UniProtKB - Q5JRP2 (Q5JRP2_HUMAN)
Protein
Submitted name:
Disintegrin and metalloproteinase domain-containing protein 12
Gene
ADAM12
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Disintegrin and metalloproteinase domain-containing protein 12Imported |
Gene namesi | Name:ADAM12Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000148848.14 |
HGNCi | HGNC:190, ADAM12 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_5004257969 | 29 – 278 | Sequence analysisAdd BLAST | 250 |
Keywords - PTMi
Disulfide bondARBA annotationProteomic databases
MaxQBi | Q5JRP2 |
PeptideAtlasi | Q5JRP2 |
PRIDEi | Q5JRP2 |
ProteomicsDBi | 63102 |
Expressioni
Gene expression databases
Bgeei | ENSG00000148848, Expressed in placenta and 175 other tissues |
ExpressionAtlasi | Q5JRP2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 211 – 278 | Peptidase M12BInterPro annotationAdd BLAST | 68 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155495 |
HOGENOMi | CLU_087486_0_0_1 |
Family and domain databases
Gene3Di | 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5JRP2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG
60 70 80 90 100
DLWIPVKSFD SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL
110 120 130 140 150
QDGTDVSLAR NYTGHCYYHG HVRGYSDSAV SLSTCSGLRG LIVFENESYV
160 170 180 190 200
LEPMKSATNR YKLFPAKKLK SVRGSCGSHH NTPNLAAKNV FPPPSQTWAR
210 220 230 240 250
RHKRETLKAT KYVELVIVAD NREFQRQGKD LEKVKQRLIE IANHVDKFYR
260 270
PLNIRIVLVG VEVWNDMDKC SVSQDPFT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketO43184 | ADA12_HUMAN | Disintegrin and metalloproteinase d... | ADAM12 MLTN, UNQ346/PRO545 | 909 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 278 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022015 Genomic DNA No translation available. AC026226 Genomic DNA No translation available. AC063963 Genomic DNA No translation available. AL589787 Genomic DNA No translation available. AL691463 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000448723; ENSP00000391268; ENSG00000148848 |
UCSCi | uc057wtm.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022015 Genomic DNA No translation available. AC026226 Genomic DNA No translation available. AC063963 Genomic DNA No translation available. AL589787 Genomic DNA No translation available. AL691463 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | Q5JRP2 |
PeptideAtlasi | Q5JRP2 |
PRIDEi | Q5JRP2 |
ProteomicsDBi | 63102 |
Protocols and materials databases
Antibodypediai | 19223, 435 antibodies |
Genome annotation databases
Ensembli | ENST00000448723; ENSP00000391268; ENSG00000148848 |
UCSCi | uc057wtm.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000148848.14 |
HGNCi | HGNC:190, ADAM12 |
OpenTargetsi | ENSG00000148848 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155495 |
HOGENOMi | CLU_087486_0_0_1 |
Miscellaneous databases
ChiTaRSi | ADAM12, human |
Gene expression databases
Bgeei | ENSG00000148848, Expressed in placenta and 175 other tissues |
ExpressionAtlasi | Q5JRP2, baseline and differential |
Family and domain databases
Gene3Di | 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N |
Pfami | View protein in Pfam PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5JRP2_HUMAN | |
Accessioni | Q5JRP2Primary (citable) accession number: Q5JRP2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 15, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | December 2, 2020 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |