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Protein

Meiosis expressed gene 1 protein homolog

Gene

MEIG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for spermiogenesis.By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis expressed gene 1 protein homolog
Gene namesi
Name:MEIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000197889.9
HGNCiHGNC:23429 MEIG1
MIMi614174 gene
neXtProtiNX_Q5JSS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197889
PharmGKBiPA134895701

Polymorphism and mutation databases

BioMutaiMEIG1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130251 – 88Meiosis expressed gene 1 protein homologAdd BLAST88

Proteomic databases

PaxDbiQ5JSS6
PRIDEiQ5JSS6
ProteomicsDBi63170

PTM databases

iPTMnetiQ5JSS6
PhosphoSitePlusiQ5JSS6

Expressioni

Gene expression databases

BgeeiENSG00000197889
CleanExiHS_MEIG1
GenevisibleiQ5JSS6 HS

Organism-specific databases

HPAiHPA044594

Interactioni

Subunit structurei

Interacts with PACRG.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PACRGQ96M98-24EBI-18583441,EBI-11945452

Protein-protein interaction databases

BioGridi569980, 1 interactor
IntActiQ5JSS6, 1 interactor
STRINGi9606.ENSP00000367486

Structurei

3D structure databases

ProteinModelPortaliQ5JSS6
SMRiQ5JSS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MEIG1 family.Curated

Phylogenomic databases

eggNOGiENOG410IZAK Eukaryota
ENOG4111XG3 LUCA
GeneTreeiENSGT00390000013550
HOGENOMiHOG000231567
HOVERGENiHBG052452
InParanoidiQ5JSS6
OMAiTFYYYNR
OrthoDBiEOG091G15MX
PhylomeDBiQ5JSS6
TreeFamiTF329080

Family and domain databases

InterProiView protein in InterPro
IPR020186 Meiosis-expressed_gene_1
PANTHERiPTHR17008 PTHR17008, 1 hit
PfamiView protein in Pfam
PF15163 Meiosis_expr, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD062760 Meiosis-expressed_gene_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JSS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSDVKPKS VSHAKKWSEE IENLYRFQQA GYRDETEYRQ VKQVSMVDRW
60 70 80
PETGYVKKLQ RRDNTFYYYN KQRECDDKEV HKVKIYAY
Length:88
Mass (Da):10,795
Last modified:February 15, 2005 - v1
Checksum:iB560DAFFB60DC274
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0539799K → T. Corresponds to variant dbSNP:rs4750568Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360083 Genomic DNA No translation available.
CCDSiCCDS31151.1
RefSeqiNP_001074305.1, NM_001080836.2
UniGeneiHs.257249
Hs.615546

Genome annotation databases

EnsembliENST00000378240; ENSP00000367486; ENSG00000197889
ENST00000407572; ENSP00000384334; ENSG00000197889
GeneIDi644890
KEGGihsa:644890
UCSCiuc009xjk.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMEIG1_HUMAN
AccessioniPrimary (citable) accession number: Q5JSS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 15, 2005
Last modified: July 18, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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