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Protein

Tctex1 domain-containing protein 4

Gene

TCTEX1D4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein phosphatase 1 binding Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Tctex1 domain-containing protein 4
Alternative name(s):
Protein N22.1
Tctex-2-beta
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000188396.3
HGNCiHGNC:32315 TCTEX1D4
MIMi611713 gene
neXtProtiNX_Q5JR98

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188396
PharmGKBiPA162405436

Polymorphism and mutation databases

BioMutaiTCTEX1D4
DMDMi74741821

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168721 – 221Tctex1 domain-containing protein 4Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5JR98
PeptideAtlasiQ5JR98
PRIDEiQ5JR98
ProteomicsDBi63077

PTM databases

iPTMnetiQ5JR98
PhosphoSitePlusiQ5JR98

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000188396 Expressed in 71 organ(s), highest expression level in right uterine tube
CleanExiHS_TCTEX1D4

Organism-specific databases

HPAiHPA062652

Interactioni

Subunit structurei

Interacts with ENG/endoglin, TGFBR2 and TGFBR3.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131262, 9 interactors
IntActiQ5JR98, 3 interactors
STRINGi9606.ENSP00000341803

Structurei

3D structure databases

ProteinModelPortaliQ5JR98
SMRiQ5JR98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4108 Eukaryota
ENOG4111RVM LUCA
GeneTreeiENSGT00530000063097
HOGENOMiHOG000154519
HOVERGENiHBG096850
InParanoidiQ5JR98
OMAiSYRTEPA
OrthoDBiEOG091G0PRF
PhylomeDBiQ5JR98
TreeFamiTF313904

Family and domain databases

Gene3Di3.30.1140.40, 1 hit
InterProiView protein in InterPro
IPR005334 Tctex
IPR038586 Tctex-1-like_sf
PANTHERiPTHR21255 PTHR21255, 1 hit
PfamiView protein in Pfam
PF03645 Tctex-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5JR98-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRPLPPGR QEEENAKDSG RKPSPVRPRG CLPSIDEARP AGPGPAPASR
60 70 80 90 100
RGSMLGLAAS FSRRNSLVGP GAGPGGQRPS LGPVPPLGSR VSFSGLPLAP
110 120 130 140 150
ARWVAPSYRT EPVPGERWEA ARAQRALEAA LAAGLHDACY SSDEAARLVR
160 170 180 190 200
ELCEQVHVRL RELSPPRYKL VCSVVLGPRA GQGVHVVSRA LWDVARDGLA
210 220
SVSYTNTSLF AVATVHGLYC E
Length:221
Mass (Da):23,353
Last modified:February 15, 2005 - v1
Checksum:i77A6BB803CC83373
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ132441 mRNA Translation: ABA06522.1
AL592166 Genomic DNA No translation available.
BC092499 mRNA Translation: AAH92499.1
CCDSiCCDS30699.1
RefSeqiNP_001013654.1, NM_001013632.3
XP_011539677.1, XM_011541375.2
XP_011539678.1, XM_011541376.2
UniGeneiHs.585137

Genome annotation databases

EnsembliENST00000339355; ENSP00000341803; ENSG00000188396
GeneIDi343521
KEGGihsa:343521
UCSCiuc057fwn.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ132441 mRNA Translation: ABA06522.1
AL592166 Genomic DNA No translation available.
BC092499 mRNA Translation: AAH92499.1
CCDSiCCDS30699.1
RefSeqiNP_001013654.1, NM_001013632.3
XP_011539677.1, XM_011541375.2
XP_011539678.1, XM_011541376.2
UniGeneiHs.585137

3D structure databases

ProteinModelPortaliQ5JR98
SMRiQ5JR98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131262, 9 interactors
IntActiQ5JR98, 3 interactors
STRINGi9606.ENSP00000341803

PTM databases

iPTMnetiQ5JR98
PhosphoSitePlusiQ5JR98

Polymorphism and mutation databases

BioMutaiTCTEX1D4
DMDMi74741821

Proteomic databases

PaxDbiQ5JR98
PeptideAtlasiQ5JR98
PRIDEiQ5JR98
ProteomicsDBi63077

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339355; ENSP00000341803; ENSG00000188396
GeneIDi343521
KEGGihsa:343521
UCSCiuc057fwn.1 human

Organism-specific databases

CTDi343521
EuPathDBiHostDB:ENSG00000188396.3
GeneCardsiTCTEX1D4
HGNCiHGNC:32315 TCTEX1D4
HPAiHPA062652
MIMi611713 gene
neXtProtiNX_Q5JR98
OpenTargetsiENSG00000188396
PharmGKBiPA162405436
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4108 Eukaryota
ENOG4111RVM LUCA
GeneTreeiENSGT00530000063097
HOGENOMiHOG000154519
HOVERGENiHBG096850
InParanoidiQ5JR98
OMAiSYRTEPA
OrthoDBiEOG091G0PRF
PhylomeDBiQ5JR98
TreeFamiTF313904

Miscellaneous databases

GenomeRNAii343521
PROiPR:Q5JR98
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188396 Expressed in 71 organ(s), highest expression level in right uterine tube
CleanExiHS_TCTEX1D4

Family and domain databases

Gene3Di3.30.1140.40, 1 hit
InterProiView protein in InterPro
IPR005334 Tctex
IPR038586 Tctex-1-like_sf
PANTHERiPTHR21255 PTHR21255, 1 hit
PfamiView protein in Pfam
PF03645 Tctex-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTC1D4_HUMAN
AccessioniPrimary (citable) accession number: Q5JR98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 15, 2005
Last modified: November 7, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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