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Protein
Submitted name:

Transcription factor 7-like 2

Gene

TCF7L2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor 7-like 2Imported
Gene namesi
Name:TCF7L2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148737.15
HGNCiHGNC:11641 TCF7L2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148737

PTM / Processingi

Proteomic databases

PeptideAtlasiQ5JRY4
PRIDEiQ5JRY4

Expressioni

Gene expression databases

BgeeiENSG00000148737 Expressed in 228 organ(s), highest expression level in lateral nuclear group of thalamus
ExpressionAtlasiQ5JRY4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5JRY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 76CTNNB1_bindingInterPro annotationAdd BLAST75

Phylogenomic databases

eggNOGiKOG3248 Eukaryota
ENOG41109RU LUCA
GeneTreeiENSGT00390000009964
HOGENOMiHOG000116032
HOVERGENiHBG000419

Family and domain databases

InterProiView protein in InterPro
IPR013558 CTNNB1-bd_N
IPR024940 TCF/LEF
PANTHERiPTHR10373 PTHR10373, 1 hit
PfamiView protein in Pfam
PF08347 CTNNB1_binding, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.iShow all

Q5JRY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNKVPVVQH PHHVHPLTPL ITYSNEHFTP GNPPPHLPAD VDPKTGIPRP
60 70 80 90 100
PHPPDISPYY PLSPGTVGQI PHPLGWLVPQ QGQPVYPITT GGFRHPYPTA
110 120 130 140 150
LTVNASMSRF PPHMVPPHHT LHTTGIPHPA IVTPTVKQES SQSDVGSLHS
160
SKHQDSKKEE EKKKPHI
Length:167
Mass (Da):18,331
Last modified:October 5, 2016 - v2
Checksum:i5E72C0E93B5E016B
GO

Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NQB0TF7L2_HUMAN
Transcription factor 7-like 2
TCF7L2 TCF4
619Annotation score:
Q5VVR7Q5VVR7_HUMAN
TCF7L2 isoform pFC8A_TCF7L2_H7_ex1-...
TCF7L2
455Annotation score:
C6ZRK5C6ZRK5_HUMAN
TCF7L2 isoform pFC8A_TCF7L2_ex1-11-...
TCF7L2 hCG_40998
579Annotation score:
E2GH26E2GH26_HUMAN
T-cell factor-4 variant L
TCF7L2
607Annotation score:
C6ZRJ7C6ZRJ7_HUMAN
TCF7L2 isoform pFC8A_TCF7L2_A3,ex1-...
TCF7L2
476Annotation score:
A0A0A0MTL7A0A0A0MTL7_HUMAN
Transcription factor 7-like 2
TCF7L2
408Annotation score:
A0A0D9SGH8A0A0D9SGH8_HUMAN
Transcription factor 7-like 2
TCF7L2
584Annotation score:
Q5JRY5Q5JRY5_HUMAN
Transcription factor 7-like 2
TCF7L2
206Annotation score:
Q5JRY3Q5JRY3_HUMAN
Transcription factor 7-like 2
TCF7L2
157Annotation score:
C6ZRJ6C6ZRJ6_HUMAN
TCF7L2 isoform pFC8A_TCF7L2_D5_ex3,...
TCF7L2
534Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei167Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135792 Genomic DNA No translation available.
AL158212 Genomic DNA No translation available.
AL445486 Genomic DNA No translation available.
AL451084 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000369389; ENSP00000358396; ENSG00000148737
UCSCiuc057wbf.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5JRY4_HUMAN
AccessioniPrimary (citable) accession number: Q5JRY4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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