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Protein
Submitted name:

Peripheral plasma membrane protein CASK

Gene

CASK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

SignaLinkiQ5JS74

Names & Taxonomyi

Protein namesi
Submitted name:
Peripheral plasma membrane protein CASKImported
Gene namesi
Name:CASKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147044.20
HGNCiHGNC:1497 CASK

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147044

PTM / Processingi

Proteomic databases

MaxQBiQ5JS74
PeptideAtlasiQ5JS74
PRIDEiQ5JS74

Expressioni

Gene expression databases

BgeeiENSG00000147044 Expressed in 231 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiQ5JS74 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5JS74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 276Protein kinaseInterPro annotationAdd BLAST265
Domaini343 – 398L27InterPro annotationAdd BLAST56
Domaini402 – 455L27InterPro annotationAdd BLAST54
Domaini490 – 571PDZInterPro annotationAdd BLAST82

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili542 – 562Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0033 Eukaryota
KOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000233034

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF02828 L27, 2 hits
PF00595 PDZ, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF101288 SSF101288, 2 hits
SSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.iShow all

Q5JS74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS
60 70 80 90 100
SPGLSTEDLK REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC
110 120 130 140 150
FEIVKRADAG FVYSEAVASH YMRQILEALR YCHDNNIIHR DVKPHCVLLA
160 170 180 190 200
SKENSAPVKL GGFGVAIQLG ESGLVAGGRV GTPHFMAPEV VKREPYGKPV
210 220 230 240 250
DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR QWSHISESAK
260 270 280 290 300
DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA
310 320 330 340 350
RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGL LAAERAVSQV
360 370 380 390 400
LDSLEEIHAL TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN
410 420 430 440 450
PPSDAVQRAK EVLEEISCYP ENNDAKELKR ILTQPHFMAL LQTHDVVAHE
460 470 480 490 500
VYSDEALRVT PPPTSPYLNG DSPESANGDM DMENVTRVRL VQFQKNTDEP
510 520 530 540 550
MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN GISVANQTVE
560 570 580 590
QLQKMLREMR GSITFKIVPS YRTQSSSCEV MTLTNHPHLL
Length:590
Mass (Da):66,603
Last modified:February 5, 2008 - v1
Checksum:i098F1681A2A21E06
GO

Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O14936CSKP_HUMAN
Peripheral plasma membrane protein ...
CASK LIN2
926Annotation score:
A0A2R8Y3B3A0A2R8Y3B3_HUMAN
Peripheral plasma membrane protein ...
CASK
555Annotation score:
A0A2R8YE77A0A2R8YE77_HUMAN
Calcium/calmodulin-dependent serine...
CASK hCG_1987160
920Annotation score:
A0A2R8Y6F8A0A2R8Y6F8_HUMAN
Peripheral plasma membrane protein ...
CASK
903Annotation score:
A0A2R8YFN5A0A2R8YFN5_HUMAN
Peripheral plasma membrane protein ...
CASK
904Annotation score:
A0A2R8YEK3A0A2R8YEK3_HUMAN
Peripheral plasma membrane protein ...
CASK
927Annotation score:
A0A2R8YEJ7A0A2R8YEJ7_HUMAN
Peripheral plasma membrane protein ...
CASK
173Annotation score:
A0A2R8Y6D8A0A2R8Y6D8_HUMAN
Peripheral plasma membrane protein ...
CASK
109Annotation score:
Q5JS72Q5JS72_HUMAN
Peripheral plasma membrane protein ...
CASK
518Annotation score:
A0A2U3TZN6A0A2U3TZN6_HUMAN
Peripheral plasma membrane protein ...
CASK
880Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL158144 Genomic DNA No translation available.
AL353691 Genomic DNA No translation available.
AL445239 Genomic DNA No translation available.
AL603754 Genomic DNA No translation available.
AL627402 Genomic DNA No translation available.
KF459071 Genomic DNA No translation available.
KF459072 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000378154; ENSP00000367396; ENSG00000147044
UCSCiuc064yqv.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5JS74_HUMAN
AccessioniPrimary (citable) accession number: Q5JS74
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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