UniProtKB - Q5JRA6 (TGO1_HUMAN)
Transport and Golgi organization protein 1 homolog
MIA3
Functioni
GO - Molecular functioni
- cargo receptor activity Source: UniProtKB
GO - Biological processi
- cell migration involved in sprouting angiogenesis Source: BHF-UCL
- cellular protein metabolic process Source: Reactome
- cellular response to oxidised low-density lipoprotein particle stimulus Source: BHF-UCL
- COPII-coated vesicle cargo loading Source: UniProtKB
- endoplasmic reticulum organization Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
- exocytosis Source: UniProtKB
- lipoprotein transport Source: UniProtKB
- negative regulation of cell adhesion Source: BHF-UCL
- negative regulation of cell migration Source: BHF-UCL
- negative regulation of leukocyte cell-cell adhesion Source: BHF-UCL
- negative regulation of lymphocyte migration Source: BHF-UCL
- positive regulation of leukocyte migration Source: BHF-UCL
- post-translational protein modification Source: Reactome
- protein localization to endoplasmic reticulum exit site Source: UniProtKB
- protein secretion Source: GO_Central
- protein transport Source: UniProtKB
- vesicle cargo loading Source: GO_Central
- wound healing Source: BHF-UCL
Keywordsi
Biological process | ER-Golgi transport, Exocytosis, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q5JRA6 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5694530, Cargo concentration in the ER R-HSA-8957275, Post-translational protein phosphorylation |
Protein family/group databases
TCDBi | 9.B.113.1.2, the collagen secretory protein, mia3 (mia3) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transport and Golgi organization protein 1 homologCuratedShort name: TANGO11 Publication Alternative name(s): C219-reactive peptide1 Publication D3201 Publication Melanoma inhibitory activity protein 3Imported |
Gene namesi | ORF Names:UNQ6077/PRO20088 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24008, MIA3 |
MIMi | 613455, gene |
neXtProti | NX_Q5JRA6 |
VEuPathDBi | HostDB:ENSG00000154305.16 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Single-pass membrane protein 1 Publication
Note: Localizes at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SEC16A is required for its proper localization to ERES. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membrane.3 Publications
Endoplasmic reticulum
- endoplasmic reticulum exit site Source: UniProtKB
- endoplasmic reticulum lumen Source: Reactome
- endoplasmic reticulum membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 1144 | LumenalSequence analysisAdd BLAST | 1122 | |
Intramembranei | 1145 – 1165 | Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1166 – 1176 | LumenalSequence analysisAdd BLAST | 11 | |
Transmembranei | 1177 – 1197 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1198 – 1907 | CytoplasmicSequence analysisAdd BLAST | 710 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 375056 |
OpenTargetsi | ENSG00000154305 |
PharmGKBi | PA143485536 |
Miscellaneous databases
Pharosi | Q5JRA6, Tbio |
Genetic variation databases
BioMutai | MIA3 |
DMDMi | 74741823 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000288998 | 23 – 1907 | Transport and Golgi organization protein 1 homologAdd BLAST | 1885 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 226 | Phosphoserine; by FAM20C1 Publication | 1 | |
Modified residuei | 229 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 246 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 589 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 727 | PhosphoserineCombined sources | 1 | |
Modified residuei | 876 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1067 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1431 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1666 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1678 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1706 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1727 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1741 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1745 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1784 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 1892 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1906 | Phosphoserine; by FAM20CCombined sources1 Publication | 1 |
Keywords - PTMi
Glycoprotein, Methylation, PhosphoproteinProteomic databases
EPDi | Q5JRA6 |
jPOSTi | Q5JRA6 |
MassIVEi | Q5JRA6 |
MaxQBi | Q5JRA6 |
PaxDbi | Q5JRA6 |
PeptideAtlasi | Q5JRA6 |
PRIDEi | Q5JRA6 |
ProteomicsDBi | 63078 [Q5JRA6-1] 63079 [Q5JRA6-2] 63080 [Q5JRA6-3] 63081 [Q5JRA6-4] |
PTM databases
GlyConnecti | 1498, 8 N-Linked glycans (3 sites) |
GlyGeni | Q5JRA6, 6 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q5JRA6 |
MetOSitei | Q5JRA6 |
PhosphoSitePlusi | Q5JRA6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000154305, Expressed in calcaneal tendon and 227 other tissues |
ExpressionAtlasi | Q5JRA6, baseline and differential |
Genevisiblei | Q5JRA6, HS |
Organism-specific databases
HPAi | ENSG00000154305, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MIA2 (PubMed:21525241).
Interacts (via SH3 domain) with COL7A1 (PubMed:19269366).
Interacts with the COPII coat subunits SEC23A, SEC23B and maybe SEC24C (PubMed:19269366, PubMed:27551091, PubMed:28442536). May interact with APOB and MIA2 (PubMed:27138255). Isoform 1 and isoform 4 interact with SEC16A (PubMed:28442536).
5 PublicationsBinary interactionsi
Hide detailsQ5JRA6
Isoform 2 [Q5JRA6-2]
With | #Exp. | IntAct |
---|---|---|
CEP55 [Q53EZ4] | 4 | EBI-10244342,EBI-747776 |
FXR2 [P51116] | 3 | EBI-10244342,EBI-740459 |
PRDM14 [Q9GZV8] | 3 | EBI-10244342,EBI-3957793 |
TRIM27 [P14373] | 3 | EBI-10244342,EBI-719493 |
Protein-protein interaction databases
BioGRIDi | 131952, 97 interactors |
CORUMi | Q5JRA6 |
IntActi | Q5JRA6, 48 interactors |
STRINGi | 9606.ENSP00000340900 |
Miscellaneous databases
RNActi | Q5JRA6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 107 | SH3PROSITE-ProRule annotationAdd BLAST | 63 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1211 – 1650 | Mediates interaction with MIA21 PublicationAdd BLAST | 440 | |
Regioni | 1751 – 1907 | Proline-rich domain (PRD); mediates interaction with the COPII coat subunits SEC23A and SEC23B3 PublicationsAdd BLAST | 157 | |
Regioni | 1788 – 1847 | SEC16A-interacting region (SIR); required for its localization to endoplasmic reticulum exit sites and for its interaction with SEC16A1 PublicationAdd BLAST | 60 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 471 – 531 | Sequence analysisAdd BLAST | 61 | |
Coiled coili | 1214 – 1396 | Sequence analysisAdd BLAST | 183 | |
Coiled coili | 1487 – 1639 | Sequence analysisAdd BLAST | 153 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1640 – 1890 | Pro-richAdd BLAST | 251 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH3 domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QS87, Eukaryota |
GeneTreei | ENSGT00950000182767 |
HOGENOMi | CLU_002106_1_0_1 |
InParanoidi | Q5JRA6 |
OMAi | APLMGDN |
OrthoDBi | 208382at2759 |
PhylomeDBi | Q5JRA6 |
TreeFami | TF333137 |
Family and domain databases
InterProi | View protein in InterPro IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF07653, SH3_2, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAPGLLVW LLVLRLPWRV PGQLDPSTGR RFSEHKLCAD DECSMLMYRG
60 70 80 90 100
EALEDFTGPD CRFVNFKKGD PVYVYYKLAR GWPEVWAGSV GRTFGYFPKD
110 120 130 140 150
LIQVVHEYTK EELQVPTDET DFVCFDGGRD DFHNYNVEEL LGFLELYNSA
160 170 180 190 200
ATDSEKAVEK TLQDMEKNPE LSKEREPEPE PVEANSEESD SVFSENTEDL
210 220 230 240 250
QEQFTTQKHH SHANSQANHA QGEQASFESF EEMLQDKLKV PESENNKTSN
260 270 280 290 300
SSQVSNEQDK IDAYKLLKKE MTLDLKTKFG STADALVSDD ETTRLVTSLE
310 320 330 340 350
DDFDEELDTE YYAVGKEDEE NQEDFDELPL LTFTDGEDMK TPAKSGVEKY
360 370 380 390 400
PTDKEQNSNE EDKVQLTVPP GIKNDDKNIL TTWGDTIFSI VTGGEETRDT
410 420 430 440 450
MDLESSSSEE EKEDDDDALV PDSKQGKPQS ATDYSDPDNV DDGLFIVDIP
460 470 480 490 500
KTNNDKEVNA EHHIKGKGRG VQESKRGLVQ DKTELEDENQ EGMTVHSSVH
510 520 530 540 550
SNNLNSMPAA EKGKDTLKSA YDDTENDLKG AAIHISKGML HEEKPGEQIL
560 570 580 590 600
EGGSESESAQ KAAGNQMNDR KIQQESLGSA PLMGDDHPNA SRDSVEGDAL
610 620 630 640 650
VNGAKLHTLS VEHQREELKE ELVLKTQNQP RFSSPDEIDL PRELEDEVPI
660 670 680 690 700
LGRNLPWQQE RDVAATASKQ MSEKIRLSEG EAKEDSLDEE FFHHKAMQGT
710 720 730 740 750
EVGQTDQTDS TGGPAFLSKV EEDDYPSEEL LEDENAINAK RSKEKNPGNQ
760 770 780 790 800
GRQFDVNLQV PDRAVLGTIH PDPEIEESKQ ETSMILDSEK TSETAAKGVN
810 820 830 840 850
TGGREPNTMV EKERPLADKK AQRPFERSDF SDSIKIQTPE LGEVFQNKDS
860 870 880 890 900
DYLKNDNPEE HLKTSGLAGE PEGELSKEDH ENTEKYMGTE SQGSAAAEPE
910 920 930 940 950
DDSFHWTPHT SVEPGHSDKR EDLLIISSFF KEQQSLQRFQ KYFNVHELEA
960 970 980 990 1000
LLQEMSSKLK SAQQESLPYN MEKVLDKVFR ASESQILSIA EKMLDTRVAE
1010 1020 1030 1040 1050
NRDLGMNENN IFEEAAVLDD IQDLIYFVRY KHSTAEETAT LVMAPPLEEG
1060 1070 1080 1090 1100
LGGAMEEMQP LHEDNFSREK TAELNVQVPE EPTHLDQRVI GDTHASEVSQ
1110 1120 1130 1140 1150
KPNTEKDLDP GPVTTEDTPM DAIDANKQPE TAAEEPASVT PLENAILLIY
1160 1170 1180 1190 1200
SFMFYLTKSL VATLPDDVQP GPDFYGLPWK PVFITAFLGI ASFAIFLWRT
1210 1220 1230 1240 1250
VLVVKDRVYQ VTEQQISEKL KTIMKENTEL VQKLSNYEQK IKESKKHVQE
1260 1270 1280 1290 1300
TRKQNMILSD EAIKYKDKIK TLEKNQEILD DTAKNLRVML ESEREQNVKN
1310 1320 1330 1340 1350
QDLISENKKS IEKLKDVISM NASEFSEVQI ALNEAKLSEE KVKSECHRVQ
1360 1370 1380 1390 1400
EENARLKKKK EQLQQEIEDW SKLHAELSEQ IKSFEKSQKD LEVALTHKDD
1410 1420 1430 1440 1450
NINALTNCIT QLNLLECESE SEGQNKGGND SDELANGEVG GDRNEKMKNQ
1460 1470 1480 1490 1500
IKQMMDVSRT QTAISVVEED LKLLQLKLRA SVSTKCNLED QVKKLEDDRN
1510 1520 1530 1540 1550
SLQAAKAGLE DECKTLRQKV EILNELYQQK EMALQKKLSQ EEYERQEREH
1560 1570 1580 1590 1600
RLSAADEKAV SAAEEVKTYK RRIEEMEDEL QKTERSFKNQ IATHEKKAHE
1610 1620 1630 1640 1650
NWLKARAAER AIAEEKREAA NLRHKLLELT QKMAMLQEEP VIVKPMPGKP
1660 1670 1680 1690 1700
NTQNPPRRGP LSQNGSFGPS PVSGGECSPP LTVEPPVRPL SATLNRRDMP
1710 1720 1730 1740 1750
RSEFGSVDGP LPHPRWSAEA SGKPSPSDPG SGTATMMNSS SRGSSPTRVL
1760 1770 1780 1790 1800
DEGKVNMAPK GPPPFPGVPL MSTPMGGPVP PPIRYGPPPQ LCGPFGPRPL
1810 1820 1830 1840 1850
PPPFGPGMRP PLGLREFAPG VPPGRRDLPL HPRGFLPGHA PFRPLGSLGP
1860 1870 1880 1890 1900
REYFIPGTRL PPPTHGPQEY PPPPAVRDLL PSGSRDEPPP ASQSTSQDCS
QALKQSP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MRH6 | A0A0A0MRH6_HUMAN | Transport and Golgi organization pr... | MIA3 | 1,015 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 46 | Missing in AAQ89449 (PubMed:12975309).Curated | 1 | |
Sequence conflicti | 1032 | H → R in BAC04810 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1443 | R → Q in AAH47116 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1754 | K → R in BAH12416 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032546 | 482 | K → E1 PublicationCorresponds to variant dbSNP:rs2936053Ensembl. | 1 | |
Natural variantiVAR_032547 | 605 | K → R. Corresponds to variant dbSNP:rs2936052Ensembl. | 1 | |
Natural variantiVAR_032548 | 881 | E → G1 PublicationCorresponds to variant dbSNP:rs2936051Ensembl. | 1 | |
Natural variantiVAR_032549 | 1659 | G → C1 PublicationCorresponds to variant dbSNP:rs17857325Ensembl. | 1 | |
Natural variantiVAR_032550 | 1723 | K → E1 PublicationCorresponds to variant dbSNP:rs17854428Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025860 | 1 – 1122 | Missing in isoform 4. 1 PublicationAdd BLAST | 1122 | |
Alternative sequenceiVSP_025861 | 493 – 500 | MTVHSSVH → FKTEPIKL in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_025862 | 501 – 1907 | Missing in isoform 3. 1 PublicationAdd BLAST | 1407 | |
Alternative sequenceiVSP_025863 | 1123 – 1159 | IDANK…YLTKS → MDSVPATVPSIAATPGDPEL VGPLSVLYAAFIAKLLE in isoform 4. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_025864 | 1304 – 1362 | Missing in isoform 2. 1 PublicationAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY359091 mRNA Translation: AAQ89449.1 AK096526 mRNA Translation: BAC04810.1 Different initiation. AK290335 mRNA Translation: BAF83024.1 Different initiation. AK296712 mRNA Translation: BAH12416.1 AL592148 Genomic DNA No translation available. D87742 mRNA Translation: BAA13448.1 L34688 mRNA Translation: AAB00324.1 DQ166034 mRNA Translation: AAZ95512.1 BC047116 mRNA Translation: AAH47116.2 |
CCDSi | CCDS41470.1 [Q5JRA6-1] CCDS73035.1 [Q5JRA6-4] |
RefSeqi | NP_001287796.1, NM_001300867.1 [Q5JRA6-4] NP_001310992.1, NM_001324063.1 [Q5JRA6-2] NP_940953.2, NM_198551.3 [Q5JRA6-1] |
Genome annotation databases
Ensembli | ENST00000340535; ENSP00000345866; ENSG00000154305 [Q5JRA6-4] ENST00000344922; ENSP00000340900; ENSG00000154305 [Q5JRA6-1] |
GeneIDi | 375056 |
KEGGi | hsa:375056 |
UCSCi | uc001hnl.4, human [Q5JRA6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY359091 mRNA Translation: AAQ89449.1 AK096526 mRNA Translation: BAC04810.1 Different initiation. AK290335 mRNA Translation: BAF83024.1 Different initiation. AK296712 mRNA Translation: BAH12416.1 AL592148 Genomic DNA No translation available. D87742 mRNA Translation: BAA13448.1 L34688 mRNA Translation: AAB00324.1 DQ166034 mRNA Translation: AAZ95512.1 BC047116 mRNA Translation: AAH47116.2 |
CCDSi | CCDS41470.1 [Q5JRA6-1] CCDS73035.1 [Q5JRA6-4] |
RefSeqi | NP_001287796.1, NM_001300867.1 [Q5JRA6-4] NP_001310992.1, NM_001324063.1 [Q5JRA6-2] NP_940953.2, NM_198551.3 [Q5JRA6-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5KYN | X-ray | 2.55 | C | 1796-1803 | [»] | |
5KYU | X-ray | 3.51 | C | 1796-1803 | [»] | |
5KYW | X-ray | 3.20 | C | 1800-1808 | [»] | |
SMRi | Q5JRA6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 131952, 97 interactors |
CORUMi | Q5JRA6 |
IntActi | Q5JRA6, 48 interactors |
STRINGi | 9606.ENSP00000340900 |
Protein family/group databases
TCDBi | 9.B.113.1.2, the collagen secretory protein, mia3 (mia3) family |
PTM databases
GlyConnecti | 1498, 8 N-Linked glycans (3 sites) |
GlyGeni | Q5JRA6, 6 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q5JRA6 |
MetOSitei | Q5JRA6 |
PhosphoSitePlusi | Q5JRA6 |
Genetic variation databases
BioMutai | MIA3 |
DMDMi | 74741823 |
Proteomic databases
EPDi | Q5JRA6 |
jPOSTi | Q5JRA6 |
MassIVEi | Q5JRA6 |
MaxQBi | Q5JRA6 |
PaxDbi | Q5JRA6 |
PeptideAtlasi | Q5JRA6 |
PRIDEi | Q5JRA6 |
ProteomicsDBi | 63078 [Q5JRA6-1] 63079 [Q5JRA6-2] 63080 [Q5JRA6-3] 63081 [Q5JRA6-4] |
Protocols and materials databases
Antibodypediai | 53971, 87 antibodies |
Genome annotation databases
Ensembli | ENST00000340535; ENSP00000345866; ENSG00000154305 [Q5JRA6-4] ENST00000344922; ENSP00000340900; ENSG00000154305 [Q5JRA6-1] |
GeneIDi | 375056 |
KEGGi | hsa:375056 |
UCSCi | uc001hnl.4, human [Q5JRA6-1] |
Organism-specific databases
CTDi | 375056 |
DisGeNETi | 375056 |
GeneCardsi | MIA3 |
HGNCi | HGNC:24008, MIA3 |
HPAi | ENSG00000154305, Low tissue specificity |
MIMi | 613455, gene |
neXtProti | NX_Q5JRA6 |
OpenTargetsi | ENSG00000154305 |
PharmGKBi | PA143485536 |
VEuPathDBi | HostDB:ENSG00000154305.16 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS87, Eukaryota |
GeneTreei | ENSGT00950000182767 |
HOGENOMi | CLU_002106_1_0_1 |
InParanoidi | Q5JRA6 |
OMAi | APLMGDN |
OrthoDBi | 208382at2759 |
PhylomeDBi | Q5JRA6 |
TreeFami | TF333137 |
Enzyme and pathway databases
PathwayCommonsi | Q5JRA6 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5694530, Cargo concentration in the ER R-HSA-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 375056, 11 hits in 988 CRISPR screens |
ChiTaRSi | MIA3, human |
GenomeRNAii | 375056 |
Pharosi | Q5JRA6, Tbio |
PROi | PR:Q5JRA6 |
RNActi | Q5JRA6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154305, Expressed in calcaneal tendon and 227 other tissues |
ExpressionAtlasi | Q5JRA6, baseline and differential |
Genevisiblei | Q5JRA6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF07653, SH3_2, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGO1_HUMAN | |
Accessioni | Q5JRA6Primary (citable) accession number: Q5JRA6 Secondary accession number(s): A8K2S0 Q92580 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | February 15, 2005 | |
Last modified: | April 7, 2021 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families