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UniProtKB - Q5JRP2 (Q5JRP2_HUMAN)
Protein
Submitted name:
Disintegrin and metalloproteinase domain-containing protein 12
Gene
ADAM12
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- metalloendopeptidase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, IntegrinImported, MetalloproteaseImported, Protease |
Protein family/group databases
MEROPSi | M12.212 |
Names & Taxonomyi
Protein namesi | Submitted name: Disintegrin and metalloproteinase domain-containing protein 12Submitted name: Metalloprotease-disintegrin 12 transmembrane isoform LaImported |
Gene namesi | Name:ADAM12Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:190, ADAM12 |
VEuPathDBi | HostDB:ENSG00000148848 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 705 – 726 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_5033704934 | 29 – 906 | Sequence analysisAdd BLAST | 878 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 479 ↔ 499 | PROSITE-ProRule annotation | ||
Disulfide bondi | 657 ↔ 667 | PROSITE-ProRule annotation | ||
Disulfide bondi | 675 ↔ 684 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotationProteomic databases
MaxQBi | Q5JRP2 |
PRIDEi | Q5JRP2 |
ProteomicsDBi | 63102 |
Expressioni
Gene expression databases
Bgeei | ENSG00000148848, Expressed in placenta and 176 other tissues |
ExpressionAtlasi | Q5JRP2, baseline and differential |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 211 – 413 | Peptidase M12BInterPro annotationAdd BLAST | 203 | |
Domaini | 421 – 507 | DisintegrinInterPro annotationAdd BLAST | 87 | |
Domaini | 653 – 685 | EGF-likeInterPro annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 819 – 859 | DisorderedSequence analysisAdd BLAST | 41 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155495 |
HOGENOMi | CLU_087486_0_0_1 |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS50026, EGF_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5JRP2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG
60 70 80 90 100
DLWIPVKSFD SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL
110 120 130 140 150
QDGTDVSLAR NYTGHCYYHG HVRGYSDSAV SLSTCSGLRG LIVFENESYV
160 170 180 190 200
LEPMKSATNR YKLFPAKKLK SVRGSCGSHH NTPNLAAKNV FPPPSQTWAR
210 220 230 240 250
RHKRETLKAT KYVELVIVAD NREFQRQGKD LEKVKQRLIE IANHVDKFYR
260 270 280 290 300
PLNIRIVLVG VEVWNDMDKC SVSQDPFTSL HEFLDWRKMK LLPRKSHDNA
310 320 330 340 350
QLVSGVYFQG TTIGMAPIMS MCTADQSGGI VMDHSDNPLG AAVTLAHELG
360 370 380 390 400
HNFGMNHDTL DRGCSCQMAV EKGGCIMNAS TGYPFPMVFS SCSRKDLETS
410 420 430 440 450
LEKGMGVCLF NLPEVRESFG GQKCGNRFVE EGEECDCGEP EECMNRCCNA
460 470 480 490 500
TTCTLKPDAV CAHGLCCEDC QLKPAGTACR DSSNSCDLPE FCTGASPHCP
510 520 530 540 550
ANVYLHDGHS CQDVDGYCYN GICQTHEQQC VTLWGPGAKP APGICFERVN
560 570 580 590 600
SAGDPYGNCG KVSKSSFAKC EMRDAKCGKI QCQGGASRPV IGTNAVSIET
610 620 630 640 650
NIPLQQGGRI LCRGTHVYLG DDMPDPGLVL AGTKCADGKI CLNRQCQNIS
660 670 680 690 700
VFGVHECAMQ CHGRGVCNNR KNCHCEAHWA PPFCDKFGFG GSTDSGPIRQ
710 720 730 740 750
ADNQGLTIGI LVTILCLLAA GFVVYLKRKT LIRLLFTNKK TTIEKLRCVR
760 770 780 790 800
PSRPPRGFQP CQAHLGHLGK GLMRKPPDSY PPKDNPRRLL QCQNVDISRP
810 820 830 840 850
LNGLNVPQPQ STQRVLPPLH RAPRAPSVPA RPLPAKPALR QAQGTCKPNP
860 870 880 890 900
PQKPLPADPL ARTTRLTHAL ARTPGQWETG LRLAPLRPAP QYPHQVPRST
HTAYIK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketO43184 | ADA12_HUMAN | Disintegrin and metalloproteinase d... | ADAM12 MLTN, UNQ346/PRO545 | 909 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022015 Genomic DNA No translation available. AC026226 Genomic DNA No translation available. AC063963 Genomic DNA No translation available. AL589787 Genomic DNA No translation available. AL691463 Genomic DNA No translation available. KF444157 mRNA Translation: AGX93290.1 |
RefSeqi | NP_001275902.1, NM_001288973.1 |
Genome annotation databases
Ensembli | ENST00000448723.2; ENSP00000391268.2; ENSG00000148848.15 |
GeneIDi | 8038 |
MANE-Selecti | ENST00000448723.2; ENSP00000391268.2; NM_001288973.2; NP_001275902.1 |
UCSCi | uc057wtm.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022015 Genomic DNA No translation available. AC026226 Genomic DNA No translation available. AC063963 Genomic DNA No translation available. AL589787 Genomic DNA No translation available. AL691463 Genomic DNA No translation available. KF444157 mRNA Translation: AGX93290.1 |
RefSeqi | NP_001275902.1, NM_001288973.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | M12.212 |
Proteomic databases
MaxQBi | Q5JRP2 |
PRIDEi | Q5JRP2 |
ProteomicsDBi | 63102 |
Protocols and materials databases
Antibodypediai | 19223, 474 antibodies from 40 providers |
DNASUi | 8038 |
Genome annotation databases
Ensembli | ENST00000448723.2; ENSP00000391268.2; ENSG00000148848.15 |
GeneIDi | 8038 |
MANE-Selecti | ENST00000448723.2; ENSP00000391268.2; NM_001288973.2; NP_001275902.1 |
UCSCi | uc057wtm.1, human |
Organism-specific databases
CTDi | 8038 |
HGNCi | HGNC:190, ADAM12 |
OpenTargetsi | ENSG00000148848 |
VEuPathDBi | HostDB:ENSG00000148848 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155495 |
HOGENOMi | CLU_087486_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 8038, 11 hits in 1074 CRISPR screens |
ChiTaRSi | ADAM12, human |
GenomeRNAii | 8038 |
Gene expression databases
Bgeei | ENSG00000148848, Expressed in placenta and 176 other tissues |
ExpressionAtlasi | Q5JRP2, baseline and differential |
Family and domain databases
CDDi | cd04269, ZnMc_adamalysin_II_like, 1 hit |
Gene3Di | 3.40.390.10, 1 hit 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR006586, ADAM_Cys-rich IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf IPR000742, EGF-like_dom IPR024079, MetalloPept_cat_dom_sf IPR001590, Peptidase_M12B IPR002870, Peptidase_M12B_N IPR034027, Reprolysin_adamalysin |
Pfami | View protein in Pfam PF08516, ADAM_CR, 1 hit PF00200, Disintegrin, 1 hit PF01562, Pep_M12B_propep, 1 hit PF01421, Reprolysin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00608, ACR, 1 hit SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS50215, ADAM_MEPRO, 1 hit PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit PS50026, EGF_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5JRP2_HUMAN | |
Accessioni | Q5JRP2Primary (citable) accession number: Q5JRP2 Secondary accession number(s): U5NE98 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 15, 2005 |
Last sequence update: | September 29, 2021 | |
Last modified: | May 25, 2022 | |
This is version 116 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |