165585468

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4817 Eukaryota
ENOG4110ERT LUCA
GeneTreeiENSGT00950000183161
InParanoidiQ5JSZ5
OMAiPRMTQGR
OrthoDBi17901at2759
PhylomeDBiQ5JSZ5
TreeFamiTF328738

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PRRC2B human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA0515

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84726
PharosiQ5JSZ5
PMAP-CutDBiQ5JSZ5

Protein Ontology

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PROi
PR:Q5JSZ5

Gene expression databases

BgeeiENSG00000130723 Expressed in 232 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiQ5JSZ5 baseline and differential
GenevisibleiQ5JSZ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR009738 BAT2_N
IPR033184 PRRC2
PANTHERiPTHR14038 PTHR14038, 1 hit
PfamiView protein in Pfam
PF07001 BAT2_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRC2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JSZ5
Secondary accession number(s): O60270
, Q5JSZ7, Q66VZ2, Q68CR0, Q96EI9, Q9H683
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 5, 2010
Last modified: October 16, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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