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UniProtKB - Q5JRA6 (TGO1_HUMAN)

Protein

Transport and Golgi organization protein 1 homolog

Gene

MIA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255).2 Publications

GO - Molecular functioni

  • lipoprotein transporter activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processER-Golgi transport, Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5694530 Cargo concentration in the ER
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

TCDBi9.B.113.1.2 the collagen secretory protein, mia3 (mia3) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transport and Golgi organization protein 1 homologCurated
Short name:
TANGO11 Publication
Alternative name(s):
C219-reactive peptide1 Publication
D3201 Publication
Melanoma inhibitory activity protein 3Imported
Gene namesi
Name:MIA3Imported
Synonyms:KIAA0268Imported, TANGO1 Publication
ORF Names:UNQ6077/PRO20088
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000154305.16
HGNCiHGNC:24008 MIA3
MIMi613455 gene
neXtProtiNX_Q5JRA6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 1144LumenalSequence analysisAdd BLAST1122
Intramembranei1145 – 1165Sequence analysisAdd BLAST21
Topological domaini1166 – 1176LumenalSequence analysisAdd BLAST11
Transmembranei1177 – 1197HelicalSequence analysisAdd BLAST21
Topological domaini1198 – 1907CytoplasmicSequence analysisAdd BLAST710

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi375056
OpenTargetsiENSG00000154305
PharmGKBiPA143485536

Polymorphism and mutation databases

BioMutaiMIA3
DMDMi74741823

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000028899823 – 1907Transport and Golgi organization protein 1 homologAdd BLAST1885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226Phosphoserine; by FAM20C1 Publication1
Modified residuei229Phosphoserine; by FAM20C1 Publication1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi589N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei727PhosphoserineCombined sources1
Modified residuei876PhosphoserineCombined sources1
Modified residuei1067PhosphoserineCombined sources1
Modified residuei1431PhosphoserineBy similarity1
Modified residuei1666PhosphoserineBy similarity1
Modified residuei1678PhosphoserineBy similarity1
Modified residuei1706PhosphoserineCombined sources1
Modified residuei1727PhosphoserineBy similarity1
Modified residuei1741PhosphoserineBy similarity1
Modified residuei1745PhosphoserineCombined sources1
Modified residuei1784Asymmetric dimethylarginineBy similarity1
Modified residuei1892PhosphoserineBy similarity1
Modified residuei1906Phosphoserine; by FAM20CCombined sources1 Publication1

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiQ5JRA6
MaxQBiQ5JRA6
PaxDbiQ5JRA6
PeptideAtlasiQ5JRA6
PRIDEiQ5JRA6
ProteomicsDBi63078
63079 [Q5JRA6-2]
63080 [Q5JRA6-3]
63081 [Q5JRA6-4]

PTM databases

iPTMnetiQ5JRA6
PhosphoSitePlusiQ5JRA6

Miscellaneous databases

PMAP-CutDBiQ5JRA6

Expressioni

Tissue specificityi

Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue.2 Publications

Gene expression databases

BgeeiENSG00000154305 Expressed in 217 organ(s), highest expression level in stomach
CleanExiHS_MIA3
ExpressionAtlasiQ5JRA6 baseline and differential
GenevisibleiQ5JRA6 HS

Organism-specific databases

HPAiHPA055922
HPA056816

Interactioni

Subunit structurei

Interacts with CTAGE5 (PubMed:21525241). Interacts (via SH3 domain) with COL7A1 (PubMed:19269366). Interacts with the COPII coat subunits SEC23A, SEC23B and maybe SEC24C (PubMed:19269366, PubMed:27551091). May interact with APOB and MIA2 (PubMed:27138255).4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi131952, 49 interactors
IntActiQ5JRA6, 27 interactors
STRINGi9606.ENSP00000340900

Structurei

3D structure databases

ProteinModelPortaliQ5JRA6
SMRiQ5JRA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 107SH3PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1211 – 1650Mediates interaction with CTAGE51 PublicationAdd BLAST440
Regioni1751 – 1907Proline-rich domain (PRD); mediates interaction with the COPII coat subunits SEC23A and SEC23B2 PublicationsAdd BLAST157

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili471 – 531Sequence analysisAdd BLAST61
Coiled coili1214 – 1396Sequence analysisAdd BLAST183
Coiled coili1487 – 1639Sequence analysisAdd BLAST153

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1640 – 1890Pro-richAdd BLAST251

Domaini

The proline-rich domain (PRD) contains repeated PPP motifs. A single PPP motif is necessary and sufficient to mediate interaction with the COPII coat subunits SEC23A and SEC23B.2 Publications
Although 2 transmembrane domains are predicted, PubMed:19269366 showed that it only contains one transmembrane domain. The other predicted transmembrane region is probably a hairpin-type region embedded into the membrane, which does not cross the membrane. It is unclear which of the 2 predicted transmembrane regions is the transmembrane or the hairpin-type region.1 Publication

Sequence similaritiesi

Belongs to the MIA/OTOR family. Tango1 subfamily.Curated

Keywords - Domaini

Coiled coil, SH3 domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFUG Eukaryota
ENOG410YVAS LUCA
GeneTreeiENSGT00530000063635
HOVERGENiHBG108133
InParanoidiQ5JRA6
OMAiIFGYFPK
OrthoDBiEOG091G0PEA
PhylomeDBiQ5JRA6
TreeFamiTF333137

Family and domain databases

InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF07653 SH3_2, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q5JRA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAPGLLVW LLVLRLPWRV PGQLDPSTGR RFSEHKLCAD DECSMLMYRG 
        60         70         80         90        100
EALEDFTGPD CRFVNFKKGD PVYVYYKLAR GWPEVWAGSV GRTFGYFPKD 
       110        120        130        140        150
LIQVVHEYTK EELQVPTDET DFVCFDGGRD DFHNYNVEEL LGFLELYNSA 
       160        170        180        190        200
ATDSEKAVEK TLQDMEKNPE LSKEREPEPE PVEANSEESD SVFSENTEDL 
       210        220        230        240        250
QEQFTTQKHH SHANSQANHA QGEQASFESF EEMLQDKLKV PESENNKTSN 
       260        270        280        290        300
SSQVSNEQDK IDAYKLLKKE MTLDLKTKFG STADALVSDD ETTRLVTSLE 
       310        320        330        340        350
DDFDEELDTE YYAVGKEDEE NQEDFDELPL LTFTDGEDMK TPAKSGVEKY 
       360        370        380        390        400
PTDKEQNSNE EDKVQLTVPP GIKNDDKNIL TTWGDTIFSI VTGGEETRDT 
       410        420        430        440        450
MDLESSSSEE EKEDDDDALV PDSKQGKPQS ATDYSDPDNV DDGLFIVDIP 
       460        470        480        490        500
KTNNDKEVNA EHHIKGKGRG VQESKRGLVQ DKTELEDENQ EGMTVHSSVH 
       510        520        530        540        550
SNNLNSMPAA EKGKDTLKSA YDDTENDLKG AAIHISKGML HEEKPGEQIL 
       560        570        580        590        600
EGGSESESAQ KAAGNQMNDR KIQQESLGSA PLMGDDHPNA SRDSVEGDAL 
       610        620        630        640        650
VNGAKLHTLS VEHQREELKE ELVLKTQNQP RFSSPDEIDL PRELEDEVPI 
       660        670        680        690        700
LGRNLPWQQE RDVAATASKQ MSEKIRLSEG EAKEDSLDEE FFHHKAMQGT 
       710        720        730        740        750
EVGQTDQTDS TGGPAFLSKV EEDDYPSEEL LEDENAINAK RSKEKNPGNQ 
       760        770        780        790        800
GRQFDVNLQV PDRAVLGTIH PDPEIEESKQ ETSMILDSEK TSETAAKGVN 
       810        820        830        840        850
TGGREPNTMV EKERPLADKK AQRPFERSDF SDSIKIQTPE LGEVFQNKDS 
       860        870        880        890        900
DYLKNDNPEE HLKTSGLAGE PEGELSKEDH ENTEKYMGTE SQGSAAAEPE 
       910        920        930        940        950
DDSFHWTPHT SVEPGHSDKR EDLLIISSFF KEQQSLQRFQ KYFNVHELEA 
       960        970        980        990       1000
LLQEMSSKLK SAQQESLPYN MEKVLDKVFR ASESQILSIA EKMLDTRVAE 
      1010       1020       1030       1040       1050
NRDLGMNENN IFEEAAVLDD IQDLIYFVRY KHSTAEETAT LVMAPPLEEG 
      1060       1070       1080       1090       1100
LGGAMEEMQP LHEDNFSREK TAELNVQVPE EPTHLDQRVI GDTHASEVSQ 
      1110       1120       1130       1140       1150
KPNTEKDLDP GPVTTEDTPM DAIDANKQPE TAAEEPASVT PLENAILLIY 
      1160       1170       1180       1190       1200
SFMFYLTKSL VATLPDDVQP GPDFYGLPWK PVFITAFLGI ASFAIFLWRT 
      1210       1220       1230       1240       1250
VLVVKDRVYQ VTEQQISEKL KTIMKENTEL VQKLSNYEQK IKESKKHVQE 
      1260       1270       1280       1290       1300
TRKQNMILSD EAIKYKDKIK TLEKNQEILD DTAKNLRVML ESEREQNVKN 
      1310       1320       1330       1340       1350
QDLISENKKS IEKLKDVISM NASEFSEVQI ALNEAKLSEE KVKSECHRVQ 
      1360       1370       1380       1390       1400
EENARLKKKK EQLQQEIEDW SKLHAELSEQ IKSFEKSQKD LEVALTHKDD 
      1410       1420       1430       1440       1450
NINALTNCIT QLNLLECESE SEGQNKGGND SDELANGEVG GDRNEKMKNQ 
      1460       1470       1480       1490       1500
IKQMMDVSRT QTAISVVEED LKLLQLKLRA SVSTKCNLED QVKKLEDDRN 
      1510       1520       1530       1540       1550
SLQAAKAGLE DECKTLRQKV EILNELYQQK EMALQKKLSQ EEYERQEREH 
      1560       1570       1580       1590       1600
RLSAADEKAV SAAEEVKTYK RRIEEMEDEL QKTERSFKNQ IATHEKKAHE 
      1610       1620       1630       1640       1650
NWLKARAAER AIAEEKREAA NLRHKLLELT QKMAMLQEEP VIVKPMPGKP 
      1660       1670       1680       1690       1700
NTQNPPRRGP LSQNGSFGPS PVSGGECSPP LTVEPPVRPL SATLNRRDMP 
      1710       1720       1730       1740       1750
RSEFGSVDGP LPHPRWSAEA SGKPSPSDPG SGTATMMNSS SRGSSPTRVL 
      1760       1770       1780       1790       1800
DEGKVNMAPK GPPPFPGVPL MSTPMGGPVP PPIRYGPPPQ LCGPFGPRPL 
      1810       1820       1830       1840       1850
PPPFGPGMRP PLGLREFAPG VPPGRRDLPL HPRGFLPGHA PFRPLGSLGP 
      1860       1870       1880       1890       1900
REYFIPGTRL PPPTHGPQEY PPPPAVRDLL PSGSRDEPPP ASQSTSQDCS 

QALKQSP
Length:1,907
Mass (Da):213,702
Last modified:February 15, 2005 - v1
Checksum:iD19C9AF1656F4B1C
GO
Isoform 2 (identifier: Q5JRA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1304-1362: Missing.

Show »
Length:1,848
Mass (Da):206,890
Checksum:iB793E3992499E137
GO
Isoform 3 (identifier: Q5JRA6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-500: MTVHSSVH → FKTEPIKL
     501-1907: Missing.

Show »
Length:500
Mass (Da):56,584
Checksum:iF785E148171092E6
GO
Isoform 4 (identifier: Q5JRA6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1122: Missing.
     1123-1159: IDANKQPETAAEEPASVTPLENAILLIYSFMFYLTKS → MDSVPATVPSIAATPGDPELVGPLSVLYAAFIAKLLE

Show »
Length:785
Mass (Da):87,438
Checksum:i0A3890131D1BA2D5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRH6A0A0A0MRH6_HUMAN
Transport and Golgi organization pr...
MIA3
1,015Annotation score:
H7C0T4H7C0T4_HUMAN
Transport and Golgi organization pr...
MIA3
107Annotation score:

Sequence cautioni

The sequence BAC04810 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF83024 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46Missing in AAQ89449 (PubMed:12975309).Curated1
Sequence conflicti1032H → R in BAC04810 (PubMed:14702039).Curated1
Sequence conflicti1443R → Q in AAH47116 (PubMed:15489334).Curated1
Sequence conflicti1754K → R in BAH12416 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032546482K → E1 PublicationCorresponds to variant dbSNP:rs2936053Ensembl.1
Natural variantiVAR_032547605K → R. Corresponds to variant dbSNP:rs2936052Ensembl.1
Natural variantiVAR_032548881E → G1 PublicationCorresponds to variant dbSNP:rs2936051Ensembl.1
Natural variantiVAR_0325491659G → C1 PublicationCorresponds to variant dbSNP:rs17857325Ensembl.1
Natural variantiVAR_0325501723K → E1 PublicationCorresponds to variant dbSNP:rs17854428Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0258601 – 1122Missing in isoform 4. 1 PublicationAdd BLAST1122
Alternative sequenceiVSP_025861493 – 500MTVHSSVH → FKTEPIKL in isoform 3. 1 Publication8
Alternative sequenceiVSP_025862501 – 1907Missing in isoform 3. 1 PublicationAdd BLAST1407
Alternative sequenceiVSP_0258631123 – 1159IDANK…YLTKS → MDSVPATVPSIAATPGDPEL VGPLSVLYAAFIAKLLE in isoform 4. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_0258641304 – 1362Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359091 mRNA Translation: AAQ89449.1
AK096526 mRNA Translation: BAC04810.1 Different initiation.
AK290335 mRNA Translation: BAF83024.1 Different initiation.
AK296712 mRNA Translation: BAH12416.1
AL592148 Genomic DNA No translation available.
D87742 mRNA Translation: BAA13448.1
L34688 mRNA Translation: AAB00324.1
DQ166034 mRNA Translation: AAZ95512.1
BC047116 mRNA Translation: AAH47116.2
CCDSiCCDS41470.1 [Q5JRA6-1]
CCDS73035.1 [Q5JRA6-4]
RefSeqiNP_001287796.1, NM_001300867.1 [Q5JRA6-4]
NP_001310992.1, NM_001324063.1 [Q5JRA6-2]
NP_940953.2, NM_198551.3 [Q5JRA6-1]
UniGeneiHs.118474

Genome annotation databases

EnsembliENST00000340535; ENSP00000345866; ENSG00000154305 [Q5JRA6-4]
ENST00000344507; ENSP00000341348; ENSG00000154305 [Q5JRA6-3]
ENST00000344922; ENSP00000340900; ENSG00000154305 [Q5JRA6-1]
GeneIDi375056
KEGGihsa:375056
UCSCiuc001hnl.4 human [Q5JRA6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359091 mRNA Translation: AAQ89449.1
AK096526 mRNA Translation: BAC04810.1 Different initiation.
AK290335 mRNA Translation: BAF83024.1 Different initiation.
AK296712 mRNA Translation: BAH12416.1
AL592148 Genomic DNA No translation available.
D87742 mRNA Translation: BAA13448.1
L34688 mRNA Translation: AAB00324.1
DQ166034 mRNA Translation: AAZ95512.1
BC047116 mRNA Translation: AAH47116.2
CCDSiCCDS41470.1 [Q5JRA6-1]
CCDS73035.1 [Q5JRA6-4]
RefSeqiNP_001287796.1, NM_001300867.1 [Q5JRA6-4]
NP_001310992.1, NM_001324063.1 [Q5JRA6-2]
NP_940953.2, NM_198551.3 [Q5JRA6-1]
UniGeneiHs.118474

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KYNX-ray2.55C1796-1803[»]
5KYUX-ray3.51C1796-1803[»]
5KYWX-ray3.20C1800-1808[»]
ProteinModelPortaliQ5JRA6
SMRiQ5JRA6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131952, 49 interactors
IntActiQ5JRA6, 27 interactors
STRINGi9606.ENSP00000340900

Protein family/group databases

TCDBi9.B.113.1.2 the collagen secretory protein, mia3 (mia3) family

PTM databases

iPTMnetiQ5JRA6
PhosphoSitePlusiQ5JRA6

Polymorphism and mutation databases

BioMutaiMIA3
DMDMi74741823

Proteomic databases

EPDiQ5JRA6
MaxQBiQ5JRA6
PaxDbiQ5JRA6
PeptideAtlasiQ5JRA6
PRIDEiQ5JRA6
ProteomicsDBi63078
63079 [Q5JRA6-2]
63080 [Q5JRA6-3]
63081 [Q5JRA6-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340535; ENSP00000345866; ENSG00000154305 [Q5JRA6-4]
ENST00000344507; ENSP00000341348; ENSG00000154305 [Q5JRA6-3]
ENST00000344922; ENSP00000340900; ENSG00000154305 [Q5JRA6-1]
GeneIDi375056
KEGGihsa:375056
UCSCiuc001hnl.4 human [Q5JRA6-1]

Organism-specific databases

CTDi375056
DisGeNETi375056
EuPathDBiHostDB:ENSG00000154305.16
GeneCardsiMIA3
H-InvDBiHIX0001613
HGNCiHGNC:24008 MIA3
HPAiHPA055922
HPA056816
MIMi613455 gene
neXtProtiNX_Q5JRA6
OpenTargetsiENSG00000154305
PharmGKBiPA143485536
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFUG Eukaryota
ENOG410YVAS LUCA
GeneTreeiENSGT00530000063635
HOVERGENiHBG108133
InParanoidiQ5JRA6
OMAiIFGYFPK
OrthoDBiEOG091G0PEA
PhylomeDBiQ5JRA6
TreeFamiTF333137

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5694530 Cargo concentration in the ER
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiMIA3 human
GenomeRNAii375056
PMAP-CutDBiQ5JRA6
PROiPR:Q5JRA6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154305 Expressed in 217 organ(s), highest expression level in stomach
CleanExiHS_MIA3
ExpressionAtlasiQ5JRA6 baseline and differential
GenevisibleiQ5JRA6 HS

Family and domain databases

InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF07653 SH3_2, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTGO1_HUMAN
AccessioniPrimary (citable) accession number: Q5JRA6
Secondary accession number(s): A8K2S0
, A8MT05, A8MT13, B7Z430, Q14083, Q3S4X3, Q5JRA5, Q5JRB0, Q5JRB1, Q5JRB2, Q6UVY8, Q86Y60, Q8N8M5, Q92580
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 15, 2005
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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