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Protein

FYVE, RhoGEF and PH domain-containing protein 3

Gene

FGD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri532 – 588FYVE-typePROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 3
Alternative name(s):
Zinc finger FYVE domain-containing protein 5
Gene namesi
Name:FGD3
Synonyms:ZFYVE5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000127084.17
HGNCiHGNC:16027 FGD3
MIMi617554 gene
neXtProtiNX_Q5JSP0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi89846
OpenTargetsiENSG00000127084
PharmGKBiPA28104

Polymorphism and mutation databases

BioMutaiFGD3
DMDMi61213216

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809441 – 725FYVE, RhoGEF and PH domain-containing protein 3Add BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5JSP0
MaxQBiQ5JSP0
PaxDbiQ5JSP0
PeptideAtlasiQ5JSP0
PRIDEiQ5JSP0
ProteomicsDBi63166
63167 [Q5JSP0-2]
TopDownProteomicsiQ5JSP0-1 [Q5JSP0-1]

PTM databases

iPTMnetiQ5JSP0
PhosphoSitePlusiQ5JSP0

Expressioni

Gene expression databases

BgeeiENSG00000127084 Expressed in 162 organ(s), highest expression level in blood
CleanExiHS_FGD3
ExpressionAtlasiQ5JSP0 baseline and differential
GenevisibleiQ5JSP0 HS

Organism-specific databases

HPAiHPA020963
HPA021018

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124618, 3 interactors
STRINGi9606.ENSP00000336914

Structurei

Secondary structure

1725
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5JSP0
SMRiQ5JSP0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5JSP0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 341DHPROSITE-ProRule annotationAdd BLAST185
Domaini370 – 469PH 1PROSITE-ProRule annotationAdd BLAST100
Domaini604 – 703PH 2PROSITE-ProRule annotationAdd BLAST100

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri532 – 588FYVE-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4424 Eukaryota
ENOG410XRXV LUCA
GeneTreeiENSGT00920000148981
HOGENOMiHOG000220866
HOVERGENiHBG007506
InParanoidiQ5JSP0
KOiK05722
OMAiRQSRVCR
OrthoDBiEOG091G03FU
PhylomeDBiQ5JSP0
TreeFamiTF316247

Family and domain databases

CDDicd13236 PH2_FGD1-4, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR035941 FGD1-4_PH2
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5JSP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESGRGSSTP PGPIAALGMP DTGPGSSSLG KLQALPVGPR AHCGDPVSLA
60 70 80 90 100
AAGDGSPDIG PTGELSGSLK IPNRDSGIDS PSSSVAGENF PCEEGLEAGP
110 120 130 140 150
SPTVLGAHAE MALDSQVPKV TPQEEADSDV GEEPDSENTP QKADKDAGLA
160 170 180 190 200
QHSGPQKLLH IAQELLHTEE TYVKRLHLLD QVFCTRLTDA GIPPEVIMGI
210 220 230 240 250
FSNISSIHRF HGQFLLPELK TRITEEWDTN PRLGDILQKL APFLKMYGEY
260 270 280 290 300
VKNFDRAVGL VSTWTQRSPL FKDVVHSIQK QEVCGNLTLQ HHMLEPVQRV
310 320 330 340 350
PRYELLLKDY LKRLPQDAPD RKDAERSLEL ISTAANHSNA AIRKVEKMHK
360 370 380 390 400
LLEVYEQLGG EEDIVNPANE LIKEGQIQKL SAKNGTPQDR HLFLFNSMIL
410 420 430 440 450
YCVPKLRLMG QKFSVREKMD ISGLQVQDIV KPNTAHTFII TGRKRSLELQ
460 470 480 490 500
TRTEEEKKEW IQIIQATIEK HKQNSETFKA FGGAFSQDED PSLSPDMPIT
510 520 530 540 550
STSPVEPVVT TEGSSGAAGL EPRKLSSKTR RDKEKQSCKS CGETFNSITK
560 570 580 590 600
RRHHCKLCGA VICGKCSEFK AENSRQSRVC RDCFLTQPVA PESTEKTPTA
610 620 630 640 650
DPQPSLLCGP LRLSESGETW SEVWAAIPMS DPQVLHLQGG SQDGRLPRTI
660 670 680 690 700
PLPSCKLSVP DPEERLDSGH VWKLQWAKQS WYLSASSAEL QQQWLETLST
710 720
AAHGDTAQDS PGALQLQVPM GAAAP
Length:725
Mass (Da):79,401
Last modified:February 15, 2005 - v1
Checksum:i665A7FF5BE16B44B
GO
Isoform 2 (identifier: Q5JSP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-634: KTPTADPQPS...AAIPMSDPQV → VGAPSSCSPP...SAFGVSLGPG
     635-725: Missing.

Note: No experimental confirmation available.
Show »
Length:634
Mass (Da):68,794
Checksum:i6EC385CE5B2CB426
GO
Isoform 3 (identifier: Q5JSP0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     596-596: Missing.

Note: No experimental confirmation available.
Show »
Length:724
Mass (Da):79,273
Checksum:i4D87C3D1D8FAB9B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021492275V → I1 PublicationCorresponds to variant dbSNP:rs3802384Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013074596 – 634KTPTA…SDPQV → VGAPSSCSPPGGAAEPPDTC SCAPAAPAASAFGVSLGPG in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_055703596Missing in isoform 3. Curated1
Alternative sequenceiVSP_013075635 – 725Missing in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY211386 mRNA Translation: AAP20645.1
AL389924 Genomic DNA No translation available.
AL451065 Genomic DNA No translation available.
BC032429 mRNA Translation: AAH32429.1
BC111054 mRNA Translation: AAI11055.1
CCDSiCCDS43849.1 [Q5JSP0-1]
CCDS69619.1 [Q5JSP0-3]
RefSeqiNP_001077005.1, NM_001083536.1 [Q5JSP0-1]
NP_001273922.1, NM_001286993.1 [Q5JSP0-3]
NP_149077.2, NM_033086.2 [Q5JSP0-1]
XP_016870763.1, XM_017015274.1 [Q5JSP0-1]
UniGeneiHs.411081

Genome annotation databases

EnsembliENST00000337352; ENSP00000336914; ENSG00000127084 [Q5JSP0-1]
ENST00000375482; ENSP00000364631; ENSG00000127084 [Q5JSP0-1]
ENST00000416701; ENSP00000413833; ENSG00000127084 [Q5JSP0-3]
ENST00000467786; ENSP00000432310; ENSG00000127084 [Q5JSP0-2]
GeneIDi89846
KEGGihsa:89846
UCSCiuc004asw.3 human [Q5JSP0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY211386 mRNA Translation: AAP20645.1
AL389924 Genomic DNA No translation available.
AL451065 Genomic DNA No translation available.
BC032429 mRNA Translation: AAH32429.1
BC111054 mRNA Translation: AAI11055.1
CCDSiCCDS43849.1 [Q5JSP0-1]
CCDS69619.1 [Q5JSP0-3]
RefSeqiNP_001077005.1, NM_001083536.1 [Q5JSP0-1]
NP_001273922.1, NM_001286993.1 [Q5JSP0-3]
NP_149077.2, NM_033086.2 [Q5JSP0-1]
XP_016870763.1, XM_017015274.1 [Q5JSP0-1]
UniGeneiHs.411081

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COCNMR-A605-703[»]
ProteinModelPortaliQ5JSP0
SMRiQ5JSP0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124618, 3 interactors
STRINGi9606.ENSP00000336914

PTM databases

iPTMnetiQ5JSP0
PhosphoSitePlusiQ5JSP0

Polymorphism and mutation databases

BioMutaiFGD3
DMDMi61213216

Proteomic databases

EPDiQ5JSP0
MaxQBiQ5JSP0
PaxDbiQ5JSP0
PeptideAtlasiQ5JSP0
PRIDEiQ5JSP0
ProteomicsDBi63166
63167 [Q5JSP0-2]
TopDownProteomicsiQ5JSP0-1 [Q5JSP0-1]

Protocols and materials databases

DNASUi89846
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337352; ENSP00000336914; ENSG00000127084 [Q5JSP0-1]
ENST00000375482; ENSP00000364631; ENSG00000127084 [Q5JSP0-1]
ENST00000416701; ENSP00000413833; ENSG00000127084 [Q5JSP0-3]
ENST00000467786; ENSP00000432310; ENSG00000127084 [Q5JSP0-2]
GeneIDi89846
KEGGihsa:89846
UCSCiuc004asw.3 human [Q5JSP0-1]

Organism-specific databases

CTDi89846
DisGeNETi89846
EuPathDBiHostDB:ENSG00000127084.17
GeneCardsiFGD3
HGNCiHGNC:16027 FGD3
HPAiHPA020963
HPA021018
MIMi617554 gene
neXtProtiNX_Q5JSP0
OpenTargetsiENSG00000127084
PharmGKBiPA28104
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4424 Eukaryota
ENOG410XRXV LUCA
GeneTreeiENSGT00920000148981
HOGENOMiHOG000220866
HOVERGENiHBG007506
InParanoidiQ5JSP0
KOiK05722
OMAiRQSRVCR
OrthoDBiEOG091G03FU
PhylomeDBiQ5JSP0
TreeFamiTF316247

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRSiFGD3 human
EvolutionaryTraceiQ5JSP0
GeneWikiiFGD3
GenomeRNAii89846
PROiPR:Q5JSP0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127084 Expressed in 162 organ(s), highest expression level in blood
CleanExiHS_FGD3
ExpressionAtlasiQ5JSP0 baseline and differential
GenevisibleiQ5JSP0 HS

Family and domain databases

CDDicd13236 PH2_FGD1-4, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR035941 FGD1-4_PH2
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 2 hits
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGD3_HUMAN
AccessioniPrimary (citable) accession number: Q5JSP0
Secondary accession number(s): F8W7P2
, Q4VX84, Q7Z7D9, Q8N5G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 15, 2005
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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