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UniProtKB - Q5JS54 (PSMG4_HUMAN)
Protein
Proteasome assembly chaperone 4
Gene
PSMG4
Organism
Homo sapiens (Human)
Status
Functioni
Chaperone protein which promotes assembly of the 20S proteasome.
By similarityGO - Molecular functioni
- protein-containing complex binding Source: UniProtKB
GO - Biological processi
- proteasome assembly Source: InterPro
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
PathwayCommonsi | Q5JS54 |
SignaLinki | Q5JS54 |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome assembly chaperone 4Short name: PAC-4 Short name: hPAC4 |
Gene namesi | Name:PSMG4 Synonyms:C6orf86, PAC4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21108, PSMG4 |
MIMi | 617550, gene |
neXtProti | NX_Q5JS54 |
VEuPathDBi | HostDB:ENSG00000180822 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 389362 |
OpenTargetsi | ENSG00000180822 |
PharmGKBi | PA162400256 |
Miscellaneous databases
Pharosi | Q5JS54, Tdark |
Genetic variation databases
BioMutai | PSMG4 |
DMDMi | 190360085 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000341397 | 1 – 123 | Proteasome assembly chaperone 4Add BLAST | 123 |
Proteomic databases
EPDi | Q5JS54 |
jPOSTi | Q5JS54 |
MassIVEi | Q5JS54 |
MaxQBi | Q5JS54 |
PeptideAtlasi | Q5JS54 |
PRIDEi | Q5JS54 |
ProteomicsDBi | 30974 63135 [Q5JS54-1] 8201 |
TopDownProteomicsi | Q5JS54-1 [Q5JS54-1] |
PTM databases
GlyGeni | Q5JS54, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q5JS54 |
PhosphoSitePlusi | Q5JS54 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180822, Expressed in quadriceps femoris and 226 other tissues |
ExpressionAtlasi | Q5JS54, baseline and differential |
Genevisiblei | Q5JS54, HS |
Organism-specific databases
HPAi | ENSG00000180822, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PSMG3. Associates with alpha subunits of the 20S proteasome.
By similarityProtein-protein interaction databases
BioGRIDi | 133110, 62 interactors |
CORUMi | Q5JS54 |
IntActi | Q5JS54, 16 interactors |
Miscellaneous databases
RNActi | Q5JS54, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q5JS54 |
SMRi | Q5JS54 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the PSMG4 family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000011804 |
HOGENOMi | CLU_138031_0_0_1 |
InParanoidi | Q5JS54 |
OMAi | CSPRDSI |
OrthoDBi | 1468993at2759 |
PhylomeDBi | Q5JS54 |
TreeFami | TF353302 |
Family and domain databases
InterProi | View protein in InterPro IPR032157, PAC4 |
PANTHERi | PTHR33559, PTHR33559, 1 hit |
Pfami | View protein in Pfam PF16093, PAC4, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5JS54-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEGLVVAAGG DVSLHNFSAR LWEQLVHFHV MRLTDSLFLW VGATPHLRNL
60 70 80 90 100
AVAMCSRYDS IPVSTSLLGD TSDTTSTGLA QRLARKTNKQ VFVSYNLQNT
110 120
DSNFALLVEN RIKEEMEAFP EKF
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C465 | H7C465_HUMAN | Proteasome assembly chaperone 4 | PSMG4 | 117 | Annotation score: | ||
D6RB92 | D6RB92_HUMAN | Proteasome assembly chaperone 4 | PSMG4 | 108 | Annotation score: | ||
D6REN3 | D6REN3_HUMAN | Proteasome assembly chaperone 4 | PSMG4 | 76 | Annotation score: | ||
E2QRC7 | E2QRC7_HUMAN | Proteasome assembly chaperone 4 | PSMG4 | 82 | Annotation score: | ||
F2Z3E0 | F2Z3E0_HUMAN | Proteasome assembly chaperone 4 | PSMG4 | 124 | Annotation score: | ||
D6R926 | D6R926_HUMAN | Proteasome assembly chaperone 4 | PSMG4 | 35 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | L → Q in CD173424 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 2 (identifier: Q5JS54-2) | |||||
Natural variantiVAR_084585 | 99 | W → R1 PublicationCorresponds to variant dbSNP:rs4959786Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046635 | 83 | L → LGLGGKTGLACECGVEWGLS KGHEAECSTLPTPQHTSCGP in isoform 2. Curated | 1 | |
Alternative sequenceiVSP_046636 | 84 – 123 | ARKTN…FPEKF → GMYPQLALHGQPGGAHSLME P in isoform 3. CuratedAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL445309 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55130.1 CD173424 mRNA No translation available. |
CCDSi | CCDS47360.1 [Q5JS54-2] CCDS47361.1 [Q5JS54-1] CCDS47362.1 [Q5JS54-3] |
RefSeqi | NP_001122063.1, NM_001128591.1 [Q5JS54-1] NP_001122064.1, NM_001128592.1 [Q5JS54-2] NP_001129222.1, NM_001135750.1 [Q5JS54-3] |
Genome annotation databases
Ensembli | ENST00000419065.6; ENSP00000392353.2; ENSG00000180822.12 [Q5JS54-2] ENST00000438998.7; ENSP00000413353.3; ENSG00000180822.12 ENST00000473000.2; ENSP00000418241.2; ENSG00000180822.12 [Q5JS54-3] |
GeneIDi | 389362 |
KEGGi | hsa:389362 |
MANE-Selecti | ENST00000438998.7; ENSP00000413353.3; NM_001128591.2; NP_001122063.1 |
UCSCi | uc003mvl.2, human [Q5JS54-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL445309 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55130.1 CD173424 mRNA No translation available. |
CCDSi | CCDS47360.1 [Q5JS54-2] CCDS47361.1 [Q5JS54-1] CCDS47362.1 [Q5JS54-3] |
RefSeqi | NP_001122063.1, NM_001128591.1 [Q5JS54-1] NP_001122064.1, NM_001128592.1 [Q5JS54-2] NP_001129222.1, NM_001135750.1 [Q5JS54-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5WTQ | X-ray | 1.90 | A/B/C/D | 1-123 | [»] | |
AlphaFoldDBi | Q5JS54 | |||||
SMRi | Q5JS54 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 133110, 62 interactors |
CORUMi | Q5JS54 |
IntActi | Q5JS54, 16 interactors |
PTM databases
GlyGeni | Q5JS54, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q5JS54 |
PhosphoSitePlusi | Q5JS54 |
Genetic variation databases
BioMutai | PSMG4 |
DMDMi | 190360085 |
Proteomic databases
EPDi | Q5JS54 |
jPOSTi | Q5JS54 |
MassIVEi | Q5JS54 |
MaxQBi | Q5JS54 |
PeptideAtlasi | Q5JS54 |
PRIDEi | Q5JS54 |
ProteomicsDBi | 30974 63135 [Q5JS54-1] 8201 |
TopDownProteomicsi | Q5JS54-1 [Q5JS54-1] |
Protocols and materials databases
Antibodypediai | 78115, 4 antibodies from 4 providers |
DNASUi | 389362 |
Genome annotation databases
Ensembli | ENST00000419065.6; ENSP00000392353.2; ENSG00000180822.12 [Q5JS54-2] ENST00000438998.7; ENSP00000413353.3; ENSG00000180822.12 ENST00000473000.2; ENSP00000418241.2; ENSG00000180822.12 [Q5JS54-3] |
GeneIDi | 389362 |
KEGGi | hsa:389362 |
MANE-Selecti | ENST00000438998.7; ENSP00000413353.3; NM_001128591.2; NP_001122063.1 |
UCSCi | uc003mvl.2, human [Q5JS54-1] |
Organism-specific databases
CTDi | 389362 |
DisGeNETi | 389362 |
GeneCardsi | PSMG4 |
HGNCi | HGNC:21108, PSMG4 |
HPAi | ENSG00000180822, Low tissue specificity |
MIMi | 617550, gene |
neXtProti | NX_Q5JS54 |
OpenTargetsi | ENSG00000180822 |
PharmGKBi | PA162400256 |
VEuPathDBi | HostDB:ENSG00000180822 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000011804 |
HOGENOMi | CLU_138031_0_0_1 |
InParanoidi | Q5JS54 |
OMAi | CSPRDSI |
OrthoDBi | 1468993at2759 |
PhylomeDBi | Q5JS54 |
TreeFami | TF353302 |
Enzyme and pathway databases
PathwayCommonsi | Q5JS54 |
SignaLinki | Q5JS54 |
Miscellaneous databases
BioGRID-ORCSi | 389362, 733 hits in 1090 CRISPR screens |
ChiTaRSi | PSMG4, human |
GenomeRNAii | 389362 |
Pharosi | Q5JS54, Tdark |
PROi | PR:Q5JS54 |
RNActi | Q5JS54, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180822, Expressed in quadriceps femoris and 226 other tissues |
ExpressionAtlasi | Q5JS54, baseline and differential |
Genevisiblei | Q5JS54, HS |
Family and domain databases
InterProi | View protein in InterPro IPR032157, PAC4 |
PANTHERi | PTHR33559, PTHR33559, 1 hit |
Pfami | View protein in Pfam PF16093, PAC4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PSMG4_HUMAN | |
Accessioni | Q5JS54Primary (citable) accession number: Q5JS54 Secondary accession number(s): C9J2F8 Q5JS56 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | May 25, 2022 | |
This is version 107 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families