Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 143 (08 May 2019)
Sequence version 1 (15 Feb 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

WD repeat-containing protein 44

Gene

WDR44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rab GTPase binding Source: GO_Central

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q5JSH3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 44
Alternative name(s):
Rabphilin-11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR44
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30512 WDR44

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5JSH3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000131725

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394668

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR44

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762196

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002627692 – 913WD repeat-containing protein 44Add BLAST912

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei11PhosphotyrosineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei158PhosphothreonineCombined sources1
Modified residuei219PhosphothreonineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei271PhosphothreonineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei349PhosphothreonineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei479PhosphotyrosineBy similarity1
Modified residuei561PhosphoserineCombined sources1
Modified residuei565PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5JSH3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5JSH3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5JSH3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5JSH3

PeptideAtlas

More...
PeptideAtlasi
Q5JSH3

PRoteomics IDEntifications database

More...
PRIDEi
Q5JSH3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
63151
63152 [Q5JSH3-2]
63153 [Q5JSH3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5JSH3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5JSH3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131725 Expressed in 219 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5JSH3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5JSH3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038084
HPA046719

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the GTP-bound form of RAB11 when membrane-associated. Does not bind to other Rab and Rho small G proteins (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120014, 39 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q5JSH3

Protein interaction database and analysis system

More...
IntActi
Q5JSH3, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000254029

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati509 – 548WD 1Add BLAST40
Repeati605 – 643WD 2Add BLAST39
Repeati645 – 685WD 3Add BLAST41
Repeati690 – 729WD 4Add BLAST40
Repeati740 – 779WD 5Add BLAST40
Repeati784 – 823WD 6Add BLAST40
Repeati876 – 913WD 7Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 170Binding activityAdd BLAST169

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili119 – 184Sequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi211 – 257Pro-richAdd BLAST47

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0283 Eukaryota
ENOG410XQPJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157557

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000267152

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5JSH3

KEGG Orthology (KO)

More...
KOi
K20241

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTDHTEV

Database of Orthologous Groups

More...
OrthoDBi
1332590at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5JSH3

TreeFam database of animal gene trees

More...
TreeFami
TF329226

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR040324 WDR44/Dgr2

The PANTHER Classification System

More...
PANTHERi
PTHR14221 PTHR14221, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5JSH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASESDTEEF YDAPEDVHLG GGYPVGSPGK VGLSTFKETE NTAYKVGNES
60 70 80 90 100
PVQELKQDVS KKIIESIIEE SQKVLQLEDD SLDSKGKELS DQATASPIVA
110 120 130 140 150
RTDLSNIPGL LAIDQVLPEE SQKAESQNTF EETELELKKC FPSDETCEKP
160 170 180 190 200
VDETTKLTQT SSTEQLNVLE TETEVLNKEA VEVKGGGDVL EPVSSDSLST
210 220 230 240 250
KDFAAVEEVA PAKPPRHLTP EPDIVASTKK PVPARPPPPT NFPPPRPPPP
260 270 280 290 300
SRPAPPPRKR KSELEFETLK TPDIDVPKEN ITSDSLLTAS MASESTVKDS
310 320 330 340 350
QPSLDLASAT SGDKIVTAQE NGKAPDGQTV AGEVMGPQRP RSNSGRELTD
360 370 380 390 400
EEILASVMIK NLDTGEEIPL SLAEEKLPTG INPLTLHIMR RTKEYVSNDA
410 420 430 440 450
AQSDDEEKLQ SQPTDTDGGR LKQKTTQLKK FLGKSVKRAK HLAEEYGERA
460 470 480 490 500
INKVKSVRDE VFHTDQDDPS SSDDEGMPYT RPVKFKAAHG FKGPYDFDQI
510 520 530 540 550
KVVQDLSGEH MGAVWTMKFS HCGRLLASAG QDNVVRIWAL KNAFDYFNNM
560 570 580 590 600
RMKYNTEGRV SPSPSQESLS SSKSDTDTGV CSGTDEDPDD KNAPFRQRPF
610 620 630 640 650
CKYKGHTADL LDLSWSKNYF LLSSSMDKTV RLWHISRREC LCCFQHIDFV
660 670 680 690 700
TAIAFHPRDD RYFLSGSLDG KLRLWNIPDK KVALWNEVDG QTKLITAANF
710 720 730 740 750
CQNGKYAVIG TYDGRCIFYD TEHLKYHTQI HVRSTRGRNK VGRKITGIEP
760 770 780 790 800
LPGENKILVT SNDSRIRLYD LRDLSLSMKY KGYVNSSSQI KASFSHDFTY
810 820 830 840 850
LVSGSEDKYV YIWSTYHDLS KFTSVRRDRN DFWEGIKAHN AVVTSAIFAP
860 870 880 890 900
NPSLMLSLDV QSEKSEGNEK SEDAEVLDAT PSGIMKTDNT EVLLSADFTG
910
AIKVFVNKRK NVS
Length:913
Mass (Da):101,366
Last modified:February 15, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E43761C542DD6B9
GO
Isoform 2 (identifier: Q5JSH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     796-803: Missing.

Note: No experimental confirmation available.
Show »
Length:905
Mass (Da):100,403
Checksum:i81A8AAA300D4FE9F
GO
Isoform 3 (identifier: Q5JSH3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-473: Missing.
     474-477: DEGM → MVNV
     884-913: IMKTDNTEVLLSADFTGAIKVFVNKRKNVS → AVAHACNPSTLGGRGRRIT

Note: No experimental confirmation available.
Show »
Length:429
Mass (Da):48,565
Checksum:iB6AA91342F478464
GO
Isoform 4 (identifier: Q5JSH3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-61: Missing.
     659-722: Missing.

Note: No experimental confirmation available.
Show »
Length:824
Mass (Da):91,272
Checksum:i015DB327476F0083
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY83H7BY83_HUMAN
WD repeat-containing protein 44
WDR44
806Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92015 differs from that shown. Reason: Frameshift at position 792.Curated
The sequence BAC03799 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti89L → P in CAD97788 (PubMed:17974005).Curated1
Sequence conflicti96S → G in CAL38210 (PubMed:17974005).Curated1
Sequence conflicti194S → P in AAH28697 (PubMed:15489334).Curated1
Sequence conflicti206V → A in CAL38662 (PubMed:17974005).Curated1
Sequence conflicti250P → L in CAL38662 (PubMed:17974005).Curated1
Sequence conflicti276V → A in BAG61611 (PubMed:14702039).Curated1
Sequence conflicti331A → P in CAD98010 (PubMed:17974005).Curated1
Sequence conflicti380G → D in CAL38210 (PubMed:17974005).Curated1
Sequence conflicti473D → N in CAL38662 (PubMed:17974005).Curated1
Sequence conflicti534V → A in CAD97788 (PubMed:17974005).Curated1
Sequence conflicti539A → L in CAD97788 (PubMed:17974005).Curated1
Sequence conflicti547F → L in BAG61611 (PubMed:14702039).Curated1
Sequence conflicti586E → G in CAD97788 (PubMed:17974005).Curated1
Sequence conflicti613L → P in CAL38662 (PubMed:17974005).Curated1
Sequence conflicti649 – 650Missing in BAA92015 (PubMed:14702039).Curated2
Sequence conflicti740K → R in CAL38210 (PubMed:17974005).Curated1
Sequence conflicti740K → R in CAL38662 (PubMed:17974005).Curated1
Sequence conflicti858L → S in CAL38662 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029538289A → T1 PublicationCorresponds to variant dbSNP:rs17271416Ensembl.1
Natural variantiVAR_029539296T → A1 PublicationCorresponds to variant dbSNP:rs17855531Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0218071 – 473Missing in isoform 3. 1 PublicationAdd BLAST473
Alternative sequenceiVSP_04663737 – 61Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_021808474 – 477DEGM → MVNV in isoform 3. 1 Publication4
Alternative sequenceiVSP_046638659 – 722Missing in isoform 4. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_021809796 – 803Missing in isoform 2. 1 Publication8
Alternative sequenceiVSP_021810884 – 913IMKTD…RKNVS → AVAHACNPSTLGGRGRRIT in isoform 3. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001978 mRNA Translation: BAA92015.1 Sequence problems.
AK092077 mRNA Translation: BAC03799.1 Different initiation.
AK127556 mRNA Translation: BAC87033.1
AK299711 mRNA Translation: BAG61611.1
AM393332 mRNA Translation: CAL38210.1
AM393787 mRNA Translation: CAL38662.1
BX537578 mRNA Translation: CAD97788.1
BX538087 mRNA Translation: CAD98010.1
AL391474 Genomic DNA No translation available.
AL391803 Genomic DNA No translation available.
AL391830 Genomic DNA No translation available.
BC028697 mRNA Translation: AAH28697.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14572.1 [Q5JSH3-1]
CCDS55482.1 [Q5JSH3-2]
CCDS55483.1 [Q5JSH3-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001171894.1, NM_001184965.1 [Q5JSH3-2]
NP_001171895.1, NM_001184966.1 [Q5JSH3-4]
NP_061918.3, NM_019045.4 [Q5JSH3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254029; ENSP00000254029; ENSG00000131725 [Q5JSH3-1]
ENST00000371822; ENSP00000360887; ENSG00000131725 [Q5JSH3-4]
ENST00000371825; ENSP00000360890; ENSG00000131725 [Q5JSH3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54521

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54521

UCSC genome browser

More...
UCSCi
uc004eqn.4 human [Q5JSH3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001978 mRNA Translation: BAA92015.1 Sequence problems.
AK092077 mRNA Translation: BAC03799.1 Different initiation.
AK127556 mRNA Translation: BAC87033.1
AK299711 mRNA Translation: BAG61611.1
AM393332 mRNA Translation: CAL38210.1
AM393787 mRNA Translation: CAL38662.1
BX537578 mRNA Translation: CAD97788.1
BX538087 mRNA Translation: CAD98010.1
AL391474 Genomic DNA No translation available.
AL391803 Genomic DNA No translation available.
AL391830 Genomic DNA No translation available.
BC028697 mRNA Translation: AAH28697.3
CCDSiCCDS14572.1 [Q5JSH3-1]
CCDS55482.1 [Q5JSH3-2]
CCDS55483.1 [Q5JSH3-4]
RefSeqiNP_001171894.1, NM_001184965.1 [Q5JSH3-2]
NP_001171895.1, NM_001184966.1 [Q5JSH3-4]
NP_061918.3, NM_019045.4 [Q5JSH3-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120014, 39 interactors
ELMiQ5JSH3
IntActiQ5JSH3, 6 interactors
STRINGi9606.ENSP00000254029

PTM databases

iPTMnetiQ5JSH3
PhosphoSitePlusiQ5JSH3

Polymorphism and mutation databases

BioMutaiWDR44
DMDMi74762196

Proteomic databases

EPDiQ5JSH3
jPOSTiQ5JSH3
MaxQBiQ5JSH3
PaxDbiQ5JSH3
PeptideAtlasiQ5JSH3
PRIDEiQ5JSH3
ProteomicsDBi63151
63152 [Q5JSH3-2]
63153 [Q5JSH3-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54521
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254029; ENSP00000254029; ENSG00000131725 [Q5JSH3-1]
ENST00000371822; ENSP00000360887; ENSG00000131725 [Q5JSH3-4]
ENST00000371825; ENSP00000360890; ENSG00000131725 [Q5JSH3-2]
GeneIDi54521
KEGGihsa:54521
UCSCiuc004eqn.4 human [Q5JSH3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54521

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR44

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0017006
HGNCiHGNC:30512 WDR44
HPAiHPA038084
HPA046719
neXtProtiNX_Q5JSH3
OpenTargetsiENSG00000131725
PharmGKBiPA128394668

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0283 Eukaryota
ENOG410XQPJ LUCA
GeneTreeiENSGT00940000157557
HOGENOMiHOG000267152
InParanoidiQ5JSH3
KOiK20241
OMAiKTDHTEV
OrthoDBi1332590at2759
PhylomeDBiQ5JSH3
TreeFamiTF329226

Enzyme and pathway databases

SignaLinkiQ5JSH3

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
WDR44

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54521

Protein Ontology

More...
PROi
PR:Q5JSH3

Gene expression databases

BgeeiENSG00000131725 Expressed in 219 organ(s), highest expression level in female gonad
ExpressionAtlasiQ5JSH3 baseline and differential
GenevisibleiQ5JSH3 HS

Family and domain databases

InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR040324 WDR44/Dgr2
PANTHERiPTHR14221 PTHR14221, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR44_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5JSH3
Secondary accession number(s): B4DSE9
, F8W913, Q0JS52, Q0JTF3, Q5JSH2, Q6ZSC1, Q7Z365, Q7Z3P6, Q8NAU8, Q8NHU5, Q9NUV4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: February 15, 2005
Last modified: May 8, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again